Characterization of organic iodides with iodine-127 nuclear magnetic resonance spectroscopy

Natsuko Kagawa; Masaaki Suzuki; Noriyuki Kogure; Kazufumi Toume

doi:10.1016/j.tetlet.2015.09.016

Characterization of organic iodides with iodine-127 nuclear magnetic resonance spectroscopy

Natsuko Kagawa^*, Masaaki Suzuki, Noriyuki Kogure, Kazufumi Toume

^*Corresponding author for this work

Department of Medicinal Resources Management, Institute of Natural Medicine

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

The spectra of the Iodine-127 nucleus could not be readily obtained since it has a spin number, I, of 5/2 and a nonspherical charge distribution. When we applied ¹²⁷I NMR to organic iodides, the I^- and IO₄^- signals of organic molecules provided a clear singlet in solutions of (CD₃)₂S(O) or (CD₃)₂NC(O)D. The spectra of ¹²⁷I NMR revealed the oxidation state of iodine atoms in the organic molecule, which would not have been evident in the ¹H and ¹³C NMR spectra. Here, we report the practical examples of the characterization of organic iodides via solution-¹²⁷I NMR spectroscopy.

Original language	English
Pages (from-to)	5795-5798
Number of pages	4
Journal	Tetrahedron Letters
Volume	56
Issue number	42
DOIs	https://doi.org/10.1016/j.tetlet.2015.09.016
State	Published - 2015/10/14

Keywords

Iodine
NMR spectroscopy
Solvent effects
Structure elucidation

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/j.tetlet.2015.09.016

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title = "Characterization of organic iodides with iodine-127 nuclear magnetic resonance spectroscopy",

abstract = "The spectra of the Iodine-127 nucleus could not be readily obtained since it has a spin number, I, of 5/2 and a nonspherical charge distribution. When we applied 127I NMR to organic iodides, the I- and IO4- signals of organic molecules provided a clear singlet in solutions of (CD3)2S(O) or (CD3)2NC(O)D. The spectra of 127I NMR revealed the oxidation state of iodine atoms in the organic molecule, which would not have been evident in the 1H and 13C NMR spectra. Here, we report the practical examples of the characterization of organic iodides via solution-127I NMR spectroscopy.",

keywords = "Iodine, NMR spectroscopy, Solvent effects, Structure elucidation",

author = "Natsuko Kagawa and Masaaki Suzuki and Noriyuki Kogure and Kazufumi Toume",

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doi = "10.1016/j.tetlet.2015.09.016",

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journal = "Tetrahedron Letters",

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T1 - Characterization of organic iodides with iodine-127 nuclear magnetic resonance spectroscopy

AU - Kagawa, Natsuko

AU - Suzuki, Masaaki

AU - Kogure, Noriyuki

AU - Toume, Kazufumi

PY - 2015/10/14

Y1 - 2015/10/14

N2 - The spectra of the Iodine-127 nucleus could not be readily obtained since it has a spin number, I, of 5/2 and a nonspherical charge distribution. When we applied 127I NMR to organic iodides, the I- and IO4- signals of organic molecules provided a clear singlet in solutions of (CD3)2S(O) or (CD3)2NC(O)D. The spectra of 127I NMR revealed the oxidation state of iodine atoms in the organic molecule, which would not have been evident in the 1H and 13C NMR spectra. Here, we report the practical examples of the characterization of organic iodides via solution-127I NMR spectroscopy.

AB - The spectra of the Iodine-127 nucleus could not be readily obtained since it has a spin number, I, of 5/2 and a nonspherical charge distribution. When we applied 127I NMR to organic iodides, the I- and IO4- signals of organic molecules provided a clear singlet in solutions of (CD3)2S(O) or (CD3)2NC(O)D. The spectra of 127I NMR revealed the oxidation state of iodine atoms in the organic molecule, which would not have been evident in the 1H and 13C NMR spectra. Here, we report the practical examples of the characterization of organic iodides via solution-127I NMR spectroscopy.

KW - Iodine

KW - NMR spectroscopy

KW - Solvent effects

KW - Structure elucidation

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DO - 10.1016/j.tetlet.2015.09.016

M3 - 学術論文

AN - SCOPUS:84941997568

SN - 0040-4039

VL - 56

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EP - 5798

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 42

ER -

Characterization of organic iodides with iodine-127 nuclear magnetic resonance spectroscopy

Abstract

Keywords

ASJC Scopus subject areas

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