Inhibition of the amyloidogenesis of transthyretin by natural products and synthetic compounds

Takeshi Yokoyama, Mineyuki Mizuguchi*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Hereditary transthyretin (TTR)-related amyloidosis is caused by mutations in the TTR gene. The mutations destabilize the tetramer and/or monomer of TTR, and thus the stabilization of TTR is a key strategy for the treatment of TTR-related amyloidosis. In this review, we summarized the natural products and synthetic compounds that have been shown to inhibit the amyloidogenesis of TTR. The stabilizers and/or the amyloid fibril disrupters isolated from natural sources may become lead compounds for the treatment of TTR-related amyloidosis.

Original languageEnglish
Pages (from-to)979-984
Number of pages6
JournalBiological and Pharmaceutical Bulletin
Volume41
Issue number7
DOIs
StatePublished - 2018

Keywords

  • Amyloid fibril disrupter
  • Amyloidosis
  • Crystal structure
  • Natural product
  • Stabilizer
  • Transthyretin

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

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