Research output per year
Research output per year
Research output
- 1 - 50 out of 402 results
Search results
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2025
Analysis of Serum microRNAs During the Development of Experimental Autoimmune Uveoretinitis in Rats
Saito, S., Keino, H., Takasaki, I., Watanabe, T. & Okada, A. A., 2025, (Accepted/In press) In: Ocular Immunology and Inflammation.Research output: Contribution to journal › Article › peer-review
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Construction of trans-2,6-Disubstituted Piperidine Skeleton and Its Application to the Total Synthesis of (−)-Myrtine and trans-Piperidine-Type Poison-Frog Alkaloids
Okada, T., Eguchi, K., Hasegawa, F., Ikhlaq, M. M., Yoshikawa, T. & Toyooka, N., 2025/02/21, In: Journal of Organic Chemistry. 90, 7, p. 2749-2759 11 p.Research output: Contribution to journal › Article › peer-review
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HMGB1 derived from macrophages and enteric glial cells contributes to the butyrate-induced colonic hypersensitivity in mice
Tsubota, M., Sasaki, K., Shin, E., Okamura, Y., Nishimura, A., Yamagata, A., Nonaka, Y., Sekiguchi, F., Tomono, Y., Nishibori, M., Okada, T., Toyooka, N. & Kawabata, A., 2025/07/15, In: European Journal of Pharmacology. 999, 177660.Research output: Contribution to journal › Article › peer-review
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Repurposing of Agrochemicals as ATTRv Amyloidosis Inhibitors
Yokoyama, T., Fujiwara, S., Nishikubo, K., Mizuguchi, M., Nabeshima, Y., Toyooka, N., Okada, T. & Nakagawa, Y., 2025/01/23, In: Journal of Medicinal Chemistry. 68, 2, p. 1572-1586 15 p.Research output: Contribution to journal › Article › peer-review
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Spinal pituitary adenylate cyclase-activating polypeptide and PAC1 receptor signaling system is involved in the oxaliplatin-induced acute cold allodynia in mice
Takasaki, I., Nagashima, R., Ueda, T., Ashihara, Y., Nakamachi, T., Okada, T., Toyooka, N., Miyata, A. & Kurihara, T., 2025/02, In: Journal of Pain. 27, 104751.Research output: Contribution to journal › Article › peer-review
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2024
Anti-allergic drug screening in single living mast cells by means of a novel surface plasmon resonance imaging system
Wang, Q., Zhang, X., Li, Q., Liu, X., Huang, Y., Shi, C., Shinohara, H., Liu, Z. & Zhu, X., 2024/04/01, In: Sensors and Actuators, B: Chemical. 404, 135286.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
Characterization of Tumor-Infiltrating Lymphocyte-Derived Atypical TCRs Recognizing Breast Cancer in an MR1-Dependent Manner
Hayee, A., Kobayashi, E., Motozono, C., Hamana, H., My, H. T. V., Okada, T., Toyooka, N., Yamaguchi, S., Ozawa, T. & Kishi, H., 2024/10, In: Cells. 13, 20, 1711.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Deletion of platelet-derived growth factor receptor β suppresses tumorigenesis in metabolic dysfunction-associated steatohepatitis (MASH) mice with diabetes
Wada, T., Takeda, Y., Okekawa, A., Komatsu, G., Iwasa, Y., Onogi, Y., Takasaki, I., Hamashima, T., Sasahara, M., Tsuneki, H. & Sasaoka, T., 2024/12, In: Scientific Reports. 14, 1, 23829.Research output: Contribution to journal › Article › peer-review
Open Access -
Development of Benziodarone Analogues with Enhanced Potency for Selective Binding to Transthyretin in Human Plasma
Mizuguchi, M., Nakagawa, Y., Yokoyama, T., Okada, T., Fujii, K., Takahashi, K., Luan, N. N. T., Nabeshima, Y., Kanamitsu, K., Nakagawa, S., Yamakawa, S., Ueda, M., Ando, Y. & Toyooka, N., 2024/05/09, In: Journal of Medicinal Chemistry. 67, 9, p. 6987-7005 19 p.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Discovery and optimization of isoliquiritigenin as a death-associated protein kinase 1 inhibitor
