Research output per year
Research output per year
- 1 - 50 out of 287 results
Search results
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2025
A New 19(10→9)Abeo-Euphane Triterpenoid with other Terpenoid Components from Trichilia dregeana Leaves and their NO Production Inhibitory Activities in LPS-Stimulated RAW264.7 Macrophages
Mba Nguekeu, Y. M., Kodama, T., Paing Htoo, Z., Matheuda, E. G., Tsepeupon Matchide, M. G., Augustin Ngouela, S., Tene, M., Ducret Awouafack, M. & Morita, H., 2025/01, In: Chemistry and Biodiversity. 22, 1, e202401919.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
A new antibacterial neo-clerodane diterpenoid and other constituents from Chasmanthera dependens Hochst. (Menispermaceae) and their chemotaxonomic significance
Ngalaha Ediah, S. H., Matheuda, E. G., Kefossang, B. A., Nguekeu, Y. M. M., Kodama, T., Hnin, S. Y. Y., Qian, Z., Awouafack, M. D., Tsopmo, A., Morita, H. & Tene, M., 2025/02, In: Biochemical Systematics and Ecology. 118, 104922.Research output: Contribution to journal › Article › peer-review
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Derivatives of the Clinically Used HIF Prolyl Hydroxylase Inhibitor Desidustat Are Efficient Inhibitors of Human γ-Butyrobetaine Hydroxylase
Corner, T. P., Tumber, A., Salah, E., Jabbary, M., Nakashima, Y., Schnaubelt, L. I., Basak, S., Alshref, F. M., Brewitz, L. & Schofield, C. J., 2025/05/08, In: Journal of Medicinal Chemistry. 68, 9, p. 9777-9798 22 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Enhanced Production of Rebaudioside D and Rebaudioside M through V155T Substitution in the Glycosyltransferase UGT91D2 from Stevia rebaudiana
Shoji, T., Tanaka, Y., Nakashima, Y., Mizohata, E., Komaki, M., Sugawara, S., Takaya, J., Yonekura-Sakakibara, K., Morita, H., Saito, K. & Hirai, T., 2025/01/22, In: Journal of Agricultural and Food Chemistry. 73, 3, p. 2019-2032 14 p.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Nelumbo nucifera Petals Ameliorate Depressive-like Symptom and Cognitive Deficit in Unpredictable Chronic Mild Stress Mouse Model
Maneenet, J., Chotritthirong, Y., Omar, A. M., Choonong, R., Daodee, S., Monthakantirat, O., Khamphukdee, C., Pitiporn, S., Awale, S., Matsumoto, K. & Chulikhit, Y., 2025/01, In: Nutrients. 17, 1, 94.Research output: Contribution to journal › Article › peer-review
Open Access -
Nontargeted Metabolomics of Streptomyces Sourced from Thailand Reveals the Presence of Bioactive Metabolites
Sunghanghwa, Y., Paemanee, A., Do, K. M., Meethangdee, M., Plechatá, M., Pathom-Aree, W., Punsawad, C., Morita, H., Tangphatsornruang, S., Kamenik, Z. & Jaisi, A., 2025/03/25, In: ACS Omega. 10, 11, p. 11567-11579 13 p.Research output: Contribution to journal › Article › peer-review
Open Access -
The genus Pittosporum: current knowledge on traditional use, phytochemistry, and pharmacological activity
Linh, N. T. T., Van Tuyen, N., Pham, T. V., Awale, S. & Son, N. T., 2025/04, In: Phytochemistry Reviews. 24, 2, p. 2015-2058 44 p., 105292.Research output: Contribution to journal › Article › peer-review
3 Citations (SciVal) -
Toyaburgine, a Synthetic N-Biphenyl-Dihydroisoquinoline Inspired by Related N,C-Coupled Naphthylisoquinoline Alkaloids, with High In Vivo Efficacy in Preclinical Pancreatic Cancer Models
Awale, S., Maneenet, J., Phan, N. D., Nguyen, H. H., Fujii, T., Ihmels, H., Soost, D., Tajuddeen, N., Feineis, D. & Bringmann, G., 2025/04/18, In: ACS Chemical Biology. 20, 4, p. 917-929 13 p.Research output: Contribution to journal › Article › peer-review
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2024
A new 3,4-seco-isopimarane and three new isopimarane diterpenoids from Kaempferia champasakensis collected from Vietnam and their cytotoxic activities
