Abstract
Hereditary transthyretin (TTR)-related amyloidosis is caused by mutations in the TTR gene. The mutations destabilize the tetramer and/or monomer of TTR, and thus the stabilization of TTR is a key strategy for the treatment of TTR-related amyloidosis. In this review, we summarized the natural products and synthetic compounds that have been shown to inhibit the amyloidogenesis of TTR. The stabilizers and/or the amyloid fibril disrupters isolated from natural sources may become lead compounds for the treatment of TTR-related amyloidosis.
| Original language | English |
|---|---|
| Pages (from-to) | 979-984 |
| Number of pages | 6 |
| Journal | Biological and Pharmaceutical Bulletin |
| Volume | 41 |
| Issue number | 7 |
| DOIs | |
| State | Published - 2018 |
Keywords
- Amyloid fibril disrupter
- Amyloidosis
- Crystal structure
- Natural product
- Stabilizer
- Transthyretin
ASJC Scopus subject areas
- Pharmacology
- Pharmaceutical Science