年別の研究成果
年別の研究成果
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2025
Analysis of Serum microRNAs During the Development of Experimental Autoimmune Uveoretinitis in Rats
Saito, S., Keino, H., Takasaki, I., Watanabe, T. & Okada, A. A., 2025, (受理済み/印刷中) In: Ocular Immunology and Inflammation.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
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Construction of trans-2,6-Disubstituted Piperidine Skeleton and Its Application to the Total Synthesis of (−)-Myrtine and trans-Piperidine-Type Poison-Frog Alkaloids
Okada, T., Eguchi, K., Hasegawa, F., Ikhlaq, M. M., Yoshikawa, T. & Toyooka, N., 2025/02/21, In: Journal of Organic Chemistry. 90, 7, p. 2749-2759 11 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
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HMGB1 derived from macrophages and enteric glial cells contributes to the butyrate-induced colonic hypersensitivity in mice
Tsubota, M., Sasaki, K., Shin, E., Okamura, Y., Nishimura, A., Yamagata, A., Nonaka, Y., Sekiguchi, F., Tomono, Y., Nishibori, M., Okada, T., Toyooka, N. & Kawabata, A., 2025/07/15, In: European Journal of Pharmacology. 999, 177660.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
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Repurposing of Agrochemicals as ATTRv Amyloidosis Inhibitors
Yokoyama, T., Fujiwara, S., Nishikubo, K., Mizuguchi, M., Nabeshima, Y., Toyooka, N., Okada, T. & Nakagawa, Y., 2025/01/23, In: Journal of Medicinal Chemistry. 68, 2, p. 1572-1586 15 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
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Spinal pituitary adenylate cyclase-activating polypeptide and PAC1 receptor signaling system is involved in the oxaliplatin-induced acute cold allodynia in mice
Takasaki, I., Nagashima, R., Ueda, T., Ashihara, Y., Nakamachi, T., Okada, T., Toyooka, N., Miyata, A. & Kurihara, T., 2025/02, In: Journal of Pain. 27, 104751.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
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2024
Anti-allergic drug screening in single living mast cells by means of a novel surface plasmon resonance imaging system
Wang, Q., Zhang, X., Li, Q., Liu, X., Huang, Y., Shi, C., Shinohara, H., Liu, Z. & Zhu, X., 2024/04/01, In: Sensors and Actuators, B: Chemical. 404, 135286.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
3 被引用数 (Scopus) -
Characterization of Tumor-Infiltrating Lymphocyte-Derived Atypical TCRs Recognizing Breast Cancer in an MR1-Dependent Manner
Hayee, A., Kobayashi, E., Motozono, C., Hamana, H., My, H. T. V., Okada, T., Toyooka, N., Yamaguchi, S., Ozawa, T. & Kishi, H., 2024/10, In: Cells. 13, 20, 1711.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access1 被引用数 (Scopus) -
Deletion of platelet-derived growth factor receptor β suppresses tumorigenesis in metabolic dysfunction-associated steatohepatitis (MASH) mice with diabetes
Wada, T., Takeda, Y., Okekawa, A., Komatsu, G., Iwasa, Y., Onogi, Y., Takasaki, I., Hamashima, T., Sasahara, M., Tsuneki, H. & Sasaoka, T., 2024/12, In: Scientific Reports. 14, 1, 23829.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access -
Development of Benziodarone Analogues with Enhanced Potency for Selective Binding to Transthyretin in Human Plasma
Mizuguchi, M., Nakagawa, Y., Yokoyama, T., Okada, T., Fujii, K., Takahashi, K., Luan, N. N. T., Nabeshima, Y., Kanamitsu, K., Nakagawa, S., Yamakawa, S., Ueda, M., Ando, Y. & Toyooka, N., 2024/05/09, In: Journal of Medicinal Chemistry. 67, 9, p. 6987-7005 19 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access3 被引用数 (Scopus) -
Discovery and optimization of isoliquiritigenin as a death-associated protein kinase 1 inhibitor