Do, K. M., Hoshino, S., Kodama, T., Nguyen, H. M., Van Le, S., Ikumi, N., Onaka, H. & Morita, H., 2024, (Accepted/In press) In: Natural Medicines.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Antibacterial activity, cytotoxicity and chemotaxonomic significance of chemical constituents from Alsophila manniana Hook R.M.Tryon (Cyatheaceae) rhizomes
Tsepeupon Matchide, M. G., Sonfack Fozeng, H. D., Tchuente Tchuenmogne, M. A., Djadock Anensong, C. S., Wembe Koagne, W., Anthonissen, S., Mba Nguekeu, Y. M., Do, K. M., Lee, Y. E., Dehaen, W., Morita, H., Tene, M., Ngouela, S. A. & Awouafack, M. D., 2024/06, In: Biochemical Systematics and Ecology. 114, 104834.Research output: Contribution to journal › Article › peer-review
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Antibacterial activity of five Indonesian medicinal plants and the isolation of compounds from Plectranthus scutellarioides
Rakainsa, S. K., Nisa, K., Ito, T. & Morita, H., 2024/05, In: Journal of Applied Pharmaceutical Science. 14, 5, p. 185-192 8 p.Research output: Contribution to journal › Article › peer-review
Open Access -
A Small-Molecule Inhibitor of Factor Inhibiting HIF Binding to a Tyrosine-Flip Pocket for the Treatment of Obesity
Wu, Y., Chen, Y., Corner, T. P., Nakashima, Y., Salah, E., Li, Z., Zhang, L., Yang, L., Tumber, A., Sun, Z., Wen, Y., Zhong, A., Yang, F., Li, X., Zhang, Z., Schofield, C. J. & Zhang, X., 2024/10/01, In: Angewandte Chemie - International Edition. 63, 40, e202410438.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
Chitosan-graft-poly(lactide) nanocarriers: An efficient antioxidant delivery system for combating oxidative stress
Goshtasbi, H., Awale, S., Amini-Fazl, M. S., Fathi, M., Movafeghi, A., Barar, J. & Omidi, Y., 2024/11, In: International Journal of Biological Macromolecules. 279, 135280.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Crystallographic and Selectivity Studies on the Approved HIF Prolyl Hydroxylase Inhibitors Desidustat and Enarodustat
Corner, T. P., Salah, E., Tumber, A., Kaur, S., Nakashima, Y., Allen, M. D., Schnaubelt, L. I., Fiorini, G., Brewitz, L. & Schofield, C. J., 2024/12/16, In: ChemMedChem. 19, 24, e202400504.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Cytotoxic potential of dihydrochalcones from Eriosema glomeratum and their semi-synthetic derivatives
Tabakam, G. T., Kodama, T., Tchuenmogne, M. A. T., Hoang, N. N., Nomin-Erdene, B., Ngouela, S. A., Tene, M., Morita, H. & Awouafack, M. D., 2024, In: Natural Product Research. 38, 2, p. 186-197 12 p.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
Droserone and dioncoquinone B, and related naphthoquinones as potent antiausterity agents against human PANC-1 pancreatic cancer cells
Maneenet, J., Tajuddeen, N., Hong Nguyen, H., Fujii, R., Kimbadi Lombe, B., Feineis, D., Awale, S. & Bringmann, G., 2024/01, In: Results in Chemistry. 7, 101352.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Effect of Diacetylcurcumin Manganese Complex on Rotenone-Induced Oxidative Stress, Mitochondria Dysfunction, and Inflammation in the SH-SY5Y Parkinson’s Disease Cell Model
Pirunkaset, E., Boonyarat, C., Maneenet, J., Khamphukdee, C., Daodee, S., Monthakantirat, O., Awale, S., Kijjoa, A. & Chulikhit, Y., 2024/03, In: Molecules. 29, 5, 957.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
Facile Synthesis of 1,2-Disubstituted Benzimidazoles as Potent Cytotoxic Agents
Bui, H. T. B., Htoo, Z. P., Hong, Q. V., Le, H. T., Tran, D. Q., Hnin, S. Y. Y., Do, K. M. & Morita, H., 2024/11, In: Chemical and Pharmaceutical Bulletin. 72, 11, p. 944-949 6 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Five pimarane diterpenoids from Kaempferia champasakensis and their cytotoxic activities
