Mineyuki Mizuguchi

2025

Repurposing of Agrochemicals as ATTRv Amyloidosis Inhibitors

Yokoyama, T., Fujiwara, S., Nishikubo, K., Mizuguchi, M., Nabeshima, Y., Toyooka, N., Okada, T. & Nakagawa, Y., 2025/01/23, In: Journal of Medicinal Chemistry. 68, 2, p. 1572-1586 15 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

2024

Development of Benziodarone Analogues with Enhanced Potency for Selective Binding to Transthyretin in Human Plasma

Mizuguchi, M., Nakagawa, Y., Yokoyama, T., Okada, T., Fujii, K., Takahashi, K., Luan, N. N. T., Nabeshima, Y., Kanamitsu, K., Nakagawa, S., Yamakawa, S., Ueda, M., Ando, Y. & Toyooka, N., 2024/05/09, In: Journal of Medicinal Chemistry. 67, 9, p. 6987-7005 19 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

3 被引用数 (Scopus)

Divergent Total Synthesis of Isoflavone Natural Products and Their Potential as Therapeutic Agents for TTR Amyloidosis

Thanh Luan, N. N., Okada, T., Yokoyama, T., Suzuki, M., Nabeshima, Y., Mizuguchi, M. & Toyooka, N., 2024/11/22, In: Journal of Natural Products. 87, 11, p. 2604-2614 11 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

1 被引用数 (Scopus)

Enzymatic activity of cGAS in the presence of three types of DNAs: limited cGAS stimulation by single-stranded HIV-1 SL2 DNA

Mizuguchi, M., Kyan, N., Nishimata, S., Nabeshima, Y. & Obita, T., 2024/04, In: Bioscience Reports. 44, 4, BSR20240269.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

SIRT5 mutants reveal the role of conserved asparagine and glutamine residues in the NAD⁺-binding pocket

Yokoyama, T., Takayama, Y., Mizuguchi, M., Nabeshima, Y. & Kusaka, K., 2024/09, In: FEBS Letters. 598, 18, p. 2269-2280 12 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Structural insights into rapamycin-induced oligomerization of a FRB–FKBP fusion protein

Inobe, T., Sakaguchi, R., Obita, T., Mukaiyama, A., Koike, S., Yokoyama, T., Mizuguchi, M. & Akiyama, S., 2024/09, In: FEBS Letters. 598, 18, p. 2292-2305 14 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

1 被引用数 (Scopus)

Trypsin-induced aggregation of transthyretin Valine 30 variants associated with hereditary amyloidosis

Mizuguchi, M., Obita, T., Yamada, S. & Nabeshima, Y., 2024/04, In: FEBS Journal. 291, 8, p. 1732-1743 12 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

1 被引用数 (Scopus)

2023

Benziodarone and 6-hydroxybenziodarone are potent and selective inhibitors of transthyretin amyloidogenesis

Mizuguchi, M., Yokoyama, T., Okada, T., Nakagawa, Y., Fujii, K., Nabeshima, Y. & Toyooka, N., 2023/07/15, In: Bioorganic and Medicinal Chemistry. 90, 117370.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

7 被引用数 (Scopus)

Design, synthesis, structure–activity relationship studies, and evaluation of novel GLS1 inhibitors

Jo, M., Koizumi, K., Suzuki, M., Kanayama, D., Watanabe, Y., Gouda, H., Mori, H., Mizuguchi, M., Obita, T., Nabeshima, Y., Toyooka, N. & Okada, T., 2023/05/01, In: Bioorganic and Medicinal Chemistry Letters. 87, 129266.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

3 被引用数 (Scopus)

Design and structural optimization of thiadiazole derivatives with potent GLS1 inhibitory activity

Okada, T., Yamabe, K., Jo, M., Sakajiri, Y., Shibata, T., Sawada, R., Yamanishi, Y., Kanayama, D., Mori, H., Mizuguchi, M., Obita, T., Nabeshima, Y., Koizumi, K. & Toyooka, N., 2023/09/01, In: Bioorganic and Medicinal Chemistry Letters. 93, 129438.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

1 被引用数 (Scopus)

Rafoxanide, a salicylanilide anthelmintic, interacts with human plasma protein transthyretin

Yokoyama, T., Mizuguchi, M., Nabeshima, Y., Nakagawa, Y., Okada, T., Toyooka, N. & Kusaka, K., 2023/11, In: FEBS Journal. 290, 21, p. 5158-5170 13 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

5 被引用数 (Scopus)

Resveratrol Derivatives Inhibit Transthyretin Fibrillization: Structural Insights into the Interactions between Resveratrol Derivatives and Transthyretin

Yokoyama, T., Kusaka, K., Mizuguchi, M., Nabeshima, Y. & Fujiwara, S., 2023/11/23, In: Journal of Medicinal Chemistry. 66, 22, p. 15511-15523 13 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

