Projects per year
Personal profile
Campus career
和漢医薬学総合研究所 助教 2011/04/01-2018/12/31
薬学科 准教授 2019/01/01-2019/09/30
臨床薬科学系 准教授 2019/01/01-2019/09/30
薬学・和漢系 准教授 2019/10/01-
薬学科 准教授 2019/10/01-
薬学部薬学科 基幹教員
学部運営への参画状況・・・有-教授会
担当授業科目に係る状況・・・主要授業科目担当
薬学科 准教授 2019/01/01-2019/09/30
臨床薬科学系 准教授 2019/01/01-2019/09/30
薬学・和漢系 准教授 2019/10/01-
薬学科 准教授 2019/10/01-
薬学部薬学科 基幹教員
学部運営への参画状況・・・有-教授会
担当授業科目に係る状況・・・主要授業科目担当
Research interests
悪性腫瘍は現在日本において死因の第一位であり,その生存率を低下させている
原因が[転移]である.特に悪性黒色腫は日本でも増加傾向にある腫瘍であり,また転移能の高い腫瘍として知られている.私はこれまでに悪性黒色腫特異的がん遺伝子である転写因子MITFを薬剤標的とすることを目的に,MITFの機能解析を主に行なってきた.今後も腫瘍における転写因子の機能解析を行い,がん転移の制圧に向けた研究を進めていく予定である.
原因が[転移]である.特に悪性黒色腫は日本でも増加傾向にある腫瘍であり,また転移能の高い腫瘍として知られている.私はこれまでに悪性黒色腫特異的がん遺伝子である転写因子MITFを薬剤標的とすることを目的に,MITFの機能解析を主に行なってきた.今後も腫瘍における転写因子の機能解析を行い,がん転移の制圧に向けた研究を進めていく予定である.
Research Fields, Keywords
- Molecular Biology
- Cancer Biology
Field of expertise (Grants-in-aid for Scientific Research classification)
- Cancer Biology
- Molecular Biology
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- 6 Similar Profiles
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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SOX10 regulates melanoma heterogeneity
Yokoyama, S. (Principal Investigator), Hayakawa, Y. (Co-Investigator(Kenkyū-buntansha)) & Hayashi, R. (Co-Investigator(Kenkyū-buntansha))
Japan Society for the Promotion of Science
2024/04/01 → 2027/03/31
Project: Research Project
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Pathophysiology and treatment of cancer from the perspective of dual-ode regulation of EGFRbactivation
Sakurai, H. (Principal Investigator), Zhou, Y. (Co-Investigator(Kenkyū-buntansha)), Hayashi, R. (Co-Investigator(Kenkyū-buntansha)) & Yokoyama, S. (Co-Investigator(Kenkyū-buntansha))
Japan Society for the Promotion of Science
2022/04/01 → 2025/03/31
Project: Research Project
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Alternative activation mechanisms of receptor tyrosine kinases in inflammation-induced cancer progression
Sakurai, H. (Principal Investigator) & Yokoyama, S. (Co-Investigator(Kenkyū-buntansha))
Japan Society for the Promotion of Science
2019/04/01 → 2022/03/31
Project: Research Project
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Phenotypic difference by the combination of both oncogenes and tumor suppressors in melanoma
Yokoyama, S. (PI)
2018/04/01 → 2021/03/31
Project: Research
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Functional Analysis of transcription factor SOX10 in melanoma for norvel therapeutics
Yokoyama, S. (PI)
2016/04/01 → 2018/03/31
Project: Research
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SOX10 Regulates Melanoma Immunogenicity through an IRF4–IRF1 Axis
Yokoyama, S., Takahashi, A., Kikuchi, R., Nishibu, S., Lo, J. A., Hejna, M., Moon, W. M., Kato, S., Zhou, Y., Hodi, F. S., Song, J. S., Sakurai, H., Fisher, D. E. & Hayakawa, Y., 2021/12/15, In: Cancer Research. 81, 24, p. 6131-6141 11 p.Research output: Contribution to journal › Article › peer-review
Open Access35 Scopus citations -
A novel recurrent mutation in MITF predisposes to familial and sporadic melanoma
Yokoyama, S., Woods, S. L., Boyle, G. M., Aoude, L. G., MacGregor, S., Zismann, V., Gartside, M., Cust, A. E., Haq, R., Harland, M., Taylor, J. C., Duffy, D. L., Holohan, K., Dutton-Regester, K., Palmer, J. M., Bonazzi, V., Stark, M. S., Symmons, J., Law, M. H. & Schmidt, C. & 27 others, , 2011/12/01, In: Nature. 480, 7375, p. 99-103 5 p.Research output: Contribution to journal › Article › peer-review
Open Access382 Scopus citations -
BCL2A1 is a lineage-specific antiapoptotic melanoma oncogene that confers resistance to BRAF inhibition
Haq, R., Yokoyama, S., Hawryluk, E. B., Jönsson, G. B., Frederick, D. T., McHenry, K., Porter, D., Tran, T. N., Love, K. T., Langer, R., Anderson, D. G., Garraway, L. A., Duncan, L. M. D., Morton, D. L., Hoon, D. S. B., Wargo, J. A., Song, J. S. & Fisher, D. E., 2013/03/12, In: Proceedings of the National Academy of Sciences of the United States of America. 110, 11, p. 4321-4326 6 p.Research output: Contribution to journal › Article › peer-review
Open Access194 Scopus citations -
Pharmacologic suppression of MITF expression via HDAC inhibitors in the melanocyte lineage
Yokoyama, S., Feige, E., Poling, L. L., Levy, C., Widlund, H. R., Khaled, M., Kung, A. L. & Fisher, D. E., 2008/08, In: Pigment Cell and Melanoma Research. 21, 4, p. 457-463 7 p.Research output: Contribution to journal › Article › peer-review
Open Access92 Scopus citations -
