Projects per year
Personal profile
Campus career
医学科 助教 2007/04/01-2015/09/30
東西統合医学系 助教 2007/04/01-2015/09/30
附属病院 助教 2015/10/01-2016/01/31
附属病院 講師 2016/02/01-2019/09/30
附属病院 講師 2019/10/01-2020/01/31
医学系 講師 2019/10/01-2020/01/31
附属病院 教授 2020/02/01-
医学系 教授 2020/02/01-
医学部医学科 基幹教員
学部運営への参画状況・・・有-教授会他
担当授業科目に係る状況・・・主要授業科目担当
東西統合医学系 助教 2007/04/01-2015/09/30
附属病院 助教 2015/10/01-2016/01/31
附属病院 講師 2016/02/01-2019/09/30
附属病院 講師 2019/10/01-2020/01/31
医学系 講師 2019/10/01-2020/01/31
附属病院 教授 2020/02/01-
医学系 教授 2020/02/01-
医学部医学科 基幹教員
学部運営への参画状況・・・有-教授会他
担当授業科目に係る状況・・・主要授業科目担当
Research interests
The failure of autophagy impairs the placental development, resulting in poor placentation and hypertensive disorder of pregnancy (HDP). From the comparative study between HDP human and murine placentas, TFEB is involved in the regulation of placental autophagy.
Research Fields, Keywords
- Obstetrics & Gynecology
- Gynecologic cancer,
- placenta
- autophagy
Field of expertise (Grants-in-aid for Scientific Research classification)
- Obstetrics and gynecology
Fingerprint
Dive into the research topics where Akitoshi Nakashima is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 1 Similar Profiles
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
-
IFN and TNF signaling in preeclampsia; effects on T cell - trophoblast interactions
Tsuda, S. (Principal Investigator), Shima, T. (Co-Investigator(Kenkyū-buntansha)) & Nakashima, A. (Co-Investigator(Kenkyū-buntansha))
Japan Society for the Promotion of Science
2025/04/01 → 2028/03/31
Project: Research Project
-
Elucidation of the mechanisms of autophagy deficiency and maternal-fetal immune tolerance induction in pregnancy-induced hypertension nephropathy
Shima, T. (Principal Investigator), Nakashima, A. (Co-Investigator(Kenkyū-buntansha)) & Tsuda, S. (Co-Investigator(Kenkyū-buntansha))
Japan Society for the Promotion of Science
2025/04/01 → 2028/03/31
Project: Research Project
-
Rejuvenation of Oocytes through a Fundamental Understanding of Aging
Koike, S. (Principal Investigator), Nakashima, A. (Co-Investigator(Kenkyū-buntansha)), Oshima, Y. (Co-Investigator(Kenkyū-buntansha)) & Okada, T. (Co-Investigator(Kenkyū-buntansha))
Japan Society for the Promotion of Science
2025/04/01 → 2028/03/31
Project: Research Project
-
-
Failure of autophagy for the therapeutic target of preeclampsia
Nakashima, A. (Principal Investigator), Shima, T. (Co-Investigator(Kenkyū-buntansha)), Koike, S. (Co-Investigator(Kenkyū-buntansha)) & Tsuda, S. (Co-Investigator(Kenkyū-buntansha))
Japan Society for the Promotion of Science
2022/04/01 → 2025/03/31
Project: Research Project
-
Novel Role of Pin1-Cis P-Tau-ApoE Axis in the Pathogenesis of Preeclampsia and Its Connection with Dementia
Amabebe, E., Huang, Z., Jash, S., Krishnan, B., Cheng, S., Nakashima, A., Li, Y., Li, Z., Wang, R., Menon, R., Zhou, X. Z., Lu, K. P. & Sharma, S., 2025/01, In: Biomedicines. 13, 1, 29.Research output: Contribution to journal › Review article › peer-review
Open Access -
Remission of intercellular IgG/IgA dermatosis after treatment for cervical cancer
Kitayama, S., Takemoto, K., Matsui, Y., Makino, T., Mizawa, M., Shima, T., Nakashima, A., Ishii, N., Hashimoto, T. & Shimizu, T., 2025/03, In: Journal of Dermatology. 52, 3, p. e218-e219Research output: Contribution to journal › Letter › peer-review
-
CD4+ T cell heterogeneity in gestational age and preeclampsia using single-cell RNA sequencing
Tsuda, S., Shichino, S., Tilburgs, T., Shima, T., Morita, K., Yamaki-Ushijima, A., Roskin, K., Tomura, M., Sameshima, A., Saito, S. & Nakashima, A., 2024, In: Frontiers in Immunology. 15, p. 1401738Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
Exploiting sweet relief for preeclampsia by targeting autophagy-lysosomal machinery and proteinopathy
Huang, Z., Cheng, S., Jash, S., Fierce, J., Agudelo, A., Higashiyama, T., Hanna, N., Nakashima, A., Saito, S., Padbury, J., Schuster, J. & Sharma, S., 2024/05, In: Experimental and Molecular Medicine. 56, 5, p. 1206-1220 15 p.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
Guideline for gynecological practice in Japan: Japan Society of Obstetrics and Gynecology and Japan Association of Obstetricians and Gynecologists 2023 edition