6 被引用数 (Scopus)

Structural and mutational analyses of decarboxylated osteocalcin provide insight into its adiponectin-inducing activity

Mizuguchi, M., Yokoyama, T., Otani, T., Kuribara, S., Nabeshima, Y., Obita, T., Hirata, M. & Kawano, K., 2023/06, In: FEBS Letters. 597, 11, p. 1479-1488 10 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

2022

Determination of Hardness of a Pharmaceutical Oral Jelly by Using T2 Relaxation Behavior Measured by Time-Domain NMR

Tsuji, T., Kobayashi, R., Hayashi, Y., Kumada, S., Mizuguchi, M., Okada, K. & Onuki, Y., 2022/08/01, In: Chemical and Pharmaceutical Bulletin. 70, 8, p. 558-565 8 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

3 被引用数 (Scopus)

The hydrophobic residue Leu73 is crucial for the high stability and low aggregation properties of murine transthyretin

Nakagawa, M., Obita, T. & Mizuguchi, M., 2022/09, In: Biochemical Journal. 479, 18, p. 1999-2011 13 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

2 被引用数 (Scopus)

2021

A chalcone derivative suppresses TSLP induction in mice and human keratinocytes through binding to BET family proteins

Segawa, R., Takeda, H., Yokoyama, T., Ishida, M., Miyata, C., Saito, T., Ishihara, R., Nakagita, T., Sasano, Y., Kanoh, N., Iwabuchi, Y., Mizuguchi, M., Hiratsuka, M. & Hirasawa, N., 2021/12, In: Biochemical Pharmacology. 194, 114819.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

4 被引用数 (Scopus)

A low amyloidogenic E61K transthyretin mutation may cause familial amyloid polyneuropathy

Murakami, T., Yokoyama, T., Mizuguchi, M., Toné, S., Takaku, S., Sango, K., Nishimura, H., Watabe, K. & Sunada, Y., 2021/03, In: Journal of Neurochemistry. 156, 6, p. 957-966 10 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

6 被引用数 (Scopus)

Crystal structure of death-associated protein kinase 1 in complex with the dietary compound resveratrol

Yokoyama, T., Suzuki, R. & Mizuguchi, M., 2021, In: IUCrJ. 8, p. 131-138 8 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

11 被引用数 (Scopus)

Expression of SOLOIST/MRTFB i4, a novel neuronal isoform of the mouse serum response factor coactivator myocardin-related transcription factor-B, negatively regulates dendritic complexity in cortical neurons

Ishibashi, Y., Shoji, S., Ihara, D., Kubo, Y., Tanaka, T., Tanabe, H., Hakamata, T., Miyata, T., Satou, N., Sakagami, H., Mizuguchi, M., Kikuchi, K., Fukuchi, M., Tsuda, M., Takasaki, I. & Tabuchi, A., 2021/11, In: Journal of Neurochemistry. 159, 4, p. 762-777 16 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

5 被引用数 (Scopus)

Inhibitory activities of anthraquinone and xanthone derivatives against transthyretin amyloidogenesis

Kitakami, R., Inui, K., Nakagawa, Y., Sawai, Y., Katayama, W., Yokoyama, T., Okada, T., Kanamitsu, K., Nakagawa, S., Toyooka, N. & Mizuguchi, M., 2021/08/15, In: Bioorganic and Medicinal Chemistry. 44, 116292.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

7 被引用数 (Scopus)

Repositioning of the Anthelmintic Drugs Bithionol and Triclabendazole as Transthyretin Amyloidogenesis Inhibitors

Yokoyama, T., Kashihara, M. & Mizuguchi, M., 2021/10/14, In: Journal of Medicinal Chemistry. 64, 19, p. 14344-14357 14 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

11 被引用数 (Scopus)

Structural and dynamics analysis of intrinsically disordered proteins by high-speed atomic force microscopy

Kodera, N., Noshiro, D., Dora, S. K., Mori, T., Habchi, J., Blocquel, D., Gruet, A., Dosnon, M., Salladini, E., Bignon, C., Fujioka, Y., Oda, T., Noda, N. N., Sato, M., Lotti, M., Mizuguchi, M., Longhi, S. & Ando, T., 2021/02, In: Nature Nanotechnology. 16, 2, p. 181-189 9 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

79 被引用数 (Scopus)

Tau activates microglia via the PQBP1-cGAS-STING pathway to promote brain inflammation

Jin, M., Shiwaku, H., Tanaka, H., Obita, T., Ohuchi, S., Yoshioka, Y., Jin, X., Kondo, K., Fujita, K., Homma, H., Nakajima, K., Mizuguchi, M. & Okazawa, H., 2021/12, In: Nature Communications. 12, 1, 6565.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

131 被引用数 (Scopus)

