Arginase inhibitory activities of guaiane sesquiterpenoids from Curcuma comosa rhizomes

Nhat Nam Hoang, Takeshi Kodama, Yu Nakashima, Kiep Minh Do, Saw Yu Yu Hnin, Yuan E. Lee, Prema, Naotaka Ikumi, Hiroyuki Morita*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Arginases are bimanganese enzymes involved in many human illnesses, and thus are targets for disease treatments. The screening of traditional medicinal plants demonstrated that an ethanol extract of Curcuma comosa rhizomes showed significant human arginase I and II inhibitory activity, and further fractionation led to the isolation of three known guaiane sesquiterpenoids, alismoxide (1), 7α,10α-epoxyguaiane-4α,11-diol (2) and guaidiol (3). Tests of their inhibitory activities on human arginases I and II revealed that 1 exhibited selective and potent competitive inhibition for human arginase I (IC50 = 30.2 μM), whereas the other compounds lacked inhibitory activities against human arginases. To the best of our knowledge, this is the first demonstration of human arginase I inhibitory activity by a sesquiterpenoid. Thus, 1 is a primary and specific inhibitory molecule against human arginase I.

Original languageEnglish
Pages (from-to)891-897
Number of pages7
JournalNatural Medicines
Volume77
Issue number4
DOIs
StatePublished - 2023/09

Keywords

  • Arginase inhibitory activity
  • Curcuma comosa
  • Guaiane sesquiterpenoids
  • Sesquiterpenoids

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

Fingerprint

Dive into the research topics of 'Arginase inhibitory activities of guaiane sesquiterpenoids from Curcuma comosa rhizomes'. Together they form a unique fingerprint.

Cite this