Research output per year
Research output per year
- 1 - 50 out of 92 results
Search results
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2025
Repurposing of Agrochemicals as ATTRv Amyloidosis Inhibitors
Yokoyama, T., Fujiwara, S., Nishikubo, K., Mizuguchi, M., Nabeshima, Y., Toyooka, N., Okada, T. & Nakagawa, Y., 2025/01/23, In: Journal of Medicinal Chemistry. 68, 2, p. 1572-1586 15 p.Research output: Contribution to journal › Article › peer-review
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2024
Development of Benziodarone Analogues with Enhanced Potency for Selective Binding to Transthyretin in Human Plasma
Mizuguchi, M., Nakagawa, Y., Yokoyama, T., Okada, T., Fujii, K., Takahashi, K., Luan, N. N. T., Nabeshima, Y., Kanamitsu, K., Nakagawa, S., Yamakawa, S., Ueda, M., Ando, Y. & Toyooka, N., 2024/05/09, In: Journal of Medicinal Chemistry. 67, 9, p. 6987-7005 19 p.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Divergent Total Synthesis of Isoflavone Natural Products and Their Potential as Therapeutic Agents for TTR Amyloidosis
Thanh Luan, N. N., Okada, T., Yokoyama, T., Suzuki, M., Nabeshima, Y., Mizuguchi, M. & Toyooka, N., 2024/11/22, In: Journal of Natural Products. 87, 11, p. 2604-2614 11 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Enzymatic activity of cGAS in the presence of three types of DNAs: limited cGAS stimulation by single-stranded HIV-1 SL2 DNA
Mizuguchi, M., Kyan, N., Nishimata, S., Nabeshima, Y. & Obita, T., 2024/04, In: Bioscience Reports. 44, 4, BSR20240269.Research output: Contribution to journal › Article › peer-review
Open Access -
SIRT5 mutants reveal the role of conserved asparagine and glutamine residues in the NAD+-binding pocket
Yokoyama, T., Takayama, Y., Mizuguchi, M., Nabeshima, Y. & Kusaka, K., 2024/09, In: FEBS Letters. 598, 18, p. 2269-2280 12 p.Research output: Contribution to journal › Article › peer-review
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Structural insights into rapamycin-induced oligomerization of a FRB–FKBP fusion protein
Inobe, T., Sakaguchi, R., Obita, T., Mukaiyama, A., Koike, S., Yokoyama, T., Mizuguchi, M. & Akiyama, S., 2024/09, In: FEBS Letters. 598, 18, p. 2292-2305 14 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Trypsin-induced aggregation of transthyretin Valine 30 variants associated with hereditary amyloidosis
Mizuguchi, M., Obita, T., Yamada, S. & Nabeshima, Y., 2024/04, In: FEBS Journal. 291, 8, p. 1732-1743 12 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
2023
Benziodarone and 6-hydroxybenziodarone are potent and selective inhibitors of transthyretin amyloidogenesis
Mizuguchi, M., Yokoyama, T., Okada, T., Nakagawa, Y., Fujii, K., Nabeshima, Y. & Toyooka, N., 2023/07/15, In: Bioorganic and Medicinal Chemistry. 90, 117370.Research output: Contribution to journal › Article › peer-review
7 Scopus citations -
Design, synthesis, structure–activity relationship studies, and evaluation of novel GLS1 inhibitors
Jo, M., Koizumi, K., Suzuki, M., Kanayama, D., Watanabe, Y., Gouda, H., Mori, H., Mizuguchi, M., Obita, T., Nabeshima, Y., Toyooka, N. & Okada, T., 2023/05/01, In: Bioorganic and Medicinal Chemistry Letters. 87, 129266.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
Design and structural optimization of thiadiazole derivatives with potent GLS1 inhibitory activity
Okada, T., Yamabe, K., Jo, M., Sakajiri, Y., Shibata, T., Sawada, R., Yamanishi, Y., Kanayama, D., Mori, H., Mizuguchi, M., Obita, T., Nabeshima, Y., Koizumi, K. & Toyooka, N., 2023/09/01, In: Bioorganic and Medicinal Chemistry Letters. 93, 129438.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Rafoxanide, a salicylanilide anthelmintic, interacts with human plasma protein transthyretin