2020

Neutron diffraction experiment with the Y116S variant of transthyretin using iBIX at J-PARC: Application of a new integration method

Kusaka, K., Yokoyama, T., Yamada, T., Yano, N., Tanaka, I. & Mizuguchi, M., 2020/11/01, In: Acta Crystallographica Section D: Structural Biology. 76, p. 1050-1056 7 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

1 被引用数 (Scopus)

New cytotoxic polyacetylene alcohols from the Egyptian marine sponge Siphonochalina siphonella

Ki, D. W., El-Desoky, A. H., Wong, C. P., Abdel-Ghani, M., El-Beih, A. A., Mizuguchi, M. & Morita, H., 2020/03/01, In: Natural Medicines. 74, 2, p. 409-414 6 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

12 被引用数 (Scopus)

New cytotoxic polyacetylene amides from the Egyptian marine sponge Siphonochalina siphonella

Ki, D. W., El-Desoky, A. H., Kodama, T., Wong, C. P., Ghani, M. A., El-Beih, A. A., Mizuguchi, M. & Morita, H., 2020/04, In: Fitoterapia. 142, 104511.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

13 被引用数 (Scopus)

Structural and thermodynamic analyses of interactions between death-associated protein kinase 1 and anthraquinones

Yokoyama, T., Wijaya, P., Kosaka, Y. & Mizuguchi, M., 2020/05/01, In: Acta Crystallographica Section D: Structural Biology. 76, p. 438-446 9 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

9 被引用数 (Scopus)

2019

Crown Ethers as Transthyretin Amyloidogenesis Inhibitors

Yokoyama, T. & Mizuguchi, M., 2019/02/28, In: Journal of Medicinal Chemistry. 62, 4, p. 2076-2082 7 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

24 被引用数 (Scopus)

Discovery of a new class of MTH1 inhibitor by X-ray crystallographic screening

Yokoyama, T., Kitakami, R. & Mizuguchi, M., 2019/04/01, In: European Journal of Medicinal Chemistry. 167, p. 153-160 8 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

15 被引用数 (Scopus)

Structural and thermodynamic characterization of the binding of isoliquiritigenin to the first bromodomain of BRD4

Yokoyama, T., Matsumoto, K., Ostermann, A., Schrader, T. E., Nabeshima, Y. & Mizuguchi, M., 2019/05, In: FEBS Journal. 286, 9, p. 1656-1667 12 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

7 被引用数 (Scopus)

Transthyretin Amyloid Fibril Disrupting Activities of Extracts and Fractions from Juglans mandshurica Maxim. Var. Cordiformis (Makino) Kitam.

Chaudhary, N., Sasaki, R., Shuto, T., Watanabe, M., Kawahara, T., Suico, M. A., Yokoyama, T., Mizuguchi, M., Kai, H. & Devkota, H. P., 2019/01/30, In: Molecules. 24, 3, , 500.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

7 被引用数 (Scopus)

2018

Design, synthesis, and evaluation of novel inhibitors for wild-type human serine racemase

Takahara, S., Nakagawa, K., Uchiyama, T., Yoshida, T., Matsumoto, K., Kawasumi, Y., Mizuguchi, M., Obita, T., Watanabe, Y., Hayakawa, D., Gouda, H., Mori, H. & Toyooka, N., 2018/02/01, In: Bioorganic and Medicinal Chemistry Letters. 28, 3, p. 441-445 5 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

12 被引用数 (Scopus)

Inhibition of the amyloidogenesis of transthyretin by natural products and synthetic compounds

Yokoyama, T. & Mizuguchi, M., 2018, In: Biological and Pharmaceutical Bulletin. 41, 7, p. 979-984 6 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

16 被引用数 (Scopus)

2017

A novel serine racemase inhibitor suppresses neuronal over-activation in vivo

Mori, H., Wada, R., Takahara, S., Horino, Y., Izumi, H., Ishimoto, T., Yoshida, T., Mizuguchi, M., Obita, T., Gouda, H., Hirono, S. & Toyooka, N., 2017, In: Bioorganic and Medicinal Chemistry. 25, 14, p. 3736-3745 10 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

13 被引用数 (Scopus)

Large-scale crystallization and neutron crystallographic analysis of HSP70 in complex with ADP

Yokoyama, T., Ostermann, A., Schrader, T. E. & Mizuguchi, M., 2017/10, In: Acta Crystallographica Section:F Structural Biology Communications. 73, 10, p. 555-559 5 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

1 被引用数 (Scopus)

Stability and crystal structures of His88 mutant human transthyretins

Yokoyama, T., Hanawa, Y., Obita, T. & Mizuguchi, M., 2017/07/01, In: FEBS Letters. 591, 13, p. 1862-1871 10 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

15 被引用数 (Scopus)

2016

Allosteric modulation of the binding affinity between PQBP1 and the spliceosomal protein U5-15kD

