Research output per year
Research output per year
- 1 - 50 out of 77 results
Search results
-
2025
Preventive Effects of Psoraleae Semen Extracts on Cognitive Dysfunction in Alzheimer’s Disease Model AppNL-P-F Mice
Hiramatsu, G., Mizutani, R., Toume, K., Inada, Y., Sawahata, M., Uta, D., Komatsu, K. & Kume, T., 2025/01, In: Biological and Pharmaceutical Bulletin. 48, 1, p. 75-79 5 p.Research output: Contribution to journal › Review article › peer-review
-
2024
Identification of herbal drug extracts that promote growth of Akkermansia muciniphila in high-fat diet fed mice
Fujisaka, S., Watanabe, Y., Toume, K., Morinaga, Y., Nawaz, A., Kado, T., Nishimura, A., Bilal, M., Aslam, M. R., Igarashi, Y., Nakagawa, Y. & Tobe, K., 2024/07, In: Diabetology International. 15, 3, p. 495-506 12 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
2023
Design, synthesis, structure–activity relationship studies, and evaluation of novel GLS1 inhibitors
Jo, M., Koizumi, K., Suzuki, M., Kanayama, D., Watanabe, Y., Gouda, H., Mori, H., Mizuguchi, M., Obita, T., Nabeshima, Y., Toyooka, N. & Okada, T., 2023/05/01, In: Bioorganic and Medicinal Chemistry Letters. 87, 129266.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
Design and structural optimization of thiadiazole derivatives with potent GLS1 inhibitory activity
Okada, T., Yamabe, K., Jo, M., Sakajiri, Y., Shibata, T., Sawada, R., Yamanishi, Y., Kanayama, D., Mori, H., Mizuguchi, M., Obita, T., Nabeshima, Y., Koizumi, K. & Toyooka, N., 2023/09/01, In: Bioorganic and Medicinal Chemistry Letters. 93, 129438.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Essential oil composition of Curcuma species and drugs from Asia analyzed by headspace solid-phase microextraction coupled with gas chromatography–mass spectrometry
Liu, Q., Komatsu, K., Toume, K., Zhu, S., Tanaka, K., Hayashi, S., Anjiki, N., Kawahara, N., Takano, A., Miyake, K., Nakamura, N., Sukrong, S., Agil, M. & Balachandra, I., 2023/01, In: Natural Medicines. 77, 1, p. 152-172 21 p.Research output: Contribution to journal › Article › peer-review
4 Scopus citations -
Female and male obese Zucker rats display differential inflammatory mediator and long non-coding RNA profiles
Patel, N. A., Lui, A., Trujillo, A. N., Motawe, Z. Y., Bader, D., Schuster, J., Burgess, A., Alves, N. G., Jo, M. & Breslin, J. W., 2023/12/15, In: Life Sciences. 335, 122285.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Impact of Goreisan components on rat mesenteric collecting lymphatic vessel pumping
Jo, M., Trujillo, A. N., Shibahara, N. & Breslin, J. W., 2023/04, In: Microcirculation. 30, 2-3, e12788.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Metabolite profiling of Drynariae Rhizoma using 1H NMR and HPLC coupled with multivariate statistical analysis
Dong, Y., Toume, K., Kimijima, S., Zhang, H., Zhu, S., He, Y., Cai, S., Maruyama, T. & Komatsu, K., 2023/09, In: Natural Medicines. 77, 4, p. 839-857 19 p.Research output: Contribution to journal › Article › peer-review
4 Scopus citations -
Metabolomics analysis of peony root using NMR spectroscopy and impact of the preprocessing method for NMR data in multivariate analysis
Dong, Y., Toume, K., Zhu, S., Shi, Y., Tamura, T., Yoshimatsu, K. & Komatsu, K., 2023/09, In: Natural Medicines. 77, 4, p. 792-816 25 p.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
Quality assessment of Rheum species cultivated in Japan by focusing on M2 polarization of microglia
Kuboyama, T., Hotta, K., Asanuma, M., Ge, Y. W., Toume, K., Yamazaki, T. & Komatsu, K., 2023/09, In: Natural Medicines. 77, 4, p. 699-711 13 p.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Uncovering the metabolomic effects of Kampo formulas using 1H-NMR spectroscopy: A case study of goreisan
