Linkage of neuronal morphology to gene expression:actin-bound transcription cofactor MKL and its regulation by BDNF

Activity-regulated cytoskeleton-associated protein （Arc) is a regulator of neuronal function. In this study, we have found that SRF cofactors, megakaryoblastic leukemia 1（MKL1) and Ets-like transcription factor 1 （Elk1), activate and inhibit Arc gene transcription, respectively. These findings, at least in part, contribute to a better understanding of brain function and provide a novel insight into SRF cofactor-based drug design.