Research output per year
Research output per year
- 1 - 50 out of 80 results
Search results
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2025
Characterization of bone marrow cells for prognosis prediction of multiple myeloma using Raman spectroscopy with optimal discriminant model
Oshima, Y., Taketani, A., Yonezawa, S., Haruki, T., Wada, A., Sato, T. & Koizumi, K., 2025, Optical Biopsy XXIII: Toward Real-Time Spectroscopic Imaging and Diagnosis. Alfano, R. R., Seddon, A. B., Shi, L. & Wu, B. (eds.). SPIE, 1331102. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; vol. 13311).Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review
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Identification of the Cellular Tipping Point in the Inflammation Model of LPS-Induced RAW264.7 Macrophages Through Raman Spectroscopy and the Dynamical Network Biomarker Theory
Taketani, A., Koshiyama, S., Haruki, T., Yonezawa, S., Tahara, J., Yamazaki, M., Oshima, Y., Wada, A., Sato, T., Koizumi, K., Kitajima, I. & Saito, S., 2025/02, In: Molecules. 30, 4, 920.Research output: Contribution to journal › Article › peer-review
Open Access -
Identifying the crucial tipping point in the maturation process of cultured neurons using Raman spectroscopy and a dynamic network biomarker (DNB) analysis
Hashimoto, K., Yonezawa, S., Haruki, T., Koizumi, K., Oshima, Y., Kitajima, I., Sato, H. & Saito, S., 2025/01, In: Biochemical and Biophysical Research Communications. 743, 151167.Research output: Contribution to journal › Article › peer-review
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Integration of Dynamical Network Biomarkers, Control Theory and Drosophila Model Identifies Vasa/DDX4 as the Potential Therapeutic Targets for Metabolic Syndrome
Akagi, K., Jin, Y. J., Koizumi, K., Oku, M., Ito, K., Shen, X., Imura, J. I., Aihara, K. & Saito, S., 2025/03, In: Cells. 14, 6, 415.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
2024
Establishing Monoclonal Gammopathy of Undetermined Significance as an Independent Pre-Disease State of Multiple Myeloma Using Raman Spectroscopy, Dynamical Network Biomarker Theory, and Energy Landscape Analysis
Yonezawa, S., Haruki, T., Koizumi, K., Taketani, A., Oshima, Y., Oku, M., Wada, A., Sato, T., Masuda, N., Tahara, J., Fujisawa, N., Koshiyama, S., Kadowaki, M., Kitajima, I. & Saito, S., 2024/02, In: International Journal of Molecular Sciences. 25, 3, 1570.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
Yuragi biomarker concept for evaluating human induced pluripotent stem cells using heterogeneity-based Raman finger-printing
Fujita, H., Haruki, T., Sudo, K., Koga, Y., Nakamura, Y., Abe, K., Yoshida, Y., Koizumi, K. & Watanabe, T. M., 2024/03/22, In: Biophysics and physicobiology. 21, p. 1 12 p., e211016.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
ラマン分光法の臨床応用と未病状態の検出に向けた取り組み
Oshima, Y., Haruki, T., Yonezawa, S., Taketani, A., Koizumi, K. & Katagiri, T., 2024/06/20, In: レーザー研究. 52, 6, p. 298 302 p.Research output: Contribution to journal › Review article
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2023
Design, synthesis, structure–activity relationship studies, and evaluation of novel GLS1 inhibitors