Yokoyama, T., Mizuguchi, M., Nabeshima, Y., Nakagawa, Y., Okada, T., Toyooka, N. & Kusaka, K., 2023/11, In: FEBS Journal. 290, 21, p. 5158-5170 13 p.Research output: Contribution to journal › Article › peer-review
5 Scopus citations -
Resveratrol Derivatives Inhibit Transthyretin Fibrillization: Structural Insights into the Interactions between Resveratrol Derivatives and Transthyretin
Yokoyama, T., Kusaka, K., Mizuguchi, M., Nabeshima, Y. & Fujiwara, S., 2023/11/23, In: Journal of Medicinal Chemistry. 66, 22, p. 15511-15523 13 p.Research output: Contribution to journal › Article › peer-review
6 Scopus citations -
Structural and mutational analyses of decarboxylated osteocalcin provide insight into its adiponectin-inducing activity
Mizuguchi, M., Yokoyama, T., Otani, T., Kuribara, S., Nabeshima, Y., Obita, T., Hirata, M. & Kawano, K., 2023/06, In: FEBS Letters. 597, 11, p. 1479-1488 10 p.Research output: Contribution to journal › Article › peer-review
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2022
Determination of Hardness of a Pharmaceutical Oral Jelly by Using T2 Relaxation Behavior Measured by Time-Domain NMR
Tsuji, T., Kobayashi, R., Hayashi, Y., Kumada, S., Mizuguchi, M., Okada, K. & Onuki, Y., 2022/08/01, In: Chemical and Pharmaceutical Bulletin. 70, 8, p. 558-565 8 p.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
The hydrophobic residue Leu73 is crucial for the high stability and low aggregation properties of murine transthyretin
Nakagawa, M., Obita, T. & Mizuguchi, M., 2022/09, In: Biochemical Journal. 479, 18, p. 1999-2011 13 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
2021
A chalcone derivative suppresses TSLP induction in mice and human keratinocytes through binding to BET family proteins
Segawa, R., Takeda, H., Yokoyama, T., Ishida, M., Miyata, C., Saito, T., Ishihara, R., Nakagita, T., Sasano, Y., Kanoh, N., Iwabuchi, Y., Mizuguchi, M., Hiratsuka, M. & Hirasawa, N., 2021/12, In: Biochemical Pharmacology. 194, 114819.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
A low amyloidogenic E61K transthyretin mutation may cause familial amyloid polyneuropathy
Murakami, T., Yokoyama, T., Mizuguchi, M., Toné, S., Takaku, S., Sango, K., Nishimura, H., Watabe, K. & Sunada, Y., 2021/03, In: Journal of Neurochemistry. 156, 6, p. 957-966 10 p.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
Crystal structure of death-associated protein kinase 1 in complex with the dietary compound resveratrol
Yokoyama, T., Suzuki, R. & Mizuguchi, M., 2021, In: IUCrJ. 8, p. 131-138 8 p.Research output: Contribution to journal › Article › peer-review
Open Access11 Scopus citations -
Expression of SOLOIST/MRTFB i4, a novel neuronal isoform of the mouse serum response factor coactivator myocardin-related transcription factor-B, negatively regulates dendritic complexity in cortical neurons
Ishibashi, Y., Shoji, S., Ihara, D., Kubo, Y., Tanaka, T., Tanabe, H., Hakamata, T., Miyata, T., Satou, N., Sakagami, H., Mizuguchi, M., Kikuchi, K., Fukuchi, M., Tsuda, M., Takasaki, I. & Tabuchi, A., 2021/11, In: Journal of Neurochemistry. 159, 4, p. 762-777 16 p.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
Inhibitory activities of anthraquinone and xanthone derivatives against transthyretin amyloidogenesis
Kitakami, R., Inui, K., Nakagawa, Y., Sawai, Y., Katayama, W., Yokoyama, T., Okada, T., Kanamitsu, K., Nakagawa, S., Toyooka, N. & Mizuguchi, M., 2021/08/15, In: Bioorganic and Medicinal Chemistry. 44, 116292.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