Awale, S., Jo, M., Watanabe, S., Shibahara, N. & Matsumoto, K., 2023/08, In: Traditional & Kampo Medicine. 10, 2, p. 142-149 8 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Uncovering the metabolomic effects of Kampo formulas using 1H-NMR spectroscopy
Awale, S., Jo, M., Watanabe, S., Shibahara, N. & Matsumoto, K., 2023, In: Uncovering the metabolomic effects of Kampo formulas using 1H-NMR spectroscopy: A case study of goreisan..Research output: Contribution to journal › Article › peer-review
-
2022
A new megastigmane, known porphyrinic and galloylated bioactive derivatives from the leaves of Gymnosporia senegalensis
Tatsimo Ndendoung, S. J., Tamokou, J. D. D., Toume, K., Havyarimana, L., Ekom, S. E. & Komatsu, K., 2022/02, In: Journal of Chemical Research. 46, 1Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
Anti-SARS-CoV-2 activity of various PET-bottled Japanese green teas and tea compounds in vitro
Ngwe Tun, M. M., Luvai, E., Nwe, K. M., Toume, K., Mizukami, S., Hirayama, K., Komatsu, K. & Morita, K., 2022/07, In: Archives of Virology. 167, 7, p. 1547-1557 11 p.Research output: Contribution to journal › Article › peer-review
Open Access19 Scopus citations -
Effects of microbial fermentation on enzyme activity and volatile properties of Massa Medicata Fermentata
Wang, Z., Okutsu, K., Yoshizaki, Y., Futagami, T., Tamaki, H., Maruyama, T., Toume, K., Komatsu, K., Hashimoto, F. & Takamine, K., 2022/04, In: Traditional & Kampo Medicine. 9, 1, p. 10-17 8 p.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Phenylpropanoid-conjugated iridoid glucosides from leaves of Morinda morindoides
Hashim, Y., Toume, K., Mizukami, S., Kitami, T., Taniguchi, M., Teklemichael, A. A., Tayama, Y., Huy, N. T., Lami, J. N., Bodi, J. M., Hirayama, K. & Komatsu, K., 2022/01, In: Natural Medicines. 76, 1, p. 281-290 10 p.Research output: Contribution to journal › Article › peer-review
5 Scopus citations -
The discovery of herbal drugs and natural compounds as inhibitors of SARS-CoV-2 infection in vitro
Ngwe Tun, M. M., Toume, K., Luvai, E., Nwe, K. M., Mizukami, S., Hirayama, K., Komatsu, K. & Morita, K., 2022/03, In: Natural Medicines. 76, 2, p. 402-409 8 p.Research output: Contribution to journal › Article › peer-review
Open Access25 Scopus citations -
Wogonin, a Compound in Scutellaria baicalensis, Activates ATF4–FGF21 Signaling in Mouse Hepatocyte AML12 Cells
Yamada, Y., Saito, H., Araki, M., Tsuchimoto, Y., Muroi, S. I., Suzuki, K., Toume, K., Kim, J. D., Matsuzaka, T., Sone, H., Shimano, H. & Nakagawa, Y., 2022/10, In: Nutrients. 14, 19, 3920.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
2021
Kihito prevents corticosterone-induced brain dysfunctions in mice
Araki, R., Tachioka, H., Kita, A., Fujiwara, H., Toume, K., Matsumoto, K. & Yabe, T., 2021/11, In: Journal of Traditional and Complementary Medicine. 11, 6, p. 513-519 7 p.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
Phenylpropanoid conjugated iridoids with anti-malarial activity from the leaves of Morinda morindoides
Hashim, Y., Toume, K., Mizukami, S., Ge, Y. W., Taniguchi, M., Teklemichael, A. A., Huy, N. T., Bodi, J. M., Hirayama, K. & Komatsu, K., 2021/09, In: Natural Medicines. 75, 4, p. 915-925 11 p.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
2020
Anti-malarial activity of traditional Kampo medicine Coptis rhizome extract and its major active compounds
