Projects per year
Personal profile
Campus career
医学科 准教授 2013/04/01-2019/09/30
認知・情動脳科学系 准教授 2013/04/01-2019/09/30
医学系 准教授 2019/10/01-
医学科 准教授 2019/10/01-
医学部医学科 基幹教員
学部運営への参画状況・・・有-教務委員会他
担当授業科目に係る状況・・・主要授業科目担当
認知・情動脳科学系 准教授 2013/04/01-2019/09/30
医学系 准教授 2019/10/01-
医学科 准教授 2019/10/01-
医学部医学科 基幹教員
学部運営への参画状況・・・有-教務委員会他
担当授業科目に係る状況・・・主要授業科目担当
Research interests
神経細胞間のコミュニケーションの場となるシナプスを分化誘導する能力を持つ細胞接着タンパク質群はシナプスオーガナイザーと呼ばれ,その遺伝子に生じる様々な変異が自閉スペクトラム症や知的障害の原因になることが知られています.私たちは様々なシナプスオーガナイザーを単離し,その機能・構造解析を通して,シナプス誘導およびシナプス標的認識の分子機構を明らかにしました.また,モデルマウスを作出して,シナプスオーガナイザー遺伝子の変異が神経発達障害を引き起こすシナプス病態および回路病態メカニズムを明らかにしました.
Research Fields, Keywords
- Molecular neurobiology
- molecular genetics
- biochemistry
Field of expertise (Grants-in-aid for Scientific Research classification)
- Neurochemistry/Neuropharmacology
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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マイクロエクソンの調節原理から紐解くヒト脳機能高度化メカニズム
Yoshida, T. (Principal Investigator)
Japan Society for the Promotion of Science
2025/06/27 → 2030/03/31
Project: Research Project
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Transcriptomics in presynaptic neurons using delayed-delivery perforated patch technique
Tabata, T. (Principal Investigator) & Yoshida, T. (Co-Investigator(Kenkyū-buntansha))
Japan Society for the Promotion of Science
2025/04/01 → 2028/03/31
Project: Research Project
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シナプスの形成と再編を司るシナプス誘導遺伝子マイクロエクソン選択の分子細胞基盤
Yoshida, T. (Principal Investigator) & 和泉宏謙 (Co-Investigator(Kenkyū-buntansha))
Japan Society for the Promotion of Science
2023/04/01 → 2026/03/31
Project: Research Project
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Investigation of molecular basis of developmental synapse pathology by glufosinate exposure
和泉宏謙 (Principal Investigator) & Yoshida, T. (Co-Investigator(Kenkyū-buntansha))
Japan Society for the Promotion of Science
2023/04/01 → 2026/03/31
Project: Research Project
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ヒトとマウスのシナプス誘導因子の動作原理の違いから紐解くヒトの脳機能進化
Yoshida, T. (Principal Investigator) & 和泉宏謙 (Co-Investigator(Kenkyū-buntansha))
Japan Society for the Promotion of Science
2023/06/30 → 2025/03/31
Project: Research Project
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Nicotinamide riboside and nicotinamide mononucleotide facilitate NAD+ synthesis via enterohepatic circulation
Yaku, K., Palikhe, S., Iqbal, T., Hayat, F., Watanabe, Y., Fujisaka, S., Izumi, H., Yoshida, T., Karim, M., Uchida, H., Nawaz, A., Tobe, K., Mori, H., Migaud, M. E. & Nakagawa, T., 2025/03/21, In: Science Advances. 11, 12, eadr1538.Research output: Contribution to journal › Article › peer-review
Open Access -
Cancer-associated point mutations within the extracellular domain of PTPRD affect protein stability and HSPG interaction
Matsui, Y., Tabata, A., Izumi, H., Yasumura, M., Makino, T., Shimizu, T., Sato, M., Mori, H. & Yoshida, T., 2024/04/15, In: FASEB Journal. 38, 7, e23609.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Development of artificial synapse organizers liganded with a peptide tag for molecularly inducible neuron-microelectrode interface
Haga, W., Sekine, K., Hamid, S. A., Imayasu, M., Yoshida, T. & Tsutsui, H., 2024/03/05, In: Biochemical and Biophysical Research Communications. 699, 149563.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Differential contribution of canonical and noncanonical NLGN3 pathways to early social development and memory performance
Li, L. Y., Imai, A., Izumi, H., Inoue, R., Koshidaka, Y., Takao, K., Mori, H. & Yoshida, T., 2024/12, In: Molecular Brain. 17, 1, 16.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Neuron-microelectrode junction induced by an engineered synapse organizer
