Projects per year
Personal profile
Campus career
医学科 助教 2011/01/01-2019/09/30
環境生体防御医学系 助教 2011/01/01-2019/09/30
医学系 助教 2019/10/01-
医学科 助教 2019/10/01-
医学部医学科 基幹教員
学部運営への参画状況・・・有-教授会
担当授業科目に係る状況・・・主要授業科目担当
環境生体防御医学系 助教 2011/01/01-2019/09/30
医学系 助教 2019/10/01-
医学科 助教 2019/10/01-
医学部医学科 基幹教員
学部運営への参画状況・・・有-教授会
担当授業科目に係る状況・・・主要授業科目担当
Research interests
抗原特異的T細胞の1個1個からT細胞のセンサーであるT細胞受容体遺伝子をクローニングし,その遺伝子の抗原特異性を評価するまでを10日間という極めて短期間で行うシステムを確立した.このシステムを用い,新たながんや感染症の治療法の開発を行っている.
Research Fields, Keywords
- Immunology
Field of expertise (Grants-in-aid for Scientific Research classification)
- Immunology
Fingerprint
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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がん治療へ向けたサポートCARによる革新的なT細胞受容体療法の開発
Kobayashi, E. (Principal Investigator) & Sato, T. (Co-Investigator(Kenkyū-buntansha))
Japan Society for the Promotion of Science
2024/04/01 → 2027/03/31
Project: Research Project
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単一T細胞上でのTCRとp/MHCの相互作用を用いたTCR抗原同定法の開発
Kishi, H. (Principal Investigator) & Kobayashi, E. (Co-Investigator(Kenkyū-buntansha))
Japan Society for the Promotion of Science
2023/04/01 → 2026/03/31
Project: Research Project
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Identification of antigens of tumor-infiltrated regulatory T cells and analysis of tumor suppression systems based on the antigens
Kobayashi, E. (PI)
2018/04/01 → 2021/03/31
Project: Research
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Development of Zika fever- and AIDS-peptide vaccine using next generation chip, T-ISAAC
Muraguchi, A. (PI), Kishi, H. (CoI), Ozawa, T. (CoI), Kobayashi, E. (CoI) & Udaka, K. (CoI)
2017/04/01 → 2020/03/31
Project: Research
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Characterization of Tumor-Infiltrating Lymphocyte-Derived Atypical TCRs Recognizing Breast Cancer in an MR1-Dependent Manner
Hayee, A., Kobayashi, E., Motozono, C., Hamana, H., My, H. T. V., Okada, T., Toyooka, N., Yamaguchi, S., Ozawa, T. & Kishi, H., 2024/10, In: Cells. 13, 20, 1711.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Parsing digital or analog TCR performance through piconewton forces
Akitsu, A., Kobayashi, E., Feng, Y., Stephens, H. M., Brazin, K. N., Masi, D. J., Kirkpatrick, E. H., Mallis, R. J., Duke-Cohan, J. S., Booker, M. A., Cinella, V., Feng, W. W., Holliday, E. L., Lee, J. J., Zienkiewicz, K. J., Tolstorukov, M. Y., Hwang, W., Lang, M. J. & Reinherz, E. L., 2024/08, In: Science Advances. 10, 33, ado4313.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Development of a Novel CD26-Targeted Chimeric Antigen Receptor T-Cell Therapy for CD26-Expressing T-Cell Malignancies
Kobayashi, E., Kamihara, Y., Arai, M., Wada, A., Kikuchi, S., Hatano, R., Iwao, N., Susukida, T., Ozawa, T., Adachi, Y., Kishi, H., Dang, N. H., Yamada, T., Hayakawa, Y., Morimoto, C. & Sato, T., 2023/08, In: Cells. 12, 16, 2059.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
DPP8 Selective Inhibitor Tominostat as a Novel and Broad-Spectrum Anticancer Agent against Hematological Malignancies
Kikuchi, S., Wada, A., Kamihara, Y., Okazaki, K., Jawaid, P., Rehman, M. U., Kobayashi, E., Susukida, T., Minemura, T., Nabe, Y., Iwao, N., Ozawa, T., Hatano, R., Yamada, M., Kishi, H., Matsuya, Y., Mizuguchi, M., Hayakawa, Y., Dang, N. H. & Sakamoto, Y. & 2 others, , 2023/04/06, In: Cells. 12, 7Research output: Contribution to journal › Article › peer-review
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DPP8 Selective Inhibitor Tominostat as a Novel and Broad-Spectrum Anticancer Agent against Hematological Malignancies
Kikuchi, S., Wada, A., Kamihara, Y., Okazaki, K., Jawaid, P., Rehman, M. U., Kobayashi, E., Susukida, T., Minemura, T., Nabe, Y., Iwao, N., Ozawa, T., Hatano, R., Yamada, M., Kishi, H., Matsuya, Y., Mizuguchi, M., Hayakawa, Y., Dang, N. H. & Sakamoto, Y. & 2 others, , 2023/04, In: Cells. 12, 7, 1100.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations
Activities
- 6 Oral presentation
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Cloning and functional analysis of human telomerase reverse transcriptase (hTERT)-specific TCRs from peptide-vaccinated patients
Kobayashi, E. (Speaker)
2013/11/11 → 2013/11/13Activity: Talk or presentation › Oral presentation
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A novel cloning system of human antigen-specific TCRs can confer the candidates for cancer gene therapy
Kobayashi, E. (Speaker)
2013/10/03 → 2013/10/05Activity: Talk or presentation › Oral presentation
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Cloning of human antigen-specific TCRs can confer the candidates for cancer gene therapy
Kobayashi, E. (Speaker)
2013/08/22 → 2013/08/27Activity: Talk or presentation › Oral presentation
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A novel human TCR efficient cloning system confers candidate for TCR gene therapy within 10 days
Kobayashi, E. (Speaker)
2012/10/26 → 2012/10/28Activity: Talk or presentation › Oral presentation
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抗原特異的T細胞受容体遺伝子の超迅速クローニングシステムの構築
Kobayashi, E. (Speaker)
2012/07/26 → 2012/07/28Activity: Talk or presentation › Oral presentation