Projects per year
Personal profile
Campus career
和漢医薬学総合研究所 助教 2011/04/01-2018/12/31
薬学科 准教授 2019/01/01-2019/09/30
臨床薬科学系 准教授 2019/01/01-2019/09/30
薬学・和漢系 准教授 2019/10/01-
薬学科 准教授 2019/10/01-
薬学部薬学科 基幹教員
学部運営への参画状況・・・有-教授会
担当授業科目に係る状況・・・主要授業科目担当
薬学科 准教授 2019/01/01-2019/09/30
臨床薬科学系 准教授 2019/01/01-2019/09/30
薬学・和漢系 准教授 2019/10/01-
薬学科 准教授 2019/10/01-
薬学部薬学科 基幹教員
学部運営への参画状況・・・有-教授会
担当授業科目に係る状況・・・主要授業科目担当
Research interests
悪性腫瘍は現在日本において死因の第一位であり,その生存率を低下させている
原因が[転移]である.特に悪性黒色腫は日本でも増加傾向にある腫瘍であり,また転移能の高い腫瘍として知られている.私はこれまでに悪性黒色腫特異的がん遺伝子である転写因子MITFを薬剤標的とすることを目的に,MITFの機能解析を主に行なってきた.今後も腫瘍における転写因子の機能解析を行い,がん転移の制圧に向けた研究を進めていく予定である.
原因が[転移]である.特に悪性黒色腫は日本でも増加傾向にある腫瘍であり,また転移能の高い腫瘍として知られている.私はこれまでに悪性黒色腫特異的がん遺伝子である転写因子MITFを薬剤標的とすることを目的に,MITFの機能解析を主に行なってきた.今後も腫瘍における転写因子の機能解析を行い,がん転移の制圧に向けた研究を進めていく予定である.
Research Fields, Keywords
- Molecular Biology
- Cancer Biology
Field of expertise (Grants-in-aid for Scientific Research classification)
- Cancer Biology
- Molecular Biology
Fingerprint
Dive into the research topics where Satoru Yokoyama is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 1 Similar Profiles
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
Projects
- 6 Finished
-
Cancer pathophysiology and treatment from the perspective of dual-mode control of EGFR
Sakurai, H. (PI), Hayashi, R. (CoPI), 越，横山 悟，櫻井 宏明石田勝也，福司弥生，周 (CoPI) & Yokoyama, S. (CoPI)
2022/04/01 → 2025/03/31
Project: Research
-
Phenotypic difference by the combination of both oncogenes and tumor suppressors in melanoma
Yokoyama, S. (PI)
2018/04/01 → 2021/03/31
Project: Research
-
Functional Analysis of transcription factor SOX10 in melanoma for norvel therapeutics
Yokoyama, S. (PI)
2016/04/01 → 2018/03/31
Project: Research
-
Identification of Scientific evidence for Traditional Kampo theory by gene expression analysis
Saiki, I. (PI) & Yokoyama, S. (CoI)
2015/04/01 → 2018/03/31
Project: Research
-
How do Kampo formulations work?
Saiki, I. (PI) & Yokoyama, S. (CoI)
2012/04/01 → 2015/03/31
Project: Research
-
SOX10 Regulates Melanoma Immunogenicity through an IRF4–IRF1 Axis
Yokoyama, S., Takahashi, A., Kikuchi, R., Nishibu, S., Lo, J. A., Hejna, M., Moon, W. M., Kato, S., Zhou, Y., Hodi, F. S., Song, J. S., Sakurai, H., Fisher, D. E. & Hayakawa, Y., 2021/12/15, In: Cancer Research. 81, 24, p. 6131-6141 11 p.Research output: Contribution to journal › Article › peer-review
Open Access39 Scopus citations -
A novel recurrent mutation in MITF predisposes to familial and sporadic melanoma
Yokoyama, S., Woods, S. L., Boyle, G. M., Aoude, L. G., MacGregor, S., Zismann, V., Gartside, M., Cust, A. E., Haq, R., Harland, M., Taylor, J. C., Duffy, D. L., Holohan, K., Dutton-Regester, K., Palmer, J. M., Bonazzi, V., Stark, M. S., Symmons, J., Law, M. H. & Schmidt, C. & 27 others, , 2011/12/01, In: Nature. 480, 7375, p. 99-103 5 p.Research output: Contribution to journal › Article › peer-review
Open Access386 Scopus citations -
BCL2A1 is a lineage-specific antiapoptotic melanoma oncogene that confers resistance to BRAF inhibition
Haq, R., Yokoyama, S., Hawryluk, E. B., Jönsson, G. B., Frederick, D. T., McHenry, K., Porter, D., Tran, T. N., Love, K. T., Langer, R., Anderson, D. G., Garraway, L. A., Duncan, L. M. D., Morton, D. L., Hoon, D. S. B., Wargo, J. A., Song, J. S. & Fisher, D. E., 2013/03/12, In: Proceedings of the National Academy of Sciences of the United States of America. 110, 11, p. 4321-4326 6 p.Research output: Contribution to journal › Article › peer-review