Jo, M., Koizumi, K., Suzuki, M., Kanayama, D., Watanabe, Y., Gouda, H., Mori, H., Mizuguchi, M., Obita, T., Nabeshima, Y., Toyooka, N. & Okada, T., 2023/05/01, In: Bioorganic and Medicinal Chemistry Letters. 87, 129266.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
Design and structural optimization of thiadiazole derivatives with potent GLS1 inhibitory activity
Okada, T., Yamabe, K., Jo, M., Sakajiri, Y., Shibata, T., Sawada, R., Yamanishi, Y., Kanayama, D., Mori, H., Mizuguchi, M., Obita, T., Nabeshima, Y., Koizumi, K. & Toyooka, N., 2023/09/01, In: Bioorganic and Medicinal Chemistry Letters. 93, 129438.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
New Possibilities for Evaluating the Development of Age-Related Pathologies Using the Dynamical Network Biomarkers Theory
Akagi, K., Koizumi, K., Kadowaki, M., Kitajima, I. & Saito, S., 2023/09, In: Cells. 12, 18, 2297.Research output: Contribution to journal › Review article › peer-review
Open Access2 Scopus citations -
Practices, Potential, and Perspectives for Detecting Predisease Using Raman Spectroscopy
Oshima, Y., Haruki, T., Koizumi, K., Yonezawa, S., Taketani, A., Kadowaki, M. & Saito, S., 2023/08, In: International Journal of Molecular Sciences. 24, 15, 12170.Research output: Contribution to journal › Review article › peer-review
Open Access9 Scopus citations -
データ駆動型アプローチによる未病の解明
Haruki, T., Koizumi, K., Yonezawa, S., Oku, M., Oshima, Y., Hayashi, S., Watanabe, T. M., Kadowaki, M. & Saito, S., 2023/10/31, In: 基礎老化研究. 47, 3, p. 35 41 p.Research output: Contribution to journal › Review article
Open Access -
未病研究の最前線
Saito, S., Haruki, T., Yonezawa, S., Oshima, Y., Kadowaki, M. & Koizumi, K., 2023/04/15, In: 生体の科学. 74, 2, p. 129 133 p.Research output: Contribution to journal › Review article
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2022
Application of the Dynamical Network Biomarker Theory to Raman Spectra
Haruki, T., Yonezawa, S., Koizumi, K., Yoshida, Y., Watanabe, T. M., Fujita, H., Oshima, Y., Oku, M., Taketani, A., Yamazaki, M., Ichimura, T., Kadowaki, M., Kitajima, I. & Saito, S., 2022/12, In: Biomolecules. 12, 12, 1730.Research output: Contribution to journal › Article › peer-review
7 Scopus citations -
Dynamical network biomarkers: Theory and applications
Aihara, K., Liu, R., Koizumi, K., Liu, X. & Chen, L., 2022/01/15, In: Gene. 808, 145997.Research output: Contribution to journal › Article › peer-review
Open Access44 Scopus citations -
2021
Erratum: Suppression of dynamical network biomarker signals at the predisease state (Mibyou) before metabolic syndrome in mice by a traditional Japanese medicine (Kampo Formula) bofutsushosan (Evidence-Based Complementary and Alternative Medicine (2020) 2020 (9129134) DOI: 10.1155/2020/9129134)
Koizumi, K., Oku, M., Hayashi, S., Inujima, A., Shibahara, N., Chen, L., Igarashi, Y., Tobe, K., Saito, S., Kadowaki, M. & Aihara, K., 2021, In: Evidence-based Complementary and Alternative Medicine. 2021, 9760307.Research output: Contribution to journal › Comment/debate
Open Access -
Survival of detached cancer cells is regulated by movement of intracellular Na+,K+-ATPase
Fujii, T., Shimizu, T., Katoh, M., Nagamori, S., Koizumi, K., Fukuoka, J., Tabuchi, Y., Sawaguchi, A., Okumura, T., Shibuya, K., Fujii, T., Takeshima, H. & Sakai, H., 2021/05/21, In: iScience. 24, 5, 102412.Research output: Contribution to journal › Article › peer-review
