Faculty of Pharmaceutical Sciences

Projects

Projects per year 1996 2012 2013 2014 2015 2016 2018 2019 2020 2021 2022 2023 2024 2025 2029

• 80 Active
• 304 Finished

Projects per year

Search results

• Engineering of DABB-family enzymes to novel polyketide cyclase

  Morita, H. (CoI)

  2017/04/01 → 2020/03/31

  Project: Research

• Engineering of plant-specific polyketide scaffold synthetic enzymes to produce structural diversity of compounds

  Morita, H. (PI), Matsui, T. (CoI) & Kodama, T. (CoI)

  2014/04/01 → 2017/03/31

  Project: Research

• Engineering of type III polyketide synthase by deletion and addition of residues

  Morita, H. (PI)

  2014/04/01 → 2016/03/31

  Project: Research

• Enhanced PDGF signaling contributes adipose tissue angiogenesis, expansion, and systemic glucose intolerance in obesity.

  Wada, T. (PI), Sasaoka, T. (CoI), Sasahara, M. (CoI) & Ishii, Y. (CoI)

  2012/04/01 → 2015/03/31

  Project: Research

• Establishment of highly effective therapy for food allergy by concomitant use of kakkonto with oral immunotherapy

  Yamamoto, T. (PI), Ito, Y. (CoI) & Nagata, Y. (CoI)

  2016/04/01 → 2019/03/31

  Project: Research

• Establishment of molecular simulation with mathematical model to enable the selection of molecular target drugs for lung cancer.

  Takaoka, Y. (Principal Investigator), Sugano, A. (Co-Investigator(Kenkyū-buntansha)), 永野達也 (Co-Investigator(Kenkyū-buntansha)) & Ota, M. (Co-Investigator(Kenkyū-buntansha))

  Japan Society for the Promotion of Science

  2021/04/01 → 2024/03/31

  Project: Research Project

• Establishment of new identification method of the endoplasmic reticulum membrane scramblases based on the amino acid primary sequence

  Nakao, H. (PI)

  2017/08/25 → 2019/03/31

  Project: Research

• Evaluation of cationic drug transport system at the blood-retinal barrier to deliver the drugs to the retina

  Hosoya, K.-I. (PI), Akanuma, S.-I. (CoI), Kubo, Y. (CoI), Matsuya, Y. (CoI) & Takashima, T. (CoI)

  2013/04/01 → 2016/03/31

  Project: Research

• Evaluation of Cx43 proteins for PGE2 release from retinal pigment epithelial cells for understanding the pathological role in age-related macular degeneration.

  Hosoya, K.-I. (PI), Kubo, Y. (CoI), Sakai, H. (CoI) & Tachikawa, M. (CoPI)

  2016/04/01 → 2018/03/31

  Project: Research

• Evaluation of the importance of intracellular metabolism in individual differences in drug hypersensitivity using a mouse model of cutaneous adverse drug reaction

  Susukida, T. (PI)

  2021/04/01 → 2024/03/31

  Project: Research

• Experimental assessment of preventive effects of kampo medicines against metabolic syndromes through the modification of intestinal bile acid metabolism

  Watanabe, S. (PI)

  2018/04/01 → 2021/03/31

  Project: Research

• Exploration of tumor-promoting inflammatory immune responses and its application for cancer treatment

  Hayakawa, Y. (PI)

  2014/04/01 → 2017/03/31

  Project: Research

• Exploratory Research for crude drugs having activated platelet-mediated inhibiting effect on diabetic microangiopathy

  Shibahara, N. (PI)

  2012/04/01 → 2015/03/31

  Project: Research

• Explore molecular basis underlying formation of chemical diversity in genus Panax through RNA-Seq analysis of three Panax species with different chemical compositions

  Zhu, S. (Principal Investigator)

  Japan Society for the Promotion of Science

  2014/04/01 → 2017/03/31

  Project: Research Project

• Investigation on naphthylisoquinoline alkaloids as potential antiausterity chemotherapy for pancreatic cancer

  Awale, S. (Principal Investigator) & Fujii, T. (Co-Investigator(Kenkyū-buntansha))

  Japan Society for the Promotion of Science

  2023/04/01 → 2028/03/31

  Project: Research Project

• Functional analysis of mutation and partial duplication of α7 nicotinic receptor subunit gene : implication in schizophrenia

  Tsuneki, H. (PI), Kurachi, M. (CoI) & Tsunoda, M. (CoI)

  2004/04/01 → 2007/03/31

  Project: Research

  • Partial Duplication 100%
  • Nicotinic Receptors 100%
  • Schizophrenia 100%
  • Functional Analysis 100%
  • Receptor Subunit 100%

• Functional analysis of RPEL/Phactr variants: relationship between cell shape and nuclear information

  Tabuchi, A. (PI)

  2007/04/01 → 2009/03/31

  Project: Research

• Functional Analysis of transcription factor SOX10 in melanoma for norvel therapeutics

  Yokoyama, S. (PI)

  2016/04/01 → 2018/03/31

  Project: Research

• Functional and structural analyses of organic cation transporter in the intestine.

