Projects per year
Personal profile
Campus career
医学科 教授 2007/05/01-2024/03/31
未病研究センター特別研究教授 2024/04/01-
Affiliated academic society
日本内科学会
日本糖尿病学会
日本肥満学会
日本内分泌学会
日本糖尿病合併症学会
日本糖尿病療養指導士認定機構
Research interests
We have been investigating the molecular mechanism of insulin resistance in obesity and type 2 diabetes. Our research focus is adipose tissue macrophages (ATMs). We demonstrated that obesity is accompanied by a transformation from an anti-inflammatory M2 form to a more inflammatory M1 form.
Research Fields, Keywords
- Diabetes
- Obesity
- Metabolic syndrome
- Endocrine
Field of expertise (Grants-in-aid for Scientific Research classification)
- Metabolism
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
Projects
- 5 Finished
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Identification of gut microbiota- derived metabolites and the mechanisms that impair glucose metabolism
Fujisaka, S. (PI) & Tobe, K. (CoI)
2017/04/01 → 2020/03/31
Project: Research
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The role of M2-like macrophages in glucose metabolism
Tobe, K. (PI)
2014/04/01 → 2017/03/31
Project: Research
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The effect of SRT1720 on HSP47 expression in murine bleomycin-induced pulmonary fibrosis
Yamada, T. (PI), Tobe, K. (CoI) & Hayashi, R. (CoI)
2013/04/01 → 2017/03/31
Project: Research
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Assessing the clinical utility of the genetic information using the genotype data for GWAS-derived type 2 diabetes susceptibility variants in a Japanese population.
Iwata, M. (PI) & Tobe, K. (CoI)
2012/04/01 → 2015/03/31
Project: Research
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Association between the type of family history of diabetes and the risk and age at onset of diabetes in the Japanese general population
Iwata, M., Okazawa, T., Higuchi, K. & Tobe, K., 2025/04, In: Diabetology International. 16, 2, p. 316-325 10 p., e0176895.Research output: Contribution to journal › Article › peer-review
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Effect of once-weekly subcutaneous semaglutide on abdominal visceral fat area in Japanese adults with overweight and obesity: A post hoc analysis of the STEP 6 trial
Kadowaki, T., Nishida, T., Ogawa, W., Overvad, M., Tobe, K. & Yamauchi, T., 2025/03/01, In: Obesity Research and Clinical Practice. 19, 2, p. 146-153 8 p.Research output: Contribution to journal › Article › peer-review
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IL-7Rα signaling in regulatory T cells of adipose tissue is essential for systemic glucose homeostasis
Tani-Ichi, S., Abe, S., Miyachi, H., Kitano, S., Shimba, A., Ejima, A., Hara, T., Cui, G., Kado, T., Hori, S., Tobe, K. & Ikuta, K., 2025/04/01, In: Journal of Immunology. 214, 4, p. 666-679 14 p.Research output: Contribution to journal › Article › peer-review
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Nicotinamide riboside and nicotinamide mononucleotide facilitate NAD+ synthesis via enterohepatic circulation
Yaku, K., Palikhe, S., Iqbal, T., Hayat, F., Watanabe, Y., Fujisaka, S., Izumi, H., Yoshida, T., Karim, M., Uchida, H., Nawaz, A., Tobe, K., Mori, H., Migaud, M. E. & Nakagawa, T., 2025/03/21, In: Science Advances. 11, 12, eadr1538.Research output: Contribution to journal › Article › peer-review
Open Access -
Role of transforming growth factor-β1 in regulating adipocyte progenitors
Phuong, N. Q., Bilal, M., Nawaz, A., Anh, L. D., Memoona, Aslam, M. R., Khalid, S., Kado, T., Watanabe, Y., Nishimura, A., Igarashi, Y., Okabe, K., Hirabayashi, K., Yamamoto, S., Nakagawa, T., Mori, H., Usui, I., Fujisaka, S., Hayashi, R. & Tobe, K., 2025/12, In: Scientific Reports. 15, 1, 941.Research output: Contribution to journal › Article › peer-review
Open Access
Datasets
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Safety and Effectiveness of Ipragliflozin in Elderly Versus Non-Elderly Japanese Patients with Type 2 Diabetes: Subgroup Analysis of STELLA-LONG TERM
Nakamura, I. (Creator), Maegawa, H. (Creator), Tobe, K. (Creator) & Uno, S. (Creator), Adis Journals, 2021
DOI: 10.6084/m9.figshare.14124275.v1, https://adisjournals.figshare.com/articles/media/Safety_and_Effectiveness_of_Ipragliflozin_in_Elderly_Versus_Non-Elderly_Japanese_Patients_with_Type_2_Diabetes_Subgroup_Analysis_of_STELLA-LONG_TERM/14124275/1
Dataset
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Safety and Effectiveness of Ipragliflozin in Elderly Versus Non-Elderly Japanese Patients with Type 2 Diabetes: Subgroup Analysis of STELLA-LONG TERM
Nakamura, I. (Creator), Maegawa, H. (Creator), Tobe, K. (Creator) & Uno, S. (Creator), Adis Journals, 2021
DOI: 10.6084/m9.figshare.14124275, https://adisjournals.figshare.com/articles/media/Safety_and_Effectiveness_of_Ipragliflozin_in_Elderly_Versus_Non-Elderly_Japanese_Patients_with_Type_2_Diabetes_Subgroup_Analysis_of_STELLA-LONG_TERM/14124275
Dataset
Courses
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内分泌・栄養・代謝・乳房
Tobe, K., Ishiki, M., Yoshioka, I., Okuno, N., Shibuya, K., Kitamura, H., Matsui, K., Fujii, T., Saitoh, J.-I., Chujo, D., Satake, T., Yanagisawa, S., Fujisaka, S. & Watanabe, T. 2024/04/01 → 2024/09/30
Course
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老年医学
Suzuki, M., Fujiuchi, Y., Tobe, K., Takahashi, T., Nakatsuji, Y., Kainuma, M., Inomata, M., Kitamura, H., Kawaguchi, Y., Fujisaka, S. & Nakane, S. 2024/04/01 → 2024/09/30
Course
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老年医学
Suzuki, M., Tobe, K., Nakatsuji, Y., Kainuma, M., Inomata, M., Kitamura, H. & Kawaguchi, Y. 2023/04/01 → 2023/09/30
Course
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内分泌・栄養・代謝・乳房
Tobe, K., Ishiki, M., Yoshioka, I., Okuno, N., Shibuya, K., Kitamura, H., Matsui, K., Fujii, T., Saitoh, J.-I., Chujo, D., Satake, T., Yanagisawa, S., Fujisaka, S. & Watanabe, T. 2023/04/01 → 2023/09/30
Course