Yokoyama, T., Hisatomi, K., Oshima, S., Tanaka, I., Okada, T. & Toyooka, N., 2024/12/05, In: European Journal of Medicinal Chemistry. 279, 116836.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
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Divergent Total Synthesis of Isoflavone Natural Products and Their Potential as Therapeutic Agents for TTR Amyloidosis
Thanh Luan, N. N., Okada, T., Yokoyama, T., Suzuki, M., Nabeshima, Y., Mizuguchi, M. & Toyooka, N., 2024/11/22, In: Journal of Natural Products. 87, 11, p. 2604-2614 11 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access1 被引用数 (Scopus) -
Impact of preS1 Evaluation in the Management of Chronic Hepatitis B Virus Infection
Hayashi, Y., Tajiri, K., Ozawa, T., Angata, K., Sato, T., Togayachi, A., Nagashima, I., Shimizu, H., Murayama, A., Muraishi, N., Narimatsu, H. & Yasuda, I., 2024/08, In: Medicina (Lithuania). 60, 8, 1334.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access -
Involvement of Cav3.2 T-type Ca2+ channels and cystathionine-β-synthase in colitis-related visceral hypersensitivity in mice
Tsubota, M., Iba, Y., Hatakeyama, T., Honda, M., Kasanami, Y., Sekiguchi, F., Kawase, A., Okada, T., Toyooka, N. & Kawabata, A., 2024/12, In: Journal of Pharmacological Sciences. 156, 4, p. 209-213 5 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access -
Rab GTPases and phosphoinositides fine-tune SNAREs dependent targeting specificity of intracellular vesicle traffic
Koike, S. & Jahn, R., 2024/12, In: Nature Communications. 15, 1, 2508.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access3 被引用数 (Scopus) -
Structural insights into rapamycin-induced oligomerization of a FRB–FKBP fusion protein
Inobe, T., Sakaguchi, R., Obita, T., Mukaiyama, A., Koike, S., Yokoyama, T., Mizuguchi, M. & Akiyama, S., 2024/09, In: FEBS Letters. 598, 18, p. 2292-2305 14 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
1 被引用数 (Scopus) -
Synthesis of 8-epi-L-swainsonine, related C6 alkylated derivatives and their α-L-rhamnosidase inhibition
Shimadate, Y., Oshima, S., Kasamatsu, N., Yamamoto, S., Taguchi, A., Nash, R. J., Fleet, G. W. J., Okada, T., Toyooka, N. & Kato, A., 2024/03/01, In: Tetrahedron Letters. p. 155008研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
2 被引用数 (Scopus) -
Targeting Pancreatic Cancer with Novel Nicolaioidesin C Derivatives: Molecular Mechanism, In Vitro, and In Vivo Evaluations
Yamazaki, T., Phan, N. D., Maneenet, J., Yamagishi, M., Nishikawa, Y., Okada, T., Okumura, T., Toyooka, N., Fujii, T. & Awale, S., 2024/08/22, In: Journal of Medicinal Chemistry. 67, 16, p. 14313-14328 16 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
3 被引用数 (Scopus) -
Threonine phosphorylation of STAT1 restricts interferon signaling and promotes innate inflammatory responses
Metwally, H., Elbrashy, M. M., Ozawa, T., Okuyama, K., White, J. T., Tulyeu, J., Søndergaard, J. N., Wing, J. B., Muratsu, A., Matsumoto, H., Ikawa, M., Kishi, H., Taniuchi, I. & Kishimoto, T., 2024/04/23, In: Proceedings of the National Academy of Sciences of the United States of America. 121, 17, e2402226121.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access3 被引用数 (Scopus) -
Transplanted artificial amnion membrane enhanced wound healing in third-degree burn injury diabetic mouse model
Arai, K., Yoshida, S., Furuichi, E., Iwanaga, S., Mir, T. A. & Yoshida, T., 2024/12, In: Regenerative Therapy. 27, p. 170-180 11 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access -
2023
Benziodarone and 6-hydroxybenziodarone are potent and selective inhibitors of transthyretin amyloidogenesis