Yokoyama, T., Hisatomi, K., Oshima, S., Tanaka, I., Okada, T. & Toyooka, N., 2024/12/05, In: European Journal of Medicinal Chemistry. 279, 116836.Research output: Contribution to journal › Article › peer-review
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Divergent Total Synthesis of Isoflavone Natural Products and Their Potential as Therapeutic Agents for TTR Amyloidosis
Thanh Luan, N. N., Okada, T., Yokoyama, T., Suzuki, M., Nabeshima, Y., Mizuguchi, M. & Toyooka, N., 2024/11/22, In: Journal of Natural Products. 87, 11, p. 2604-2614 11 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Impact of preS1 Evaluation in the Management of Chronic Hepatitis B Virus Infection
Hayashi, Y., Tajiri, K., Ozawa, T., Angata, K., Sato, T., Togayachi, A., Nagashima, I., Shimizu, H., Murayama, A., Muraishi, N., Narimatsu, H. & Yasuda, I., 2024/08, In: Medicina (Lithuania). 60, 8, 1334.Research output: Contribution to journal › Article › peer-review
Open Access -
Involvement of Cav3.2 T-type Ca2+ channels and cystathionine-β-synthase in colitis-related visceral hypersensitivity in mice
Tsubota, M., Iba, Y., Hatakeyama, T., Honda, M., Kasanami, Y., Sekiguchi, F., Kawase, A., Okada, T., Toyooka, N. & Kawabata, A., 2024/12, In: Journal of Pharmacological Sciences. 156, 4, p. 209-213 5 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Rab GTPases and phosphoinositides fine-tune SNAREs dependent targeting specificity of intracellular vesicle traffic
Koike, S. & Jahn, R., 2024/12, In: Nature Communications. 15, 1, 2508.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Structural insights into rapamycin-induced oligomerization of a FRB–FKBP fusion protein
Inobe, T., Sakaguchi, R., Obita, T., Mukaiyama, A., Koike, S., Yokoyama, T., Mizuguchi, M. & Akiyama, S., 2024/09, In: FEBS Letters. 598, 18, p. 2292-2305 14 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Synthesis of 8-epi-L-swainsonine, related C6 alkylated derivatives and their α-L-rhamnosidase inhibition
Shimadate, Y., Oshima, S., Kasamatsu, N., Yamamoto, S., Taguchi, A., Nash, R. J., Fleet, G. W. J., Okada, T., Toyooka, N. & Kato, A., 2024/03/01, In: Tetrahedron Letters. p. 155008Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Targeting Pancreatic Cancer with Novel Nicolaioidesin C Derivatives: Molecular Mechanism, In Vitro, and In Vivo Evaluations
Yamazaki, T., Phan, N. D., Maneenet, J., Yamagishi, M., Nishikawa, Y., Okada, T., Okumura, T., Toyooka, N., Fujii, T. & Awale, S., 2024/08/22, In: Journal of Medicinal Chemistry. 67, 16, p. 14313-14328 16 p.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
Threonine phosphorylation of STAT1 restricts interferon signaling and promotes innate inflammatory responses
Metwally, H., Elbrashy, M. M., Ozawa, T., Okuyama, K., White, J. T., Tulyeu, J., Søndergaard, J. N., Wing, J. B., Muratsu, A., Matsumoto, H., Ikawa, M., Kishi, H., Taniuchi, I. & Kishimoto, T., 2024/04/23, In: Proceedings of the National Academy of Sciences of the United States of America. 121, 17, e2402226121.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Transplanted artificial amnion membrane enhanced wound healing in third-degree burn injury diabetic mouse model
Arai, K., Yoshida, S., Furuichi, E., Iwanaga, S., Mir, T. A. & Yoshida, T., 2024/12, In: Regenerative Therapy. 27, p. 170-180 11 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2023
Benziodarone and 6-hydroxybenziodarone are potent and selective inhibitors of transthyretin amyloidogenesis