Open Access13 Scopus citations -
2020
Suppression of Dynamical Network Biomarker Signals at the Predisease State (Mibyou) before Metabolic Syndrome in Mice by a Traditional Japanese Medicine (Kampo Formula) Bofutsushosan
Koizumi, K., Oku, M., Hayashi, S., Inujima, A., Shibahara, N., Chen, L., Igarashi, Y., Tobe, K., Saito, S., Kadowaki, M. & Aihara, K., 2020, In: Evidence-based Complementary and Alternative Medicine. 2020, 9129134.Research output: Contribution to journal › Article › peer-review
Open Access17 Scopus citations -
2019
Identifying pre-disease signals before metabolic syndrome in mice by dynamical network biomarkers
Koizumi, K., Oku, M., Hayashi, S., Inujima, A., Shibahara, N., Chen, L., Igarashi, Y., Tobe, K., Saito, S., Kadowaki, M. & Aihara, K., 2019/12/01, In: Scientific Reports. 9, 1, 8767.Research output: Contribution to journal › Article › peer-review
Open Access44 Scopus citations -
2018
Discovery of a sugar-based nanoparticle universally existing in boiling herbal water extracts and their immunostimulant effect
Iitsuka, H., Koizumi, K., Inujima, A., Suzaki, M., Mizuno, Y., Takeshita, Y., Eto, T., Otsuka, Y., Shimada, R., Liu, M., Ikeda, K., Nakano, M., Suzuki, R., Maruyama, K., Zhou, Y., Sakurai, H. & Shibahara, N., 2018/12, In: Biochemistry and Biophysics Reports. 16, p. 62-68 7 p.Research output: Contribution to journal › Article › peer-review
Open Access22 Scopus citations -
Partial depletion of CD206-positive M2-like macrophages induces proliferation of beige progenitors and enhances browning after cold stimulation
Igarashi, Y., Nawaz, A., Kado, T., Bilal, M., Kuwano, T., Yamamoto, S., Sasahara, M., Jiuxiang, X., Inujima, A., Koizumi, K., Imura, J., Shibahara, N., Usui, I., Fujisaka, S. & Tobe, K., 2018/12/01, In: Scientific Reports. 8, 1, 14567.Research output: Contribution to journal › Article › peer-review
Open Access27 Scopus citations -
2016
Efficient use of a crude drug/herb library reveals Ephedra herb as a specific antagonist for T H 2-specific chemokine receptors CCR3, CCR4, and CCR8
Matsuo, K., Koizumi, K., Fujita, M., Morikawa, T., Jo, M., Shibahara, N., Saiki, I., Yoshie, O. & Nakayama, T., 2016/06/07, In: Frontiers in Cell and Developmental Biology. 4, JUN, 54.Research output: Contribution to journal › Article › peer-review
Open Access11 Scopus citations -
HIF-1α in myeloid cells promotes adipose tissue remodeling toward insulin resistance
Takikawa, A., Mahmood, A., Nawaz, A., Kado, T., Okabe, K., Yamamoto, S., Aminuddin, A., Senda, S., Tsuneyama, K., Ikutani, M., Watanabe, Y., Igarashi, Y., Nagai, Y., Takatsu, K., Koizumi, K., Imura, J., Goda, N., Sasahara, M., Matsumoto, M. & Saeki, K. & 4 others, , 2016/12/01, In: Diabetes. 65, 12, p. 3649-3659 11 p.Research output: Contribution to journal › Article › peer-review
95 Scopus citations -
2015
Crucial roles of RSK in cell motility by catalysing serine phosphorylation of EphA2
Zhou, Y., Yamada, N., Tanaka, T., Hori, T., Yokoyama, S., Hayakawa, Y., Yano, S., Fukuoka, J., Koizumi, K., Saiki, I. & Sakurai, H., 2015/07/09, In: Nature Communications. 6, 7679.Research output: Contribution to journal › Article › peer-review
Open Access119 Scopus citations -
Herbal plant-derived compound, 1,2,3,4,6-penta-O-galloyl-β-d-glucose, increases cross-presentation by dendritic cells
