Projects per year
Personal profile
Campus career
創薬科学科 教授 2009/04/01-2019/09/30
生命分子薬学系 教授 2009/04/01-2019/09/30
大学院生命融合科学教育部 部長（学部長含む） 2015/04/01-2017/03/31
薬学・和漢系 教授 2019/10/01-
創薬科学科 教授 2019/10/01-
薬学部創薬科学科 基幹教員
学部運営への参画状況・・・有-教授会他
担当授業科目に係る状況・・・主要授業科目担当
生命分子薬学系 教授 2009/04/01-2019/09/30
大学院生命融合科学教育部 部長（学部長含む） 2015/04/01-2017/03/31
薬学・和漢系 教授 2019/10/01-
創薬科学科 教授 2019/10/01-
薬学部創薬科学科 基幹教員
学部運営への参画状況・・・有-教授会他
担当授業科目に係る状況・・・主要授業科目担当
Affiliated academic society
日本アミロイドーシス学会 所属期間：2018/08/25-
Research interests
Structural Biology of Disease Mechanism
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research Fields, Keywords
- Structural Biology
- Protein Science
- Biophysics
Field of expertise (Grants-in-aid for Scientific Research classification)
- Biophysics
- Structural biochemistry
- Physical pharmacy
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
Projects
- 9 Finished
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自然免疫に重要なcGASを活性化するZCCHC3の作用機構の解明
Mizuguchi, M. (Principal Investigator) & Obita, T. (Co-Investigator(Kenkyū-buntansha))
Japan Society for the Promotion of Science
2022/04/01 → 2025/03/31
Project: Research Project
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PQBP1はcGASによるI型インターフェロンの発現誘導をどのように抑制するのか
Mizuguchi, M. (PI) & Obita, T. (CoI)
2019/04/01 → 2022/03/31
Project: Research
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Elucidation of the splicing regulatory function of an intrinsically disordered protein PQBP1
Mizuguchi, M. (PI) & Obita, T. (CoI)
2015/04/01 → 2018/03/31
Project: Research
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Verification of the connector function of the transcription and splicing factor PQBP1
Mizuguchi, M. (PI) & Obita, T. (CoI)
2012/04/01 → 2015/03/31
Project: Research
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精神遅滞関連蛋白質ＰＱＢＰ－１の揺らぎと機能の解明
Mizuguchi, M. (Principal Investigator)
Japan Society for the Promotion of Science
2011/04/01 → 2013/03/31
Project: Public
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Repurposing of Agrochemicals as ATTRv Amyloidosis Inhibitors
Yokoyama, T., Fujiwara, S., Nishikubo, K., Mizuguchi, M., Nabeshima, Y., Toyooka, N., Okada, T. & Nakagawa, Y., 2025/01/23, In: Journal of Medicinal Chemistry. 68, 2, p. 1572-1586 15 p.Research output: Contribution to journal › Article › peer-review
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Development of Benziodarone Analogues with Enhanced Potency for Selective Binding to Transthyretin in Human Plasma
Mizuguchi, M., Nakagawa, Y., Yokoyama, T., Okada, T., Fujii, K., Takahashi, K., Luan, N. N. T., Nabeshima, Y., Kanamitsu, K., Nakagawa, S., Yamakawa, S., Ueda, M., Ando, Y. & Toyooka, N., 2024/05/09, In: Journal of Medicinal Chemistry. 67, 9, p. 6987-7005 19 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Divergent Total Synthesis of Isoflavone Natural Products and Their Potential as Therapeutic Agents for TTR Amyloidosis
Thanh Luan, N. N., Okada, T., Yokoyama, T., Suzuki, M., Nabeshima, Y., Mizuguchi, M. & Toyooka, N., 2024/11/22, In: Journal of Natural Products. 87, 11, p. 2604-2614 11 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Does the structure of transthyretin amyloid fibrils vary depending on the organ of accumulation?
