Michiko Jo - University of Toyama

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Research activity per year

Campus career

和漢医薬学総合研究所　助教　2010/04/01-2019/09/30
薬学・和漢系　助教　2019/10/01-
和漢医薬学総合研究所　助教　2019/10/01-

Research interests

ピオグリタゾンは画期的な薬剤であるが,深刻な末梢性浮腫が生じることが重要な問題となっている.その対処療法として利尿薬が用いられているが,ピオグリタゾンで生じる過剰な水分の体内貯留には無効なことが多く,長期的な使用では糖尿病を悪化させる危険性が指摘されている.そのため,体内の水分代謝調節作用を持ち,電解質異常改善効果や腎保護作用を併せ持つ五苓散を用いることで末梢性浮腫を改善することが可能か否か,さらに糖尿病に対する治療効果について検討している.

Research Fields, Keywords

pre-disease signals
glutaminase Inhibitor
lymphatic vessel
Kampo

Field of expertise (Grants-in-aid for Scientific Research classification)

General internal medicine (including psychosomatic medicine)

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3 Finished

漢方方剤による二次性リンパ浮腫改善機序の解明
Jo, M. (PI)
2020/04/01 → 2025/03/31
Project: Research
Effect of goreisan on rat mesenteric lymphtic vessels.
Jo, M. (PI)
2017/04/01 → 2020/03/31
Project: Research
Effect of Goreisan on edema improvement mechanism and expression of aquaporin 2.
Jo, M. (PI)
2013/04/01 → 2015/03/31
Project: Research

18 Article

Design, synthesis, structure–activity relationship studies, and evaluation of novel GLS1 inhibitors
Jo, M., Koizumi, K., Suzuki, M., Kanayama, D., Watanabe, Y., Gouda, H., Mori, H., Mizuguchi, M., Obita, T., Nabeshima, Y., Toyooka, N. & Okada, T., 2023/05/01, In: Bioorganic and Medicinal Chemistry Letters. 87, 129266.
Research output: Contribution to journal › Article › peer-review
3 Scopus citations
Design and structural optimization of thiadiazole derivatives with potent GLS1 inhibitory activity
Okada, T., Yamabe, K., Jo, M., Sakajiri, Y., Shibata, T., Sawada, R., Yamanishi, Y., Kanayama, D., Mori, H., Mizuguchi, M., Obita, T., Nabeshima, Y., Koizumi, K. & Toyooka, N., 2023/09/01, In: Bioorganic and Medicinal Chemistry Letters. 93, 129438.
Research output: Contribution to journal › Article › peer-review
1 Scopus citations
Female and male obese Zucker rats display differential inflammatory mediator and long non-coding RNA profiles
Patel, N. A., Lui, A., Trujillo, A. N., Motawe, Z. Y., Bader, D., Schuster, J., Burgess, A., Alves, N. G., Jo, M. & Breslin, J. W., 2023/12/15, In: Life Sciences. 335, 122285.
Research output: Contribution to journal › Article › peer-review

Open Access
1 Scopus citations
Impact of Goreisan components on rat mesenteric collecting lymphatic vessel pumping
Jo, M., Trujillo, A. N., Shibahara, N. & Breslin, J. W., 2023/04, In: Microcirculation. 30, 2-3, e12788.
Research output: Contribution to journal › Article › peer-review

Open Access
4 Scopus citations
Uncovering the metabolomic effects of Kampo formulas using ¹H-NMR spectroscopy: A case study of goreisan
Awale, S., Jo, M., Watanabe, S., Shibahara, N. & Matsumoto, K., 2023/08, In: Traditional & Kampo Medicine. 10, 2, p. 142-149 8 p.
Research output: Contribution to journal › Article › peer-review

Open Access
2 Scopus citations

和漢医薬学入門

Fujimoto, M., Kainuma, M., Kato, A., Yamada, R., Yamamura, Y., Lee, J., Watanabe, S., Shibahara, N., Toda, M., Tohda, C., Koizumi, K., Morita, H., Hayakawa, Y., Nakagawa, Y., Kim, J., Yang, X., Susukida, T., Kodama, T., Oku, M., Jo, M., Inada, Y., Sasaki, S., Nakashima, Y., Shoji, T. & Akagi, K.

2024/04/01 → 2024/09/30

Course

和漢医薬学入門

Fujimoto, M., Kainuma, M., Kato, A., Yamada, R., Yamamura, Y., Lee, J., Watanabe, S., Shibahara, N., Toda, M., Tohda, C., Koizumi, K., Morita, H., Hayakawa, Y., Nakagawa, Y., Kim, J., Yang, X., Susukida, T., Kodama, T., Oku, M., Jo, M., Inada, Y., Sasaki, S., Nakashima, Y., Shoji, T., Akagi, K., Shimada, Y., Fujimoto, M., Kainuma, M., Taura, F., Kato, A., Yamada, R., Komatsu, K., Watanabe, S., Shibahara, N., Toda, M., Tohda, C., Koizumi, K., Morita, H., Hayakawa, Y., Toume, K., Nakagawa, Y., Kim, J., Yang, X., Susukida, T., Zhu, S., Kodama, T., Oku, M., Jo, M., Inada, Y., Sasaki, S. & Nakashima, Y.

2024/04/01 → 2024/09/30

Course

和漢医薬学入門

Kadowaki, M., Kainuma, M., Kato, A., Yamada, R., Yamamura, Y., Lee, J., Watanabe, S., Shibahara, N., Toda, M., Tohda, C., Koizumi, K., Morita, H., Hayakawa, Y., Toume, K., Yamamoto, T., Nakagawa, Y., Kim, J., Yang, X., Susukida, T., Kodama, T., Oku, M., Jo, M., Inada, Y., Sasaki, S., Nakashima, Y. & Hayashi, S.

2024/04/01 → 2024/09/30

Course

東西医薬学Ⅰ
Kato, A., Watanabe, S., Tohda, C., Koizumi, K., Morita, H., Hayakawa, Y., Awale, S., Nakagawa, Y., Kim, J., Oku, M., Jo, M., Sasaki, S., Nakashima, Y. & Shoji, T.
2024/04/01 → 2024/09/30
Course
東西医薬学Ⅰ
Kato, A., Watanabe, S., Tohda, C., Koizumi, K., Morita, H., Hayakawa, Y., Toume, K., Awale, S., Nakagawa, Y., Kim, J., Oku, M., Jo, M., Hayashi, S. & Shoji, T.
2023/10/01 → 2024/03/31
Course