Projects per year
Personal profile
Campus career
機能性分子創成変換システム学系 教授 2010/04/01-2019/09/30
生命工学科（廃止） 教授 2010/04/01-2018/03/31
大学院生命融合科学教育部 部長（学部長含む） 2017/04/01-2019/03/31
工学科 教授 2018/04/01-2019/09/30
工学系 教授 2019/10/01-
工学科 教授 2019/10/01-
工学部工学科 基幹教員
学部運営への参画状況・・・有-教授会他
担当授業科目に係る状況・・・主要授業科目担当
生命工学科（廃止） 教授 2010/04/01-2018/03/31
大学院生命融合科学教育部 部長（学部長含む） 2017/04/01-2019/03/31
工学科 教授 2018/04/01-2019/09/30
工学系 教授 2019/10/01-
工学科 教授 2019/10/01-
工学部工学科 基幹教員
学部運営への参画状況・・・有-教授会他
担当授業科目に係る状況・・・主要授業科目担当
Research biography
AKR阻害剤の開発研究 共同研究 期間：2010/04－
PAC1受容体アンタゴニストの創薬研究 ライフサイエンス基礎科学研究 期間：2014/04－
SHIP2阻害剤の開発研究 共同研究 期間：2010/04－
フコシダーゼ、ラムノシダーゼ阻害剤の開発研究 共同研究 期間：2009/04－
運動学習能力を指標とした新規中枢神経作用薬 共同研究 期間：2012/04－
栄養飢餓耐性解除に基づく新規すい臓がん治療薬の開発研究 共同研究 期間：2010/04－
新規糖尿病治療薬の開発研究 共同研究 期間：2010/04－
毒ガエルアルカロイド類の合成とニコチン受容体抑制活性評価 基礎科学研究 期間：2002/04－
PAC1受容体アンタゴニストの創薬研究 ライフサイエンス基礎科学研究 期間：2014/04－
SHIP2阻害剤の開発研究 共同研究 期間：2010/04－
フコシダーゼ、ラムノシダーゼ阻害剤の開発研究 共同研究 期間：2009/04－
運動学習能力を指標とした新規中枢神経作用薬 共同研究 期間：2012/04－
栄養飢餓耐性解除に基づく新規すい臓がん治療薬の開発研究 共同研究 期間：2010/04－
新規糖尿病治療薬の開発研究 共同研究 期間：2010/04－
毒ガエルアルカロイド類の合成とニコチン受容体抑制活性評価 基礎科学研究 期間：2002/04－
Qualification
薬剤師
Affiliated academic society
日本薬学会 所属期間：1984/04-
有機合成化学協会 所属期間：2000/04-
有機合成化学協会 所属期間：2000/04-
Research interests
Drug discovery based upon organic synthesis
Field of expertise (Grants-in-aid for Scientific Research classification)
- Organic chemistry
- Medical pharmacy
Fingerprint
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- 6 Similar Profiles
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Research and development of autophagy-specific inhibitors
Toyooka, N. (Principal Investigator) & 遠藤智史 (Co-Investigator(Kenkyū-buntansha))
Japan Society for the Promotion of Science
2023/04/01 → 2026/03/31
Project: Research Project
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脳クレアチン供給を実現するモノカルボン酸輸送体認識型プロドラッグ開発とその有用性
Hosoya, K.-I. (Principal Investigator), 正憲立川 (Co-Investigator(Kenkyū-buntansha)), Toyooka, N. (Co-Investigator(Kenkyū-buntansha)) & Akanuma, S.-I. (Co-Investigator(Kenkyū-buntansha))
Japan Society for the Promotion of Science
2023/04/01 → 2026/03/31
Project: Research Project
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Studies on novel insulin-sensitizing agent based on SHIP2 inhibitors
Toyooka, N. (PI), Sasaoka, T. (CoI), Wada, T. (CoI) & Goda, H. H. (CoI)
2015/04/01 → 2018/03/31
Project: Research
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Elucidation of the mechanisms of chronic pain by PAC1 receptor and drug discovery.
