Projects per year
Personal profile
Campus career
医学科 教授 2007/05/01-2024/03/31
未病研究センター特別研究教授 2024/04/01-
Affiliated academic society
日本内科学会
日本糖尿病学会
日本肥満学会
日本内分泌学会
日本糖尿病合併症学会
日本糖尿病療養指導士認定機構
Research interests
We have been investigating the molecular mechanism of insulin resistance in obesity and type 2 diabetes. Our research focus is adipose tissue macrophages (ATMs). We demonstrated that obesity is accompanied by a transformation from an anti-inflammatory M2 form to a more inflammatory M1 form.
Research Fields, Keywords
- Diabetes
- Obesity
- Metabolic syndrome
- Endocrine
Field of expertise (Grants-in-aid for Scientific Research classification)
- Metabolism
Fingerprint
Dive into the research topics where Kazuyuki Tobe is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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The mechanism how adipose tissue M2 macrophages regulate insulin sensitivity
Tobe, K. (Principal Investigator), Takikawa, A. (Co-Investigator(Kenkyū-buntansha)) & 宏一生田 (Co-Investigator(Kenkyū-buntansha))
Japan Society for the Promotion of Science
2024/04/01 → 2027/03/31
Project: Research Project
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Development of prevention and progression control methods for metabolic syndrome by introducing a personal health code
Hisae, H. (Principal Investigator), Tobe, K. (Co-Investigator(Kenkyū-buntansha)) & 八木邦公 (Co-Investigator(Kenkyū-buntansha))
Japan Society for the Promotion of Science
2020/04/01 → 2024/03/31
Project: Research Project
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Identification of gut microbiota- derived metabolites and the mechanisms that impair glucose metabolism
Fujisaka, S. (PI) & Tobe, K. (CoI)
2017/04/01 → 2020/03/31
Project: Research
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The role of M2-like macrophages in glucose metabolism
Tobe, K. (PI)
2014/04/01 → 2017/03/31
Project: Research
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Association between the type of family history of diabetes and the risk and age at onset of diabetes in the Japanese general population
Iwata, M., Okazawa, T., Higuchi, K. & Tobe, K., 2025, (Accepted/In press) In: Diabetology International. e0176895.Research output: Contribution to journal › Article › peer-review
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Role of transforming growth factor-β1 in regulating adipocyte progenitors
Phuong, N. Q., Bilal, M., Nawaz, A., Anh, L. D., Memoona, Aslam, M. R., Khalid, S., Kado, T., Watanabe, Y., Nishimura, A., Igarashi, Y., Okabe, K., Hirabayashi, K., Yamamoto, S., Nakagawa, T., Mori, H., Usui, I., Fujisaka, S., Hayashi, R. & Tobe, K., 2025/12, In: Scientific Reports. 15, 1, 941.Research output: Contribution to journal › Article › peer-review
Open Access -
A case of vanishing bile duct syndrome during treatment of microscopic polyangiitis with avacopan
Yamaguchi, S., Yamazaki, M., Kido, T., Hounoki, H., Muraishi, N., Tajiri, K., Tanaka, S., Tobe, K. & Shinoda, K., 2024/04/01, In: Rheumatology (United Kingdom). 63, 4, p. e120-e122Research output: Contribution to journal › Letter › peer-review
7 Scopus citations -
An autopsy case of anti-MDA5 antibody-positive amyopathic dermatomyositis with an initial manifestation of panniculitis on the left upper arm
Onose, T., Kido, T., Okada, I., Yamazaki, M., Hounoki, H., Makino, T., Yamauchi, N., Matsushita, T., Tobe, K. & Shinoda, K., 2024/01/01, In: Modern Rheumatology Case Reports. 8, 1, p. 86-90 5 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Characterization of Diabetic Striatopathy With Repeated Follow-Up Using Multiple Imaging Studies
Nishimura, A., Kado, T. & Tobe, K., 2024/01, In: Cureus. 16, 1, p. e52223Research output: Contribution to journal › Article › peer-review
