Projects per year
Personal profile
Campus career
創薬科学科 教授 2009/04/01-2019/09/30
生命分子薬学系 教授 2009/04/01-2019/09/30
大学院生命融合科学教育部 部長（学部長含む） 2015/04/01-2017/03/31
薬学・和漢系 教授 2019/10/01-
創薬科学科 教授 2019/10/01-
薬学部創薬科学科 基幹教員
学部運営への参画状況・・・有-教授会他
担当授業科目に係る状況・・・主要授業科目担当
生命分子薬学系 教授 2009/04/01-2019/09/30
大学院生命融合科学教育部 部長（学部長含む） 2015/04/01-2017/03/31
薬学・和漢系 教授 2019/10/01-
創薬科学科 教授 2019/10/01-
薬学部創薬科学科 基幹教員
学部運営への参画状況・・・有-教授会他
担当授業科目に係る状況・・・主要授業科目担当
Affiliated academic society
日本アミロイドーシス学会 所属期間：2018/08/25-
Research interests
Structural Biology of Disease Mechanism
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research Fields, Keywords
- Structural Biology
- Protein Science
- Biophysics
Field of expertise (Grants-in-aid for Scientific Research classification)
- Biophysics
- Structural biochemistry
- Physical pharmacy
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
Projects
- 8 Finished
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PQBP1はcGASによるI型インターフェロンの発現誘導をどのように抑制するのか
Mizuguchi, M. (PI) & Obita, T. (CoI)
2019/04/01 → 2022/03/31
Project: Research
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Elucidation of the splicing regulatory function of an intrinsically disordered protein PQBP1
Mizuguchi, M. (PI) & Obita, T. (CoI)
2015/04/01 → 2018/03/31
Project: Research
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Verification of the connector function of the transcription and splicing factor PQBP1
Mizuguchi, M. (PI) & Obita, T. (CoI)
2012/04/01 → 2015/03/31
Project: Research
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天然変性タンパク質の動的構造解析
Akashi, S. (PI), Sugase, K. (CoI), Mizuguchi, M. (CoI) & Nishimura, Y. (CoI)
2009/07/23 → 2014/03/31
Project: Research
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Divergent total synthesis of natural products bearing isoflavone and 2-oxabicyclo[3.3.1]nonane skeleton using phloroglucinol and their application in drug discovery
Okada, T., Mizuguchi, M., Yokoyama, T., Awale, S. & Toyooka, N., 2025, (Accepted/In press) Advances in Heterocyclic Chemistry. Academic Press Inc., (Advances in Heterocyclic Chemistry).Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
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Repurposing of Agrochemicals as ATTRv Amyloidosis Inhibitors
Yokoyama, T., Fujiwara, S., Nishikubo, K., Mizuguchi, M., Nabeshima, Y., Toyooka, N., Okada, T. & Nakagawa, Y., 2025/01/23, In: Journal of Medicinal Chemistry. 68, 2, p. 1572-1586 15 p.Research output: Contribution to journal › Article › peer-review
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Development of Benziodarone Analogues with Enhanced Potency for Selective Binding to Transthyretin in Human Plasma
Mizuguchi, M., Nakagawa, Y., Yokoyama, T., Okada, T., Fujii, K., Takahashi, K., Luan, N. N. T., Nabeshima, Y., Kanamitsu, K., Nakagawa, S., Yamakawa, S., Ueda, M., Ando, Y. & Toyooka, N., 2024/05/09, In: Journal of Medicinal Chemistry. 67, 9, p. 6987-7005 19 p.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Divergent Total Synthesis of Isoflavone Natural Products and Their Potential as Therapeutic Agents for TTR Amyloidosis
Thanh Luan, N. N., Okada, T., Yokoyama, T., Suzuki, M., Nabeshima, Y., Mizuguchi, M. & Toyooka, N., 2024/11/22, In: Journal of Natural Products. 87, 11, p. 2604-2614 11 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Does the structure of transthyretin amyloid fibrils vary depending on the organ of accumulation?