Teklemichael, A. A., Teklemichael, A. A., Teklemichael, A. A., Mizukami, S., Mizukami, S., Toume, K., Mosaddeque, F., Mosaddeque, F., Kamel, M. G., Kaneko, O., Kaneko, O., Kaneko, O., Komatsu, K., Karbwang, J., Karbwang, J., Huy, N. T. & Hirayama, K., 2020/06/08, In: Malaria Journal. 19, 1, 204.Research output: Contribution to journal › Article › peer-review
Open Access16 Scopus citations -
Metabolomic profiling of Saposhnikoviae Radix from Mongolia by LC–IT–TOF–MS/MS and multivariate statistical analysis
Batsukh, Z., Toume, K., Javzan, B., Kazuma, K., Cai, S. Q., Hayashi, S., Kawahara, N., Maruyama, T. & Komatsu, K., 2020/01/01, In: Natural Medicines. 74, 1, p. 170-188 19 p.Research output: Contribution to journal › Article › peer-review
15 Scopus citations -
Microbial Community Structure and Chemical Constituents in Shinkiku, a Fermented Crude Drug Used in Kampo Medicine
Wang, Z., Okutsu, K., Futagami, T., Yoshizaki, Y., Tamaki, H., Maruyama, T., Toume, K., Komatsu, K., Hashimoto, F. & Takamine, K., 2020/07/31, In: Frontiers in Nutrition. 7, 115.Research output: Contribution to journal › Article › peer-review
Open Access12 Scopus citations -
2019
Evidence of functional ryanodine receptors in rat mesenteric collecting lymphatic vessels
Jo, M., Trujillo, A. N., Yang, Y. & Breslin, J. W., 2019/09, In: American Journal of Physiology - Heart and Circulatory Physiology. 317, 3, p. H561-H574Research output: Contribution to journal › Article › peer-review
Open Access20 Scopus citations -
Kami-shoyo-san ameliorates sociability deficits in ovariectomized mice, a putative female model of autism spectrum disorder, via facilitating dopamine D 1 and GABA A receptor functions
Guo, Q., Ebihara, K., Fujiwara, H., Toume, K., Awale, S., Araki, R., Yabe, T., Dong, E. & Matsumoto, K., 2019/05/23, In: Journal of Ethnopharmacology. 236, p. 231-239 9 p.Research output: Contribution to journal › Article › peer-review
7 Scopus citations -
Kami-shoyo-san improves ASD-like behaviors caused by decreasing allopregnanolone biosynthesis in an SKF mouse model of autism
Guo, Q. Y., Ebihara, K., Shimodaira, T., Fujiwara, H., Toume, K., Dibwe, D. F., Awale, S., Araki, R., Yabe, T. & Matsumoto, K., 2019/01, In: PLoS ONE. 14, 1, e0211266.Research output: Contribution to journal › Article › peer-review
Open Access12 Scopus citations -
Kamiuntanto increases prefrontal extracellular serotonin levels and ameliorates depression-like behaviors in mice
Hiraki, Y., Araki, R., Fujiwara, H., Ago, Y., Tanaka, T., Toume, K., Matsumoto, K. & Yabe, T., 2019/02, In: Journal of Pharmacological Sciences. 139, 2, p. 72-76 5 p.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Monoglycerol ester, galloylglucoside and phenolic derivatives from Gymnosporia senegalensis leaves
Tatsimo, J. S. N., Toume, K., Nagata, T., Havyarimana, L., Fujii, T. & Komatsu, K., 2019/04, In: Biochemical Systematics and Ecology. 83, p. 33-38 6 p.Research output: Contribution to journal › Article › peer-review
12 Scopus citations -
Screening inducers of neuronal BDNF gene transcription using primary cortical cell cultures from BDNF-luciferase transgenic mice
Fukuchi, M., Okuno, Y., Nakayama, H., Nakano, A., Mori, H., Mitazaki, S., Nakano, Y., Toume, K., Jo, M., Takasaki, I., Watanabe, K., Shibahara, N., Komatsu, K., Tabuchi, A. & Tsuda, M., 2019/12/01, In: Scientific Reports. 9, 1, 11833.Research output: Contribution to journal › Article › peer-review
Open Access19 Scopus citations -
Search of anti-allodynic compounds from Plantaginis Semen, a crude drug ingredient of Kampo formula “Goshajinkigan”
Toume, K., Hou, Z., Yu, H., Kato, M., Maesaka, M., Bai, Y., Hanazawa, S., Ge, Y., Andoh, T. & Komatsu, K., 2019/09/13, In: Natural Medicines. 73, 4, p. 761-768 8 p.Research output: Contribution to journal › Article › peer-review
