TY - JOUR
T1 - Effect of hachimijiogan against renal dysfunction and involvement of hypoxia-inducible factor-1 in the remnant kidney model
AU - Goto, Hirozo
AU - Oka, Hiroshi
AU - Koizumi, Keiichi
AU - Nakamura, Shin
AU - Tsuneyama, Koichi
AU - Zhou, Yue
AU - Jo, Michiko
AU - Fujimoto, Takako
AU - Sakurai, Hiroaki
AU - Shibahara, Naotoshi
AU - Saiki, Ikuo
AU - Shimada, Yutaka
PY - 2011
Y1 - 2011
N2 - In chronic renal failure, hypoxia of renal tissue is thought to be the common final pathway leading to end-stage renal failure. In this study the effects of hachimijiogan, a Kampo formula, were studied with respect to hypoxia-inducible factor (HIF). Using remnant kidney rats, we studied the effects of hachimijiogan on renal function in comparison with angiotensin II receptor blocker. The result showed that oral administration of hachimijiogan for seven days suppressed urinary protein excretion and urinary 8-OHdG, a marker of antioxidant activity, equally as well as oral administration of candesartan cilexetil. In contrast, the protein volume of HIF-1 in the renal cortex was not increased in the candesartan cilexetil group, but that in the hachimijiogan group was increased. In immunohistochemical studies as well, the expression of HIF-1 of the high-dose hachimijiogan group increased compared to that of the control group. Vascular endothelial growth factor and glucose transporter 1, target genes of HIF-1, were also increased in the hachimijiogan group. These results suggest that hachimijiogan produces a protective effect by a mechanism different from that of candesartan cilexetil.
AB - In chronic renal failure, hypoxia of renal tissue is thought to be the common final pathway leading to end-stage renal failure. In this study the effects of hachimijiogan, a Kampo formula, were studied with respect to hypoxia-inducible factor (HIF). Using remnant kidney rats, we studied the effects of hachimijiogan on renal function in comparison with angiotensin II receptor blocker. The result showed that oral administration of hachimijiogan for seven days suppressed urinary protein excretion and urinary 8-OHdG, a marker of antioxidant activity, equally as well as oral administration of candesartan cilexetil. In contrast, the protein volume of HIF-1 in the renal cortex was not increased in the candesartan cilexetil group, but that in the hachimijiogan group was increased. In immunohistochemical studies as well, the expression of HIF-1 of the high-dose hachimijiogan group increased compared to that of the control group. Vascular endothelial growth factor and glucose transporter 1, target genes of HIF-1, were also increased in the hachimijiogan group. These results suggest that hachimijiogan produces a protective effect by a mechanism different from that of candesartan cilexetil.
UR - http://www.scopus.com/inward/record.url?scp=79955087505&partnerID=8YFLogxK
U2 - 10.1155/2011/348686
DO - 10.1155/2011/348686
M3 - 学術論文
AN - SCOPUS:79955087505
SN - 1741-427X
VL - 2011
JO - Evidence-based Complementary and Alternative Medicine
JF - Evidence-based Complementary and Alternative Medicine
M1 - 348686
ER -