A new flavanone derivative from the rhizomes of Boesenbergia pandurata

Mai Thanh Thi Nguyen, Hai Xuan Nguyen, Tho Huu Le, Truong Nhat Van Do, Phu Hoang Dang, Tung Van Pham, Truc Thanh Minh Giang, Sijia Sun, Min Jo Kim, Ahmed M. Tawila, Ashraf M. Omar, Suresh Awale, Nhan Trung Nguyen*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

From the methanolic extract of the rhizomes of Boesenbergia pandurata, a new flavanone derivative named (2R,7″S)-8-(1-phenyl-2-carboxyethyl)pinocembrin (1) and four known flavonoids (2–5) were isolated. Its absolute configuration was concluded by NMR and MS spectroscopic analysis, together with comparison between experimental and calculated ECD data. In turn, compound 1 exhibited strong cytotoxicity against the PANC-1 human pancreatic cancer cell line with a PC50 value of 6.4 µM under nutrient-deprived conditions, comparable with that of arctigenin (PC50, 0.83 µM).

Original languageEnglish
Pages (from-to)1959-1965
Number of pages7
JournalNatural Product Research
Volume36
Issue number8
DOIs
StatePublished - 2022

Keywords

  • Boesenbergia pandurata
  • PANC-1
  • cytotoxicity
  • flavanone

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Plant Science
  • Organic Chemistry

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