Open Access195 Scopus citations -
Pharmacologic suppression of MITF expression via HDAC inhibitors in the melanocyte lineage
Yokoyama, S., Feige, E., Poling, L. L., Levy, C., Widlund, H. R., Khaled, M., Kung, A. L. & Fisher, D. E., 2008/08, In: Pigment Cell and Melanoma Research. 21, 4, p. 457-463 7 p.Research output: Contribution to journal › Article › peer-review
Open Access92 Scopus citations -
Rational combination therapy for melanoma with dinaciclib by targeting BAK-dependent cell death
Xu, X., Eshima, S., Kato, S., Fisher, D. E., Sakurai, H., Hayakawa, Y. & Yokoyama, S., 2020/02, In: Molecular Cancer Therapeutics. 19, 2, p. 627-636 10 p.Research output: Contribution to journal › Article › peer-review
Open Access9 Scopus citations
Datasets
-
CCDC 878005: Experimental Crystal Structure Determination
Awale, S. (Creator), Ueda, J.-Y. (Creator), Athikomkulchai, S. (Creator), Abdelhamed, S. (Creator), Yokoyama, S. (Creator), Saiki, I. (Creator) & Miyatake, R. (Creator), Cambridge Crystallographic Data Centre, 2013
DOI: 10.5517/ccygmrr, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccygmrr&sid=DataCite
Dataset
Courses
-
薬物治療学特論
Hosoya, K.-I., Sakai, H., Tabuchi, A., Hirose, Y., Morita, M., Shimizu, T., Akanuma, S.-I., Fujii, T., Uta, D., So, T., Kume, T., Yokoyama, S., Sakurai, H. & Tabuchi, Y. 2024/04/01 → 2024/09/30
Course
-
分子生物薬科学特論
Hosoya, K.-I., Sakai, H., Tabuchi, A., Hirose, Y., Morita, M., Shimizu, T., Akanuma, S.-I., Fujii, T., Uta, D., So, T., Kume, T., Yokoyama, S., Sakurai, H. & Tabuchi, Y. 2024/04/01 → 2024/09/30
Course
-
特別専門実習
Mori, H., Ichijo, H., Nishimaru, H., Yamamoto, S., Ito, T., Hosoya, K.-I., Tomohiro, T., Mizuguchi, M., Sakai, H., Tabuchi, A., Hirose, Y., Morita, M., Nitta, A., Wada, T., Naruse, R., Tanioka, M., Kuniishi, M., Tega, Y., Sasaoka, T., Tsuneki, H., Taguchi, M., Zhou, Y., Kato, A., Shimizu, T., To, H., Chiba, J., Akanuma, S.-I., Fujii, T., Tanaka, A., Ikeda, K., Uta, D., So, T., Kume, T., Ihara, D., Ohishi, Y., Yokoyama, S., Yamamura, Y., Lee, J., Izuo, N., Nakao, H., Seto, Y., Tanimoto, H., Asano, T., Sawahata, M., Inoue, D., Okada, K., Okitsu, T., Sakurai, H., Tohda, C., Koizumi, K., Morita, H., Hayakawa, Y., Nakagawa, Y., Shoji, T. & Tabuchi, Y. 2023/10/01 → 2024/03/31
Course
-
薬学英語Ⅱ（専門）
Kimura, Y., Sakai, H., Tabuchi, A., Hirose, Y., Morita, M., Tanioka, M., Kuniishi, M., Shimizu, T., Chiba, J., Sugimoto, K., Fujii, T., Tanaka, A., So, T., Kume, T., Ihara, D., Ohishi, Y., Yokoyama, S., Lee, J., Okada, K. & Onuki, Y. 2023/10/01 → 2024/03/31
Course
-
製薬企業と創薬
Hosoya, K.-I., Tomohiro, T., Mizuguchi, M., Sakai, H., Tabuchi, A., Yakura, T., Hirose, Y., Nitta, A., Wada, T., Tega, Y., Sasaoka, T., Tsuneki, H., Taguchi, M., Zhou, Y., Katagiri, T., Kato, A., Matsuya, Y., Shimizu, T., To, H., Chiba, J., Akanuma, S.-I., Nakano, M., Fujii, T., Tanaka, A., So, T., Kume, T., Ohishi, Y., Yokoyama, S., Lee, J., Okada, K., Sakurai, H., Koizumi, K., Hayakawa, Y., Nakagawa, Y., Kim, J., Shoji, T., Tabuchi, Y. & Hirano, T. 2023/10/01 → 2024/03/31
Course