  Hashimoto, Y. (PI)

  2015/04/01 → 2018/03/31

  Project: Research

• Functional coupling between ion channels and scramblases in human TMEM16F-expressing cells

  Shimizu, T. (PI)

  2013/04/01 → 2016/03/31

  Project: Research

• Functional interactions between inflammatory signal and growth singaling in the Warburg effect in cancer cells

  Sakurai, H. (PI)

  2016/04/01 → 2018/03/31

  Project: Research

• I型アレルギー疾患の制御にむけたFDCによるIgA抗体の産生制御機構の基礎的研究

  Kuniishi, M. (Principal Investigator)

  Japan Society for the Promotion of Science

  2022/04/01 → 2025/03/31

  Project: Research Project

• Genomic analysis of Shati/Nat8l to protect use methamphetamine

  Nitta, A. (PI)

  2017/06/30 → 2019/03/31

  Project: Research

  • Shati 100%
  • Nucleus Accumbens 65%
  • N-Acetyltransferase 56%
  • Knock-in Mouse Model 55%
  • Conditioned Place Preference 53%

• How do Kampo formulations work?

  Saiki, I. (PI) & Yokoyama, S. (CoI)

  2012/04/01 → 2015/03/31

  Project: Research

• Identification of roles of PRMT8 with dual catalytic activity in the brain

  Kim, J. (PI)

  2018/04/01 → 2022/03/31

  Project: Research

• Identification of Scientific evidence for Traditional Kampo theory by gene expression analysis

  Saiki, I. (PI) & Yokoyama, S. (CoI)

  2015/04/01 → 2018/03/31

  Project: Research

• Impact of obesity-induced dysregulation of renin-angiotensin-aldosterone system in the hypothalamus on the homeostasis of energy metabolism.

  Wada, T. (PI)

  2010/04/01 → 2012/03/31

  Project: Research

  • Dysregulation 100%
  • Mineralocorticoid Receptor Antagonists 100%
  • Homeostasis 100%
  • Energy Metabolism 100%
  • Obesity 100%

• Impact of the cooperative effect of estrogen and orexin on abnormalities with emotion and metabolism in menopausal mice

  Sasaoka, T. (PI), Wada, T. (CoI) & Tsuneki, H. (CoI)

  2015/04/01 → 2017/03/31

  Project: Research

• Influx transport system for nutrients and drugs at the blood-testis barrier and its application

  Kubo, Y. (Principal Investigator), Hosoya, K.-I. (Co-Investigator(Kenkyū-buntansha)) & Akanuma, S.-I. (Co-Investigator(Kenkyū-buntansha))

  Japan Society for the Promotion of Science

  2020/04/01 → 2024/03/31

  Project: Research Project

• Inhibition activities of iminosugars against glycoprotein processing

  Adachi, I. (PI), Takahata, H. (CoI) & Kato, A. (CoI)

  2010/04/01 → 2012/03/31

  Project: Research

  • Inhibition Activity 100%
  • Azetidine 100%
  • Glycoprotein 100%
  • Iminosugars 100%
  • Enantiomer 100%

• Investigation of pathogenic mechanisms and Kampo medicine-based preventive and therapeutic strategy for ADHD using an epigenetic animal model.

  Matsumoto, K. (PI), Awale, S. (CoI), 藤原, 博典 (CoI) & Hori, E. (CoI)

  2015/04/01 → 2018/03/31

  Project: Research

• Investigation of the immunological function of the NASH-inducing transplanted NKT, and drug discovery

  Koizumi, K. (PI)

  2013/04/01 → 2015/03/31

  Project: Research

• In vivo patch-clamp analysis of itch transmission in central nerve system

  Uta, D. (PI)

  2013/04/01 → 2015/03/31

  Project: Research

• Involvement of hypothalamic orexin in the development of insulin resistance associated with depression

  Tsuneki, H. (PI) & Sasaoka, T. (CoI)

  2009/04/01 → 2012/03/31

  Project: Research

  • Orexin 100%
  • Insulin Resistance 100%
  • Non Insulin Dependent Diabetes Mellitus 66%
  • Mouse Model of Depression 50%
  • Depressive Symptoms 50%