Inujima, A., Yamada, M., Takeno, N., Hoshina, A., Oe, M., Shinohara, K., Shibahara, N., Sakurai, H., Saiki, I. & Koizumi, K., 2015/09, In: Traditional & Kampo Medicine. 2, 2, p. 43-49 7 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Immune adjuvant effect of juzentaihoto, a Japanese traditional herbal medicine, on tumor vaccine therapy in a mouse model
Takeno, N., Inujima, A., Shinohara, K., Yamada, M., Shibahara, N., Sakurai, H., Saiki, I. & Koizumi, K., 2015/12, In: International Journal of Oncology. 47, 6, p. 2115-2122 8 p.Research output: Contribution to journal › Article › peer-review
Open Access15 Scopus citations -
Inhibitory effect of Moutan Cortex aqueous fraction on mast cell-mediated allergic inflammation
Kee, J. Y., Inujima, A., Andoh, T., Tanaka, K., Li, F., Kuraishi, Y., Sakurai, H., Shibahara, N., Saiki, I. & Koizumi, K., 2015/04, In: Natural Medicines. 69, 2, p. 209-217 9 p.Research output: Contribution to journal › Article › peer-review
17 Scopus citations -
Role of chemokine CX3CL1 in progression of multiple myeloma via CX3CR1 in bone microenvironments
Wada, A., Ito, A., Iitsuka, H., Tsuneyama, K., Miyazono, T., Murakami, J., Shibahara, N., Sakurai, H., Saiki, I., Nakayama, T., Yoshie, O., Koizumi, K. & Sugiyama, T., 2015/06/01, In: Oncology Reports. 33, 6, p. 2935-2939 5 p.Research output: Contribution to journal › Article › peer-review
Open Access20 Scopus citations -
2014
CXCL16 suppresses liver metastasis of colorectal cancer by promoting TNF-α-induced apoptosis by tumor-associated macrophages
Kee, J. Y., Ito, A., Hojo, S., Hashimoto, I., Igarashi, Y., Tsuneyama, K., Tsukada, K., Irimura, T., Shibahara, N., Takasaki, I., Inujima, A., Nakayama, T., Yoshie, O., Sakurai, H., Saiki, I. & Koizumi, K., 2014/12/15, In: BMC Cancer. 14, 1, 949.Research output: Contribution to journal › Article › peer-review
Open Access46 Scopus citations -
2013
Chemokine CXCL16 suppresses liver metastasis of colorectal cancer via augmentation of tumor-infiltrating natural killer T cells in a murine model
Kee, J. Y., Ito, A., Hojo, S., Hashimoto, I., Igarashi, Y., Tsukada, K., Irimura, T., Shibahara, N., Nakayama, T., Yoshie, O., Sakurai, H., Saiki, I. & Koizumi, K., 2013/03, In: Oncology Reports. 29, 3, p. 975-982 8 p.Research output: Contribution to journal › Article › peer-review
Open Access41 Scopus citations -
Impaired autophagy by soluble endoglin, under physiological hypoxia in early pregnant period, is involved in poor placentation in preeclampsia
Nakashima, A., Yamanaka-Tatematsu, M., Fujita, N., Koizumi, K., Shima, T., Yoshida, T., Nikaido, T., Okamoto, A., Yoshimori, T. & Saito, S., 2013/03, In: Autophagy. 9, 3, p. 303-316 14 p.Research output: Contribution to journal › Article › peer-review
Open Access163 Scopus citations -
Inverse correlation between Thr-669 and constitutive tyrosine phosphorylation in the asymmetric epidermal growth factor receptor dimer conformation
Sato, K., Shin, M. S., Sakimura, A., Zhou, Y., Tanaka, T., Kawanishi, M., Kawasaki, Y., Yokoyama, S., Koizumi, K., Saiki, I. & Sakurai, H., 2013/10, In: Cancer Science. 104, 10, p. 1315-1322 8 p.Research output: Contribution to journal › Article › peer-review
Open Access32 Scopus citations -
Structure, synthesis, and biological activity of a C-20 bisacetylenic alcohol from a marine sponge Callyspongia sp.
