New cytotoxic polyacetylene alcohols from the Egyptian marine sponge Siphonochalina siphonella

Dae Won Ki; Ahmed H. El-Desoky; Chin Piow Wong; Mohamed Abdel-Ghani; Ahmed A. El-Beih; Mineyuki Mizuguchi; Hiroyuki Morita

doi:10.1007/s11418-019-01377-6

New cytotoxic polyacetylene alcohols from the Egyptian marine sponge Siphonochalina siphonella

Dae Won Ki, Ahmed H. El-Desoky^*, Chin Piow Wong, Mohamed Abdel-Ghani, Ahmed A. El-Beih, Mineyuki Mizuguchi, Hiroyuki Morita

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Three new polyacetylenic alcohols, siphonellanols A–C (1–3), together with two known polyacetylenic alcohols (4–5), were isolated from the CHCl₃-soluble fraction of the methanolic extract of the marine sponge Siphonochalina siphonella, collected in Egypt. The structures of 1–3 were determined by spectroscopic analyses of their 1D-, 2D-NMR, and MS spectra and by comparisons with reported data. The cytotoxicity assay revealed that 1–3 exhibited moderate cytotoxic activities against a human cervical cancer cell line (HeLa), a human breast cancer cell line (MCF-7), and a human lung cancer cell line (A549) with IC₅₀ values ranging from 25.9 to 69.2 μM.

Original language	English
Pages (from-to)	409-414
Number of pages	6
Journal	Natural Medicines
Volume	74
Issue number	2
DOIs	https://doi.org/10.1007/s11418-019-01377-6
State	Published - 2020/03/01

Keywords

Cytotoxic
Marine sponge
Polyacetylene
Red Sea
Siphonellanol
Siphonochalina siphonella

ASJC Scopus subject areas

Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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title = "New cytotoxic polyacetylene alcohols from the Egyptian marine sponge Siphonochalina siphonella",

abstract = "Three new polyacetylenic alcohols, siphonellanols A–C (1–3), together with two known polyacetylenic alcohols (4–5), were isolated from the CHCl3-soluble fraction of the methanolic extract of the marine sponge Siphonochalina siphonella, collected in Egypt. The structures of 1–3 were determined by spectroscopic analyses of their 1D-, 2D-NMR, and MS spectra and by comparisons with reported data. The cytotoxicity assay revealed that 1–3 exhibited moderate cytotoxic activities against a human cervical cancer cell line (HeLa), a human breast cancer cell line (MCF-7), and a human lung cancer cell line (A549) with IC50 values ranging from 25.9 to 69.2 μM.",

keywords = "Cytotoxic, Marine sponge, Polyacetylene, Red Sea, Siphonellanol, Siphonochalina siphonella",

author = "Ki, {Dae Won} and El-Desoky, {Ahmed H.} and Wong, {Chin Piow} and Mohamed Abdel-Ghani and El-Beih, {Ahmed A.} and Mineyuki Mizuguchi and Hiroyuki Morita",

note = "Publisher Copyright: {\textcopyright} 2019, The Japanese Society of Pharmacognosy.",

year = "2020",

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day = "1",

doi = "10.1007/s11418-019-01377-6",

language = "英語",

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T1 - New cytotoxic polyacetylene alcohols from the Egyptian marine sponge Siphonochalina siphonella

AU - Ki, Dae Won

AU - El-Desoky, Ahmed H.

AU - Wong, Chin Piow

AU - Abdel-Ghani, Mohamed

AU - El-Beih, Ahmed A.

AU - Mizuguchi, Mineyuki

AU - Morita, Hiroyuki

PY - 2020/3/1

Y1 - 2020/3/1

N2 - Three new polyacetylenic alcohols, siphonellanols A–C (1–3), together with two known polyacetylenic alcohols (4–5), were isolated from the CHCl3-soluble fraction of the methanolic extract of the marine sponge Siphonochalina siphonella, collected in Egypt. The structures of 1–3 were determined by spectroscopic analyses of their 1D-, 2D-NMR, and MS spectra and by comparisons with reported data. The cytotoxicity assay revealed that 1–3 exhibited moderate cytotoxic activities against a human cervical cancer cell line (HeLa), a human breast cancer cell line (MCF-7), and a human lung cancer cell line (A549) with IC50 values ranging from 25.9 to 69.2 μM.

AB - Three new polyacetylenic alcohols, siphonellanols A–C (1–3), together with two known polyacetylenic alcohols (4–5), were isolated from the CHCl3-soluble fraction of the methanolic extract of the marine sponge Siphonochalina siphonella, collected in Egypt. The structures of 1–3 were determined by spectroscopic analyses of their 1D-, 2D-NMR, and MS spectra and by comparisons with reported data. The cytotoxicity assay revealed that 1–3 exhibited moderate cytotoxic activities against a human cervical cancer cell line (HeLa), a human breast cancer cell line (MCF-7), and a human lung cancer cell line (A549) with IC50 values ranging from 25.9 to 69.2 μM.

KW - Cytotoxic

KW - Marine sponge

KW - Polyacetylene

KW - Red Sea

KW - Siphonellanol

KW - Siphonochalina siphonella

UR - http://www.scopus.com/inward/record.url?scp=85076266944&partnerID=8YFLogxK

U2 - 10.1007/s11418-019-01377-6

DO - 10.1007/s11418-019-01377-6

M3 - 学術論文

C2 - 31834571

AN - SCOPUS:85076266944

SN - 1340-3443

VL - 74

SP - 409

EP - 414

JO - Natural Medicines

JF - Natural Medicines

IS - 2

ER -

New cytotoxic polyacetylene alcohols from the Egyptian marine sponge Siphonochalina siphonella

Abstract

Keywords

ASJC Scopus subject areas

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