Projects per year
Personal profile
Campus career
医学科 教授 2007/05/01-2024/03/31
未病研究センター特別研究教授 2024/04/01-
Affiliated academic society
日本内科学会
日本糖尿病学会
日本肥満学会
日本内分泌学会
日本糖尿病合併症学会
日本糖尿病療養指導士認定機構
Research interests
We have been investigating the molecular mechanism of insulin resistance in obesity and type 2 diabetes. Our research focus is adipose tissue macrophages (ATMs). We demonstrated that obesity is accompanied by a transformation from an anti-inflammatory M2 form to a more inflammatory M1 form.
Research Fields, Keywords
- Diabetes
- Obesity
- Metabolic syndrome
- Endocrine
Field of expertise (Grants-in-aid for Scientific Research classification)
- Metabolism
Fingerprint
Dive into the research topics where Kazuyuki Tobe is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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The mechanism how adipose tissue M2 macrophages regulate insulin sensitivity
Tobe, K. (Principal Investigator), Takikawa, A. (Co-Investigator(Kenkyū-buntansha)) & 生田宏一 (Co-Investigator(Kenkyū-buntansha))
Japan Society for the Promotion of Science
2024/04/01 → 2027/03/31
Project: Research Project
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Development of prevention and progression control methods for metabolic syndrome by introducing a personal health code
Honoki, H. (Principal Investigator), Tobe, K. (Co-Investigator(Kenkyū-buntansha)) & Yagi, K. (Co-Investigator(Kenkyū-buntansha))
Japan Society for the Promotion of Science
2020/04/01 → 2024/03/31
Project: Research Project
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M2 macrophages as a novel therapeutic target in high-fat diet-induced cardiomyopathy
Yagi, K. (Principal Investigator) & Tobe, K. (Co-Investigator(Kenkyū-buntansha))
Japan Society for the Promotion of Science
2018/04/01 → 2021/03/31
Project: Research Project
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Identification of gut microbiota- derived metabolites and the mechanisms that impair glucose metabolism
Fujisaka, S. (PI) & Tobe, K. (CoI)
2017/04/01 → 2020/03/31
Project: Research
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Association between the type of family history of diabetes and the risk and age at onset of diabetes in the Japanese general population
Iwata, M., Okazawa, T., Higuchi, K. & Tobe, K., 2025/04, In: Diabetology International. 16, 2, p. 316-325 10 p., e0176895.Research output: Contribution to journal › Article › peer-review
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Effect of once-weekly subcutaneous semaglutide on abdominal visceral fat area in Japanese adults with overweight and obesity: A post hoc analysis of the STEP 6 trial
Kadowaki, T., Nishida, T., Ogawa, W., Overvad, M., Tobe, K. & Yamauchi, T., 2025/03/01, In: Obesity Research and Clinical Practice. 19, 2, p. 146-153 8 p.Research output: Contribution to journal › Article › peer-review
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Nicotinamide riboside and nicotinamide mononucleotide facilitate NAD+ synthesis via enterohepatic circulation
Yaku, K., Palikhe, S., Iqbal, T., Hayat, F., Watanabe, Y., Fujisaka, S., Izumi, H., Yoshida, T., Karim, M., Uchida, H., Nawaz, A., Tobe, K., Mori, H., Migaud, M. E. & Nakagawa, T., 2025/03/21, In: Science Advances. 11, 12, eadr1538.Research output: Contribution to journal › Article › peer-review
Open Access -
Role of transforming growth factor-β1 in regulating adipocyte progenitors
Phuong, N. Q., Bilal, M., Nawaz, A., Anh, L. D., Memoona, Aslam, M. R., Khalid, S., Kado, T., Watanabe, Y., Nishimura, A., Igarashi, Y., Okabe, K., Hirabayashi, K., Yamamoto, S., Nakagawa, T., Mori, H., Usui, I., Fujisaka, S., Hayashi, R. & Tobe, K., 2025/12, In: Scientific Reports. 15, 1, 941.Research output: Contribution to journal › Article › peer-review
Open Access -
A case of vanishing bile duct syndrome during treatment of microscopic polyangiitis with avacopan