Nishio, E., Ishitani, K., Arimoto, T., Igarashi, T., Ishikawa, T., Iwase, A., Ogawa, M., Ozawa, N., Kajiyama, H., Kawasaki, K., Kudo, R., Kumakiri, J., Komura, H., Komai, K., Sato, S., Shinohara, K., Takahashi, T., Tanaka, K., Tanebe, K. & Deguchi, M. & 16 others, , 2024/07, In: Journal of Obstetrics and Gynaecology Research. 50, 7, p. 1073-1094 22 p.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations
Datasets
-
Silver nanoparticles suppress forskolin-induced syncytialization in BeWo cells
Sakahashi, Y. (Creator), Higashisaka, K. (Creator), Isaka, R. (Creator), Izutani, R. (Creator), Seo, J. (Creator), Furuta, A. (Creator), Yamaki-Ushijima, A. (Creator), Tsujino, H. (Creator), Haga, Y. (Creator), Nakashima, A. (Creator) & Tsutsumi, Y. (Creator), Taylor & Francis, 2023
DOI: 10.6084/m9.figshare.21807000, https://tandf.figshare.com/articles/presentation/Silver_nanoparticles_suppress_forskolin-induced_syncytialization_in_BeWo_cells/21807000
Dataset
-
Evidence for lysosomal biogenesis proteome defect and impaired autophagy in preeclampsia
Nakashima, A. (Creator), Cheng, S.-B. (Creator), Ikawa, M. (Creator), Yoshimori, T. (Creator), Huber, W. J. (Creator), Menon, R. (Contributor), Huang, Z. (Contributor), Fierce, J. (Creator), Padbury, J. F. (Creator), Sadovsky, Y. (Creator), Saito, S. (Creator) & Sharma, S. (Contributor), Taylor & Francis, 2019
DOI: 10.6084/m9.figshare.11416755, https://tandf.figshare.com/articles/dataset/Evidence_for_lysosomal_biogenesis_proteome_defect_and_impaired_autophagy_in_preeclampsia/11416755
Dataset
-
Evidence for lysosomal biogenesis proteome defect and impaired autophagy in preeclampsia
Nakashima, A. (Creator), Cheng, S.-B. (Creator), Ikawa, M. (Creator), Yoshimori, T. (Creator), Huber, W. J. (Creator), Menon, R. (Contributor), Huang, Z. (Contributor), Fierce, J. (Creator), Padbury, J. F. (Creator), Sadovsky, Y. (Creator), Saito, S. (Creator) & Sharma, S. (Contributor), Taylor & Francis, 2019
DOI: 10.6084/m9.figshare.11416755.v1, https://tandf.figshare.com/articles/dataset/Evidence_for_lysosomal_biogenesis_proteome_defect_and_impaired_autophagy_in_preeclampsia/11416755/1
Dataset
-
Silver nanoparticles suppress forskolin-induced syncytialization in BeWo cells
Sakahashi, Y. (Creator), Higashisaka, K. (Creator), Isaka, R. (Creator), Izutani, R. (Creator), Seo, J. (Creator), Furuta, A. (Creator), Yamaki-Ushijima, A. (Creator), Tsujino, H. (Creator), Haga, Y. (Creator), Nakashima, A. (Creator) & Tsutsumi, Y. (Creator), Taylor & Francis, 2023
DOI: 10.6084/m9.figshare.21807000.v1, https://tandf.figshare.com/articles/presentation/Silver_nanoparticles_suppress_forskolin-induced_syncytialization_in_BeWo_cells/21807000/1
Dataset
-
supplemental_figure_2 - Sphingosine 1 Phosphate (S1P) Increased IL-6 Expression and Cell Growth in Endometriotic Cells
Yoshino, O. (Creator), Yamada-Nomoto, K. (Creator), Kano, K. (Contributor), Ono, Y. (Creator), Kobayashi, M. (Creator), Ito, M. (Creator), Yoneda, S. (Creator), Nakashima, A. (Creator), Shima, T. (Creator), Onda, T. (Creator), Osuga, Y. (Creator), Aoki, J. (Contributor) & Saito, S. (Creator), SAGE Journals, 2019
DOI: 10.25384/sage.7751576, https://sage.figshare.com/articles/supplemental_figure_2_-_Sphingosine_1_Phosphate_S1P_Increased_IL-6_Expression_and_Cell_Growth_in_Endometriotic_Cells/7751576
Dataset
Prizes
Activities
- 20 Oral presentation
-
Symposium “Pathophysiology of PE” The role of autophagy in pathophysiology of PE.
Nakashima, A. (Speaker)
2021/09/15 → 2021/09/28Activity: Talk or presentation › Oral presentation
-
教育講演 オートファジーと妊娠高血圧症候群 (Hypertensive disorders of pregnancy, HDP).
Nakashima, A. (Speaker)
2021/04/22 → 2021/05/07Activity: Talk or presentation › Oral presentation
-
オートファジー破綻は妊娠高血圧腎症胎盤におけるトランスサイレチン蓄積に関与する．
Nakashima, A. (Speaker)
2017/03/04Activity: Talk or presentation › Oral presentation
-
“Preeclampsia serum disrupts the autophagy/lysosome pathway cooperated with endoplasmic reticulum (ER) stress“
Nakashima, A. (Speaker)
2016/12/05 → 2016/12/08Activity: Talk or presentation › Oral presentation
-
シンポジウム1”トロホブラスト・リサーチCurrent Topics and Future Goals” 妊娠高血圧腎症患者血清は小胞体ストレスと共に絨毛細胞のオートファジーを破綻させる．
Nakashima, A. (Speaker)
2016/11/25 → 2016/11/26Activity: Talk or presentation › Oral presentation
Courses
-
高度先進医療実践学特論
Yoshimura, N., Hayashi, R., Nakashima, A., Tsuchiya, T., Kitamura, H., Fujii, T., Satake, T. & Doi, T. 2024/12/04 → 2025/03/31
Course
-
-
-
生殖系
Fujiuchi, Y., Nakashima, A., Ito, M., Takemura, K., Kitamura, H., Shima, T., Saitoh, J.-I., Okabe, M. & Watanabe, A. 2024/10/01 → 2025/03/31
Course
-