A New Sterol From the Polypore Fungus Ganoderma luteomarginatum and Its Cytotoxic Activities

Zin Paing Htoo; Takeshi Kodama; Nwet Nwet Win; Naotaka Ikumi; Ken Ichi Shiokawa; Hiroyuki Morita

doi:10.1177/1934578X221098852

A New Sterol From the Polypore Fungus Ganoderma luteomarginatum and Its Cytotoxic Activities

Zin Paing Htoo, Takeshi Kodama, Nwet Nwet Win, Naotaka Ikumi, Ken Ichi Shiokawa, Hiroyuki Morita^*

^*Corresponding author for this work

Section of Natural Products & Drug Discovery, Division of Medicinal Resources, Institute of Natural Medicine

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

A new sterol, ganolutol A (1), together with 4 known compounds 2 to 5, were isolated from the polypore fungus Ganoderma luteomarginatum collected in Myanmar. The chemical structures of the isolated compounds were determined based on extensive spectroscopic analyses in conjunction with comparisons with published data. Compounds 1 to 4 exhibited moderate cytotoxic activities against A549 (lung), MCF-7 (breast), and HeLa (cervical) human cancer cell lines, with IC₅₀ values ranging from 10.1 to 86.6 μM.

Original language	English
Journal	Natural Product Communications
Volume	17
Issue number	5
DOIs	https://doi.org/10.1177/1934578X221098852
State	Published - 2022/05

Keywords

Ganoderma luteomarginatum
Ganodermataceae
cytotoxicity
ergostane
polypore fungus

ASJC Scopus subject areas

Drug Discovery
Complementary and alternative medicine
Plant Science
Pharmacology

Access to Document

10.1177/1934578X221098852

Cite this

@article{33082da10a214084896bafc34467a468,

title = "A New Sterol From the Polypore Fungus Ganoderma luteomarginatum and Its Cytotoxic Activities",

abstract = "A new sterol, ganolutol A (1), together with 4 known compounds 2 to 5, were isolated from the polypore fungus Ganoderma luteomarginatum collected in Myanmar. The chemical structures of the isolated compounds were determined based on extensive spectroscopic analyses in conjunction with comparisons with published data. Compounds 1 to 4 exhibited moderate cytotoxic activities against A549 (lung), MCF-7 (breast), and HeLa (cervical) human cancer cell lines, with IC50 values ranging from 10.1 to 86.6 μM.",

keywords = "Ganoderma luteomarginatum, Ganodermataceae, cytotoxicity, ergostane, polypore fungus",

author = "Htoo, {Zin Paing} and Takeshi Kodama and Win, {Nwet Nwet} and Naotaka Ikumi and Shiokawa, {Ken Ichi} and Hiroyuki Morita",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2022.",

year = "2022",

month = may,

doi = "10.1177/1934578X221098852",

language = "英語",

volume = "17",

journal = "Natural Product Communications",

issn = "1934-578X",

publisher = "SAGE Publications Inc.",

number = "5",

}

TY - JOUR

T1 - A New Sterol From the Polypore Fungus Ganoderma luteomarginatum and Its Cytotoxic Activities

AU - Htoo, Zin Paing

AU - Kodama, Takeshi

AU - Win, Nwet Nwet

AU - Ikumi, Naotaka

AU - Shiokawa, Ken Ichi

AU - Morita, Hiroyuki

N1 - Publisher Copyright: © The Author(s) 2022.

PY - 2022/5

Y1 - 2022/5

N2 - A new sterol, ganolutol A (1), together with 4 known compounds 2 to 5, were isolated from the polypore fungus Ganoderma luteomarginatum collected in Myanmar. The chemical structures of the isolated compounds were determined based on extensive spectroscopic analyses in conjunction with comparisons with published data. Compounds 1 to 4 exhibited moderate cytotoxic activities against A549 (lung), MCF-7 (breast), and HeLa (cervical) human cancer cell lines, with IC50 values ranging from 10.1 to 86.6 μM.

AB - A new sterol, ganolutol A (1), together with 4 known compounds 2 to 5, were isolated from the polypore fungus Ganoderma luteomarginatum collected in Myanmar. The chemical structures of the isolated compounds were determined based on extensive spectroscopic analyses in conjunction with comparisons with published data. Compounds 1 to 4 exhibited moderate cytotoxic activities against A549 (lung), MCF-7 (breast), and HeLa (cervical) human cancer cell lines, with IC50 values ranging from 10.1 to 86.6 μM.

KW - Ganoderma luteomarginatum

KW - Ganodermataceae

KW - cytotoxicity

KW - ergostane

KW - polypore fungus

UR - http://www.scopus.com/inward/record.url?scp=85131154711&partnerID=8YFLogxK

U2 - 10.1177/1934578X221098852

DO - 10.1177/1934578X221098852

M3 - 学術論文

AN - SCOPUS:85131154711

SN - 1934-578X

VL - 17

JO - Natural Product Communications

JF - Natural Product Communications

IS - 5

ER -

A New Sterol From the Polypore Fungus Ganoderma luteomarginatum and Its Cytotoxic Activities

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Fingerprint

Cite this