Mizuguchi, M., 2024/12/05, In: Structure. 32, 12, p. 2181-2182 2 p.Research output: Contribution to journal › Comment/debate
Datasets
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Crystal structure of the first bromodomain of BRD4 in complex with 16D10
Segawa, R. (Contributor), Takeda, H. (Contributor), Yokoyama, T. (Contributor), Ishida, M. (Contributor), Miyata, C. (Contributor), Saito, T. (Contributor), Ishihara, R. (Contributor), Nakagita, T. (Contributor), Sasano, Y. (Contributor), Kanoh, N. (Contributor), Iwabuchi, Y. (Contributor), Mizuguchi, M. (Contributor), Hiratsuka, M. (Contributor) & Hirasawa, N. (Contributor), Protein Data Bank (PDB), 2022/08/03
DOI: 10.2210/pdb7FH2/pdb, https://www.wwpdb.org/pdb?id=pdb_00007fh2
Dataset
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Crystal structure of V30M mutated transthyretin in complex with 8-chloro-9-oxo-9H-xanthene-3-carboxylic acid
Kitakami, R. (Contributor), Inui, K. (Contributor), Nakagawa, Y. (Contributor), Sawai, Y. (Contributor), Katayama, W. (Contributor), Yokoyama, T. (Contributor), Okada, T. (Contributor), Kanamitsu, K. (Contributor), Nakagawa, S. (Contributor), Toyooka, N. (Contributor) & Mizuguchi, M. (Contributor), Protein Data Bank (PDB), 2021/10/13
DOI: 10.2210/pdb7EJR/pdb, https://www.wwpdb.org/pdb?id=pdb_00007ejr
Dataset
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Crystal structure of human transthyretin in complex with 4-chloro-9,10-dioxo-9,10-dihydroanthracene-2-carboxylic acid
Kitakami, R. (Contributor), Inui, K. (Contributor), Nakagawa, Y. (Contributor), Sawai, Y. (Contributor), Katayama, W. (Contributor), Yokoyama, T. (Contributor), Okada, T. (Contributor), Kanamitsu, K. (Contributor), Nakagawa, S. (Contributor), Toyooka, N. (Contributor) & Mizuguchi, M. (Contributor), Protein Data Bank (PDB), 2021/10/13
DOI: 10.2210/pdb7DT3/pdb, https://www.wwpdb.org/pdb?id=pdb_00007dt3
Dataset
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Crystal structure of human transthyretin in complex with 4-chloro-9-oxo-9H-xanthene-2-carboxylic acid
Kitakami, R. (Contributor), Inui, K. (Contributor), Nakagawa, Y. (Contributor), Sawai, Y. (Contributor), Katayama, W. (Contributor), Yokoyama, T. (Contributor), Okada, T. (Contributor), Kanamitsu, K. (Contributor), Nakagawa, S. (Contributor), Toyooka, N. (Contributor) & Mizuguchi, M. (Contributor), Protein Data Bank (PDB), 2021/10/13
DOI: 10.2210/pdb7DT5/pdb, https://www.wwpdb.org/pdb?id=pdb_00007dt5
Dataset
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Crystal structure of V30M mutated transthyretin in complex with purpurin
Kitakami, R. (Contributor), Inui, K. (Contributor), Nakagawa, Y. (Contributor), Sawai, Y. (Contributor), Katayama, W. (Contributor), Yokoyama, T. (Contributor), Okada, T. (Contributor), Kanamitsu, K. (Contributor), Nakagawa, S. (Contributor), Toyooka, N. (Contributor) & Mizuguchi, M. (Contributor), Protein Data Bank (PDB), 2021/10/13
DOI: 10.2210/pdb7DT6/pdb, https://www.wwpdb.org/pdb?id=pdb_00007dt6
Dataset
Courses
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データサイエンスの世界
Ito, T., Kamiyama, A., Movshuk, O., Kimura, I., Kurimoto, T., Kobayashi, K., Yonemoto, N., Mizuguchi, M., Taguchi, M., Horita, Y., Hirobayashi, S., Ohashi, H., Takitani, H., Park, E. K., Oku, M. & Suzuki, K. 2024/10/01 → 2024/12/03
Course
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医薬品製剤開発学実習
Tomohiro, T., Mizuguchi, M., Sakai, H., Yakura, T., Hirose, Y., Matsuya, Y., Shimizu, T., Chiba, J., Nakano, M., Fujii, T., Lee, J., Okitsu, T., Morita, H. & Shoji, T. 2024/10/01 → 2025/03/31
Course
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医薬品製剤開発学実習
Tomohiro, T., Mizuguchi, M., Sakai, H., Yakura, T., Hirose, Y., Matsuya, Y., Shimizu, T., Chiba, J., Nakano, M., Fujii, T., Lee, J., Okitsu, T., Morita, H. & Shoji, T. 2024/10/01 → 2025/03/31
Course
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