Do, K. M., Hoshino, S., Kodama, T., Nguyen, H. M., Ikumi, N., Onaka, H. & Morita, H., 2024/09, In: Natural Medicines. 78, 4, p. 908-918 11 p.Research output: Contribution to journal › Article › peer-review
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Goreisan-induced modulation of fecal bile acid composition and gut microbiota in mice
Watanabe, S., Takahashi, K., Awale, S., Furusawa, Y., Tabuchi, Y., Nishidono, Y. & Tanaka, K., 2024/04, In: Traditional & Kampo Medicine. 11, 1, p. 46-53 8 p.Research output: Contribution to journal › Article › peer-review
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Justicidin B and related lignans from two South African Monsonia species with potent activity against HeLa cervical cancer cells
Tajuddeen, N., Muyisa, S., Maneenet, J., Nguyen, H. H., Naidoo-Maharaj, D., Maharaj, V., Awale, S. & Bringmann, G., 2024/04, In: Phytochemistry Letters. 60, p. 234-238 5 p.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
New 19(10 → 9)abeo-euphane-type triterpenoids from Trichilia dregeana leaves and NO production inhibitory activities
Mba Nguekeu, Y. M., Kodama, T., Tsepeupon Matchide, M. G., Do, K. M., Nghokeng, J., Tabakam, G. T., Tsuge, K., Ngouela, S. A., Mathieu, T., Awouafack, M. D. & Morita, H., 2024/07, In: Fitoterapia. 176, 106001.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Peptide Epimerase Responsible for d-Amino Acid Introduction in Poly-γ-glutamic Acid Biosynthesis
Kato, H., Sakuta, M., Tsunoda, T., Nakashima, Y., Morita, H., Ogasawara, Y. & Dairi, T., 2024/01/08, In: Biomacromolecules. 25, 1, p. 349-354 6 p.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Solvent-free strategy for facile synthesis and cytotoxicity evaluation of benzimidazole derivatives
Bui, H. T. B., Do, K. M., Hong, Q. V., Le, H. T., Hnin, S. Y. Y., Tran, D. Q., Mai, H. V., Nguyen, T. T. T., Mai, T. T. K. & Morita, H., 2024/04/28, In: Tetrahedron. 156, 133940.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Structure-Based Catalytic Mechanism of Amaryllidaceae O-Methyltransferases
Hnin, S. Y. Y., Nakashima, Y., Kodama, T. & Morita, H., 2024/08/02, In: ACS Catalysis. 14, 15, p. 11865-11880 16 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Substrate-Dependent Alteration in the C- and O-Prenylation Specificities of Cannabis Prenyltransferase
Tanaya, R., Kodama, T., Maneenet, J., Yasuno, Y., Nakayama, A., Shinada, T., Takahashi, H., Ito, T., Morita, H., Awale, S. & Taura, F., 2024/02, In: Biological and Pharmaceutical Bulletin. 47, 2, p. 449-453 5 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Substrate Flexibilities of Norbelladine Synthase and Noroxomaritidine/ Norcraugsodine Reductase for Hydroxylated and/or Methoxylated Aldehydes
Hnin, S. Y. Y., Nakashima, Y. & Morita, H., 2024, In: Chemical and Pharmaceutical Bulletin. 72, 5, p. 507-511 5 p.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
Syntheses and Cytotoxicities of Quinazolinone-Based Conjugates
Le, H. T., Do, K. M., Nguyen, Q. P., Doan, C. N. M., Nguyen, N. A., Phan, T. T., Tran, X. T. C., Ha, Q. T. K., Tran, D. Q., Morita, H. & Bui, H. T. B., 2024/01/20, In: Chemical and Pharmaceutical Bulletin. 72, 1, p. 61-67 7 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Targeting Pancreatic Cancer with Novel Nicolaioidesin C Derivatives: Molecular Mechanism, In Vitro, and In Vivo Evaluations
Yamazaki, T., Phan, N. D., Maneenet, J., Yamagishi, M., Nishikawa, Y., Okada, T., Okumura, T., Toyooka, N., Fujii, T. & Awale, S., 2024/08/22, In: Journal of Medicinal Chemistry. 67, 16, p. 14313-14328 16 p.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
Three neo-Clerodane Diterpenoids from Tinospora cordifolia Stems and Their Arginase Inhibitory Activities
