Two new neo-clerodane diterpenoids from Tinospora cordifolia stems

Nhat Nam Hoang, Shotaro Hoshino, Takeshi Kodama, Thao Xuan Hoang, Hiroyasu Onaka*, Hiroyuki Morita

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Phytochemical studies of the 70 % ethanol extract of Tinospora cordifolia stems led to the isolation of two new neo-clerodane diterpenoids, including tinocordifoliols C (1) and D (2). Their structures were determined by experimental 1D and 2D NMR, HR-ESI-MS, ECD, and statistical analyses, including DP4+ probability based on DFT calculations of NMR chemical shifts. According to the previous report for two neo-clerodane diterpenoids, tinocordifoliols A and B, the inhibitory activities of 1 and 2 against human arginases I and II were also evaluated. In contrast to the previously reported two neo-clerodane diterpenoids, 1 and 2 did not show inhibitory activities against human arginases I and II. These results provide insight into the structure-activity relationship of neo-clerodane diterpenoids.

Original languageEnglish
Pages (from-to)54-59
Number of pages6
JournalPhytochemistry Letters
Volume63
DOIs
StatePublished - 2024/10

Keywords

  • Arginase inhibitory activity
  • Diterpenoids
  • Neo-clerodane diterpenoids
  • Tinospora cordifolia

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Agronomy and Crop Science
  • Plant Science

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