Tsutomu Wada - University of Toyama

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Campus career

薬学科　講師　2013/05/01-2019/09/30
臨床薬科学系　講師　2013/05/01-2019/09/30
薬学・和漢系　講師　2019/10/01-
薬学科　講師　2019/10/01-
薬学部薬学科　基幹教員
学部運営への参画状況・・・有-教授会
担当授業科目に係る状況・・・主要授業科目担当

Research biography

Central versus peripheral impact of estradiol on the impaired glucose metabolism in ovariectomized mice on a high-fat diet　Grant-in-Aid for Scientific Research Project year:2009/04－2012/05
肝特異的SREBP1c過剰発現マウスを用いた新規非アルコール性脂肪肝炎（NASH）モデルの作成と、MR阻害剤による肝線維化抑制作用と糖脂質代謝改善作用の検討　科学研究費補助金　期間：2009/04－2013/10

Qualification

医師

Affiliated academic society

日本内科学会　所属期間：1995/10-
日本糖尿病学会　所属期間：1995/11-
日本内分泌学会　所属期間：1998/04-
日本産科婦人科学会　所属期間：2010/10-

Research interests

私は糖尿病やメタボリックシンドロームの基盤病態であるインスリン抵抗性の病態解明と,これを改善する新たな分子機構を探索し新規治療法の開発につなぐことを目指して研究を行ってきました.
全身の代謝は中枢神経系を中心とし,肝臓,脂肪などの各末梢組織と機能的な連携をとりながら調節されていることから,これらの臓器連携に影響をおよぼす新たな作用を見出し,特にインスリン抵抗性と関連が深い脂肪組織の肥大化と慢性炎症の進展抑制に着目した研究に取り組んでおります.
また我々が同定したSHIP2がインスリンシグナルを負に制御することから,共同研究を通じてインスリン抵抗性を改善する新規SHIP2阻害剤の開発に向けた創薬研究も行っています.

Education/Academic qualification

M.D., Ph.D.

Field of expertise (Grants-in-aid for Scientific Research classification)

Metabolomics

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9 Similar Profiles

5 Active
11 Finished

脂肪組織の可塑性メモリーを規定するエピゲノム制御による肥満リバウンド抑止法の開発
Wada, T. (Principal Investigator), Sasaoka, T. (Co-Investigator(Kenkyū-buntansha)), Tsuneki, H. (Co-Investigator(Kenkyū-buntansha)) & Onogi, Y. (Co-Investigator(Kenkyū-buntansha))
Japan Society for the Promotion of Science
2024/04/01 → 2028/03/31
Project: Research Project
Development of a novel treatment for diabetes and depression by promoting olfactory and orexin system
Sasaoka, T. (Principal Investigator), Tsuneki, H. (Co-Investigator(Kenkyū-buntansha)) & Wada, T. (Co-Investigator(Kenkyū-buntansha))
Japan Society for the Promotion of Science
2023/04/01 → 2026/03/31
Project: Research Project
飽食病態改善のための「嗅覚」刺激を介した飢餓対応型代謝の活用と脂質利用の拡大
Tsuneki, H. (Principal Investigator), Sasaoka, T. (Co-Investigator(Kenkyū-buntansha)) & Wada, T. (Co-Investigator(Kenkyū-buntansha))
Japan Society for the Promotion of Science
2022/04/01 → 2026/03/31
Project: Research Project
病態制御薬理学研究室　和田努　講師に対する教育研究助成
Wada, T. (PI)
2016/10/27 → …
Project: Research
病態制御薬理学研究室　和田努　講師に対する研究助成
Wada, T. (PI)
2015/07/03 → …
Project: Research