Hoang, N. N., Hoshino, S., Kodama, T., Nakashima, Y., Do, K. M., Thao, H. X., Ikumi, N., Onaka, H. & Morita, H., 2024/06, In: Chemical and Pharmaceutical Bulletin. 72, 6, p. 540-546 7 p.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Two new neo-clerodane diterpenoids from Tinospora cordifolia stems
Hoang, N. N., Hoshino, S., Kodama, T., Hoang, T. X., Onaka, H. & Morita, H., 2024/10, In: Phytochemistry Letters. 63, p. 54-59 6 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
2023
5-Substituted Pyridine-2,4-dicarboxylate Derivatives Have Potential for Selective Inhibition of Human Jumonji-C Domain-Containing Protein 5
Brewitz, L., Nakashima, Y., Piasecka, S. K., Salah, E., Fletcher, S. C., Tumber, A., Corner, T. P., Kennedy, T. J., Fiorini, G., Thalhammer, A., Christensen, K. E., Coleman, M. L. & Schofield, C. J., 2023/08/10, In: Journal of Medicinal Chemistry. 66, 15, p. 10849-10865 17 p.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
Antidepressant-like Effect of Oroxylum indicum Seed Extract in Mice Model of Unpredictable Chronic Mild Stress
Chalermwongkul, C., Khamphukdee, C., Maneenet, J., Daodee, S., Monthakantirat, O., Boonyarat, C., Chotritthirong, Y., Awale, S., Kijjoa, A. & Chulikhit, Y., 2023/11, In: Nutrients. 15, 22, 4742.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Arginase inhibitory activities of guaiane sesquiterpenoids from Curcuma comosa rhizomes
Hoang, N. N., Kodama, T., Nakashima, Y., Do, K. M., Hnin, S. Y. Y., Lee, Y. E., Prema, Ikumi, N. & Morita, H., 2023/09, In: Natural Medicines. 77, 4, p. 891-897 7 p.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
Catalytic Potential of Cannabis Prenyltransferase to Expand Cannabinoid Scaffold Diversity
Tanaya, R., Kodama, T., Lee, Y. E., Yasuno, Y., Shinada, T., Takahashi, H., Ito, T., Morita, H., Awale, S. & Taura, F., 2023/12/08, In: Organic Letters. 25, 48, p. 8601-8605 5 p.Research output: Contribution to journal › Article › peer-review
5 Scopus citations -
Dioncophyllidine E: The first configurationally semi-stable, 7,3′-coupled naphthyldihydroisoquinoline alkaloid, from Ancistrocladus abbreviatus, with antiausterity activity against PANC-1 human pancreatic cancer cells
Fayez, S., Cacciatore, A., Maneenet, J., Nguyen, H. H., Tajuddeen, N., Feineis, D., Assi, L. A., Awale, S. & Bringmann, G., 2023/04/15, In: Bioorganic and Medicinal Chemistry Letters. 86, 129234.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Dryoptkirbioside, A New Fructofuranoside Glycerol, and Other Constituents from Dryopteris kirbi Hook et Grav Rhizomes
Matchide, M. G. T., Hnin, S. Y. Y., Nguekeu, Y. M. M., Matheuda, E. G., Nghokeng, J., Tabakam, G. T., Djoumbissie, R. A. D., Ngouela, S. A., Lee, Y. E., Tene, M., Morita, H. & Awouafack, M. D., 2023/09, In: Chemistry and Biodiversity. 20, 9, e202301127.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Multi-Target Actions of Flavonoid Derivatives from Mesua ferrea Linn Flower against Alzheimer’s disease Pathogenesis
Plekratoke, K., Waiwut, P., Yenjai, C., Monthakantirat, O., Takomthong, P., Nualkaew, N., Awale, S., Chulikhit, Y., Daodee, S., Khamphukdee, C. & Boonyarat, C., 2023/10/01, In: Biomedical Sciences and Clinical Medicine. 62, 4, p. 169-180 12 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Nicolaioidesin C: An Antiausterity Agent Shows Promising Antitumor Activity in a Pancreatic Cancer Xenograft Mouse Model
Phan, N. D., Omar, A. M., Takahashi, I., Baba, H., Okumura, T., Imura, J., Okada, T., Toyooka, N., Fujii, T. & Awale, S., 2023/06/23, In: Journal of Natural Products. 86, 6, p. 1402-1410 9 p.Research output: Contribution to journal › Article › peer-review
7 Scopus citations -
Phenolic Derivatives with Anti-Acetylcholinesterase Inhibitory Activities from Galeola nudifolia in Vietnam