Yamaguchi, S., Yamazaki, M., Kido, T., Hounoki, H., Muraishi, N., Tajiri, K., Tanaka, S., Tobe, K. & Shinoda, K., 2024/04/01, In: Rheumatology (United Kingdom). 63, 4, p. e120-e122Research output: Contribution to journal › Letter › peer-review
11 Scopus citations
Datasets
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Safety and Effectiveness of Ipragliflozin in Elderly Versus Non-Elderly Japanese Patients with Type 2 Diabetes: Subgroup Analysis of STELLA-LONG TERM
Nakamura, I. (Creator), Maegawa, H. (Creator), Tobe, K. (Creator) & Uno, S. (Creator), Adis Journals, 2021
DOI: 10.6084/m9.figshare.14124275, https://adisjournals.figshare.com/articles/media/Safety_and_Effectiveness_of_Ipragliflozin_in_Elderly_Versus_Non-Elderly_Japanese_Patients_with_Type_2_Diabetes_Subgroup_Analysis_of_STELLA-LONG_TERM/14124275
Dataset
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Safety and Effectiveness of Ipragliflozin in Elderly Versus Non-Elderly Japanese Patients with Type 2 Diabetes: Subgroup Analysis of STELLA-LONG TERM
Nakamura, I. (Creator), Maegawa, H. (Creator), Tobe, K. (Creator) & Uno, S. (Creator), Adis Journals, 2021
DOI: 10.6084/m9.figshare.14124275.v1, https://adisjournals.figshare.com/articles/media/Safety_and_Effectiveness_of_Ipragliflozin_in_Elderly_Versus_Non-Elderly_Japanese_Patients_with_Type_2_Diabetes_Subgroup_Analysis_of_STELLA-LONG_TERM/14124275/1
Dataset
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Safety and Effectiveness of Ipragliflozin for Type 2 Diabetes in Japan: 12-Month Interim Results of the STELLA-LONG TERM Post-Marketing Surveillance Study
Nakamura, I. (Creator), Maegawa, H. (Creator), Tobe, K. (Creator) & Uno, S. (Creator), Adis Journals, 2019
DOI: 10.6084/m9.figshare.7629557, https://adisjournals.figshare.com/articles/Safety_and_Effectiveness_of_Ipragliflozin_for_Type_2_Diabetes_in_Japan_12-Month_Interim_Results_of_the_STELLA-LONG_TERM_Post-Marketing_Surveillance_Study/7629557
Dataset
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非小細胞肺癌術後再発症例に対する化学放射線療法の効果と安全性．
Tobe, K. (Speaker)
2016/11/05 → 2016/11/06Activity: Talk or presentation › Oral presentation
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肺切除術で診断したmarginal zone B-cell Lymphomaの1例．
Tobe, K. (Speaker)
2016/11/05 → 2016/11/06Activity: Talk or presentation › Oral presentation
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肺腺癌骨転移の再生検にて新たにEGFR遺伝子変異を認めた一症例．
Tobe, K. (Speaker)
2016/11/05 → 2016/11/06Activity: Talk or presentation › Oral presentation
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急速に抑うつ症状と認知機能低下の進行を呈したサブクリニカルクッシング症候群の1例．
Tobe, K. (Speaker)
2016/10/22Activity: Talk or presentation › Oral presentation
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緩和的放射線照射下にニボルマブを投与した巨大左下葉肺腺癌の1例．
Tobe, K. (Speaker)
2016/07/09Activity: Talk or presentation › Oral presentation
Courses
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呼吸器系
Tobe, K., Hayashi, R., Tsuchiya, T., Imanishi, S., Okazawa, S., Inomata, M., Saitoh, J.-I., Okabe, M., Kamisaki, Y. & Hirabayashi, K. 2024/04/01 → 2024/09/30
Course
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老年医学
Suzuki, M., Fujiuchi, Y., Tobe, K., Takahashi, T., Nakatsuji, Y., Kainuma, M., Inomata, M., Kitamura, H., Kawaguchi, Y., Fujisaka, S. & Nakane, S. 2024/04/01 → 2024/09/30
Course
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第一内科
Tobe, K., Shinoda, K., Imanishi, S., Okazawa, S., Inomata, M., Fujisaka, S. & Honoki, H. 2024/04/01 → 2025/03/31
Course
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医科分子生物学
Mori, H., Tobe, K., Inokuchi, K., Yoshida, T., Nomoto, M., Kaida, D., Ishimoto, T., Nakagawa, T., Inoue, R. & Miyamoto, D. 2024/04/01 → 2024/09/30
Course
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内分泌・栄養・代謝・乳房
Tobe, K., Ishiki, M., Yoshioka, I., Okuno, N., Shibuya, K., Kitamura, H., Matsui, K., Fujii, T., Saitoh, J.-I., Chujo, D., Satake, T., Yanagisawa, S., Fujisaka, S. & Watanabe, T. 2024/04/01 → 2024/09/30
Course