Projects per year
Personal profile
Campus career
和漢医薬学総合研究所 助教 2021/01/01-
薬学・和漢系 助教 2021/01/01-
薬学・和漢系 助教 2021/01/01-
Research Fields, Keywords
- Natural product
- X-ray crystallography
Field of expertise (Grants-in-aid for Scientific Research classification)
- Natural medicines
Fingerprint
Dive into the research topics where Yu Nakashima is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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FIHを標的とした代謝異常関連脂肪肝MAFLDの治療に有効なシード化合物の探索
Nakashima, Y. (Principal Investigator)
Japan Society for the Promotion of Science
2024/04/01 → 2026/03/31
Project: Research Project
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Searching for effective anti-cancer seed compounds for refractory cancers targeting AspH
Nakashima, Y. (Principal Investigator)
Japan Society for the Promotion of Science
2022/04/01 → 2024/03/31
Project: Research Project
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AchE阻害活性アルカロイドの骨格生合成酵素の機能解析と改変
Morita, H. (Principal Investigator), 猛児玉 (Co-Investigator(Kenkyū-buntansha)) & Nakashima, Y. (Co-Investigator(Kenkyū-buntansha))
Japan Society for the Promotion of Science
2022/04/01 → 2025/03/31
Project: Research Project
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Enhanced Production of Rebaudioside D and Rebaudioside M through V155T Substitution in the Glycosyltransferase UGT91D2 from Stevia rebaudiana
Shoji, T., Tanaka, Y., Nakashima, Y., Mizohata, E., Komaki, M., Sugawara, S., Takaya, J., Yonekura-Sakakibara, K., Morita, H., Saito, K. & Hirai, T., 2025/01/22, In: Journal of Agricultural and Food Chemistry. 73, 3, p. 2019-2032 14 p.Research output: Contribution to journal › Article › peer-review
Open Access -
A Small-Molecule Inhibitor of Factor Inhibiting HIF Binding to a Tyrosine-Flip Pocket for the Treatment of Obesity
Wu, Y., Chen, Y., Corner, T. P., Nakashima, Y., Salah, E., Li, Z., Zhang, L., Yang, L., Tumber, A., Sun, Z., Wen, Y., Zhong, A., Yang, F., Li, X., Zhang, Z., Schofield, C. J. & Zhang, X., 2024/10/01, In: Angewandte Chemie - International Edition. 63, 40, e202410438.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Peptide Epimerase Responsible for d-Amino Acid Introduction in Poly-γ-glutamic Acid Biosynthesis
Kato, H., Sakuta, M., Tsunoda, T., Nakashima, Y., Morita, H., Ogasawara, Y. & Dairi, T., 2024/01/08, In: Biomacromolecules. 25, 1, p. 349-354 6 p.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Structure-Based Catalytic Mechanism of Amaryllidaceae O-Methyltransferases
Hnin, S. Y. Y., Nakashima, Y., Kodama, T. & Morita, H., 2024/08/02, In: ACS Catalysis. 14, 15, p. 11865-11880 16 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Substrate Flexibilities of Norbelladine Synthase and Noroxomaritidine/ Norcraugsodine Reductase for Hydroxylated and/or Methoxylated Aldehydes
Hnin, S. Y. Y., Nakashima, Y. & Morita, H., 2024, In: Chemical and Pharmaceutical Bulletin. 72, 5, p. 507-511 5 p.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations
Datasets
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FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH ZN(II) AND 3-methyl-2-oxoglutarate
Nakashima, Y. (Contributor), Brewitz, L. (Contributor), Tumber, A. (Contributor), Salah, E. (Contributor) & Schofield, C. J. (Contributor), Protein Data Bank (PDB), 2021/08/25
DOI: 10.2210/pdb7A1L/pdb, https://www.wwpdb.org/pdb?id=pdb_00007a1l
Dataset
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FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH ZN(II) AND 3-(3-phenylpropyl)-2-oxoglutarate
Nakashima, Y. (Contributor), Brewitz, L. (Contributor), Tumber, A. (Contributor), Salah, E. (Contributor) & Schofield, C. J. (Contributor), Protein Data Bank (PDB), 2021/08/25
DOI: 10.2210/pdb7A1J/pdb, https://www.wwpdb.org/pdb?id=pdb_00007a1j
Dataset
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Polyketide cyclase OAC-F24I mutant from Cannabis sativa in complex with olivetolic acid
