Effect of hachimijiogan against renal dysfunction and involvement of hypoxia-inducible factor-1 in the remnant kidney model

Hirozo Goto*, Hiroshi Oka, Keiichi Koizumi, Shin Nakamura, Koichi Tsuneyama, Yue Zhou, Michiko Jo, Takako Fujimoto, Hiroaki Sakurai, Naotoshi Shibahara, Ikuo Saiki, Yutaka Shimada

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

In chronic renal failure, hypoxia of renal tissue is thought to be the common final pathway leading to end-stage renal failure. In this study the effects of hachimijiogan, a Kampo formula, were studied with respect to hypoxia-inducible factor (HIF). Using remnant kidney rats, we studied the effects of hachimijiogan on renal function in comparison with angiotensin II receptor blocker. The result showed that oral administration of hachimijiogan for seven days suppressed urinary protein excretion and urinary 8-OHdG, a marker of antioxidant activity, equally as well as oral administration of candesartan cilexetil. In contrast, the protein volume of HIF-1 in the renal cortex was not increased in the candesartan cilexetil group, but that in the hachimijiogan group was increased. In immunohistochemical studies as well, the expression of HIF-1 of the high-dose hachimijiogan group increased compared to that of the control group. Vascular endothelial growth factor and glucose transporter 1, target genes of HIF-1, were also increased in the hachimijiogan group. These results suggest that hachimijiogan produces a protective effect by a mechanism different from that of candesartan cilexetil.

Original languageEnglish
Article number348686
JournalEvidence-based Complementary and Alternative Medicine
Volume2011
DOIs
StatePublished - 2011

ASJC Scopus subject areas

  • Complementary and alternative medicine

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