年別の研究成果
年別の研究成果
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2025
Preventive Effects of Psoraleae Semen Extracts on Cognitive Dysfunction in Alzheimer’s Disease Model AppNL-P-F Mice
Hiramatsu, G., Mizutani, R., Toume, K., Inada, Y., Sawahata, M., Uta, D., Komatsu, K. & Kume, T., 2025/01, In: Biological and Pharmaceutical Bulletin. 48, 1, p. 75-79 5 p.研究成果: ジャーナルへの寄稿 › 総説 › 査読
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2024
Identification of herbal drug extracts that promote growth of Akkermansia muciniphila in high-fat diet fed mice
Fujisaka, S., Watanabe, Y., Toume, K., Morinaga, Y., Nawaz, A., Kado, T., Nishimura, A., Bilal, M., Aslam, M. R., Igarashi, Y., Nakagawa, Y. & Tobe, K., 2024/07, In: Diabetology International. 15, 3, p. 495-506 12 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
1 被引用数 (Scopus) -
2023
Design, synthesis, structure–activity relationship studies, and evaluation of novel GLS1 inhibitors
Jo, M., Koizumi, K., Suzuki, M., Kanayama, D., Watanabe, Y., Gouda, H., Mori, H., Mizuguchi, M., Obita, T., Nabeshima, Y., Toyooka, N. & Okada, T., 2023/05/01, In: Bioorganic and Medicinal Chemistry Letters. 87, 129266.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
3 被引用数 (Scopus) -
Design and structural optimization of thiadiazole derivatives with potent GLS1 inhibitory activity
Okada, T., Yamabe, K., Jo, M., Sakajiri, Y., Shibata, T., Sawada, R., Yamanishi, Y., Kanayama, D., Mori, H., Mizuguchi, M., Obita, T., Nabeshima, Y., Koizumi, K. & Toyooka, N., 2023/09/01, In: Bioorganic and Medicinal Chemistry Letters. 93, 129438.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
1 被引用数 (Scopus) -
Essential oil composition of Curcuma species and drugs from Asia analyzed by headspace solid-phase microextraction coupled with gas chromatography–mass spectrometry
Liu, Q., Komatsu, K., Toume, K., Zhu, S., Tanaka, K., Hayashi, S., Anjiki, N., Kawahara, N., Takano, A., Miyake, K., Nakamura, N., Sukrong, S., Agil, M. & Balachandra, I., 2023/01, In: Natural Medicines. 77, 1, p. 152-172 21 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
4 被引用数 (Scopus) -
Female and male obese Zucker rats display differential inflammatory mediator and long non-coding RNA profiles
Patel, N. A., Lui, A., Trujillo, A. N., Motawe, Z. Y., Bader, D., Schuster, J., Burgess, A., Alves, N. G., Jo, M. & Breslin, J. W., 2023/12/15, In: Life Sciences. 335, 122285.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access1 被引用数 (Scopus) -
Impact of Goreisan components on rat mesenteric collecting lymphatic vessel pumping
Jo, M., Trujillo, A. N., Shibahara, N. & Breslin, J. W., 2023/04, In: Microcirculation. 30, 2-3, e12788.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access4 被引用数 (Scopus) -
Metabolite profiling of Drynariae Rhizoma using 1H NMR and HPLC coupled with multivariate statistical analysis
Dong, Y., Toume, K., Kimijima, S., Zhang, H., Zhu, S., He, Y., Cai, S., Maruyama, T. & Komatsu, K., 2023/09, In: Natural Medicines. 77, 4, p. 839-857 19 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
4 被引用数 (Scopus) -
Metabolomics analysis of peony root using NMR spectroscopy and impact of the preprocessing method for NMR data in multivariate analysis
Dong, Y., Toume, K., Zhu, S., Shi, Y., Tamura, T., Yoshimatsu, K. & Komatsu, K., 2023/09, In: Natural Medicines. 77, 4, p. 792-816 25 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access5 被引用数 (Scopus) -
Quality assessment of Rheum species cultivated in Japan by focusing on M2 polarization of microglia
Kuboyama, T., Hotta, K., Asanuma, M., Ge, Y. W., Toume, K., Yamazaki, T. & Komatsu, K., 2023/09, In: Natural Medicines. 77, 4, p. 699-711 13 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
2 被引用数 (Scopus) -
Uncovering the metabolomic effects of Kampo formulas using 1H-NMR spectroscopy: A case study of goreisan
Awale, S., Jo, M., Watanabe, S., Shibahara, N. & Matsumoto, K., 2023/08, In: Traditional & Kampo Medicine. 10, 2, p. 142-149 8 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access2 被引用数 (Scopus) -
Uncovering the metabolomic effects of Kampo formulas using 1H-NMR spectroscopy