Open Access14 Scopus citations -
2018
Coculture of a Pathogenic Actinomycete and Animal Cells to Produce Nocarjamide, a Cyclic Nonapeptide with Wnt Signal-Activating Effect
Hara, Y., Arai, M. A., Toume, K., Masu, H., Sato, T., Komatsu, K., Yaguchi, T. & Ishibashi, M., 2018/09/21, In: Organic Letters. 20, 18, p. 5831-5834 4 p.Research output: Contribution to journal › Article › peer-review
21 Scopus citations -
Polygalae radix extract ameliorates behavioral and neuromorphological abnormalities in chronic corticosterone-treated mice
Araki, R., Fujiwara, H., Matsumoto, K., Toume, K. & Yabe, T., 2018/10, In: Traditional & Kampo Medicine. 5, 2, p. 89-97 9 p.Research output: Contribution to journal › Article › peer-review
6 Scopus citations -
2017
Hirsutine, an indole alkaloid of uncaria rhynchophylla, inhibits late step in dengue virus lifecycle
Hishiki, T., Kato, F., Tajima, S., Toume, K., Umezaki, M., Takasaki, T. & Miura, T., 2017/08/30, In: Frontiers in Microbiology. 8, AUG, 1674.Research output: Contribution to journal › Article › peer-review
Open Access43 Scopus citations -
Identification of BMI1 Promoter Inhibitors from Beaumontia murtonii and Eugenia operculata
Kaneta, Y., Arai, M. A., Ishikawa, N., Toume, K., Koyano, T., Kowithayakorn, T., Chiba, T., Iwama, A. & Ishibashi, M., 2017/06/23, In: Journal of Natural Products. 80, 6, p. 1853-1859 7 p.Research output: Contribution to journal › Article › peer-review
12 Scopus citations -
Prophylactic administration of aucubin inhibits paclitaxel-induced mechanical allodynia via the inhibition of endoplasmic reticulum stress in peripheral Schwann cells
Andoh, T., Uta, D., Kato, M., Toume, K., Komatsu, K. & Kuraishi, Y., 2017, In: Biological and Pharmaceutical Bulletin. 40, 4, p. 473-478 6 p.Research output: Contribution to journal › Article › peer-review
Open Access24 Scopus citations -
2016
Anticancer effect of a Kampo preparation Daikenchuto
Nagata, T., Toume, K., Long, L. X., Hirano, K., Watanabe, T., Sekine, S., Okumura, T., Komatsu, K. & Tsukada, K., 2016/07/01, In: Natural Medicines. 70, 3, p. 627-633 7 p.Research output: Contribution to journal › Article › peer-review
14 Scopus citations -
Cerasoidine, a Bis-aporphine Alkaloid Isolated from Polyalthia cerasoides during Screening for Wnt Signal Inhibitors
Shono, T., Ishikawa, N., Toume, K., Arai, M. A., Masu, H., Koyano, T., Kowithayakorn, T. & Ishibashi, M., 2016/08/26, In: Journal of Natural Products. 79, 8, p. 2083-2088 6 p.Research output: Contribution to journal › Article › peer-review
23 Scopus citations -
Characterization and quantification of monoterpenoids in different types of peony root and the related Paeonia species by liquid chromatography coupled with ion trap and time-of-flight mass spectrometry
Shi, Y. H., Zhu, S., Ge, Y. W., Toume, K., Wang, Z., Batkhuu, J. & Komatsu, K., 2016/09/10, In: Journal of Pharmaceutical and Biomedical Analysis. 129, p. 581-592 12 p.Research output: Contribution to journal › Article › peer-review
67 Scopus citations -
Constituents from Entada scandens with TRAIL-resistance Overcoming Activity
Ahmed, F., Toume, K., Ishikawa, N., Arai, M. A., Sadhu, S. K. & Ishibashi, M., 2016/07, In: Natural Product Communications. 11, 7, p. 993-995 3 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Efficient use of a crude drug/herb library reveals Ephedra herb as a specific antagonist for T H 2-specific chemokine receptors CCR3, CCR4, and CCR8
Matsuo, K., Koizumi, K., Fujita, M., Morikawa, T., Jo, M., Shibahara, N., Saiki, I., Yoshie, O. & Nakayama, T., 2016/06/07, In: Frontiers in Cell and Developmental Biology. 4, JUN, 54.Research output: Contribution to journal › Article › peer-review