Takasaki, I. (PI), Kurihara, T. (CoI), Toyooka, N. (CoI) & Gouda, H. (CoI)
2014/04/01 → 2017/03/31
Project: Research
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Analysis of D-serine dynamics in the brain and development of novel drugs against excitotoxicity
Mori, H. (PI) & Toyooka, N. (CoI)
2013/04/01 → 2016/03/31
Project: Research
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Construction of trans-2,6-Disubstituted Piperidine Skeleton and Its Application to the Total Synthesis of (−)-Myrtine and trans-Piperidine-Type Poison-Frog Alkaloids
Okada, T., Eguchi, K., Hasegawa, F., Ikhlaq, M. M., Yoshikawa, T. & Toyooka, N., 2025/02/21, In: Journal of Organic Chemistry. 90, 7, p. 2749-2759 11 p.Research output: Contribution to journal › Article › peer-review
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Repurposing of Agrochemicals as ATTRv Amyloidosis Inhibitors
Yokoyama, T., Fujiwara, S., Nishikubo, K., Mizuguchi, M., Nabeshima, Y., Toyooka, N., Okada, T. & Nakagawa, Y., 2025/01/23, In: Journal of Medicinal Chemistry. 68, 2, p. 1572-1586 15 p.Research output: Contribution to journal › Article › peer-review
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Spinal pituitary adenylate cyclase-activating polypeptide and PAC1 receptor signaling system is involved in the oxaliplatin-induced acute cold allodynia in mice
Takasaki, I., Nagashima, R., Ueda, T., Ashihara, Y., Nakamachi, T., Okada, T., Toyooka, N., Miyata, A. & Kurihara, T., 2025/02, In: Journal of Pain. 27, 104751.Research output: Contribution to journal › Article › peer-review
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Characterization of Tumor-Infiltrating Lymphocyte-Derived Atypical TCRs Recognizing Breast Cancer in an MR1-Dependent Manner
Hayee, A., Kobayashi, E., Motozono, C., Hamana, H., My, H. T. V., Okada, T., Toyooka, N., Yamaguchi, S., Ozawa, T. & Kishi, H., 2024/10, In: Cells. 13, 20, 1711.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Development of Benziodarone Analogues with Enhanced Potency for Selective Binding to Transthyretin in Human Plasma
Mizuguchi, M., Nakagawa, Y., Yokoyama, T., Okada, T., Fujii, K., Takahashi, K., Luan, N. N. T., Nabeshima, Y., Kanamitsu, K., Nakagawa, S., Yamakawa, S., Ueda, M., Ando, Y. & Toyooka, N., 2024/05/09, In: Journal of Medicinal Chemistry. 67, 9, p. 6987-7005 19 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations
Datasets
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Crystal structure of V30M-TTR in complex with naringenin derivative-14
Mizuguchi, M. (Contributor), Nakagawa, Y. (Contributor), Inui, K. (Contributor), Katayama, W. (Contributor), Sawai, Y. (Contributor), Shimane, A. (Contributor), Kitakami, R. (Contributor), Okada, T. (Contributor), Nabeshima, Y. (Contributor), Yokoyama, T. (Contributor), Kanamitsu, K. (Contributor), Nakagawa, S. (Contributor) & Toyooka, N. (Contributor), Protein Data Bank (PDB), 2022/12/14
DOI: 10.2210/pdb7W9Q/pdb, https://www.wwpdb.org/pdb?id=pdb_00007w9q
Dataset
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CCDC 163035: Experimental Crystal Structure Determination
Toyooka, N. (Creator), Nagaoka, M. (Creator), Kakuda, H. (Creator) & Nemoto, H. (Creator), Cambridge Crystallographic Data Centre, 2002
DOI: 10.5517/cc5gn6g, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/cc5gn6g&sid=DataCite
Dataset