Rational combination therapy for melanoma with dinaciclib by targeting BAK-dependent cell death
Xu, X., Eshima, S., Kato, S., Fisher, D. E., Sakurai, H., Hayakawa, Y. & Yokoyama, S., 2020/02, In: Molecular Cancer Therapeutics. 19, 2, p. 627-636 10 p.Research output: Contribution to journal › Article › peer-review
Open Access9 Scopus citations
Datasets
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Additional file 2 of Anti-inflammatory effects of Morus alba Linne bark on the activation of toll-like receptors and imiquimod-induced ear edema in mice
Umeyama, L. (Creator), Hardianti, B. (Contributor), Kasahara, S. (Creator), Dibwe, D. F. (Contributor), Awale, S. (Creator), Yokoyama, S. (Creator) & Hayakawa, Y. (Creator), figshare, 2021
DOI: 10.6084/m9.figshare.14396845, https://springernature.figshare.com/articles/presentation/Additional_file_2_of_Anti-inflammatory_effects_of_Morus_alba_Linne_bark_on_the_activation_of_toll-like_receptors_and_imiquimod-induced_ear_edema_in_mice/14396845
Dataset
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Anti-inflammatory effects of Morus alba Linne bark on the activation of toll-like receptors and imiquimod-induced ear edema in mice
Umeyama, L. (Creator), Hardianti, B. (Contributor), Kasahara, S. (Creator), Dibwe, D. F. (Contributor), Awale, S. (Creator), Yokoyama, S. (Creator) & Hayakawa, Y. (Creator), figshare, 2021
DOI: 10.6084/m9.figshare.c.5371306.v1, https://springernature.figshare.com/collections/Anti-inflammatory_effects_of_Morus_alba_Linne_bark_on_the_activation_of_toll-like_receptors_and_imiquimod-induced_ear_edema_in_mice/5371306/1
Dataset
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Additional file 2 of Anti-inflammatory effects of Morus alba Linne bark on the activation of toll-like receptors and imiquimod-induced ear edema in mice
Umeyama, L. (Creator), Hardianti, B. (Contributor), Kasahara, S. (Creator), Dibwe, D. F. (Contributor), Awale, S. (Creator), Yokoyama, S. (Creator) & Hayakawa, Y. (Creator), figshare, 2021
DOI: 10.6084/m9.figshare.14396845.v1, https://springernature.figshare.com/articles/presentation/Additional_file_2_of_Anti-inflammatory_effects_of_Morus_alba_Linne_bark_on_the_activation_of_toll-like_receptors_and_imiquimod-induced_ear_edema_in_mice/14396845/1
Dataset
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Gene expression profile of MITF expressing cells
Haq, R. (Contributor), Shoag, J. (Contributor), Andreu-Perez, P. (Contributor), Yokoyama, S. (Contributor), Edelman, H. (Contributor), Nellore, A. (Contributor) & Arany, Z. (Contributor), ArrayExpress, 2013
https://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-38007
Dataset
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Anti-inflammatory effects of Morus alba Linne bark on the activation of toll-like receptors and imiquimod-induced ear edema in mice
Umeyama, L. (Creator), Hardianti, B. (Contributor), Kasahara, S. (Creator), Dibwe, D. F. (Contributor), Awale, S. (Creator), Yokoyama, S. (Creator) & Hayakawa, Y. (Creator), figshare, 2021
DOI: 10.6084/m9.figshare.c.5371306, https://springernature.figshare.com/collections/Anti-inflammatory_effects_of_Morus_alba_Linne_bark_on_the_activation_of_toll-like_receptors_and_imiquimod-induced_ear_edema_in_mice/5371306
Dataset
Activities
- 45 Oral presentation
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Anti-melanoma effect of CDK inhibitor and its combination strategy with BRAF inhibition
Yokoyama, S. (Speaker)
2018/09Activity: Talk or presentation › Oral presentation
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COPS5はSNAILの脱ユビキチン化を介して、がん転移を制御する
Yokoyama, S. (Speaker)
2018/07Activity: Talk or presentation › Oral presentation
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Anti-inflammatory effect of Morus alba L. bark to suppresses Toll-like receptor activation in RAW264.7 macrophages
Yokoyama, S. (Speaker)
2017/10Activity: Talk or presentation › Oral presentation
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オウレンはBAX / BAK の活性化によるアポトーシスを誘導し，悪性黒色腫の成長を阻害する
Yokoyama, S. (Speaker)
2017/09Activity: Talk or presentation › Oral presentation
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Courses
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先端生命薬学
Tabuchi, A., Hirose, Y., Morita, M., Kuniishi, M., Tanaka, A., So, T., Ihara, D., Yokoyama, S. & Sakurai, H. 2024/10/01 → 2025/03/31
Course
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分子細胞生物学特論
Zhou, Y., Katagiri, T., Yokoyama, S., Sakurai, H., Koizumi, K. & Akagi, K. 2024/06/12 → 2024/09/30
Course