Repositioning of the Anthelmintic Drugs Bithionol and Triclabendazole as Transthyretin Amyloidogenesis Inhibitors
Yokoyama, T., Kashihara, M. & Mizuguchi, M., 2021/10/14, In: Journal of Medicinal Chemistry. 64, 19, p. 14344-14357 14 p.Research output: Contribution to journal › Article › peer-review
11 Scopus citations -
Structural and dynamics analysis of intrinsically disordered proteins by high-speed atomic force microscopy
Kodera, N., Noshiro, D., Dora, S. K., Mori, T., Habchi, J., Blocquel, D., Gruet, A., Dosnon, M., Salladini, E., Bignon, C., Fujioka, Y., Oda, T., Noda, N. N., Sato, M., Lotti, M., Mizuguchi, M., Longhi, S. & Ando, T., 2021/02, In: Nature Nanotechnology. 16, 2, p. 181-189 9 p.Research output: Contribution to journal › Article › peer-review
79 Scopus citations -
Tau activates microglia via the PQBP1-cGAS-STING pathway to promote brain inflammation
Jin, M., Shiwaku, H., Tanaka, H., Obita, T., Ohuchi, S., Yoshioka, Y., Jin, X., Kondo, K., Fujita, K., Homma, H., Nakajima, K., Mizuguchi, M. & Okazawa, H., 2021/12, In: Nature Communications. 12, 1, 6565.Research output: Contribution to journal › Article › peer-review
Open Access131 Scopus citations -
2020
Neutron diffraction experiment with the Y116S variant of transthyretin using iBIX at J-PARC: Application of a new integration method
Kusaka, K., Yokoyama, T., Yamada, T., Yano, N., Tanaka, I. & Mizuguchi, M., 2020/11/01, In: Acta Crystallographica Section D: Structural Biology. 76, p. 1050-1056 7 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
New cytotoxic polyacetylene alcohols from the Egyptian marine sponge Siphonochalina siphonella
Ki, D. W., El-Desoky, A. H., Wong, C. P., Abdel-Ghani, M., El-Beih, A. A., Mizuguchi, M. & Morita, H., 2020/03/01, In: Natural Medicines. 74, 2, p. 409-414 6 p.Research output: Contribution to journal › Article › peer-review
12 Scopus citations -
New cytotoxic polyacetylene amides from the Egyptian marine sponge Siphonochalina siphonella
Ki, D. W., El-Desoky, A. H., Kodama, T., Wong, C. P., Ghani, M. A., El-Beih, A. A., Mizuguchi, M. & Morita, H., 2020/04, In: Fitoterapia. 142, 104511.Research output: Contribution to journal › Article › peer-review
13 Scopus citations -
Structural and thermodynamic analyses of interactions between death-associated protein kinase 1 and anthraquinones
Yokoyama, T., Wijaya, P., Kosaka, Y. & Mizuguchi, M., 2020/05/01, In: Acta Crystallographica Section D: Structural Biology. 76, p. 438-446 9 p.Research output: Contribution to journal › Article › peer-review
9 Scopus citations -
2019
Crown Ethers as Transthyretin Amyloidogenesis Inhibitors
Yokoyama, T. & Mizuguchi, M., 2019/02/28, In: Journal of Medicinal Chemistry. 62, 4, p. 2076-2082 7 p.Research output: Contribution to journal › Article › peer-review
24 Scopus citations -
Discovery of a new class of MTH1 inhibitor by X-ray crystallographic screening
Yokoyama, T., Kitakami, R. & Mizuguchi, M., 2019/04/01, In: European Journal of Medicinal Chemistry. 167, p. 153-160 8 p.Research output: Contribution to journal › Article › peer-review
15 Scopus citations -
Structural and thermodynamic characterization of the binding of isoliquiritigenin to the first bromodomain of BRD4
Yokoyama, T., Matsumoto, K., Ostermann, A., Schrader, T. E., Nabeshima, Y. & Mizuguchi, M., 2019/05, In: FEBS Journal. 286, 9, p. 1656-1667 12 p.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
Transthyretin Amyloid Fibril Disrupting Activities of Extracts and Fractions from Juglans mandshurica Maxim. Var. Cordiformis (Makino) Kitam.