Shirouzu, T., Watari, K., Ono, M., Koizumi, K., Saiki, I., Tanaka, C., Van Soest, R. W. M. & Miyamoto, T., 2013/07/26, In: Journal of Natural Products. 76, 7, p. 1337-1342 6 p.Research output: Contribution to journal › Article › peer-review
19 Scopus citations -
Studies on lymphangiogenesis inhibitors from Korean and Japanese crude drugs
Jeong, D., Watari, K., Shirouzu, T., Ono, M., Koizumi, K., Saiki, I., Kim, Y. C., Tanaka, C., Higuchi, R. & Miyamoto, T., 2013/01, In: Biological and Pharmaceutical Bulletin. 36, 1, p. 152-157 6 p.Research output: Contribution to journal › Article › peer-review
Open Access20 Scopus citations -
The long-term effects of a Kampo medicine, juzentaihoto, on maintenance of antibody titer in elderly people after influenza vaccination
Saiki, I., Koizumi, K., Goto, H., Inujima, A., Namiki, T., Raimura, M., Kogure, T., Tatsumi, T., Inoue, H., Sakai, S., Oka, H., Fujimoto, M., Hikiami, H., Sakurai, H., Shibahara, N., Shimada, Y. & Origasa, H., 2013, In: Evidence-based Complementary and Alternative Medicine. 2013, 568074.Research output: Contribution to journal › Article › peer-review
Open Access18 Scopus citations -
2012
Calpain 1 and -2 play opposite roles in cord formation of lymphatic endothelial cells via eNOS regulation
Prangsaengtong, O., Senda, K., Doki, Y., Park, J. Y., Jo, M., Sakurai, H., Shibahara, N., Saiki, I. & Koizumi, K., 2012/06, In: Human cell : official journal of Human Cell Research Society. 25, 2, p. 36-44 9 p.Research output: Contribution to journal › Article › peer-review
9 Scopus citations -
Periostin Directly and Indirectly Promotes Tumor Lymphangiogenesis of Head and Neck Cancer
Kudo, Y., Iizuka, S., Yoshida, M., Nguyen, P. T., Siriwardena, S. B. S. M., Tsunematsu, T., Ohbayashi, M., Ando, T., Hatakeyama, D., Shibata, T., Koizumi, K., Maeda, M., Ishimaru, N., Ogawa, I. & Takata, T., 2012/08/30, In: PLoS ONE. 7, 8, e44488.Research output: Contribution to journal › Article › peer-review
Open Access54 Scopus citations -
Synthesis and evaluation of 1-(substituted)-3-prop-2-ynylureas as antiangiogenic agents
Sanphanya, K., Wattanapitayakul, S. K., Prangsaengtong, O., Jo, M., Koizumi, K., Shibahara, N., Priprem, A., Fokin, V. V. & Vajragupta, O., 2012/04/15, In: Bioorganic and Medicinal Chemistry Letters. 22, 8, p. 3001-3005 5 p.Research output: Contribution to journal › Article › peer-review
12 Scopus citations -
Therapeutics target of CXCR4 and its downstream in peritoneal carcinomatosis of gastric cancer
Koizumi, K., Kato, S., Sakurai, H., Hashimoto, I., Yasumoto, K. & Saiki, I., 2012/01/01, In: Frontiers in Bioscience - Scholar. 4 S, 1, p. 269-276 8 p.Research output: Contribution to journal › Article › peer-review
Open Access17 Scopus citations -
2011
Cinnamaldehyde and paeonol increase HIF-1α Activity in proximal tubular epithelial cells under hypoxia
Oka, H., Goto, H., Nogami, T., Watari, H., Shimada, Y., Koizumi, K., Shibahara, N., Nakamura, S., Zhou, Y., Sakurai, H. & Saiki, I., 2011, In: Journal of Traditional Medicines. 28, 3, p. 149-157 9 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Distinct roles of transforming growth factor-β-activated kinase 1 (TAK1)-c-Rel and interferon regulatory factor 4 (IRF4) pathways in human T cell lymphotropic virus 1-transformed T helper 17 cells producing interleukin-9
Refaat, A., Zhou, Y., Suzuki, S., Takasaki, I., Koizumi, K., Yamaoka, S., Tabuchi, Y., Saiki, I. & Sakurai, H., 2011/06/17, In: Journal of Biological Chemistry. 286, 24, p. 21092-21099 8 p.Research output: Contribution to journal › Article › peer-review