• MK2を介した非定型的活性型EphA2によるがん悪性進展の制御機構

  Zhou, Y. (Principal Investigator)

  Japan Society for the Promotion of Science

  2022/04/01 → 2025/03/31

  Project: Research Project

• mRNAキャップ特異的m6Amメチル化酵素PCIF1による遺伝子発現制御機構の解明

  Hirose, Y. (Principal Investigator) & Tanaka, A. (Co-Investigator(Kenkyū-buntansha))

  Japan Society for the Promotion of Science

  2025/04/01 → 2028/03/31

  Project: Research Project

• NMR緩和を活用したメソポーラスシリカから放出される薬物のin situ解析

  Okada, K. (Principal Investigator)

  Japan Society for the Promotion of Science

  2022/04/01 → 2025/03/31

  Project: Research Project

• Linkage of neuronal morphology to gene expression:actin-bound transcription cofactor MKL and its regulation by BDNF

  Tabuchi, A. (PI)

  2010/04/01 → 2013/03/31

  Project: Research

  • Actin 100%
  • Brain-Derived Neurotrophic Factor 100%
  • Cytoskeleton 100%
  • Transcription Factors 100%
  • Arc (Protein) 100%

• LIPID NANOPARTICLES OF NONBILAYER STRUCTURE IN BIOINTERFACIAL SCIENCE AND PHARMACEUTICAL FORMAULATION

  Handa, T. (PI) & Nakano, M. (CoI)

  2000/04/01 → 2004/03/31

  Project: Research

  • Lipid Nanoparticles 100%
  • Emulsion 100%
  • Lecithin 100%
  • Egg Lecithin 100%
  • Phosphatidylcholine 80%

• PD-1+/CD8+T細胞の日周リズムを利用した時間免疫療法の構築

  Seto, Y. (Principal Investigator)

  Japan Society for the Promotion of Science

  2025/04/01 → 2028/03/31

  Project: Research Project

• Mechanism of adipose angiogenesis by the cooperative action of angiogenic factors

  Wada, T. (PI)

  2018/04/01 → 2021/03/31

  Project: Research

• Mechanisms for the pharmacokinetic variability in patients with right-sided heart failure: A longitudinal data analysis for optimization of the dosage regimen.

  Taguchi, M. (PI)

  2021/04/01 → 2024/03/31

  Project: Research

• Mechanisms of the pharmacokinetic variability and optimization of drug therapy in children with congenital heart disease

  Taguchi, M. (PI), Ichida, F. (CoI) & Hirono, K. (CoI)

  2015/04/01 → 2018/03/31

  Project: Research

• Mechanistic elucidation of the preventive effect of pig-derived bile acids on life-related diseases through the improvement of gut barrier impairment

  Watanabe, S. (Principal Investigator), 古澤之裕 (Co-Investigator(Kenkyū-buntansha)) & Tabuchi, Y. (Co-Investigator(Kenkyū-buntansha))

  Japan Society for the Promotion of Science

  2024/04/01 → 2027/03/31

  Project: Research Project

• Metabolomic profiling of Wakan-yaku for quality evaluation

  Toume, K. (PI)

  2021/04/01 → 2024/03/31

  Project: Research

• PI3キナーゼ代謝産物の制御がインスリン作用に及ぼす影響と病態での意義の解析

  Sasaoka, T. (PI)

  1999/04/01 → 2001/03/31

  Project: Research

• PQBP1はcGASによるI型インターフェロンの発現誘導をどのように抑制するのか

  Mizuguchi, M. (PI) & Obita, T. (CoI)

  2019/04/01 → 2022/03/31

  Project: Research

• Mode-of-action analysis of Kampo formulae and prediction of their new indications for a wide range of diseases

  Kadowaki, M. (PI), Shibahara, N. (CoI), Tohda, C. (CoI), Hayashi, S. (CoI), Yamanishi, Y. (CoI), Yamamoto, T. (CoI) & Umezaki, M. (CoI)

  2016/04/01 → 2019/03/31

  Project: Research

• PRMT1の標的基質の網羅的探索から紐解く還元ストレスと心機能障害に至る分子機構

  Kim, J. (Principal Investigator)

  Japan Society for the Promotion of Science

  2024/04/01 → 2027/03/31

  Project: Research Project

• Molecular and structural basis of natural moisturizing factor production mechanisms by profilaggrin-degrading enzymes.

  Obita, T. (Principal Investigator)

  Japan Society for the Promotion of Science

  2024/04/01 → 2027/03/31

  Project: Research Project