Mizuguchi, M., Yokoyama, T., Okada, T., Nakagawa, Y., Fujii, K., Nabeshima, Y. & Toyooka, N., 2023/07/15, In: Bioorganic and Medicinal Chemistry. 90, 117370.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
7 被引用数 (Scopus) -
Cloning of human anti-factor XIII monoclonal antibody dissects mechanisms of polyclonal antibodies in a single patient
Souri, M., Ozawa, T., Osaki, T., Koyama, T., Muraguchi, A. & Ichinose, A., 2023/02, In: Journal of Thrombosis and Haemostasis. 21, 2, p. 255-268 14 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access7 被引用数 (Scopus) -
Concise Total Synthesis of rac-Betuphenone F
Luan, N. N. T., Okada, T. & Toyooka, N., 2023/03/21, In: European Journal of Organic Chemistry. 26, 12, e202300047.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
3 被引用数 (Scopus) -
Design, synthesis, structure–activity relationship studies, and evaluation of novel GLS1 inhibitors
Jo, M., Koizumi, K., Suzuki, M., Kanayama, D., Watanabe, Y., Gouda, H., Mori, H., Mizuguchi, M., Obita, T., Nabeshima, Y., Toyooka, N. & Okada, T., 2023/05/01, In: Bioorganic and Medicinal Chemistry Letters. 87, 129266.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
3 被引用数 (Scopus) -
Design and structural optimization of thiadiazole derivatives with potent GLS1 inhibitory activity
Okada, T., Yamabe, K., Jo, M., Sakajiri, Y., Shibata, T., Sawada, R., Yamanishi, Y., Kanayama, D., Mori, H., Mizuguchi, M., Obita, T., Nabeshima, Y., Koizumi, K. & Toyooka, N., 2023/09/01, In: Bioorganic and Medicinal Chemistry Letters. 93, 129438.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
1 被引用数 (Scopus) -
Development of a Novel CD26-Targeted Chimeric Antigen Receptor T-Cell Therapy for CD26-Expressing T-Cell Malignancies
Kobayashi, E., Kamihara, Y., Arai, M., Wada, A., Kikuchi, S., Hatano, R., Iwao, N., Susukida, T., Ozawa, T., Adachi, Y., Kishi, H., Dang, N. H., Yamada, T., Hayakawa, Y., Morimoto, C. & Sato, T., 2023/08, In: Cells. 12, 16, 2059.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access5 被引用数 (Scopus) -
Epitope analysis of human monoclonal antibodies from a patient with autoimmune factor XIII deficiency reveals their inhibitory mechanisms
Osaki, T., Souri, M., Ozawa, T., Muraguchi, A. & Ichinose, A., 2023/05, In: FEBS Letters. 597, 9, p. 1275-1289 15 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
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GSTA4 Governs Melanoma Immune Resistance and Metastasis
Ucche, S., Yokoyama, S., Mojic, M., Oki, K., Ohshima, C., Tsuihiji, H., Takasaki, I., Tahara, H. & Hayakawa, Y., 2023/01/01, In: Molecular Cancer Research. 21, 1, p. 76-85 10 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access2 被引用数 (Scopus) -
High-throughput droplet-based analysis of influenza A virus genetic reassortment by single-virus RNA sequencing
Chen, K. Y., Karuppusamy, J., O’Neill, M. B., Opuu, V., Bahin, M., Foulon, S., Ibanez, P., Quintana-Murci, L., Ozawa, T., van der Werf, S., Nghe, P., Naffakh, N., Griffiths, A. & Isel, C., 2023/02/07, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 6, e2211098120.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access10 被引用数 (Scopus) -
Nicolaioidesin C: An Antiausterity Agent Shows Promising Antitumor Activity in a Pancreatic Cancer Xenograft Mouse Model
Phan, N. D., Omar, A. M., Takahashi, I., Baba, H., Okumura, T., Imura, J., Okada, T., Toyooka, N., Fujii, T. & Awale, S., 2023/06/23, In: Journal of Natural Products. 86, 6, p. 1402-1410 9 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
7 被引用数 (Scopus) -
Rafoxanide, a salicylanilide anthelmintic, interacts with human plasma protein transthyretin
Yokoyama, T., Mizuguchi, M., Nabeshima, Y., Nakagawa, Y., Okada, T., Toyooka, N. & Kusaka, K., 2023/11, In: FEBS Journal. 290, 21, p. 5158-5170 13 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
