Abstract
Pancreatic cancer is a highly aggressive form of cancer with a poor prognosis, partly due to ‘austerity’, a phenomenon of tolerance to nutrient deprivation and survival in its hypovascular tumor microenvironment. Anti-austerity agents which preferentially diminish the survival of cancer cells under nutrition starvation is regarded as new generation anti-cancer agents. This study investigated the potential of Piper longum constituents as anti-austerity agents. The ethanolic extract of Piper longum was found to have preferential cytotoxicity towards PANC-1 human pancreatic cancer cells in a nutrient-deprived medium (NDM). Further investigation led to the identification of pipernonaline (3) as the lead compound with the strongest anti-austerity activity, inducing cell death and inhibiting migration in a normal nutrient medium, as well as strongly inhibiting the Akt/mTOR/autophagy pathway. Therefore, pipernonaline (3) holds promise as a novel antiausterity agent for the treatment of pancreatic cancer.
| Original language | English |
|---|---|
| Article number | e202300280 |
| Journal | Chemistry and Biodiversity |
| Volume | 20 |
| Issue number | 9 |
| DOIs | |
| State | Published - 2023/09 |
Keywords
- PANC-1
- Piper longum
- antiausterity agent
- pancreatic cancer
- pipernonaline
ASJC Scopus subject areas
- Bioengineering
- Biochemistry
- General Chemistry
- Molecular Medicine
- Molecular Biology
