TY - JOUR
T1 - Seco- and isopimarane diterpenoids from Kaempferia marginata rhizomes and their NO inhibition activities
AU - Do, Kiep Minh
AU - Kodama, Takeshi
AU - Nguyen, Hien Minh
AU - Ikumi, Naoki
AU - Soeda, Chigusa
AU - Shiokawa, Ken ichi
AU - Morita, Hiroyuki
N1 - Publisher Copyright:
© 2022 Elsevier Ltd
PY - 2023/1
Y1 - 2023/1
N2 - Three undescribed 9,10-seco-isopimarane diterpenoids, marginols I–K, and an unprecedent isopimara-8(9),15-diene diterpene, 14-epi-boesenberol F, together with a known 9,10-seco-isopimarane diterpenoid, kaemgalangol A, were isolated from the rhizomes of Vietnamese Kaempferia marginata. Marginols I and J contained a naturally very rare 6-oxabicyclo[3.2.1]octane-5-ol ring, while marginol K had a naturally rare oxepan-2-one ring in its structure. The unprecedented structures were elucidated by spectroscopic techniques, including HR-ESI-TOF-MS, UV, IR, and 1D and 2D NMR. The absolute configurations of marginols I–K and 14-epi-boesenberol F were determined by ECD calculations. The NO production inhibitory assay revealed that the isolated compounds, except marginol J, exhibited NO inhibitory activities with IC50 values ranging from 65.06 to 87.70 μM against lipopolysaccharide (LPS)-induced RAW264.7 cells.
AB - Three undescribed 9,10-seco-isopimarane diterpenoids, marginols I–K, and an unprecedent isopimara-8(9),15-diene diterpene, 14-epi-boesenberol F, together with a known 9,10-seco-isopimarane diterpenoid, kaemgalangol A, were isolated from the rhizomes of Vietnamese Kaempferia marginata. Marginols I and J contained a naturally very rare 6-oxabicyclo[3.2.1]octane-5-ol ring, while marginol K had a naturally rare oxepan-2-one ring in its structure. The unprecedented structures were elucidated by spectroscopic techniques, including HR-ESI-TOF-MS, UV, IR, and 1D and 2D NMR. The absolute configurations of marginols I–K and 14-epi-boesenberol F were determined by ECD calculations. The NO production inhibitory assay revealed that the isolated compounds, except marginol J, exhibited NO inhibitory activities with IC50 values ranging from 65.06 to 87.70 μM against lipopolysaccharide (LPS)-induced RAW264.7 cells.
KW - Kaempferia marginata Carey ex roscoe
KW - Marginols
KW - NO production Inhibitory activity
KW - Seco-isopimarane diterpenoids
KW - Zingiberaceae
UR - http://www.scopus.com/inward/record.url?scp=85141806025&partnerID=8YFLogxK
U2 - 10.1016/j.phytochem.2022.113510
DO - 10.1016/j.phytochem.2022.113510
M3 - 学術論文
C2 - 36379318
AN - SCOPUS:85141806025
SN - 0031-9422
VL - 205
JO - Phytochemistry
JF - Phytochemistry
M1 - 113510
ER -