5 被引用数 (Scopus) -
Safe, rapid, and easy electro-orientation-based viability assay using a disposable insulating envelope within non-spherical yeast cells
Suga, M., Okuhara, T., Ikeuchi, S. & Shinohara, H., 2023/05/01, In: Sensors and Actuators, B: Chemical. 382, 133513.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
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Selection of highly responsive T cell receptors by an analysis combining the expression of multiple markers
Thi Viet Ha, M., Hamana, H., Shitaoka, K., Hayee, A., Kobayashi, E., Yoshikawa, T., Nakatsura, T., Saikawa, R., Sato, E., Osawa, M., Hitoshi, Y., Son Dang, T., Ozawa, T. & Kishi, H., 2023/06, In: Cancer Science. 114, 6, p. 2254-2264 11 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access -
The autotaxin-LPA axis promotes membrane trafficking and secretion in yolk sac visceral endoderm cells
Koike, S., Keino-Masu, K., Tanimoto, Y., Takahashi, S. & Masu, M., 2023/11, In: Biology Open. 12, 11, bio060081.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access -
The development of a highly sensitive and quantitative SARS-CoV-2 rapid antigen test applying newly developed monoclonal antibodies to an automated chemiluminescent flow-through membrane immunoassay device
Nishimura, K., Kitazawa, H., Kawahata, T., Yuhara, K., Masuya, T., Kuroita, T., Waki, K., Koike, S., Isobe, M. & Kurosawa, N., 2023/12, In: BMC Immunology. 24, 1, 34.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access1 被引用数 (Scopus) -
2022
Abietane diterpenes from Abies spectabilis and their anti-pancreatic cancer activity against the MIA PaCa-2 cell line
Phan, N. D., Omar, A. M., Sun, S., Maneenet, J., Dibwe, D. F., Sato, M., Kalauni, S. K., Toyooka, N., Fujii, T. & Awale, S., 2022/06/15, In: Bioorganic and Medicinal Chemistry Letters. 66, 128723.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access9 被引用数 (Scopus) -
Design and synthesis of novel pipernonaline derivatives as anti-austerity agents against human pancreatic cancer PANC-1 cells
Okada, T., Chino, Y., Yokoyama, K., Fujihashi, Y., Duy Phan, N., Maneenet, J., Prudhvi, L., Awale, S. & Toyooka, N., 2022/10/01, In: Bioorganic and Medicinal Chemistry. 71, 116963.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access7 被引用数 (Scopus) -
Design and synthesis of pyrido[2,3-d]pyrimidine derivatives for a novel PAC1 receptor antagonist
Takasaki, I., Watanabe, A., Okada, T., Kanayama, D., Nagashima, R., Shudo, M., Shimodaira, A., Nunomura, K., Lin, B., Watanabe, Y., Gouda, H., Miyata, A., Kurihara, T. & Toyooka, N., 2022/03/05, In: European Journal of Medicinal Chemistry. 231, 114160.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
10 被引用数 (Scopus) -
Discovery and Structure-Based Optimization of Novel Atg4B Inhibitors for the Treatment of Castration-Resistant Prostate Cancer
Kudo, Y., Endo, S., Fujita, M., Ota, A., Kamatari, Y. O., Tanaka, Y., Ishikawa, T., Ikeda, H., Okada, T., Toyooka, N., Fujimoto, N., Matsunaga, T. & Ikari, A., 2022/03/24, In: Journal of Medicinal Chemistry. 65, 6, p. 4878-4892 15 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
8 被引用数 (Scopus) -
Discovery of pimozide derivatives as novel T-type calcium channel inhibitors with little binding affinity to dopamine D2 receptors for treatment of somatic and visceral pain
Kasanami, Y., Ishikawa, C., Kino, T., Chonan, M., Toyooka, N., Takashima, Y., Iba, Y., Sekiguchi, F., Tsubota, M., Ohkubo, T., Yoshida, S., Kawase, A., Okada, T. & Kawabata, A., 2022/12/05, In: European Journal of Medicinal Chemistry. 243, 114716.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access8 被引用数 (Scopus) -
Divergent synthesis of decahydroquinoline-type poison-frog alkaloids.
