Coculture of a Pathogenic Actinomycete and Animal Cells to Produce Nocarjamide, a Cyclic Nonapeptide with Wnt Signal-Activating Effect

Yasumasa Hara; Midori A. Arai; Kazufumi Toume; Hyuma Masu; Tomoyuki Sato; Katsuko Komatsu; Takashi Yaguchi; Masami Ishibashi

doi:10.1021/acs.orglett.8b02522

Coculture of a Pathogenic Actinomycete and Animal Cells to Produce Nocarjamide, a Cyclic Nonapeptide with Wnt Signal-Activating Effect

Yasumasa Hara, Midori A. Arai, Kazufumi Toume, Hyuma Masu, Tomoyuki Sato, Katsuko Komatsu, Takashi Yaguchi, Masami Ishibashi^*

^*Corresponding author for this work

Department of Medicinal Resources Management, Institute of Natural Medicine
Section of Pharmacognosy, Division of Medicinal Resources, Institute of Natural Medicine

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

A coculture method with a pathogenic actinomycete of the genus Nocardia and an animal cell line was designed to reconstruct and emulate the initial infection state, and a new cyclic nonapeptide, named nocarjamide (1), was obtained by coculture of Nocardia tenerifensis IFM 10554^T and the mouse macrophage-like cell line J774.1 in a modified Czapek-Dox medium. Nocarjamide (1) exhibited Wnt signal-activating effects.

Original language	English
Pages (from-to)	5831-5834
Number of pages	4
Journal	Organic Letters
Volume	20
Issue number	18
DOIs	https://doi.org/10.1021/acs.orglett.8b02522
State	Published - 2018/09/21

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

Access to Document

10.1021/acs.orglett.8b02522

Cite this

@article{f0ddd853615c43cc9aa1b837ad12cbb2,

title = "Coculture of a Pathogenic Actinomycete and Animal Cells to Produce Nocarjamide, a Cyclic Nonapeptide with Wnt Signal-Activating Effect",

abstract = "A coculture method with a pathogenic actinomycete of the genus Nocardia and an animal cell line was designed to reconstruct and emulate the initial infection state, and a new cyclic nonapeptide, named nocarjamide (1), was obtained by coculture of Nocardia tenerifensis IFM 10554T and the mouse macrophage-like cell line J774.1 in a modified Czapek-Dox medium. Nocarjamide (1) exhibited Wnt signal-activating effects.",

author = "Yasumasa Hara and Arai, {Midori A.} and Kazufumi Toume and Hyuma Masu and Tomoyuki Sato and Katsuko Komatsu and Takashi Yaguchi and Masami Ishibashi",

note = "Publisher Copyright: Copyright {\textcopyright} 2018 American Chemical Society.",

year = "2018",

month = sep,

day = "21",

doi = "10.1021/acs.orglett.8b02522",

language = "英語",

volume = "20",

pages = "5831--5834",

journal = "Organic Letters",

issn = "1523-7060",

publisher = "American Chemical Society",

number = "18",

}

TY - JOUR

T1 - Coculture of a Pathogenic Actinomycete and Animal Cells to Produce Nocarjamide, a Cyclic Nonapeptide with Wnt Signal-Activating Effect

AU - Hara, Yasumasa

AU - Arai, Midori A.

AU - Toume, Kazufumi

AU - Masu, Hyuma

AU - Sato, Tomoyuki

AU - Komatsu, Katsuko

AU - Yaguchi, Takashi

AU - Ishibashi, Masami

PY - 2018/9/21

Y1 - 2018/9/21

N2 - A coculture method with a pathogenic actinomycete of the genus Nocardia and an animal cell line was designed to reconstruct and emulate the initial infection state, and a new cyclic nonapeptide, named nocarjamide (1), was obtained by coculture of Nocardia tenerifensis IFM 10554T and the mouse macrophage-like cell line J774.1 in a modified Czapek-Dox medium. Nocarjamide (1) exhibited Wnt signal-activating effects.

AB - A coculture method with a pathogenic actinomycete of the genus Nocardia and an animal cell line was designed to reconstruct and emulate the initial infection state, and a new cyclic nonapeptide, named nocarjamide (1), was obtained by coculture of Nocardia tenerifensis IFM 10554T and the mouse macrophage-like cell line J774.1 in a modified Czapek-Dox medium. Nocarjamide (1) exhibited Wnt signal-activating effects.

UR - http://www.scopus.com/inward/record.url?scp=85052932092&partnerID=8YFLogxK

U2 - 10.1021/acs.orglett.8b02522

DO - 10.1021/acs.orglett.8b02522

M3 - 学術論文

C2 - 30156858

AN - SCOPUS:85052932092

SN - 1523-7060

VL - 20

SP - 5831

EP - 5834

JO - Organic Letters

JF - Organic Letters

IS - 18

ER -

Coculture of a Pathogenic Actinomycete and Animal Cells to Produce Nocarjamide, a Cyclic Nonapeptide with Wnt Signal-Activating Effect

Abstract

ASJC Scopus subject areas

Access to Document

Fingerprint

Cite this