Mizuguchi, M., Yokoyama, T., Okada, T., Nakagawa, Y., Fujii, K., Nabeshima, Y. & Toyooka, N., 2023/07/15, In: Bioorganic and Medicinal Chemistry. 90, 117370.Research output: Contribution to journal › Article › peer-review
7 Scopus citations -
Cloning of human anti-factor XIII monoclonal antibody dissects mechanisms of polyclonal antibodies in a single patient
Souri, M., Ozawa, T., Osaki, T., Koyama, T., Muraguchi, A. & Ichinose, A., 2023/02, In: Journal of Thrombosis and Haemostasis. 21, 2, p. 255-268 14 p.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
Concise Total Synthesis of rac-Betuphenone F
Luan, N. N. T., Okada, T. & Toyooka, N., 2023/03/21, In: European Journal of Organic Chemistry. 26, 12, e202300047.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
Design, synthesis, structure–activity relationship studies, and evaluation of novel GLS1 inhibitors
Jo, M., Koizumi, K., Suzuki, M., Kanayama, D., Watanabe, Y., Gouda, H., Mori, H., Mizuguchi, M., Obita, T., Nabeshima, Y., Toyooka, N. & Okada, T., 2023/05/01, In: Bioorganic and Medicinal Chemistry Letters. 87, 129266.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
Design and structural optimization of thiadiazole derivatives with potent GLS1 inhibitory activity
Okada, T., Yamabe, K., Jo, M., Sakajiri, Y., Shibata, T., Sawada, R., Yamanishi, Y., Kanayama, D., Mori, H., Mizuguchi, M., Obita, T., Nabeshima, Y., Koizumi, K. & Toyooka, N., 2023/09/01, In: Bioorganic and Medicinal Chemistry Letters. 93, 129438.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Development of a Novel CD26-Targeted Chimeric Antigen Receptor T-Cell Therapy for CD26-Expressing T-Cell Malignancies
Kobayashi, E., Kamihara, Y., Arai, M., Wada, A., Kikuchi, S., Hatano, R., Iwao, N., Susukida, T., Ozawa, T., Adachi, Y., Kishi, H., Dang, N. H., Yamada, T., Hayakawa, Y., Morimoto, C. & Sato, T., 2023/08, In: Cells. 12, 16, 2059.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
Epitope analysis of human monoclonal antibodies from a patient with autoimmune factor XIII deficiency reveals their inhibitory mechanisms
Osaki, T., Souri, M., Ozawa, T., Muraguchi, A. & Ichinose, A., 2023/05, In: FEBS Letters. 597, 9, p. 1275-1289 15 p.Research output: Contribution to journal › Article › peer-review
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GSTA4 Governs Melanoma Immune Resistance and Metastasis
Ucche, S., Yokoyama, S., Mojic, M., Oki, K., Ohshima, C., Tsuihiji, H., Takasaki, I., Tahara, H. & Hayakawa, Y., 2023/01/01, In: Molecular Cancer Research. 21, 1, p. 76-85 10 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
High-throughput droplet-based analysis of influenza A virus genetic reassortment by single-virus RNA sequencing
Chen, K. Y., Karuppusamy, J., O’Neill, M. B., Opuu, V., Bahin, M., Foulon, S., Ibanez, P., Quintana-Murci, L., Ozawa, T., van der Werf, S., Nghe, P., Naffakh, N., Griffiths, A. & Isel, C., 2023/02/07, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 6, e2211098120.Research output: Contribution to journal › Article › peer-review
Open Access10 Scopus citations -
Nicolaioidesin C: An Antiausterity Agent Shows Promising Antitumor Activity in a Pancreatic Cancer Xenograft Mouse Model
Phan, N. D., Omar, A. M., Takahashi, I., Baba, H., Okumura, T., Imura, J., Okada, T., Toyooka, N., Fujii, T. & Awale, S., 2023/06/23, In: Journal of Natural Products. 86, 6, p. 1402-1410 9 p.Research output: Contribution to journal › Article › peer-review
7 Scopus citations -
Rafoxanide, a salicylanilide anthelmintic, interacts with human plasma protein transthyretin
Yokoyama, T., Mizuguchi, M., Nabeshima, Y., Nakagawa, Y., Okada, T., Toyooka, N. & Kusaka, K., 2023/11, In: FEBS Journal. 290, 21, p. 5158-5170 13 p.Research output: Contribution to journal › Article › peer-review
5 Scopus citations -