Mizuguchi, M., Obita, T., Kajiyama, A., Kozakai, Y., Nakai, T., Nabeshima, Y. & Okazawa, H., 2016/07/01, In: FEBS Letters. p. 2221-2231 11 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

8 被引用数 (Scopus)

Characterization of the interaction between Trypanosoma brucei Pex5p and its receptor Pex14p

Watanabe, Y., Kawaguchi, K., Okuyama, N., Sugawara, Y., Obita, T., Mizuguchi, M., Morita, M. & Imanaka, T., 2016/01/01, In: FEBS Letters. 590, 2, p. 242-250 9 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

7 被引用数 (Scopus)

Crystal Structure of Human General Transcription Factor TFIIE at Atomic Resolution

Miwa, K., Kojima, R., Obita, T., Ohkuma, Y., Tamura, Y. & Mizuguchi, M., 2016/10/23, In: Journal of Molecular Biology. 428, 21, p. 4258-4266 9 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

15 被引用数 (Scopus)

Structural Fine-Tuning of MIT-Interacting Motif 2 (MIM2) and Allosteric Regulation of ESCRT-III by Vps4 in Yeast

Kojima, R., Obita, T., Onoue, K. & Mizuguchi, M., 2016/06/05, In: Journal of Molecular Biology. 428, 11, p. 2392-2404 13 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

12 被引用数 (Scopus)

2015

Discovery of γ-Mangostin as an Amyloidogenesis Inhibitor

Yokoyama, T., Ueda, M., Ando, Y. & Mizuguchi, M., 2015/08/27, In: Scientific Reports. 5, 13570.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

26 被引用数 (Scopus)

Frameshift mutations in the PQBP1 gene prevent its interaction with the splicing factor U5-15kD

Mizuguchi, M., 2015, In: Seikagaku. 87, 4, p. 478-480 3 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Phenolic compounds prevent the oligomerization of α-synuclein and reduce synaptic toxicity

Takahashi, R., Ono, K., Takamura, Y., Mizuguchi, M., Ikeda, T., Nishijo, H. & Yamada, M., 2015/09/01, In: Journal of Neurochemistry. 134, 5, p. 943-955 13 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

90 被引用数 (Scopus)

Protonation State and Hydration of Bisphosphonate Bound to Farnesyl Pyrophosphate Synthase

Yokoyama, T., Mizuguchi, M., Ostermann, A., Kusaka, K., Niimura, N., Schrader, T. E. & Tanaka, I., 2015/09/24, In: Journal of Medicinal Chemistry. 58, 18, p. 7549-7556 8 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

26 被引用数 (Scopus)

Structural Insight into the Interactions between Death-Associated Protein Kinase 1 and Natural Flavonoids

Yokoyama, T., Kosaka, Y. & Mizuguchi, M., 2015/09/24, In: Journal of Medicinal Chemistry. 58, 18, p. 7400-7408 9 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

69 被引用数 (Scopus)

Structural stabilization of transthyretin by a new compound, 6-benzoyl-2-hydroxy-1H-benzo[de]isoquinoline-1,3(2H)-dione

Yokoyama, T., Takaki, S., Chosa, K., Sato, T., Suico, M. A., Teranishi, Y., Shuto, T., Mizuguchi, M. & Kai, H., 2015/12, In: Journal of Pharmacological Sciences. 129, 4, p. 240-243 4 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

5 被引用数 (Scopus)

2014

Crystallization and preliminary neutron diffraction experiment of human farnesyl pyrophosphate synthase complexed with risedronate

Yokoyama, T., Ostermann, A., Mizuguchi, M., Niimura, N., Schrader, T. E. & Tanaka, I., 2014/04, In: Acta Crystallographica Section:F Structural Biology Communications. 70, 4, p. 470-472 3 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

8 被引用数 (Scopus)

Crystal structures of human transthyretin complexed with glabridin

Yokoyama, T., Kosaka, Y. & Mizuguchi, M., 2014/02/13, In: Journal of Medicinal Chemistry. 57, 3, p. 1090-1096 7 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

32 被引用数 (Scopus)

Exogenous amyloidogenic proteins function as seeds in amyloid β-protein aggregation

Ono, K., Takahashi, R., Ikeda, T., Mizuguchi, M., Hamaguchi, T. & Yamada, M., 2014/04, In: Biochimica et Biophysica Acta - Molecular Basis of Disease. 1842, 4, p. 646-653 8 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

67 被引用数 (Scopus)

Inhibitory activities of propolis and its promising component, caffeic acid phenethyl ester, against amyloidogenesis of human transthyretin

Yokoyama, T., Kosaka, Y. & Mizuguchi, M., 2014/11/13, In: Journal of Medicinal Chemistry. 57, 21, p. 8928-8935 8 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

42 被引用数 (Scopus)

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