Open Access27 Scopus citations -
Effect of hachimijiogan against renal dysfunction and involvement of hypoxia-inducible factor-1 in the remnant kidney model
Goto, H., Oka, H., Koizumi, K., Nakamura, S., Tsuneyama, K., Zhou, Y., Jo, M., Fujimoto, T., Sakurai, H., Shibahara, N., Saiki, I. & Shimada, Y., 2011, In: Evidence-based Complementary and Alternative Medicine. 2011, 348686.Research output: Contribution to journal › Article › peer-review
Open Access10 Scopus citations -
ENOS and Hsp90 interaction directly correlates with cord formation in human lymphatic endothelial cells
Prangsaengtong, O., Koizumi, K., Senda, K., Sakurai, H. & Saiki, I., 2011/03/01, In: Lymphatic Research and Biology. 9, 1, p. 53-59 7 p.Research output: Contribution to journal › Article › peer-review
8 Scopus citations -
Gomisin N enhances TNF-α-induced apoptosis via inhibition of the NF-κB and EGFR survival pathways
Waiwut, P., Shin, M. S., Inujima, A., Zhou, Y., Koizumi, K., Saiki, I. & Sakurai, H., 2011/04, In: Molecular and Cellular Biochemistry. 350, 1-2, p. 169-175 7 p.Research output: Contribution to journal › Article › peer-review
21 Scopus citations -
2010
Human T cell lymphotropic virus 1 manipulates interferon regulatory signals by controlling the TAK1-IRF3 and IRF4 pathways
Suzuki, S., Zhou, Y., Refaat, A., Takasaki, I., Koizumi, K., Yamaoka, S., Tabuchi, Y., Saiki, I. & Sakurai, H., 2010/02/12, In: Journal of Biological Chemistry. 285, 7, p. 4441-4446 6 p.Research output: Contribution to journal › Article › peer-review
Open Access29 Scopus citations -
2009
Inducible capillary formation in lymphatic endothelial cells by blocking lipid phosphate phosphatase-3 activity
Senda, K., Koizumi, K., Prangsaengtong, O., Minami, T., Suzuki, S., Takasaki, I., Tabuchi, Y., Sakurai, H., Doki, Y., Misaki, T. & Saiki, I., 2009/06/01, In: Lymphatic Research and Biology. 7, 2, p. 69-74 6 p.Research output: Contribution to journal › Article › peer-review
7 Scopus citations -
Role of CX3CL1/fractalkine in osteoclast differentiation and bone resorption
Koizumi, K., Saitoh, Y., Minami, T., Takeno, N., Tsuneyama, K., Miyahara, T., Nakayama, T., Sakurai, H., Takano, Y., Nishimura, M., Imai, T., Yoshie, O. & Saiki, I., 2009/12/15, In: Journal of Immunology. 183, 12, p. 7825-7831 7 p.Research output: Contribution to journal › Article › peer-review
Open Access122 Scopus citations -
Serum active hepatocyte growth factor (AHGF) in benign prostatic disease and prostate cancer
Yasuda, K., Nagakawa, O., Akashi, T., Fujiuchi, Y., Koizumi, K., Komiya, A., Saiki, I. & Fuse, H., 2009/03/01, In: Prostate. 69, 4, p. 346-351 6 p.Research output: Contribution to journal › Article › peer-review
27 Scopus citations -
2008
Blocking on the CXCR4/mTOR signalling pathway induces the anti-metastatic properties and autophagic cell death in peritoneal disseminated gastric cancer cells
Hashimoto, I., Koizumi, K., Tatematsu, M., Minami, T., Cho, S., Takeno, N., Nakashima, A., Sakurai, H., Saito, S., Tsukada, K. & Saiki, I., 2008/05, In: European Journal of Cancer. 44, 7, p. 1022-1029 8 p.Research output: Contribution to journal › Article › peer-review
123 Scopus citations -
Heregulin-induced activation of ErbB3 by EGFR tyrosine kinase activity promotes tumor growth and metastasis in melanoma cells
Ueno, Y., Sakurai, H., Tsunoda, S., Choo, M. K., Matsuo, M., Koizumi, K. & Saiki, I., 2008/07/15, In: International Journal of Cancer. 123, 2, p. 340-347 8 p.Research output: Contribution to journal › Article › peer-review
70 Scopus citations