Sekine, K., Haga, W., Kim, S., Imayasu, M., Yoshida, T. & Tsutsui, H., 2024/06/18, In: Biochemical and Biophysical Research Communications. 712-713, 149935.Research output: Contribution to journal › Article › peer-review
1 Scopus citations
Datasets
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Crystal structure of PTPdelta Ig1-Ig3 in complex with SALM2 LRR-Ig
Goto-Ito, S. (Contributor), Yamagata, A. (Contributor), Sato, Y. (Contributor), Uemura, T. (Contributor), Shiroshima, T. (Contributor), Maeda, A. (Contributor), Imai, A. (Contributor), Mori, H. (Contributor), Yoshida, T. (Contributor) & Fukai, S. (Contributor), Protein Data Bank (PDB), 2018/06/06
DOI: 10.2210/pdb5XWU/pdb, https://www.wwpdb.org/pdb?id=pdb_00005xwu
Dataset
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Functional characterization of rare NRXN1 variants identified in autism spectrum disorders and schizophrenia
Ishizuka, K. (Creator), Yoshida, T. (Creator), Kawabata, T. (Creator), Imai, A. (Creator), Mori, H. (Creator), Kimura, H. (Creator), Inada, T. (Creator), Okahisa, Y. (Creator), Egawa, J. (Creator), Usami, M. (Creator), Kushima, I. (Contributor), Morikawa, M. (Creator), Okada, T. (Creator), Ikeda, M. (Creator), Branko, A. (Contributor), Mori, D. (Creator), Someya, T. (Creator), Iwata, N. (Contributor) & Ozaki, N. (Creator), figshare, 2020
DOI: 10.6084/m9.figshare.c.5125518, https://springernature.figshare.com/collections/Functional_characterization_of_rare_NRXN1_variants_identified_in_autism_spectrum_disorders_and_schizophrenia/5125518
Dataset
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Crystal structure of PTPRD phosphatase domain in complex with Liprin-alpha3 tandem SAM domains
Wakita, M. (Contributor), Yamagata, A. (Contributor), Shiroshima, T. (Contributor), Izumi, H. (Contributor), Maeda, A. (Contributor), Sendo, M. (Contributor), Imai, A. (Contributor), Kubota, K. (Contributor), Goto-Ito, S. (Contributor), Sato, Y. (Contributor), Mori, H. (Contributor), Yoshida, T. (Contributor) & Fukai, S. (Contributor), Protein Data Bank (PDB), 2020/02/12
DOI: 10.2210/pdb6KIP/pdb, https://www.wwpdb.org/pdb?id=pdb_00006kip
Dataset
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Crystal structure of PTP delta Fn1-Fn2
Yamagata, A. (Contributor), Yoshida, T. (Contributor), Sato, Y. (Contributor), Goto-Ito, S. (Contributor), Uemura, T. (Contributor), Maeda, A. (Contributor), Shiroshima, T. (Contributor), Iwasawa-Okamoto, S. (Contributor), Mori, H. (Contributor), Mishina, M. (Contributor) & Fukai, S. (Contributor), Protein Data Bank (PDB), 2015/05/06
DOI: 10.2210/pdb4YFE/pdb, https://www.wwpdb.org/pdb?id=pdb_00004yfe
Dataset
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Crystal structure of SALM5 LRR-Ig
Goto-Ito, S. (Contributor), Yamagata, A. (Contributor), Sato, Y. (Contributor), Uemura, T. (Contributor), Shiroshima, T. (Contributor), Maeda, A. (Contributor), Imai, A. (Contributor), Mori, H. (Contributor), Yoshida, T. (Contributor) & Fukai, S. (Contributor), Protein Data Bank (PDB), 2018/06/06
DOI: 10.2210/pdb5XWS/pdb, https://www.wwpdb.org/pdb?id=pdb_00005xws
Dataset
Courses
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知能情報工学特論（認知・情動脳科学概論）
Yoshida, T., Ichijo, H., Nishimaru, H., Yamamoto, S., Ito, T., Takaoka, Y. & Takao, K. 2024/06/14 → 2024/09/30
Course
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生命工学特論（認知・情動脳科学概論）
Yoshida, T., Ichijo, H., Nishimaru, H., Yamamoto, S., Ito, T., Takaoka, Y. & Takao, K. 2024/06/14 → 2024/09/30
Course
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