Mizuguchi, M., 2024/12/05, In: Structure. 32, 12, p. 2181-2182 2 p.Research output: Contribution to journal › Comment/debate
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Enzymatic activity of cGAS in the presence of three types of DNAs: limited cGAS stimulation by single-stranded HIV-1 SL2 DNA
Mizuguchi, M., Kyan, N., Nishimata, S., Nabeshima, Y. & Obita, T., 2024/04, In: Bioscience Reports. 44, 4, BSR20240269.Research output: Contribution to journal › Article › peer-review
Open Access
Datasets
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Crystal structure of V30M-TTR in complex with naringenin derivative-14
Mizuguchi, M. (Contributor), Nakagawa, Y. (Contributor), Inui, K. (Contributor), Katayama, W. (Contributor), Sawai, Y. (Contributor), Shimane, A. (Contributor), Kitakami, R. (Contributor), Okada, T. (Contributor), Nabeshima, Y. (Contributor), Yokoyama, T. (Contributor), Kanamitsu, K. (Contributor), Nakagawa, S. (Contributor) & Toyooka, N. (Contributor), Protein Data Bank (PDB), 2022/12/14
DOI: 10.2210/pdb7W9Q/pdb, https://www.wwpdb.org/pdb?id=pdb_00007w9q
Dataset
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Solution structure of big defensin
Kouno, T. (Contributor), Fujitani, N. (Contributor), Mizuguchi, M. (Contributor), Osaki, T. (Contributor), Nishimura, S.-I. (Contributor), Kawabata, S.-I. (Contributor), Aizawa, T. (Contributor), Demura, M. (Contributor), Nitta, K. (Contributor) & Kawano, K. (Contributor), Protein Data Bank (PDB), 2008/10/14
DOI: 10.2210/pdb2RNG/pdb, https://www.wwpdb.org/pdb?id=pdb_00002rng
Dataset
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Tachyplesin I in water
Kushibiki, T. (Contributor), Kamiya, M. (Contributor), Aizawa, T. (Contributor), Kumaki, Y. (Contributor), Kikukawa, T. (Contributor), Mizuguchi, M. (Contributor), Demura, M. (Contributor), Kawabata, S.-I. (Contributor) & Kawano, K. (Contributor), Protein Data Bank (PDB), 2014/02/19
DOI: 10.2210/pdb2RTV/pdb, https://www.wwpdb.org/pdb?id=pdb_00002rtv
Dataset
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NMR Structure of human Epiregulin
Sato, K. (Contributor), Nakamura, T. (Contributor), Mizuguchi, M. (Contributor), Miura, K. (Contributor), Tada, M. (Contributor), Aizawa, T. (Contributor), Gomi, T. (Contributor), Miyamoto, K. (Contributor) & Kawano, K. (Contributor), Protein Data Bank (PDB), 2003/09/30
DOI: 10.2210/pdb1K37/pdb, https://www.wwpdb.org/pdb?id=pdb_00001k37
Dataset
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Solution structure of paralytic peptide of the silkworm, Bombyx mori
Miura, K. (Contributor), Kamimura, M. (Contributor), Aizawa, T. (Contributor), Kiuchi, M. (Contributor), Hayakawa, Y. (Contributor), Mizuguchi, M. (Contributor) & Kawano, K. (Contributor), Protein Data Bank (PDB), 2003/02/11
DOI: 10.2210/pdb1IRR/pdb, https://www.wwpdb.org/pdb?id=pdb_00001irr
Dataset
Courses
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生物物理学特論
Tomohiro, T., Mizuguchi, M., Obita, T., Nakano, M., Ikeda, K. & Tanimoto, H. 2024/12/04 → 2025/03/31
Course
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生物物理学序論
Tomohiro, T., Mizuguchi, M., Obita, T., Nakano, M., Ikeda, K. & Tanimoto, H. 2024/10/02 → 2024/12/03
Course
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医薬品製剤開発学実習
Tomohiro, T., Mizuguchi, M., Sakai, H., Yakura, T., Hirose, Y., Matsuya, Y., Shimizu, T., Chiba, J., Nakano, M., Fujii, T., Lee, J., Okitsu, T., Morita, H. & Shoji, T. 2024/10/01 → 2025/03/31
Course
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分子薬科学特論
Tomohiro, T., Mizuguchi, M., Yakura, T., Matsuya, Y., Obita, T., Chiba, J., Nakano, M., Ikeda, K., Lee, J., Tanimoto, H. & Okitsu, T. 2024/10/01 → 2025/03/31
Course