Abstract
From the methanolic extract of the rhizomes of Boesenbergia pandurata, a new flavanone derivative named (2R,7″S)-8-(1-phenyl-2-carboxyethyl)pinocembrin (1) and four known flavonoids (2–5) were isolated. Its absolute configuration was concluded by NMR and MS spectroscopic analysis, together with comparison between experimental and calculated ECD data. In turn, compound 1 exhibited strong cytotoxicity against the PANC-1 human pancreatic cancer cell line with a PC50 value of 6.4 µM under nutrient-deprived conditions, comparable with that of arctigenin (PC50, 0.83 µM).
Original language | English |
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Pages (from-to) | 1959-1965 |
Number of pages | 7 |
Journal | Natural Product Research |
Volume | 36 |
Issue number | 8 |
DOIs | |
State | Published - 2022 |
Keywords
- Boesenbergia pandurata
- PANC-1
- cytotoxicity
- flavanone
ASJC Scopus subject areas
- Analytical Chemistry
- Biochemistry
- Plant Science
- Organic Chemistry