Safe, rapid, and easy electro-orientation-based viability assay using a disposable insulating envelope within non-spherical yeast cells
Suga, M., Okuhara, T., Ikeuchi, S. & Shinohara, H., 2023/05/01, In: Sensors and Actuators, B: Chemical. 382, 133513.Research output: Contribution to journal › Article › peer-review
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Selection of highly responsive T cell receptors by an analysis combining the expression of multiple markers
Thi Viet Ha, M., Hamana, H., Shitaoka, K., Hayee, A., Kobayashi, E., Yoshikawa, T., Nakatsura, T., Saikawa, R., Sato, E., Osawa, M., Hitoshi, Y., Son Dang, T., Ozawa, T. & Kishi, H., 2023/06, In: Cancer Science. 114, 6, p. 2254-2264 11 p.Research output: Contribution to journal › Article › peer-review
Open Access -
The autotaxin-LPA axis promotes membrane trafficking and secretion in yolk sac visceral endoderm cells
Koike, S., Keino-Masu, K., Tanimoto, Y., Takahashi, S. & Masu, M., 2023/11, In: Biology Open. 12, 11, bio060081.Research output: Contribution to journal › Article › peer-review
Open Access -
The development of a highly sensitive and quantitative SARS-CoV-2 rapid antigen test applying newly developed monoclonal antibodies to an automated chemiluminescent flow-through membrane immunoassay device
Nishimura, K., Kitazawa, H., Kawahata, T., Yuhara, K., Masuya, T., Kuroita, T., Waki, K., Koike, S., Isobe, M. & Kurosawa, N., 2023/12, In: BMC Immunology. 24, 1, 34.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
2022
Abietane diterpenes from Abies spectabilis and their anti-pancreatic cancer activity against the MIA PaCa-2 cell line
Phan, N. D., Omar, A. M., Sun, S., Maneenet, J., Dibwe, D. F., Sato, M., Kalauni, S. K., Toyooka, N., Fujii, T. & Awale, S., 2022/06/15, In: Bioorganic and Medicinal Chemistry Letters. 66, 128723.Research output: Contribution to journal › Article › peer-review
Open Access9 Scopus citations -
Design and synthesis of novel pipernonaline derivatives as anti-austerity agents against human pancreatic cancer PANC-1 cells
Okada, T., Chino, Y., Yokoyama, K., Fujihashi, Y., Duy Phan, N., Maneenet, J., Prudhvi, L., Awale, S. & Toyooka, N., 2022/10/01, In: Bioorganic and Medicinal Chemistry. 71, 116963.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
Design and synthesis of pyrido[2,3-d]pyrimidine derivatives for a novel PAC1 receptor antagonist
Takasaki, I., Watanabe, A., Okada, T., Kanayama, D., Nagashima, R., Shudo, M., Shimodaira, A., Nunomura, K., Lin, B., Watanabe, Y., Gouda, H., Miyata, A., Kurihara, T. & Toyooka, N., 2022/03/05, In: European Journal of Medicinal Chemistry. 231, 114160.Research output: Contribution to journal › Article › peer-review
10 Scopus citations -
Discovery and Structure-Based Optimization of Novel Atg4B Inhibitors for the Treatment of Castration-Resistant Prostate Cancer
Kudo, Y., Endo, S., Fujita, M., Ota, A., Kamatari, Y. O., Tanaka, Y., Ishikawa, T., Ikeda, H., Okada, T., Toyooka, N., Fujimoto, N., Matsunaga, T. & Ikari, A., 2022/03/24, In: Journal of Medicinal Chemistry. 65, 6, p. 4878-4892 15 p.Research output: Contribution to journal › Article › peer-review
8 Scopus citations -
Discovery of pimozide derivatives as novel T-type calcium channel inhibitors with little binding affinity to dopamine D2 receptors for treatment of somatic and visceral pain
Kasanami, Y., Ishikawa, C., Kino, T., Chonan, M., Toyooka, N., Takashima, Y., Iba, Y., Sekiguchi, F., Tsubota, M., Ohkubo, T., Yoshida, S., Kawase, A., Okada, T. & Kawabata, A., 2022/12/05, In: European Journal of Medicinal Chemistry. 243, 114716.Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations -
Divergent synthesis of decahydroquinoline-type poison-frog alkaloids.
