A new flavanone derivative from the rhizomes of Boesenbergia pandurata

Mai Thanh Thi Nguyen; Hai Xuan Nguyen; Tho Huu Le; Truong Nhat Van Do; Phu Hoang Dang; Tung Van Pham; Truc Thanh Minh Giang; Sijia Sun; Min Jo Kim; Ahmed M. Tawila; Ashraf M. Omar; Suresh Awale; Nhan Trung Nguyen

doi:10.1080/14786419.2020.1837822

A new flavanone derivative from the rhizomes of Boesenbergia pandurata

Mai Thanh Thi Nguyen, Hai Xuan Nguyen, Tho Huu Le, Truong Nhat Van Do, Phu Hoang Dang, Tung Van Pham, Truc Thanh Minh Giang, Sijia Sun, Min Jo Kim, Ahmed M. Tawila, Ashraf M. Omar, Suresh Awale, Nhan Trung Nguyen^*

^*Corresponding author for this work

Section of Natural Products & Drug Discovery, Division of Medicinal Resources, Institute of Natural Medicine

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

From the methanolic extract of the rhizomes of Boesenbergia pandurata, a new flavanone derivative named (2R,7″S)-8-(1-phenyl-2-carboxyethyl)pinocembrin (1) and four known flavonoids (2–5) were isolated. Its absolute configuration was concluded by NMR and MS spectroscopic analysis, together with comparison between experimental and calculated ECD data. In turn, compound 1 exhibited strong cytotoxicity against the PANC-1 human pancreatic cancer cell line with a PC₅₀ value of 6.4 µM under nutrient-deprived conditions, comparable with that of arctigenin (PC₅₀, 0.83 µM).

Original language	English
Pages (from-to)	1959-1965
Number of pages	7
Journal	Natural Product Research
Volume	36
Issue number	8
DOIs	https://doi.org/10.1080/14786419.2020.1837822
State	Published - 2022

Keywords

Boesenbergia pandurata
PANC-1
cytotoxicity
flavanone

ASJC Scopus subject areas

Analytical Chemistry
Biochemistry
Plant Science
Organic Chemistry

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10.1080/14786419.2020.1837822

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title = "A new flavanone derivative from the rhizomes of Boesenbergia pandurata",

abstract = "From the methanolic extract of the rhizomes of Boesenbergia pandurata, a new flavanone derivative named (2R,7″S)-8-(1-phenyl-2-carboxyethyl)pinocembrin (1) and four known flavonoids (2–5) were isolated. Its absolute configuration was concluded by NMR and MS spectroscopic analysis, together with comparison between experimental and calculated ECD data. In turn, compound 1 exhibited strong cytotoxicity against the PANC-1 human pancreatic cancer cell line with a PC50 value of 6.4 µM under nutrient-deprived conditions, comparable with that of arctigenin (PC50, 0.83 µM).",

keywords = "Boesenbergia pandurata, PANC-1, cytotoxicity, flavanone",

author = "Nguyen, {Mai Thanh Thi} and Nguyen, {Hai Xuan} and Le, {Tho Huu} and Do, {Truong Nhat Van} and Dang, {Phu Hoang} and Pham, {Tung Van} and Giang, {Truc Thanh Minh} and Sijia Sun and Kim, {Min Jo} and Tawila, {Ahmed M.} and Omar, {Ashraf M.} and Suresh Awale and Nguyen, {Nhan Trung}",

note = "Publisher Copyright: {\textcopyright} 2020 Informa UK Limited, trading as Taylor & Francis Group.",

year = "2022",

doi = "10.1080/14786419.2020.1837822",

language = "英語",

volume = "36",

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AU - Nguyen, Mai Thanh Thi

AU - Nguyen, Hai Xuan

AU - Le, Tho Huu

AU - Do, Truong Nhat Van

AU - Dang, Phu Hoang

AU - Pham, Tung Van

AU - Giang, Truc Thanh Minh

AU - Sun, Sijia

AU - Kim, Min Jo

AU - Tawila, Ahmed M.

AU - Omar, Ashraf M.

AU - Awale, Suresh

AU - Nguyen, Nhan Trung

PY - 2022

Y1 - 2022

N2 - From the methanolic extract of the rhizomes of Boesenbergia pandurata, a new flavanone derivative named (2R,7″S)-8-(1-phenyl-2-carboxyethyl)pinocembrin (1) and four known flavonoids (2–5) were isolated. Its absolute configuration was concluded by NMR and MS spectroscopic analysis, together with comparison between experimental and calculated ECD data. In turn, compound 1 exhibited strong cytotoxicity against the PANC-1 human pancreatic cancer cell line with a PC50 value of 6.4 µM under nutrient-deprived conditions, comparable with that of arctigenin (PC50, 0.83 µM).

AB - From the methanolic extract of the rhizomes of Boesenbergia pandurata, a new flavanone derivative named (2R,7″S)-8-(1-phenyl-2-carboxyethyl)pinocembrin (1) and four known flavonoids (2–5) were isolated. Its absolute configuration was concluded by NMR and MS spectroscopic analysis, together with comparison between experimental and calculated ECD data. In turn, compound 1 exhibited strong cytotoxicity against the PANC-1 human pancreatic cancer cell line with a PC50 value of 6.4 µM under nutrient-deprived conditions, comparable with that of arctigenin (PC50, 0.83 µM).

KW - Boesenbergia pandurata

KW - PANC-1

KW - cytotoxicity

KW - flavanone

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DO - 10.1080/14786419.2020.1837822

M3 - 学術論文

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AN - SCOPUS:85095794276

SN - 1478-6419

VL - 36

SP - 1959

EP - 1965

JO - Natural Product Research

JF - Natural Product Research

IS - 8

ER -

A new flavanone derivative from the rhizomes of Boesenbergia pandurata

Abstract

Keywords

ASJC Scopus subject areas

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