80 Article
77 Presentation
4 Review article
1 Chapter
More
- 1 Comment/debate

C-terminal peptide of preproorexin enhances brain-derived neurotrophic factor expression in rat cerebrocortical cells and recognition memory in mice
Tsuneki, H., Honda, K., Sekine, Y., Yahata, K., Yasue, M., Fujishima, M., Takeda, R., Wada, T. & Sasaoka, T., 2024/02/05, In: European Journal of Pharmacology. 964, 176306.
Research output: Contribution to journal › Article › peer-review

Open Access
1 Scopus citations
Deletion of platelet-derived growth factor receptor β suppresses tumorigenesis in metabolic dysfunction-associated steatohepatitis (MASH) mice with diabetes
Wada, T., Takeda, Y., Okekawa, A., Komatsu, G., Iwasa, Y., Onogi, Y., Takasaki, I., Hamashima, T., Sasahara, M., Tsuneki, H. & Sasaoka, T., 2024/12, In: Scientific Reports. 14, 1, 23829.
Research output: Contribution to journal › Article › peer-review

Open Access
Platelet-derived growth factor signaling in pericytes promotes hypothalamic inflammation and obesity
Okekawa, A., Wada, T., Onogi, Y., Takeda, Y., Miyazawa, Y., Sasahara, M., Tsuneki, H. & Sasaoka, T., 2024/12, In: Molecular Medicine. 30, 1, 21.
Research output: Contribution to journal › Article › peer-review

Open Access
3 Scopus citations
2型糖尿病予防に関わるマウス嗅覚―代謝連係を促進する薬物制御法の解析．
杉山聖典, 恒枝宏史, 山岸永和, 松田大樹, 和田　努 & 笹岡利安．, 2023.
Research output: Contribution to conference › Presentation
A transdermal treatment with MC903 ameliorates diet-induced obesity by reducing visceral fat and increasing myofiber thickness and energy consumption in mice
Wada, T., Miyazawa, Y., Ikurumi, M., Fuse, K., Okekawa, A., Onogi, Y., Saito, S., Tsuneki, H. & Sasaoka, T., 2023/12, In: Nutrition and Metabolism. 20, 1, 10.
Research output: Contribution to journal › Article › peer-review

Open Access
2 Scopus citations

Additional file 1 of Platelet-derived growth factor signaling in pericytes promotes hypothalamic inflammation and obesity
Sasaoka, T. (Creator), Onogi, Y. (Creator), Takeda, Y. (Creator), Okekawa, A. (Creator), Sasahara, M. (Creator), Miyazawa, Y. (Creator), Wada, T. (Creator) & Tsuneki, H. (Creator), figshare, 2024
DOI: 10.6084/m9.figshare.26677148, https://springernature.figshare.com/articles/presentation/Additional_file_1_of_Platelet-derived_growth_factor_signaling_in_pericytes_promotes_hypothalamic_inflammation_and_obesity/26677148
Dataset
Additional file 1 of Platelet-derived growth factor signaling in pericytes promotes hypothalamic inflammation and obesity
Takeda, Y. (Creator), Onogi, Y. (Creator), Tsuneki, H. (Creator), Sasaoka, T. (Creator), Wada, T. (Creator), Sasahara, M. (Creator), Okekawa, A. (Creator) & Miyazawa, Y. (Creator), figshare, 2024
DOI: 10.6084/m9.figshare.26677148.v1, https://springernature.figshare.com/articles/presentation/Additional_file_1_of_Platelet-derived_growth_factor_signaling_in_pericytes_promotes_hypothalamic_inflammation_and_obesity/26677148/1
Dataset
A transdermal treatment with MC903 ameliorates diet-induced obesity by reducing visceral fat and increasing myofiber thickness and energy consumption in mice
Ikurumi, M. (Creator), Fuse, K. (Creator), Onogi, Y. (Creator), Okekawa, A. (Creator), Wada, T. (Creator), Tsuneki, H. (Creator), Miyazawa, Y. (Creator), Sasaoka, T. (Creator) & Saito, S. (Creator), figshare, 2024
DOI: 10.6084/m9.figshare.c.6587371, https://springernature.figshare.com/collections/A_transdermal_treatment_with_MC903_ameliorates_diet-induced_obesity_by_reducing_visceral_fat_and_increasing_myofiber_thickness_and_energy_consumption_in_mice/6587371
Dataset
Platelet-derived growth factor signaling in pericytes promotes hypothalamic inflammation and obesity
Onogi, Y. (Creator), Takeda, Y. (Creator), Sasaoka, T. (Creator), Okekawa, A. (Creator), Sasahara, M. (Creator), Miyazawa, Y. (Creator), Wada, T. (Creator) & Tsuneki, H. (Creator), figshare, 2024
DOI: 10.6084/m9.figshare.c.7061173.v1, https://springernature.figshare.com/collections/Platelet-derived_growth_factor_signaling_in_pericytes_promotes_hypothalamic_inflammation_and_obesity/7061173/1
Dataset
Platelet-derived growth factor signaling in pericytes promotes hypothalamic inflammation and obesity
Sasaoka, T. (Creator), Onogi, Y. (Creator), Miyazawa, Y. (Creator), Okekawa, A. (Creator), Tsuneki, H. (Creator), Takeda, Y. (Creator), Sasahara, M. (Creator) & Wada, T. (Creator), figshare, 2024
DOI: 10.6084/m9.figshare.c.7061173, https://springernature.figshare.com/collections/Platelet-derived_growth_factor_signaling_in_pericytes_promotes_hypothalamic_inflammation_and_obesity/7061173
Dataset

