TY - JOUR
T1 - The long-term effects of a Kampo medicine, juzentaihoto, on maintenance of antibody titer in elderly people after influenza vaccination
AU - Saiki, Ikuo
AU - Koizumi, Keiichi
AU - Goto, Hirozo
AU - Inujima, Akiko
AU - Namiki, Takao
AU - Raimura, Masaki
AU - Kogure, Toshiaki
AU - Tatsumi, Takeshi
AU - Inoue, Hiroki
AU - Sakai, Shinya
AU - Oka, Hiroshi
AU - Fujimoto, Makoto
AU - Hikiami, Hiroaki
AU - Sakurai, Hiroaki
AU - Shibahara, Naotoshi
AU - Shimada, Yutaka
AU - Origasa, Hideki
N1 - Funding Information:
This work was supported by grants from the National Natural Science Foundation of China ( 81974302 ), the Program for Youth Talent of Higher Learning Institutions of Hebei Province ( BJ2018045 ), and Hebei Province’s Program for Talents Returning from Studying Overseas ( CN201707 ).
PY - 2013
Y1 - 2013
N2 - We have performed a broad-ranging analysis of the adjuvant effect of a Kampo medicine, juzentaihoto (JTT), on influenza vaccination in a multicenter randomized controlled trial. In this study, the enhancing effect of JTT on antibody titer after influenza vaccination was studied for 28 weeks in elderly people who were in the high-risk group for influenza infection. In total, 91 subjects over 65 years old were recruited from four long-term-care facilities located in Chiba, Gunma, and Toyama prefectures in Japan. Participants were randomly assigned to the JTT and the control groups. Blood samples were taken at 4 weeks before vaccination, at the time of vaccination, and then at 4, 8, 12, and 24 weeks after vaccination. The hemagglutination inhibition (HI) titers against A/California/7/2009 (H1N1), A/Victoria/210/2009 (H3N2), and B/Brisbane/60/2008 were then manually measured. A significant increase in HI titer against H3N2 was observed at week 8 after vaccination in the JTT group compared with the control group (P = 0.0229), and the HI titer of the JTT group significantly increased from 4 to 24 weeks (P = 0.0468), compared with the control group. In conclusion, our results indicated that JTT increased and prolonged antibody production against A/Victoria/210/2009 (H3N2), in particular, after influenza vaccination.
AB - We have performed a broad-ranging analysis of the adjuvant effect of a Kampo medicine, juzentaihoto (JTT), on influenza vaccination in a multicenter randomized controlled trial. In this study, the enhancing effect of JTT on antibody titer after influenza vaccination was studied for 28 weeks in elderly people who were in the high-risk group for influenza infection. In total, 91 subjects over 65 years old were recruited from four long-term-care facilities located in Chiba, Gunma, and Toyama prefectures in Japan. Participants were randomly assigned to the JTT and the control groups. Blood samples were taken at 4 weeks before vaccination, at the time of vaccination, and then at 4, 8, 12, and 24 weeks after vaccination. The hemagglutination inhibition (HI) titers against A/California/7/2009 (H1N1), A/Victoria/210/2009 (H3N2), and B/Brisbane/60/2008 were then manually measured. A significant increase in HI titer against H3N2 was observed at week 8 after vaccination in the JTT group compared with the control group (P = 0.0229), and the HI titer of the JTT group significantly increased from 4 to 24 weeks (P = 0.0468), compared with the control group. In conclusion, our results indicated that JTT increased and prolonged antibody production against A/Victoria/210/2009 (H3N2), in particular, after influenza vaccination.
UR - http://www.scopus.com/inward/record.url?scp=84890106353&partnerID=8YFLogxK
U2 - 10.1155/2013/568074
DO - 10.1155/2013/568074
M3 - 学術論文
C2 - 24348705
AN - SCOPUS:84890106353
SN - 1741-427X
VL - 2013
JO - Evidence-based Complementary and Alternative Medicine
JF - Evidence-based Complementary and Alternative Medicine
M1 - 568074
ER -