Datasets
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Safety and Effectiveness of Ipragliflozin in Elderly Versus Non-Elderly Japanese Patients with Type 2 Diabetes: Subgroup Analysis of STELLA-LONG TERM
Nakamura, I. (Creator), Maegawa, H. (Creator), Tobe, K. (Creator) & Uno, S. (Creator), Adis Journals, 2021
DOI: 10.6084/m9.figshare.14124275.v1, https://adisjournals.figshare.com/articles/media/Safety_and_Effectiveness_of_Ipragliflozin_in_Elderly_Versus_Non-Elderly_Japanese_Patients_with_Type_2_Diabetes_Subgroup_Analysis_of_STELLA-LONG_TERM/14124275/1
Dataset
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Safety and Effectiveness of Ipragliflozin in Elderly Versus Non-Elderly Japanese Patients with Type 2 Diabetes: Subgroup Analysis of STELLA-LONG TERM
Nakamura, I. (Creator), Maegawa, H. (Creator), Tobe, K. (Creator) & Uno, S. (Creator), Adis Journals, 2021
DOI: 10.6084/m9.figshare.14124275, https://adisjournals.figshare.com/articles/media/Safety_and_Effectiveness_of_Ipragliflozin_in_Elderly_Versus_Non-Elderly_Japanese_Patients_with_Type_2_Diabetes_Subgroup_Analysis_of_STELLA-LONG_TERM/14124275
Dataset
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Safety and Effectiveness of Ipragliflozin for Type 2 Diabetes in Japan: 12-Month Interim Results of the STELLA-LONG TERM Post-Marketing Surveillance Study
Nakamura, I. (Creator), Maegawa, H. (Creator), Tobe, K. (Creator) & Uno, S. (Creator), Adis Journals, 2019
DOI: 10.6084/m9.figshare.7629557, https://adisjournals.figshare.com/articles/Safety_and_Effectiveness_of_Ipragliflozin_for_Type_2_Diabetes_in_Japan_12-Month_Interim_Results_of_the_STELLA-LONG_TERM_Post-Marketing_Surveillance_Study/7629557
Dataset
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肺腺癌骨転移の再生検にて新たにEGFR遺伝子変異を認めた一症例．
Tobe, K. (Speaker)
2016/11/05 → 2016/11/06Activity: Talk or presentation › Oral presentation
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肺切除術で診断したmarginal zone B-cell Lymphomaの1例．
Tobe, K. (Speaker)
2016/11/05 → 2016/11/06Activity: Talk or presentation › Oral presentation
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非小細胞肺癌術後再発症例に対する化学放射線療法の効果と安全性．
Tobe, K. (Speaker)
2016/11/05 → 2016/11/06Activity: Talk or presentation › Oral presentation
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急速に抑うつ症状と認知機能低下の進行を呈したサブクリニカルクッシング症候群の1例．
Tobe, K. (Speaker)
2016/10/22Activity: Talk or presentation › Oral presentation
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繰り返した気管支鏡で診断がつかず鋳型状粘液栓で窒息した肺腺癌の1例．
Tobe, K. (Speaker)
2016/07/09Activity: Talk or presentation › Oral presentation
Courses
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第一内科
Tobe, K., Shinoda, K., Imanishi, S., Okazawa, S., Inomata, M., Fujisaka, S. & Honoki, H. 2024/04/01 → 2025/03/31
Course
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内分泌・栄養・代謝・乳房
Tobe, K., Ishiki, M., Yoshioka, I., Okuno, N., Shibuya, K., Kitamura, H., Matsui, K., Fujii, T., Saitoh, J.-I., Chujo, D., Satake, T., Yanagisawa, S., Fujisaka, S. & Watanabe, T. 2024/04/01 → 2024/09/30
Course
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老年医学
Suzuki, M., Fujiuchi, Y., Tobe, K., Takahashi, T., Nakatsuji, Y., Kainuma, M., Inomata, M., Kitamura, H., Kawaguchi, Y., Fujisaka, S. & Nakane, S. 2024/04/01 → 2024/09/30
Course
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医科分子生物学
Mori, H., Tobe, K., Inokuchi, K., Yoshida, T., Nomoto, M., Kaida, D., Ishimoto, T., Nakagawa, T., Inoue, R. & Miyamoto, D. 2024/04/01 → 2024/09/30
Course
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呼吸器系
Tobe, K., Hayashi, R., Tsuchiya, T., Imanishi, S., Okazawa, S., Inomata, M., Saitoh, J.-I., Okabe, M., Kamisaki, Y. & Hirabayashi, K. 2024/04/01 → 2024/09/30
Course