Projects per year
UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. Our work contributes towards the following SDG(s):
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Dive into the research topics where Structural Biology is active. These topic labels come from the works of this organization's members. Together they form a unique fingerprint.
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
Profiles
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Molecular and structural basis of natural moisturizing factor production mechanisms by profilaggrin-degrading enzymes.
Obita, T. (Principal Investigator)
Japan Society for the Promotion of Science
2024/04/01 → 2027/03/31
Project: Research Project
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中性子解析に基づく分子標的薬の選択性向上と治療薬開発
Yokoyama, T. (Principal Investigator) & Okada, T. (Co-Investigator(Kenkyū-buntansha))
Japan Society for the Promotion of Science
2024/04/01 → 2027/03/31
Project: Research Project
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自然免疫に重要なcGASを活性化するZCCHC3の作用機構の解明
Mizuguchi, M. (Principal Investigator) & Obita, T. (Co-Investigator(Kenkyū-buntansha))
Japan Society for the Promotion of Science
2022/04/01 → 2025/03/31
Project: Research Project
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Repurposing of Agrochemicals as ATTRv Amyloidosis Inhibitors
Yokoyama, T., Fujiwara, S., Nishikubo, K., Mizuguchi, M., Nabeshima, Y., Toyooka, N., Okada, T. & Nakagawa, Y., 2025/01/23, In: Journal of Medicinal Chemistry. 68, 2, p. 1572-1586 15 p.Research output: Contribution to journal › Article › peer-review
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Development of Benziodarone Analogues with Enhanced Potency for Selective Binding to Transthyretin in Human Plasma
Mizuguchi, M., Nakagawa, Y., Yokoyama, T., Okada, T., Fujii, K., Takahashi, K., Luan, N. N. T., Nabeshima, Y., Kanamitsu, K., Nakagawa, S., Yamakawa, S., Ueda, M., Ando, Y. & Toyooka, N., 2024/05/09, In: Journal of Medicinal Chemistry. 67, 9, p. 6987-7005 19 p.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Discovery and optimization of isoliquiritigenin as a death-associated protein kinase 1 inhibitor
Yokoyama, T., Hisatomi, K., Oshima, S., Tanaka, I., Okada, T. & Toyooka, N., 2024/12/05, In: European Journal of Medicinal Chemistry. 279, 116836.Research output: Contribution to journal › Article › peer-review
1 Scopus citations
Datasets
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Crystal structure of human transthyretin in complex with 4-chloro-9-oxo-9H-xanthene-2-carboxylic acid
Kitakami, R. (Contributor), Inui, K. (Contributor), Nakagawa, Y. (Contributor), Sawai, Y. (Contributor), Katayama, W. (Contributor), Yokoyama, T. (Contributor), Okada, T. (Contributor), Kanamitsu, K. (Contributor), Nakagawa, S. (Contributor), Toyooka, N. (Contributor) & Mizuguchi, M. (Contributor), Protein Data Bank (PDB), 2021/10/13
DOI: 10.2210/pdb7DT5/pdb, https://www.wwpdb.org/pdb?id=pdb_00007dt5
Dataset
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Crystal structure of the first bromodomain of BRD4 in complex with 16D10
Segawa, R. (Contributor), Takeda, H. (Contributor), Yokoyama, T. (Contributor), Ishida, M. (Contributor), Miyata, C. (Contributor), Saito, T. (Contributor), Ishihara, R. (Contributor), Nakagita, T. (Contributor), Sasano, Y. (Contributor), Kanoh, N. (Contributor), Iwabuchi, Y. (Contributor), Mizuguchi, M. (Contributor), Hiratsuka, M. (Contributor) & Hirasawa, N. (Contributor), Protein Data Bank (PDB), 2022/08/03
DOI: 10.2210/pdb7FH2/pdb, https://www.wwpdb.org/pdb?id=pdb_00007fh2
Dataset
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Crystal structure of V30M-TTR in complex with naringenin derivative-14
Mizuguchi, M. (Contributor), Nakagawa, Y. (Contributor), Inui, K. (Contributor), Katayama, W. (Contributor), Sawai, Y. (Contributor), Shimane, A. (Contributor), Kitakami, R. (Contributor), Okada, T. (Contributor), Nabeshima, Y. (Contributor), Yokoyama, T. (Contributor), Kanamitsu, K. (Contributor), Nakagawa, S. (Contributor) & Toyooka, N. (Contributor), Protein Data Bank (PDB), 2022/12/14
DOI: 10.2210/pdb7W9Q/pdb, https://www.wwpdb.org/pdb?id=pdb_00007w9q
Dataset