寄稿の翻訳タイトル :Divergent synthesis of decahydroquinoline-type poison-frog alkaloids. 研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
5 被引用数 (Scopus) -
Hypothalamic orexin prevents non-alcoholic steatohepatitis and hepatocellular carcinoma in obesity
Tsuneki, H., Maeda, T., Takata, S., Sugiyama, M., Otsuka, K., Ishizuka, H., Onogi, Y., Tokai, E., Koshida, C., Kon, K., Takasaki, I., Hamashima, T., Sasahara, M., Rudich, A., Koya, D., Sakurai, T., Yanagisawa, M., Yamanaka, A., Wada, T. & Sasaoka, T., 2022/10/18, In: Cell Reports. 41, 3, 111497.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access16 被引用数 (Scopus) -
Novel super-neutralizing antibody UT28K is capable of protecting against infection from a wide variety of SARS-CoV-2 variants
Ozawa, T., Tani, H., Anraku, Y., Kita, S., Igarashi, E., Saga, Y., Inasaki, N., Kawasuji, H., Yamada, H., Sasaki, S. I., Somekawa, M., Sasaki, J., Hayakawa, Y., Yamamoto, Y., Morinaga, Y., Kurosawa, N., Isobe, M., Fukuhara, H., Maenaka, K. & Hashiguchi, T. & 4 others, , 2022, In: mAbs. 14, 1, 2072455.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access9 被引用数 (Scopus) -
Rapid cloning of antigen-specific T-cell receptors by leveraging the cis activation of T cells
Kobayashi, E., Jin, A., Hamana, H., Shitaoka, K., Tajiri, K., Kusano, S., Yokoyama, S., Ozawa, T., Obata, T., Muraguchi, A. & Kishi, H., 2022/07, In: Nature Biomedical Engineering. 6, 7, p. 806-818 13 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
10 被引用数 (Scopus) -
Simple optical analysis of viability of fission yeast based on electro-orientation with transparent electrodes
Suga, M., Inaba, R., Ookami, K. & Shinohara, H., 2022/04/15, In: Sensors and Actuators, B: Chemical. 357, 131425.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access1 被引用数 (Scopus) -
SIPA1L1/SPAR1 Interacts with the Neurabin Family of Proteins and is Involved in GPCR Signaling
Matsuura, K., Kobayashi, S., Konno, K., Yamasaki, M., Horiuchi, T., Senda, T., Hayashi, T., Satoh, K., Arima-Yoshida, F., Iwasaki, K., Negishi, L., Yasui-Shimizu, N., Kohu, K., Kawahara, S., Kirino, Y., Nakamura, T., Watanabe, M., Yamamoto, T., Manabe, T. & Akiyama, T., 2022/03/23, In: Journal of Neuroscience. 42, 12, p. 2448-2473 26 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access7 被引用数 (Scopus) -
Small-molecule non-peptide antagonists of the PACAP receptor attenuate acute restraint stress-induced anxiety-like behaviors in mice
Shintani, Y., Yamano, Y., kuta, M., Takeshita, R., Takuma, K., Okada, T., Toyooka, N., Takasaki, I., Miyata, A., Kurihara, T., Hashimoto, H. & Hayata-Takano, A., 2022/11/26, In: Biochemical and Biophysical Research Communications. 631, p. 146-151 6 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access4 被引用数 (Scopus) -
Spinal Astrocyte-Neuron Lactate Shuttle Contributes to the Pituitary Adenylate Cyclase-Activating Polypeptide/PAC1 Receptor-Induced Nociceptive Behaviors in Mice
Kambe, Y., Youkai, M., Hashiguchi, K., Sameshima, Y., Takasaki, I., Miyata, A. & Kurihara, T., 2022/12, In: Biomolecules. 12, 12, 1859.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access2 被引用数 (Scopus) -
Structure-activity relationship study of 4′-O-methylgrynullarin derivatives for the development of novel anticancer agents based on anti-austerity strategy
Thanh Luan, N. N., Okada, T., Arata, R., Prudhvi, L., Miyaguchi, M., Kodama, Y., Awale, S. & Toyooka, N., 2022/09/10, In: Tetrahedron. 122, 132931.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access8 被引用数 (Scopus) -
Suvorexant and mirtazapine improve chronic pain-related changes in parameters of sleep and voluntary physical performance in mice with sciatic nerve ligation
Ito, H., Tsuneki, H., Sasaoka, T., Toyooka, N., Matsuo, M. & Yamazaki, M., 2022/02, In: PLoS ONE. 17, 2 February, e0264386.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access12 被引用数 (Scopus) -
Total Synthesis of 4’-O-Methylgrynullarin and Related Isoflavone Natural Products
Okada, T., Ngoc Thanh Luan, N., Arata, R., Awale, S. & Toyooka, N., 2022/04/21, In: ChemistrySelect. 7, 15, e202201136.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
8 被引用数 (Scopus)