Lee, Y.-E. (Contributor), Nakashima, Y. (Contributor), Kodama, T. (Contributor), Chen, X. (Contributor) & Morita, H. (Contributor), Protein Data Bank (PDB), 2022/02/02
DOI: 10.2210/pdb7W6D/pdb, https://www.wwpdb.org/pdb?id=pdb_00007w6d
Dataset
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FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH ZN(II), 3-methyl-2-oxoglutarate, AND CONSENSUS ANKYRIN REPEAT DOMAIN (20-MER)
Nakashima, Y. (Contributor), Brewitz, L. (Contributor), Tumber, A. (Contributor), Salah, E. (Contributor) & Schofield, C. J. (Contributor), Protein Data Bank (PDB), 2021/08/25
DOI: 10.2210/pdb7A1N/pdb, https://www.wwpdb.org/pdb?id=pdb_00007a1n
Dataset
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TKS-L190G mutant from Cannabis sativa in complex with lauroyl-CoA
Lee, Y.-E. (Contributor), Nakashima, Y. (Contributor), Kodama, T. (Contributor), Chen, X. (Contributor) & Morita, H. (Contributor), Protein Data Bank (PDB), 2022/02/02
DOI: 10.2210/pdb7W6G/pdb, https://www.wwpdb.org/pdb?id=pdb_00007w6g
Dataset
Prizes
Activities
- 4 Oral presentation
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Structural-Based Design of Selective Enhancement or Inhibition of Human 2-Oxoglutarate Dependent Oxygenases
Nakashima, Y. (Speaker)
2022/06/12Activity: Talk or presentation › Oral presentation
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抗生物質 glycylthricin 生合成酵素に見られる基質特異性の解明
Nakashima, Y. (Speaker)
2022/03/25 → 2022/03/28Activity: Talk or presentation › Oral presentation
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2-オキソグルタル酸依存性酸化酵素の選択的阻害剤の開発
Nakashima, Y. (Speaker)
2022/01/27Activity: Talk or presentation › Oral presentation
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X 線結晶構造解析に基づく抗生物質 glycylthricin 生合成酵素に見られる基質特異性の解明
Nakashima, Y. (Speaker)
2021/11/14Activity: Talk or presentation › Oral presentation
Courses
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和漢医薬学入門
Kadowaki, M., Kainuma, M., Kato, A., Yamada, R., Yamamura, Y., Lee, J., Watanabe, S., Shibahara, N., Toda, M., Tohda, C., Koizumi, K., Morita, H., Hayakawa, Y., Toume, K., Yamamoto, T., Nakagawa, Y., Kim, J., Yang, X., Susukida, T., Kodama, T., Oku, M., Jo, M., Inada, Y., Sasaki, S., Nakashima, Y. & Hayashi, S. 2024/04/01 → 2024/09/30
Course
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和漢医薬学入門
Fujimoto, M., Kainuma, M., Kato, A., Yamada, R., Yamamura, Y., Lee, J., Watanabe, S., Shibahara, N., Toda, M., Tohda, C., Koizumi, K., Morita, H., Hayakawa, Y., Nakagawa, Y., Kim, J., Yang, X., Susukida, T., Kodama, T., Oku, M., Jo, M., Inada, Y., Sasaki, S., Nakashima, Y., Shoji, T. & Akagi, K. 2024/04/01 → 2024/09/30
Course
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東西医薬学Ⅰ
Kato, A., Watanabe, S., Tohda, C., Koizumi, K., Morita, H., Hayakawa, Y., Awale, S., Nakagawa, Y., Kim, J., Oku, M., Jo, M., Sasaki, S., Nakashima, Y. & Shoji, T. 2024/04/01 → 2024/09/30
Course
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和漢医薬学入門
Fujimoto, M., Kainuma, M., Kato, A., Yamada, R., Yamamura, Y., Lee, J., Watanabe, S., Shibahara, N., Toda, M., Tohda, C., Koizumi, K., Morita, H., Hayakawa, Y., Nakagawa, Y., Kim, J., Yang, X., Susukida, T., Kodama, T., Oku, M., Jo, M., Inada, Y., Sasaki, S., Nakashima, Y., Shoji, T., Akagi, K., Shimada, Y., Fujimoto, M., Kainuma, M., Taura, F., Kato, A., Yamada, R., Komatsu, K., Watanabe, S., Shibahara, N., Toda, M., Tohda, C., Koizumi, K., Morita, H., Hayakawa, Y., Toume, K., Nakagawa, Y., Kim, J., Yang, X., Susukida, T., Zhu, S., Kodama, T., Oku, M., Jo, M., Inada, Y., Sasaki, S. & Nakashima, Y. 2024/04/01 → 2024/09/30
Course
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和漢医薬学入門
Fujimoto, M., Kainuma, M., Kato, A., Yamada, R., Yamamura, Y., Lee, J., Watanabe, S., Shibahara, N., Toda, M., Tohda, C., Koizumi, K., Morita, H., Hayakawa, Y., Toume, K., Nakagawa, Y., Kim, J., Yang, X., Susukida, T., Kodama, T., Oku, M., Jo, M., Inada, Y., Sasaki, S., Nakashima, Y., Hayashi, S. & Akagi, K. 2023/04/01 → 2023/09/30
Course