Open Access11 Scopus citations -
Prophylactic administration of an extract from Plantaginis Semen and its major component aucubin inhibits mechanical allodynia caused by paclitaxel in mice
Andoh, T., Kato, M., Kitamura, R., Mizoguchi, S., Uta, D., Toume, K., Komatsu, K. & Kuraishi, Y., 2016/07/01, In: Journal of Traditional and Complementary Medicine. 6, 3, p. 305-308 4 p.Research output: Contribution to journal › Article › peer-review
Open Access15 Scopus citations -
2015
9-Hydroxycanthin-6-one, a β-carboline alkaloid from eurycoma longifolia, is the first wnt signal inhibitor through activation of glycogen synthase kinase 3β without depending on casein kinase 1α
Ohishi, K., Toume, K., Arai, M. A., Koyano, T., Kowithayakorn, T., Mizoguchi, T., Itoh, M. & Ishibashi, M., 2015/05/22, In: Journal of Natural Products. 78, 5, p. 1139-1146 8 p.Research output: Contribution to journal › Article › peer-review
39 Scopus citations -
Boehmenan, a lignan from Hibiscus ficulneus, showed Wnt signal inhibitory activity
Shono, T., Ishikawa, N., Toume, K., Arai, M. A., Ahmed, F., Sadhu, S. K. & Ishibashi, M., 2015/06/04, In: Bioorganic and Medicinal Chemistry Letters. 25, 14, p. 2735-2738 4 p.Research output: Contribution to journal › Article › peer-review
9 Scopus citations -
Characterization of organic iodides with iodine-127 nuclear magnetic resonance spectroscopy
Kagawa, N., Suzuki, M., Kogure, N. & Toume, K., 2015/10/14, In: Tetrahedron Letters. 56, 42, p. 5795-5798 4 p.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
Coronaridine, an iboga type alkaloid from Tabernaemontana divaricata, inhibits the Wnt signaling pathway by decreasing β-catenin mRNA expression
Ohishi, K., Toume, K., Arai, M. A., Sadhu, S. K., Ahmed, F. & Ishibashi, M., 2015/08/17, In: Bioorganic and Medicinal Chemistry Letters. 25, 18, p. 3937-3940 4 p., 22925.Research output: Contribution to journal › Article › peer-review
14 Scopus citations -
Correction to Prenylated Flavonoids and Resveratrol Derivatives Isolated from Artocarpus communis with the Ability to Overcome TRAIL Resistance
Toume, K., Habu, T., Arai, M. A., Koyano, T., Kowithayakorn, T. & Ishibashi, M., 2015/04/24, In: Journal of Natural Products. 78, 4, p. 968 1 p.Research output: Contribution to journal › Comment/debate
Open Access1 Scopus citations -
Isolation of alkamides with death receptor-enhancing activities from Piper Chaba
Tahmina, H., Toume, K., Arai, M. A., Sadhu, S. K., Ahmed, F. & Ishibashi, M., 2015, In: Heterocycles. 90, 2, p. 1317-1322 6 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Limonoids with Wnt signal inhibitory activity isolated from the fruits of Azadirachta excelsa
Fuentes, R. G., Toume, K., Arai, M. A., Sadhu, S. K., Ahmed, F. & Ishibashi, M., 2015/03, In: Phytochemistry Letters. 11, p. 280-285 6 p.Research output: Contribution to journal › Article › peer-review
9 Scopus citations -
Novel cytotoxic isobenzofuran derivatives from Streptomyces sp. IFM 11490
Yixizhuoma, Tsukahara, K., Toume, K., Ishikawa, N., Abdelfattah, M. S. & Ishibashi, M., 2015/11/18, In: Tetrahedron Letters. 56, 46, p. 6345-6347 3 p.Research output: Contribution to journal › Article › peer-review
16 Scopus citations -
Prenylated flavonoids and resveratrol derivatives isolated from artocarpus communis with the ability to overcome TRAIL resistance
Toume, K., Habu, T., Arai, M. A., Koyano, T., Kowithayakorn, T. & Ishibashi, M., 2015/01/23, In: Journal of Natural Products. 78, 1, p. 103-110 8 p.Research output: Contribution to journal › Article › peer-review
32 Scopus citations