Projects per year
Personal profile
Campus career
創薬科学科 助教 2011/06/01-2019/09/30
生命分子薬学系 助教 2011/06/01-2019/09/30
薬学・和漢系 助教 2019/10/01-
薬学科 助教 2019/10/01-
生命分子薬学系 助教 2011/06/01-2019/09/30
薬学・和漢系 助教 2019/10/01-
薬学科 助教 2019/10/01-
Affiliated academic society
日本生物物理学会 所属期間：2009/04-
日本中性子科学会 所属期間：2011/04-
日本蛋白質科学会 所属期間：2012/04-
日本中性子科学会 所属期間：2011/04-
日本蛋白質科学会 所属期間：2012/04-
Research interests
・X線および中性子などの量子ビームを利用した構造生物学
・立体構造情報を利用した医薬品化学研究
・立体構造情報を利用した医薬品化学研究
Field of expertise (Grants-in-aid for Scientific Research classification)
- Biophysics
- Structural biochemistry
- Physical pharmacy
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
Projects
- 4 Finished
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Development of a selective BRD4 inhibitor by neutron protein crystallographic analysis
Yokoyama, T. (PI)
2019/04/01 → 2022/03/31
Project: Research
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Development of a TTR amyloidogenesis inhibitor based on the capture of transthyretin monomers
Yokoyama, T. (PI)
2016/04/01 → 2019/03/31
Project: Research
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Neutron Diffraction Analysis of Human Farnesyl Pyrophosphate Synthase in Complex with Bisphosphonate
Yokoyama, T. (PI)
2013/04/01 → 2016/03/31
Project: Research
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Neutron crystallographic analysis of human transthyretin
Yokoyama, T. (PI)
2009/04/01 → 2012/03/31
Project: Research
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Divergent total synthesis of natural products bearing isoflavone and 2-oxabicyclo[3.3.1]nonane skeleton using phloroglucinol and their application in drug discovery
Okada, T., Mizuguchi, M., Yokoyama, T., Awale, S. & Toyooka, N., 2025, (Accepted/In press) Advances in Heterocyclic Chemistry. Academic Press Inc., (Advances in Heterocyclic Chemistry).Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
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Repurposing of Agrochemicals as ATTRv Amyloidosis Inhibitors
Yokoyama, T., Fujiwara, S., Nishikubo, K., Mizuguchi, M., Nabeshima, Y., Toyooka, N., Okada, T. & Nakagawa, Y., 2025/01/23, In: Journal of Medicinal Chemistry. 68, 2, p. 1572-1586 15 p.Research output: Contribution to journal › Article › peer-review
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Development of Benziodarone Analogues with Enhanced Potency for Selective Binding to Transthyretin in Human Plasma
Mizuguchi, M., Nakagawa, Y., Yokoyama, T., Okada, T., Fujii, K., Takahashi, K., Luan, N. N. T., Nabeshima, Y., Kanamitsu, K., Nakagawa, S., Yamakawa, S., Ueda, M., Ando, Y. & Toyooka, N., 2024/05/09, In: Journal of Medicinal Chemistry. 67, 9, p. 6987-7005 19 p.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Discovery and optimization of isoliquiritigenin as a death-associated protein kinase 1 inhibitor
Yokoyama, T., Hisatomi, K., Oshima, S., Tanaka, I., Okada, T. & Toyooka, N., 2024/12/05, In: European Journal of Medicinal Chemistry. 279, 116836.Research output: Contribution to journal › Article › peer-review
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Divergent Total Synthesis of Isoflavone Natural Products and Their Potential as Therapeutic Agents for TTR Amyloidosis
Thanh Luan, N. N., Okada, T., Yokoyama, T., Suzuki, M., Nabeshima, Y., Mizuguchi, M. & Toyooka, N., 2024/11/22, In: Journal of Natural Products. 87, 11, p. 2604-2614 11 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations
Datasets
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Crystal structure of the first bromodomain of BRD4 in complex with 16D10
Segawa, R. (Contributor), Takeda, H. (Contributor), Yokoyama, T. (Contributor), Ishida, M. (Contributor), Miyata, C. (Contributor), Saito, T. (Contributor), Ishihara, R. (Contributor), Nakagita, T. (Contributor), Sasano, Y. (Contributor), Kanoh, N. (Contributor), Iwabuchi, Y. (Contributor), Mizuguchi, M. (Contributor), Hiratsuka, M. (Contributor) & Hirasawa, N. (Contributor), Protein Data Bank (PDB), 2022/08/03
DOI: 10.2210/pdb7FH2/pdb, https://www.wwpdb.org/pdb?id=pdb_00007fh2
Dataset
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Crystal structure of V30M mutated transthyretin in complex with 8-chloro-9-oxo-9H-xanthene-3-carboxylic acid
Kitakami, R. (Contributor), Inui, K. (Contributor), Nakagawa, Y. (Contributor), Sawai, Y. (Contributor), Katayama, W. (Contributor), Yokoyama, T. (Contributor), Okada, T. (Contributor), Kanamitsu, K. (Contributor), Nakagawa, S. (Contributor), Toyooka, N. (Contributor) & Mizuguchi, M. (Contributor), Protein Data Bank (PDB), 2021/10/13
DOI: 10.2210/pdb7EJR/pdb, https://www.wwpdb.org/pdb?id=pdb_00007ejr
Dataset
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Crystal structure of human transthyretin in complex with 4-chloro-9,10-dioxo-9,10-dihydroanthracene-2-carboxylic acid
Kitakami, R. (Contributor), Inui, K. (Contributor), Nakagawa, Y. (Contributor), Sawai, Y. (Contributor), Katayama, W. (Contributor), Yokoyama, T. (Contributor), Okada, T. (Contributor), Kanamitsu, K. (Contributor), Nakagawa, S. (Contributor), Toyooka, N. (Contributor) & Mizuguchi, M. (Contributor), Protein Data Bank (PDB), 2021/10/13
DOI: 10.2210/pdb7DT3/pdb, https://www.wwpdb.org/pdb?id=pdb_00007dt3
Dataset
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Crystal structure of human transthyretin in complex with 4-chloro-9-oxo-9H-xanthene-2-carboxylic acid
Kitakami, R. (Contributor), Inui, K. (Contributor), Nakagawa, Y. (Contributor), Sawai, Y. (Contributor), Katayama, W. (Contributor), Yokoyama, T. (Contributor), Okada, T. (Contributor), Kanamitsu, K. (Contributor), Nakagawa, S. (Contributor), Toyooka, N. (Contributor) & Mizuguchi, M. (Contributor), Protein Data Bank (PDB), 2021/10/13
DOI: 10.2210/pdb7DT5/pdb, https://www.wwpdb.org/pdb?id=pdb_00007dt5
Dataset
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Crystal structure of V30M mutated transthyretin in complex with purpurin
Kitakami, R. (Contributor), Inui, K. (Contributor), Nakagawa, Y. (Contributor), Sawai, Y. (Contributor), Katayama, W. (Contributor), Yokoyama, T. (Contributor), Okada, T. (Contributor), Kanamitsu, K. (Contributor), Nakagawa, S. (Contributor), Toyooka, N. (Contributor) & Mizuguchi, M. (Contributor), Protein Data Bank (PDB), 2021/10/13
DOI: 10.2210/pdb7DT6/pdb, https://www.wwpdb.org/pdb?id=pdb_00007dt6
Dataset