Do, K. M., Nakashima, Y., Kodama, T., Lee, Y. E., Nguyen, H. M., Ikumi, N. & Morita, H., 2023/12, In: Chemistry and Biodiversity. 20, 12, e202301482.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Piper longum Constituents Induce PANC-1 Human Pancreatic Cancer Cell Death under Nutrition Starvation
Fujihashi, Y., Jo Kim, M., Maneenet, J. & Awale, S., 2023/09, In: Chemistry and Biodiversity. 20, 9, e202300280.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Seco- and isopimarane diterpenoids from Kaempferia marginata rhizomes and their NO inhibition activities
Do, K. M., Kodama, T., Nguyen, H. M., Ikumi, N., Soeda, C., Shiokawa, K. I. & Morita, H., 2023/01, In: Phytochemistry. 205, 113510.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Structural basis for binding of the renal carcinoma target hypoxia-inducible factor 2α to prolyl hydroxylase domain 2
Figg, W. D., Fiorini, G., Chowdhury, R., Nakashima, Y., Tumber, A., McDonough, M. A. & Schofield, C. J., 2023/11, In: Proteins: Structure, Function and Genetics. 91, 11, p. 1510-1524 15 p.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
Structure-guided optimisation of N-hydroxythiazole-derived inhibitors of factor inhibiting hypoxia-inducible factor-α
Corner, T. P., Teo, R. Z. R., Wu, Y., Salah, E., Nakashima, Y., Fiorini, G., Tumber, A., Brasnett, A., Holt-Martyn, J. P., Figg, W. D., Zhang, X., Brewitz, L. & Schofield, C. J., 2023/10/27, In: Chemical Science. 14, 43, p. 12098-12120 23 p.Research output: Contribution to journal › Article › peer-review
Open Access10 Scopus citations -
Structure of lasso peptide epimerase MslH reveals metal-dependent acid/base catalytic mechanism
Nakashima, Y., Kawakami, A., Ogasawara, Y., Maeki, M., Tokeshi, M., Dairi, T. & Morita, H., 2023/12, In: Nature Communications. 14, 1, 4752.Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations -
The Effect of Ethanol Extract from Mesua ferrea Linn Flower on Alzheimer’s Disease and Its Underlying Mechanism
Plekratoke, K., Boonyarat, C., Monthakantirat, O., Nualkaew, N., Wangboonskul, J., Awale, S., Chulikhit, Y., Daodee, S., Khamphukdee, C., Chaiwiwatrakul, S. & Waiwut, P., 2023/05, In: Current Issues in Molecular Biology. 45, 5, p. 4063-4079 17 p.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
Ugi Adducts as Novel Anti-austerity Agents against PANC-1 Human Pancreatic Cancer Cell Line: A Rapid Synthetic Approach
Tomohara, K., Maneenet, J., Ohashi, N., Nose, T., Fujii, R., Kim, M. J., Sun, S. & Awale, S., 2023, In: Biological and Pharmaceutical Bulletin. 46, 10, p. 1412-1420 9 p.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Uncovering the metabolomic effects of Kampo formulas using 1H-NMR spectroscopy: A case study of goreisan
Awale, S., Jo, M., Watanabe, S., Shibahara, N. & Matsumoto, K., 2023/08, In: Traditional & Kampo Medicine. 10, 2, p. 142-149 8 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Uncovering the metabolomic effects of Kampo formulas using 1H-NMR spectroscopy
Awale, S., Jo, M., Watanabe, S., Shibahara, N. & Matsumoto, K., 2023, In: Uncovering the metabolomic effects of Kampo formulas using 1H-NMR spectroscopy: A case study of goreisan..Research output: Contribution to journal › Article › peer-review
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2022
Abietane diterpenes from Abies spectabilis and their anti-pancreatic cancer activity against the MIA PaCa-2 cell line
Phan, N. D., Omar, A. M., Sun, S., Maneenet, J., Dibwe, D. F., Sato, M., Kalauni, S. K., Toyooka, N., Fujii, T. & Awale, S., 2022/06/15, In: Bioorganic and Medicinal Chemistry Letters. 66, 128723.Research output: Contribution to journal › Article › peer-review
Open Access9 Scopus citations