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Crystal structures of AKR1C3 ternary complex with NADP+ and the chromene derivative 2j
Endo, S. (Contributor), Oguri, H. (Contributor), Segawa, J. (Contributor), Kawai, M. (Contributor), Hu, D. (Contributor), Xia, S. (Contributor), Okada, T. (Contributor), Irie, K. (Contributor), Fujii, S. (Contributor), Gouda, H. (Contributor), Iguchi, K. (Contributor), Matsukawa, T. (Contributor), Fujimoto, N. (Contributor), Nakayama, T. (Contributor), Toyooka, N. (Contributor), Matsunaga, T. (Contributor) & Ikari, A. (Contributor), Protein Data Bank (PDB), 2020/09/23
DOI: 10.2210/pdb7C7G/pdb, https://www.wwpdb.org/pdb?id=pdb_00007c7g
Dataset
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Crystal structures of AKR1C3 ternary complex with NADP+ and the chromene derivative 2l
Endo, S. (Contributor), Oguri, H. (Contributor), Segawa, J. (Contributor), Kawai, M. (Contributor), Hu, D. (Contributor), Xia, S. (Contributor), Okada, T. (Contributor), Irie, K. (Contributor), Fujii, S. (Contributor), Gouda, H. (Contributor), Iguchi, K. (Contributor), Matsukawa, T. (Contributor), Fujimoto, N. (Contributor), Nakayama, T. (Contributor), Toyooka, N. (Contributor), Matsunaga, T. (Contributor) & Ikari, A. (Contributor), Protein Data Bank (PDB), 2020/09/23
DOI: 10.2210/pdb7C7H/pdb, https://www.wwpdb.org/pdb?id=pdb_00007c7h
Dataset
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Crystal structure of V30M-TTR in complex with naringenin derivative-18
Mizuguchi, M. (Contributor), Nakagawa, Y. (Contributor), Inui, K. (Contributor), Katayama, W. (Contributor), Sawai, Y. (Contributor), Shimane, A. (Contributor), Kitakami, R. (Contributor), Okada, T. (Contributor), Nabeshima, Y. (Contributor), Yokoyama, T. (Contributor), Kanamitsu, K. (Contributor), Nakagawa, S. (Contributor) & Toyooka, N. (Contributor), Protein Data Bank (PDB), 2022/12/14
DOI: 10.2210/pdb7W9R/pdb, https://www.wwpdb.org/pdb?id=pdb_00007w9r
Dataset
Prizes
Activities
- 5 Oral presentation
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Total synthesis of poison-frog alkaloids ent-cis-195A and 211A
Toyooka, N. (Speaker)
2016/09/12 → 2016/09/13Activity: Talk or presentation › Oral presentation
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Stereodivergent Synthesis of Decahydroquinoline-Type Poison Frog Alkaloids II
Toyooka, N. (Speaker)
2015/08/23 → 2015/08/28Activity: Talk or presentation › Oral presentation
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Laboratory and practical synthesis of Suvorexant, a selective dual orexin receptor antagonist
Toyooka, N. (Speaker)
2015/08/23 → 2015/08/28Activity: Talk or presentation › Oral presentation
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Stereodivergent Synthesis of Decahydroquinoline-Type Poison Frog Alkaloids I
Toyooka, N. (Speaker)
2015/08/23 → 2015/08/28Activity: Talk or presentation › Oral presentation
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Synthesis of Poison-Frog Alkaloids
Toyooka, N. (Speaker)
2015/08/23 → 2015/08/28Activity: Talk or presentation › Oral presentation
Courses
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データサイエンス特論
Movshuk, O., Fujita, Y., Chujo, D., Toyooka, N., Misawa, T., Haruki, T., Nagaoka, R. & Oku, M. 2024/10/02 → 2024/12/03
Course
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