Projects per year
Personal profile
Campus career
和漢医薬学総合研究所 教授 2012/04/01-2019/09/30
薬学・和漢系 教授 2019/10/01-
和漢医薬学総合研究所 教授 2019/10/01-
薬学・和漢系 教授 2019/10/01-
和漢医薬学総合研究所 教授 2019/10/01-
Research interests
天然には人が医薬品として求める多様な構造と生物活性を有する天然有機化合物があります.一方,資源が枯渇しつつある今日にあって,新規生理活性物質を天然から見いだすことが困難になりつつあります.私は,天然物化学研究を基盤に,構造生物学,酵素工学に至る幅広い分野の方法論を取り入れ,医薬品開発等に有用な新規シード化合物を見いだすことで社会に貢献することを目的に,下記,主要テーマに取り組んでいます.
1.天然有機化合物の生合成研究
2.二次代謝酵素の立体構造解析
3.二次代謝酵素の機能改変と新規有用物質の創製
4.天然資源からの抗ウイルス,抗菌,抗がん活性化合物の単離・構造決定
1.天然有機化合物の生合成研究
2.二次代謝酵素の立体構造解析
3.二次代謝酵素の機能改変と新規有用物質の創製
4.天然資源からの抗ウイルス,抗菌,抗がん活性化合物の単離・構造決定
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research Fields, Keywords
- Natural products
- Biosynthesis, Structre analysis
- Enzyme engineering
- Plants, Sponges
Field of expertise (Grants-in-aid for Scientific Research classification)
- Natural medicines
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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神経軸索伸長活性アルカロイドの創出を指向したアルカロイド生合成酵素の機能改変
Morita, H. (Principal Investigator)
Japan Society for the Promotion of Science
2025/04/01 → 2028/03/31
Project: Research Project
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AchE阻害活性アルカロイドの骨格生合成酵素の機能解析と改変
Morita, H. (Principal Investigator), 猛児玉 (Co-Investigator(Kenkyū-buntansha)) & Nakashima, Y. (Co-Investigator(Kenkyū-buntansha))
Japan Society for the Promotion of Science
2022/04/01 → 2025/03/31
Project: Research Project
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ポリケタイド閉環酵素とバイヤービリガー酵素の機能改変と新規化合物の創出
Morita, H. (Principal Investigator)
Japan Society for the Promotion of Science
2019/04/01 → 2021/03/31
Project: Public
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Engineering of DABB-family enzymes to novel polyketide cyclase
Morita, H. (CoI)
2017/04/01 → 2020/03/31
Project: Research
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植物由来新規ポリケタイド閉環酵素の探索と物質生産
Morita, H. (Principal Investigator)
Japan Society for the Promotion of Science
2017/04/01 → 2019/03/31
Project: Public
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A New 19(10→9)Abeo-Euphane Triterpenoid with other Terpenoid Components from Trichilia dregeana Leaves and their NO Production Inhibitory Activities in LPS-Stimulated RAW264.7 Macrophages
Mba Nguekeu, Y. M., Kodama, T., Paing Htoo, Z., Matheuda, E. G., Tsepeupon Matchide, M. G., Augustin Ngouela, S., Tene, M., Ducret Awouafack, M. & Morita, H., 2025/01, In: Chemistry and Biodiversity. 22, 1, e202401919.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Enhanced Production of Rebaudioside D and Rebaudioside M through V155T Substitution in the Glycosyltransferase UGT91D2 from Stevia rebaudiana
Shoji, T., Tanaka, Y., Nakashima, Y., Mizohata, E., Komaki, M., Sugawara, S., Takaya, J., Yonekura-Sakakibara, K., Morita, H., Saito, K. & Hirai, T., 2025/01/22, In: Journal of Agricultural and Food Chemistry. 73, 3, p. 2019-2032 14 p.Research output: Contribution to journal › Article › peer-review
Open Access -
A new 3,4-seco-isopimarane and three new isopimarane diterpenoids from Kaempferia champasakensis collected from Vietnam and their cytotoxic activities
Do, K. M., Hoshino, S., Kodama, T., Nguyen, H. M., Van Le, S., Ikumi, N., Onaka, H. & Morita, H., 2024, (Accepted/In press) In: Natural Medicines.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Antibacterial activity, cytotoxicity and chemotaxonomic significance of chemical constituents from Alsophila manniana Hook R.M.Tryon (Cyatheaceae) rhizomes
Tsepeupon Matchide, M. G., Sonfack Fozeng, H. D., Tchuente Tchuenmogne, M. A., Djadock Anensong, C. S., Wembe Koagne, W., Anthonissen, S., Mba Nguekeu, Y. M., Do, K. M., Lee, Y. E., Dehaen, W., Morita, H., Tene, M., Ngouela, S. A. & Awouafack, M. D., 2024/06, In: Biochemical Systematics and Ecology. 114, 104834.Research output: Contribution to journal › Article › peer-review
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Antibacterial activity of five Indonesian medicinal plants and the isolation of compounds from Plectranthus scutellarioides
Rakainsa, S. K., Nisa, K., Ito, T. & Morita, H., 2024/05, In: Journal of Applied Pharmaceutical Science. 14, 5, p. 185-192 8 p.Research output: Contribution to journal › Article › peer-review
Open Access
Datasets
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Bioinspired computational design of lankacidin derivatives for improvement in antitumor activity - supplement information
