Practices, Potential, and Perspectives for Detecting Predisease Using Raman Spectroscopy

Yusuke Oshima*, Takayuki Haruki, Keiichi Koizumi, Shota Yonezawa, Akinori Taketani, Makoto Kadowaki, Shigeru Saito

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations

Abstract

Raman spectroscopy shows great potential for practical clinical applications. By analyzing the structure and composition of molecules through real-time, non-destructive measurements of the scattered light from living cells and tissues, it offers valuable insights. The Raman spectral data directly link to the molecular composition of the cells and tissues and provides a “molecular fingerprint” for various disease states. This review focuses on the practical and clinical applications of Raman spectroscopy, especially in the early detection of human diseases. Identifying predisease, which marks the transition from a healthy to a disease state, is crucial for effective interventions to prevent disease onset. Raman spectroscopy can reveal biological processes occurring during the transition states and may eventually detect the molecular dynamics in predisease conditions.

Original languageEnglish
Article number12170
JournalInternational Journal of Molecular Sciences
Volume24
Issue number15
DOIs
StatePublished - 2023/08

Keywords

  • DNB
  • Raman spectroscopy
  • clinical application
  • dynamical network biomarker
  • molecular fingerprint
  • predisease
  • state transition

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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