Projects per year
UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. Our work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
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Profiles
Projects
- 16 Finished
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Structural study of pro-filaggrin recognition by SASPase
Obita, T. (PI)
2020/04/01 → 2023/03/31
Project: Research
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Development of a selective BRD4 inhibitor by neutron protein crystallographic analysis
Yokoyama, T. (PI)
2019/04/01 → 2022/03/31
Project: Research
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PQBP1はcGASによるI型インターフェロンの発現誘導をどのように抑制するのか
Mizuguchi, M. (PI) & Obita, T. (CoI)
2019/04/01 → 2022/03/31
Project: Research
Research output
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Divergent total synthesis of natural products bearing isoflavone and 2-oxabicyclo[3.3.1]nonane skeleton using phloroglucinol and their application in drug discovery
Okada, T., Mizuguchi, M., Yokoyama, T., Awale, S. & Toyooka, N., 2025, (Accepted/In press) Advances in Heterocyclic Chemistry. Academic Press Inc., (Advances in Heterocyclic Chemistry).Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
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Repurposing of Agrochemicals as ATTRv Amyloidosis Inhibitors
Yokoyama, T., Fujiwara, S., Nishikubo, K., Mizuguchi, M., Nabeshima, Y., Toyooka, N., Okada, T. & Nakagawa, Y., 2025/01/23, In: Journal of Medicinal Chemistry. 68, 2, p. 1572-1586 15 p.Research output: Contribution to journal › Article › peer-review
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Development of Benziodarone Analogues with Enhanced Potency for Selective Binding to Transthyretin in Human Plasma
Mizuguchi, M., Nakagawa, Y., Yokoyama, T., Okada, T., Fujii, K., Takahashi, K., Luan, N. N. T., Nabeshima, Y., Kanamitsu, K., Nakagawa, S., Yamakawa, S., Ueda, M., Ando, Y. & Toyooka, N., 2024/05/09, In: Journal of Medicinal Chemistry. 67, 9, p. 6987-7005 19 p.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations
Datasets
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Crystal structure of the first bromodomain of BRD4 in complex with 16D10
Segawa, R. (Contributor), Takeda, H. (Contributor), Yokoyama, T. (Contributor), Ishida, M. (Contributor), Miyata, C. (Contributor), Saito, T. (Contributor), Ishihara, R. (Contributor), Nakagita, T. (Contributor), Sasano, Y. (Contributor), Kanoh, N. (Contributor), Iwabuchi, Y. (Contributor), Mizuguchi, M. (Contributor), Hiratsuka, M. (Contributor) & Hirasawa, N. (Contributor), Protein Data Bank (PDB), 2022/08/03
DOI: 10.2210/pdb7FH2/pdb, https://www.wwpdb.org/pdb?id=pdb_00007fh2
Dataset
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Crystal structure of V30M mutated transthyretin in complex with 8-chloro-9-oxo-9H-xanthene-3-carboxylic acid
Kitakami, R. (Contributor), Inui, K. (Contributor), Nakagawa, Y. (Contributor), Sawai, Y. (Contributor), Katayama, W. (Contributor), Yokoyama, T. (Contributor), Okada, T. (Contributor), Kanamitsu, K. (Contributor), Nakagawa, S. (Contributor), Toyooka, N. (Contributor) & Mizuguchi, M. (Contributor), Protein Data Bank (PDB), 2021/10/13
DOI: 10.2210/pdb7EJR/pdb, https://www.wwpdb.org/pdb?id=pdb_00007ejr
Dataset
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Crystal structure of human transthyretin in complex with 4-chloro-9,10-dioxo-9,10-dihydroanthracene-2-carboxylic acid
Kitakami, R. (Contributor), Inui, K. (Contributor), Nakagawa, Y. (Contributor), Sawai, Y. (Contributor), Katayama, W. (Contributor), Yokoyama, T. (Contributor), Okada, T. (Contributor), Kanamitsu, K. (Contributor), Nakagawa, S. (Contributor), Toyooka, N. (Contributor) & Mizuguchi, M. (Contributor), Protein Data Bank (PDB), 2021/10/13
DOI: 10.2210/pdb7DT3/pdb, https://www.wwpdb.org/pdb?id=pdb_00007dt3
Dataset