Translated title of the contribution :Divergent synthesis of decahydroquinoline-type poison-frog alkaloids. Research output: Contribution to journal › Article › peer-review
5 Scopus citations -
Hypothalamic orexin prevents non-alcoholic steatohepatitis and hepatocellular carcinoma in obesity
Tsuneki, H., Maeda, T., Takata, S., Sugiyama, M., Otsuka, K., Ishizuka, H., Onogi, Y., Tokai, E., Koshida, C., Kon, K., Takasaki, I., Hamashima, T., Sasahara, M., Rudich, A., Koya, D., Sakurai, T., Yanagisawa, M., Yamanaka, A., Wada, T. & Sasaoka, T., 2022/10/18, In: Cell Reports. 41, 3, 111497.Research output: Contribution to journal › Article › peer-review
Open Access16 Scopus citations -
Novel super-neutralizing antibody UT28K is capable of protecting against infection from a wide variety of SARS-CoV-2 variants
Ozawa, T., Tani, H., Anraku, Y., Kita, S., Igarashi, E., Saga, Y., Inasaki, N., Kawasuji, H., Yamada, H., Sasaki, S. I., Somekawa, M., Sasaki, J., Hayakawa, Y., Yamamoto, Y., Morinaga, Y., Kurosawa, N., Isobe, M., Fukuhara, H., Maenaka, K. & Hashiguchi, T. & 4 others, , 2022, In: mAbs. 14, 1, 2072455.Research output: Contribution to journal › Article › peer-review
Open Access9 Scopus citations -
Rapid cloning of antigen-specific T-cell receptors by leveraging the cis activation of T cells
Kobayashi, E., Jin, A., Hamana, H., Shitaoka, K., Tajiri, K., Kusano, S., Yokoyama, S., Ozawa, T., Obata, T., Muraguchi, A. & Kishi, H., 2022/07, In: Nature Biomedical Engineering. 6, 7, p. 806-818 13 p.Research output: Contribution to journal › Article › peer-review
10 Scopus citations -
Simple optical analysis of viability of fission yeast based on electro-orientation with transparent electrodes
Suga, M., Inaba, R., Ookami, K. & Shinohara, H., 2022/04/15, In: Sensors and Actuators, B: Chemical. 357, 131425.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
SIPA1L1/SPAR1 Interacts with the Neurabin Family of Proteins and is Involved in GPCR Signaling
Matsuura, K., Kobayashi, S., Konno, K., Yamasaki, M., Horiuchi, T., Senda, T., Hayashi, T., Satoh, K., Arima-Yoshida, F., Iwasaki, K., Negishi, L., Yasui-Shimizu, N., Kohu, K., Kawahara, S., Kirino, Y., Nakamura, T., Watanabe, M., Yamamoto, T., Manabe, T. & Akiyama, T., 2022/03/23, In: Journal of Neuroscience. 42, 12, p. 2448-2473 26 p.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
Small-molecule non-peptide antagonists of the PACAP receptor attenuate acute restraint stress-induced anxiety-like behaviors in mice
Shintani, Y., Yamano, Y., kuta, M., Takeshita, R., Takuma, K., Okada, T., Toyooka, N., Takasaki, I., Miyata, A., Kurihara, T., Hashimoto, H. & Hayata-Takano, A., 2022/11/26, In: Biochemical and Biophysical Research Communications. 631, p. 146-151 6 p.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Spinal Astrocyte-Neuron Lactate Shuttle Contributes to the Pituitary Adenylate Cyclase-Activating Polypeptide/PAC1 Receptor-Induced Nociceptive Behaviors in Mice
Kambe, Y., Youkai, M., Hashiguchi, K., Sameshima, Y., Takasaki, I., Miyata, A. & Kurihara, T., 2022/12, In: Biomolecules. 12, 12, 1859.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Structure-activity relationship study of 4′-O-methylgrynullarin derivatives for the development of novel anticancer agents based on anti-austerity strategy
Thanh Luan, N. N., Okada, T., Arata, R., Prudhvi, L., Miyaguchi, M., Kodama, Y., Awale, S. & Toyooka, N., 2022/09/10, In: Tetrahedron. 122, 132931.Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations -
Suvorexant and mirtazapine improve chronic pain-related changes in parameters of sleep and voluntary physical performance in mice with sciatic nerve ligation
Ito, H., Tsuneki, H., Sasaoka, T., Toyooka, N., Matsuo, M. & Yamazaki, M., 2022/02, In: PLoS ONE. 17, 2 February, e0264386.Research output: Contribution to journal › Article › peer-review
Open Access12 Scopus citations -
Total Synthesis of 4’-O-Methylgrynullarin and Related Isoflavone Natural Products
Okada, T., Ngoc Thanh Luan, N., Arata, R., Awale, S. & Toyooka, N., 2022/04/21, In: ChemistrySelect. 7, 15, e202201136.Research output: Contribution to journal › Article › peer-review
8 Scopus citations