Ayoub, A. T. (Creator), Nishiura, N. (Creator), Teshima, A. (Creator), Elrefaiy, M. A. (Creator), Muslimin, R. (Creator), Do, K. M. (Creator), Kodama, T. (Creator), Lewis, C. W. (Creator), Chan, G. (Creator), Morita, H. (Creator) & Arakawa, K. (Creator), Taylor & Francis, 2022
DOI: 10.25402/fmc.21062833.v1, https://tandf.figshare.com/articles/figure/Bioinspired_computational_design_of_lankacidin_derivatives_for_improvement_in_antitumor_activity_-_supplement_information/21062833/1
Dataset
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CCDC 681486: Experimental Crystal Structure Determination
Sheikh, M. C. (Contributor), Iwasawa, T. (Creator), Nakajima, A. (Creator), Tsubaki, N. (Creator), Miyatake, R. (Creator), Yoshimura, T. (Creator) & Morita, H. (Creator), Cambridge Crystallographic Data Centre, 2013
DOI: 10.5517/ccqw4f4, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccqw4f4&sid=DataCite
Dataset
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CCDC 681484: Experimental Crystal Structure Determination
Sheikh, M. C. (Contributor), Iwasawa, T. (Creator), Nakajima, A. (Creator), Tsubaki, N. (Creator), Miyatake, R. (Creator), Yoshimura, T. (Creator) & Morita, H. (Creator), Cambridge Crystallographic Data Centre, 2013
DOI: 10.5517/ccqw4c2, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccqw4c2&sid=DataCite
Dataset
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CCDC 600496: Experimental Crystal Structure Determination
Fujii, T. (Creator), Takano, T. (Creator), Asai, S. (Creator), Morita, H. (Creator), Hirata, M. (Creator) & Yoshimura, T. (Creator), Cambridge Crystallographic Data Centre, 2006
DOI: 10.5517/ccn4vvg, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccn4vvg&sid=DataCite
Dataset
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Antimicrobial and antioxidant activities of triterpenoid and phenolic derivatives from two Cameroonian Melastomataceae plants: Dissotis senegambiensis and Amphiblemma monticola
Nzogong, R. T. (Creator), Ndjateu, F. S. T. (Creator), Ekom, S. E. (Creator), Fosso, J.-A. M. (Creator), Awouafack, M. D. (Creator), Tene, M. (Creator), Tane, P. (Creator), Morita, H. (Creator), Choudhary, M. I. (Creator) & Tamokou, J.-D.-D. (Creator), figshare, 2018
DOI: 10.6084/m9.figshare.c.4102883.v1, https://springernature.figshare.com/collections/Antimicrobial_and_antioxidant_activities_of_triterpenoid_and_phenolic_derivatives_from_two_Cameroonian_Melastomataceae_plants_Dissotis_senegambiensis_and_Amphiblemma_monticola/4102883/1
Dataset
Prizes
Activities
- 50 Oral presentation
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Biosynthesis of 2-alkylquinolone in the medicinal plant Evodia rutaecarpa
Morita, H. (Speaker)
2018/11/05Activity: Talk or presentation › Oral presentation
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芳香族ドデカケタイドを生産する機能改変型アロエ由来Ⅲ型ポリケタイド合成酵素のX線結晶構造解析
Morita, H. (Speaker)
2014/03/28 → 2014/03/30Activity: Talk or presentation › Oral presentation
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Preferential Cytotoxicity of Citrus microcarpa peel against Pancreatic Cancer Cell Lines in Nutrient Deprived Conditions
Morita, H. (Speaker)
2014/03/28 → 2014/03/30Activity: Talk or presentation › Oral presentation
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Polyoxygenated cyclohexane from Kaempferia rotunda and their cytotoxic activity
Morita, H. (Speaker)
2014/03/28 → 2014/03/30Activity: Talk or presentation › Oral presentation
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アサ由来オリベトール酸閉環酵素のあらたな酵素触媒機能の開拓
Morita, H. (Speaker)
2014/03/28 → 2014/03/30Activity: Talk or presentation › Oral presentation
Courses
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応用和漢医薬学特論
Watanabe, S., Tohda, C., Morita, H., Hayakawa, Y., Awale, S., Nakagawa, Y., Kim, J. & Oku, M. 2024/12/04 → 2025/03/31
Course
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医薬品製剤開発学実習
Tomohiro, T., Mizuguchi, M., Sakai, H., Yakura, T., Hirose, Y., Matsuya, Y., Shimizu, T., Chiba, J., Nakano, M., Fujii, T., Lee, J., Okitsu, T., Morita, H. & Shoji, T. 2024/10/01 → 2025/03/31
Course
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医薬品製剤開発学実習
Tomohiro, T., Mizuguchi, M., Sakai, H., Yakura, T., Hirose, Y., Matsuya, Y., Shimizu, T., Chiba, J., Nakano, M., Fujii, T., Lee, J., Okitsu, T., Morita, H. & Shoji, T. 2024/10/01 → 2025/03/31
Course