Projects per year
Personal profile
Campus career
創薬科学科 助教 2011/06/01-2019/09/30
生命分子薬学系 助教 2011/06/01-2019/09/30
薬学・和漢系 助教 2019/10/01-
薬学科 助教 2019/10/01-
生命分子薬学系 助教 2011/06/01-2019/09/30
薬学・和漢系 助教 2019/10/01-
薬学科 助教 2019/10/01-
Affiliated academic society
日本生物物理学会 所属期間：2009/04-
日本中性子科学会 所属期間：2011/04-
日本蛋白質科学会 所属期間：2012/04-
日本中性子科学会 所属期間：2011/04-
日本蛋白質科学会 所属期間：2012/04-
Research interests
・X線および中性子などの量子ビームを利用した構造生物学
・立体構造情報を利用した医薬品化学研究
・立体構造情報を利用した医薬品化学研究
Field of expertise (Grants-in-aid for Scientific Research classification)
- Biophysics
- Structural biochemistry
- Physical pharmacy
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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中性子解析に基づく分子標的薬の選択性向上と治療薬開発
Yokoyama, T. (Principal Investigator) & Okada, T. (Co-Investigator(Kenkyū-buntansha))
Japan Society for the Promotion of Science
2024/04/01 → 2027/03/31
Project: Research Project
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Development of a selective BRD4 inhibitor by neutron protein crystallographic analysis
Yokoyama, T. (PI)
2019/04/01 → 2022/03/31
Project: Research
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Development of a TTR amyloidogenesis inhibitor based on the capture of transthyretin monomers
Yokoyama, T. (PI)
2016/04/01 → 2019/03/31
Project: Research
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Neutron Diffraction Analysis of Human Farnesyl Pyrophosphate Synthase in Complex with Bisphosphonate
Yokoyama, T. (PI)
2013/04/01 → 2016/03/31
Project: Research
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Neutron crystallographic analysis of human transthyretin
Yokoyama, T. (PI)
2009/04/01 → 2012/03/31
Project: Research
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Repurposing of Agrochemicals as ATTRv Amyloidosis Inhibitors
Yokoyama, T., Fujiwara, S., Nishikubo, K., Mizuguchi, M., Nabeshima, Y., Toyooka, N., Okada, T. & Nakagawa, Y., 2025/01/23, In: Journal of Medicinal Chemistry. 68, 2, p. 1572-1586 15 p.Research output: Contribution to journal › Article › peer-review
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Development of Benziodarone Analogues with Enhanced Potency for Selective Binding to Transthyretin in Human Plasma
Mizuguchi, M., Nakagawa, Y., Yokoyama, T., Okada, T., Fujii, K., Takahashi, K., Luan, N. N. T., Nabeshima, Y., Kanamitsu, K., Nakagawa, S., Yamakawa, S., Ueda, M., Ando, Y. & Toyooka, N., 2024/05/09, In: Journal of Medicinal Chemistry. 67, 9, p. 6987-7005 19 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Discovery and optimization of isoliquiritigenin as a death-associated protein kinase 1 inhibitor
Yokoyama, T., Hisatomi, K., Oshima, S., Tanaka, I., Okada, T. & Toyooka, N., 2024/12/05, In: European Journal of Medicinal Chemistry. 279, 116836.Research output: Contribution to journal › Article › peer-review
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Divergent Total Synthesis of Isoflavone Natural Products and Their Potential as Therapeutic Agents for TTR Amyloidosis
Thanh Luan, N. N., Okada, T., Yokoyama, T., Suzuki, M., Nabeshima, Y., Mizuguchi, M. & Toyooka, N., 2024/11/22, In: Journal of Natural Products. 87, 11, p. 2604-2614 11 p.Research output: Contribution to journal › Article › peer-review
Open Access -
SIRT5 mutants reveal the role of conserved asparagine and glutamine residues in the NAD+-binding pocket
Yokoyama, T., Takayama, Y., Mizuguchi, M., Nabeshima, Y. & Kusaka, K., 2024/09, In: FEBS Letters. 598, 18, p. 2269-2280 12 p.Research output: Contribution to journal › Article › peer-review
Datasets
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Crystal structure of V30M-TTR in complex with naringenin derivative-14
Mizuguchi, M. (Contributor), Nakagawa, Y. (Contributor), Inui, K. (Contributor), Katayama, W. (Contributor), Sawai, Y. (Contributor), Shimane, A. (Contributor), Kitakami, R. (Contributor), Okada, T. (Contributor), Nabeshima, Y. (Contributor), Yokoyama, T. (Contributor), Kanamitsu, K. (Contributor), Nakagawa, S. (Contributor) & Toyooka, N. (Contributor), Protein Data Bank (PDB), 2022/12/14
DOI: 10.2210/pdb7W9Q/pdb, https://www.wwpdb.org/pdb?id=pdb_00007w9q
Dataset
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Crystal structure of E61K mutated transthyretin
Murakami, T. (Contributor), Yokoyama, T. (Contributor), Mizuguchi, M. (Contributor), Toné, S. (Contributor), Takaku, S. (Contributor), Sango, K. (Contributor), Nishimura, H. (Contributor), Watabe, K. (Contributor) & Sunada, Y. (Contributor), Protein Data Bank (PDB), 2020/07/22
DOI: 10.2210/pdb6KGB/pdb, https://www.wwpdb.org/pdb?id=pdb_00006kgb
Dataset
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Crystal structure of V30M-TTR in complex with naringenin derivative-18
Mizuguchi, M. (Contributor), Nakagawa, Y. (Contributor), Inui, K. (Contributor), Katayama, W. (Contributor), Sawai, Y. (Contributor), Shimane, A. (Contributor), Kitakami, R. (Contributor), Okada, T. (Contributor), Nabeshima, Y. (Contributor), Yokoyama, T. (Contributor), Kanamitsu, K. (Contributor), Nakagawa, S. (Contributor) & Toyooka, N. (Contributor), Protein Data Bank (PDB), 2022/12/14
DOI: 10.2210/pdb7W9R/pdb, https://www.wwpdb.org/pdb?id=pdb_00007w9r
Dataset
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Crystal structure of the first bromodomain of BRD4 in complex with 16D10
Segawa, R. (Contributor), Takeda, H. (Contributor), Yokoyama, T. (Contributor), Ishida, M. (Contributor), Miyata, C. (Contributor), Saito, T. (Contributor), Ishihara, R. (Contributor), Nakagita, T. (Contributor), Sasano, Y. (Contributor), Kanoh, N. (Contributor), Iwabuchi, Y. (Contributor), Mizuguchi, M. (Contributor), Hiratsuka, M. (Contributor) & Hirasawa, N. (Contributor), Protein Data Bank (PDB), 2022/08/03
DOI: 10.2210/pdb7FH2/pdb, https://www.wwpdb.org/pdb?id=pdb_00007fh2
Dataset
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Crystal structure of WT-TTR in complex with bithionol
Yokoyama, T. (Contributor), Kashihara, M. (Contributor) & Mizuguchi, M. (Contributor), Protein Data Bank (PDB), 2021/11/24
DOI: 10.2210/pdb7ERH/pdb, https://www.wwpdb.org/pdb?id=pdb_00007erh
Dataset
Courses
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生物物理学特論
Tomohiro, T., Mizuguchi, M., Obita, T., Yokoyama, T., Nakano, M., Ikeda, K., Nakao, H. & Tanimoto, H. 2023/12/04 → 2024/03/31
Course