Chaudhary, N., Sasaki, R., Shuto, T., Watanabe, M., Kawahara, T., Suico, M. A., Yokoyama, T., Mizuguchi, M., Kai, H. & Devkota, H. P., 2019/01/30, In: Molecules. 24, 3, , 500.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
2018
Design, synthesis, and evaluation of novel inhibitors for wild-type human serine racemase
Takahara, S., Nakagawa, K., Uchiyama, T., Yoshida, T., Matsumoto, K., Kawasumi, Y., Mizuguchi, M., Obita, T., Watanabe, Y., Hayakawa, D., Gouda, H., Mori, H. & Toyooka, N., 2018/02/01, In: Bioorganic and Medicinal Chemistry Letters. 28, 3, p. 441-445 5 p.Research output: Contribution to journal › Article › peer-review
12 Scopus citations -
Inhibition of the amyloidogenesis of transthyretin by natural products and synthetic compounds
Yokoyama, T. & Mizuguchi, M., 2018, In: Biological and Pharmaceutical Bulletin. 41, 7, p. 979-984 6 p.Research output: Contribution to journal › Article › peer-review
Open Access16 Scopus citations -
2017
A novel serine racemase inhibitor suppresses neuronal over-activation in vivo
Mori, H., Wada, R., Takahara, S., Horino, Y., Izumi, H., Ishimoto, T., Yoshida, T., Mizuguchi, M., Obita, T., Gouda, H., Hirono, S. & Toyooka, N., 2017, In: Bioorganic and Medicinal Chemistry. 25, 14, p. 3736-3745 10 p.Research output: Contribution to journal › Article › peer-review
13 Scopus citations -
Large-scale crystallization and neutron crystallographic analysis of HSP70 in complex with ADP
Yokoyama, T., Ostermann, A., Schrader, T. E. & Mizuguchi, M., 2017/10, In: Acta Crystallographica Section:F Structural Biology Communications. 73, 10, p. 555-559 5 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Stability and crystal structures of His88 mutant human transthyretins
Yokoyama, T., Hanawa, Y., Obita, T. & Mizuguchi, M., 2017/07/01, In: FEBS Letters. 591, 13, p. 1862-1871 10 p.Research output: Contribution to journal › Article › peer-review
Open Access15 Scopus citations -
2016
Allosteric modulation of the binding affinity between PQBP1 and the spliceosomal protein U5-15kD
Mizuguchi, M., Obita, T., Kajiyama, A., Kozakai, Y., Nakai, T., Nabeshima, Y. & Okazawa, H., 2016/07/01, In: FEBS Letters. p. 2221-2231 11 p.Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations -
Characterization of the interaction between Trypanosoma brucei Pex5p and its receptor Pex14p
Watanabe, Y., Kawaguchi, K., Okuyama, N., Sugawara, Y., Obita, T., Mizuguchi, M., Morita, M. & Imanaka, T., 2016/01/01, In: FEBS Letters. 590, 2, p. 242-250 9 p.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
Crystal Structure of Human General Transcription Factor TFIIE at Atomic Resolution
Miwa, K., Kojima, R., Obita, T., Ohkuma, Y., Tamura, Y. & Mizuguchi, M., 2016/10/23, In: Journal of Molecular Biology. 428, 21, p. 4258-4266 9 p.Research output: Contribution to journal › Article › peer-review
15 Scopus citations -
Structural Fine-Tuning of MIT-Interacting Motif 2 (MIM2) and Allosteric Regulation of ESCRT-III by Vps4 in Yeast
Kojima, R., Obita, T., Onoue, K. & Mizuguchi, M., 2016/06/05, In: Journal of Molecular Biology. 428, 11, p. 2392-2404 13 p.Research output: Contribution to journal › Article › peer-review
12 Scopus citations -
2015