米田幸雄賞
Wada, T. (Recipient), 2022/04/03
Prize
第30回とやま賞
Wada, T. (Recipient), 2013/05
Prize
International Aldosterone Forum in Japan-Award
Wada, T. (Recipient), 2010/05
Prize
日本内分泌学会若手研究奨励賞
Wada, T. (Recipient), 2003/05
Prize

115 Oral presentation

脂肪組織肥大化におけるPDGF依存的血管新生の意義
Wada, T. (Speaker)
2015/12/05
Activity: Talk or presentation › Oral presentation
視床下部オレキシンによる自律神経系と小胞体ストレス応答を介したマウス肝糖産生の調節機構．
Wada, T. (Speaker)
2015/12/01 → 2015/12/04
Activity: Talk or presentation › Oral presentation
オレキシン系を標的とした生体リズム制御による2型糖尿病マウスの糖代謝改善効果．
Wada, T. (Speaker)
2015/11/15
Activity: Talk or presentation › Oral presentation
選択的Mineralocorticoid Receptor (MR) 阻害剤エプレレノンによる糖代謝改善機構の解明．
Wada, T. (Speaker)
2015/11/15
Activity: Talk or presentation › Oral presentation
制御性T細胞の性特異的な脂肪組織局在が肥満に伴う慢性炎症と糖代謝に及ぼす影響．
Wada, T. (Speaker)
2015/11/15
Activity: Talk or presentation › Oral presentation

薬理学特論
Nitta, A., Wada, T., Sasaoka, T., Tsuneki, H., Uta, D., Kume, T. & Kadowaki, M.
2024/12/04 → 2025/03/31
Course
専門英語Ⅱ（病態制御薬理学・臨床薬品作用学）
Wada, T., Sasaoka, T. & Tsuneki, H.
2024/10/01 → 2025/03/31
Course
薬理学特論
Nitta, A., Wada, T., Sasaoka, T., Tsuneki, H., Uta, D., Kume, T. & Kadowaki, M.
2024/04/11 → 2024/06/11
Course
専門英語Ⅰ（病態制御薬理学・臨床薬品作用学）
Wada, T., Sasaoka, T. & Tsuneki, H.
2024/04/01 → 2024/09/30
Course
卒業研究（病態制御薬理学・臨床薬品作用学）薬4年用
Wada, T., Sasaoka, T. & Tsuneki, H.
2024/04/01 → 2025/03/31
Course