Discovery of γ-Mangostin as an Amyloidogenesis Inhibitor
Yokoyama, T., Ueda, M., Ando, Y. & Mizuguchi, M., 2015/08/27, In: Scientific Reports. 5, 13570.Research output: Contribution to journal › Article › peer-review
Open Access26 Scopus citations -
Frameshift mutations in the PQBP1 gene prevent its interaction with the splicing factor U5-15kD
Mizuguchi, M., 2015, In: Seikagaku. 87, 4, p. 478-480 3 p.Research output: Contribution to journal › Article › peer-review
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Phenolic compounds prevent the oligomerization of α-synuclein and reduce synaptic toxicity
Takahashi, R., Ono, K., Takamura, Y., Mizuguchi, M., Ikeda, T., Nishijo, H. & Yamada, M., 2015/09/01, In: Journal of Neurochemistry. 134, 5, p. 943-955 13 p.Research output: Contribution to journal › Article › peer-review
Open Access90 Scopus citations -
Protonation State and Hydration of Bisphosphonate Bound to Farnesyl Pyrophosphate Synthase
Yokoyama, T., Mizuguchi, M., Ostermann, A., Kusaka, K., Niimura, N., Schrader, T. E. & Tanaka, I., 2015/09/24, In: Journal of Medicinal Chemistry. 58, 18, p. 7549-7556 8 p.Research output: Contribution to journal › Article › peer-review
26 Scopus citations -
Structural Insight into the Interactions between Death-Associated Protein Kinase 1 and Natural Flavonoids
Yokoyama, T., Kosaka, Y. & Mizuguchi, M., 2015/09/24, In: Journal of Medicinal Chemistry. 58, 18, p. 7400-7408 9 p.Research output: Contribution to journal › Article › peer-review
69 Scopus citations -
Structural stabilization of transthyretin by a new compound, 6-benzoyl-2-hydroxy-1H-benzo[de]isoquinoline-1,3(2H)-dione
Yokoyama, T., Takaki, S., Chosa, K., Sato, T., Suico, M. A., Teranishi, Y., Shuto, T., Mizuguchi, M. & Kai, H., 2015/12, In: Journal of Pharmacological Sciences. 129, 4, p. 240-243 4 p.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
2014
Crystallization and preliminary neutron diffraction experiment of human farnesyl pyrophosphate synthase complexed with risedronate
Yokoyama, T., Ostermann, A., Mizuguchi, M., Niimura, N., Schrader, T. E. & Tanaka, I., 2014/04, In: Acta Crystallographica Section:F Structural Biology Communications. 70, 4, p. 470-472 3 p.Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations -
Crystal structures of human transthyretin complexed with glabridin
Yokoyama, T., Kosaka, Y. & Mizuguchi, M., 2014/02/13, In: Journal of Medicinal Chemistry. 57, 3, p. 1090-1096 7 p.Research output: Contribution to journal › Article › peer-review
32 Scopus citations -
Exogenous amyloidogenic proteins function as seeds in amyloid β-protein aggregation
Ono, K., Takahashi, R., Ikeda, T., Mizuguchi, M., Hamaguchi, T. & Yamada, M., 2014/04, In: Biochimica et Biophysica Acta - Molecular Basis of Disease. 1842, 4, p. 646-653 8 p.Research output: Contribution to journal › Article › peer-review
Open Access67 Scopus citations -
Inhibitory activities of propolis and its promising component, caffeic acid phenethyl ester, against amyloidogenesis of human transthyretin
Yokoyama, T., Kosaka, Y. & Mizuguchi, M., 2014/11/13, In: Journal of Medicinal Chemistry. 57, 21, p. 8928-8935 8 p.Research output: Contribution to journal › Article › peer-review
42 Scopus citations