Awale, S., Jo, M., Watanabe, S., Shibahara, N. & Matsumoto, K., 2023, In: Uncovering the metabolomic effects of Kampo formulas using 1H-NMR spectroscopy: A case study of goreisan..研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
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2022
A new megastigmane, known porphyrinic and galloylated bioactive derivatives from the leaves of Gymnosporia senegalensis
Tatsimo Ndendoung, S. J., Tamokou, J. D. D., Toume, K., Havyarimana, L., Ekom, S. E. & Komatsu, K., 2022/02, In: Journal of Chemical Research. 46, 1研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access6 被引用数 (Scopus) -
Anti-SARS-CoV-2 activity of various PET-bottled Japanese green teas and tea compounds in vitro
Ngwe Tun, M. M., Luvai, E., Nwe, K. M., Toume, K., Mizukami, S., Hirayama, K., Komatsu, K. & Morita, K., 2022/07, In: Archives of Virology. 167, 7, p. 1547-1557 11 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access19 被引用数 (Scopus) -
Effects of microbial fermentation on enzyme activity and volatile properties of Massa Medicata Fermentata
Wang, Z., Okutsu, K., Yoshizaki, Y., Futagami, T., Tamaki, H., Maruyama, T., Toume, K., Komatsu, K., Hashimoto, F. & Takamine, K., 2022/04, In: Traditional & Kampo Medicine. 9, 1, p. 10-17 8 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access3 被引用数 (Scopus) -
Phenylpropanoid-conjugated iridoid glucosides from leaves of Morinda morindoides
Hashim, Y., Toume, K., Mizukami, S., Kitami, T., Taniguchi, M., Teklemichael, A. A., Tayama, Y., Huy, N. T., Lami, J. N., Bodi, J. M., Hirayama, K. & Komatsu, K., 2022/01, In: Natural Medicines. 76, 1, p. 281-290 10 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
5 被引用数 (Scopus) -
The discovery of herbal drugs and natural compounds as inhibitors of SARS-CoV-2 infection in vitro
Ngwe Tun, M. M., Toume, K., Luvai, E., Nwe, K. M., Mizukami, S., Hirayama, K., Komatsu, K. & Morita, K., 2022/03, In: Natural Medicines. 76, 2, p. 402-409 8 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access25 被引用数 (Scopus) -
Wogonin, a Compound in Scutellaria baicalensis, Activates ATF4–FGF21 Signaling in Mouse Hepatocyte AML12 Cells
Yamada, Y., Saito, H., Araki, M., Tsuchimoto, Y., Muroi, S. I., Suzuki, K., Toume, K., Kim, J. D., Matsuzaka, T., Sone, H., Shimano, H. & Nakagawa, Y., 2022/10, In: Nutrients. 14, 19, 3920.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access4 被引用数 (Scopus) -
2021
Kihito prevents corticosterone-induced brain dysfunctions in mice
Araki, R., Tachioka, H., Kita, A., Fujiwara, H., Toume, K., Matsumoto, K. & Yabe, T., 2021/11, In: Journal of Traditional and Complementary Medicine. 11, 6, p. 513-519 7 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access6 被引用数 (Scopus) -
Phenylpropanoid conjugated iridoids with anti-malarial activity from the leaves of Morinda morindoides
Hashim, Y., Toume, K., Mizukami, S., Ge, Y. W., Taniguchi, M., Teklemichael, A. A., Huy, N. T., Bodi, J. M., Hirayama, K. & Komatsu, K., 2021/09, In: Natural Medicines. 75, 4, p. 915-925 11 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access7 被引用数 (Scopus) -
2020
Anti-malarial activity of traditional Kampo medicine Coptis rhizome extract and its major active compounds
Teklemichael, A. A., Teklemichael, A. A., Teklemichael, A. A., Mizukami, S., Mizukami, S., Toume, K., Mosaddeque, F., Mosaddeque, F., Kamel, M. G., Kaneko, O., Kaneko, O., Kaneko, O., Komatsu, K., Karbwang, J., Karbwang, J., Huy, N. T. & Hirayama, K., 2020/06/08, In: Malaria Journal. 19, 1, 204.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access16 被引用数 (Scopus) -
Metabolomic profiling of Saposhnikoviae Radix from Mongolia by LC–IT–TOF–MS/MS and multivariate statistical analysis
Batsukh, Z., Toume, K., Javzan, B., Kazuma, K., Cai, S. Q., Hayashi, S., Kawahara, N., Maruyama, T. & Komatsu, K., 2020/01/01, In: Natural Medicines. 74, 1, p. 170-188 19 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
15 被引用数 (Scopus) -
Microbial Community Structure and Chemical Constituents in Shinkiku, a Fermented Crude Drug Used in Kampo Medicine
Wang, Z., Okutsu, K., Futagami, T., Yoshizaki, Y., Tamaki, H., Maruyama, T., Toume, K., Komatsu, K., Hashimoto, F. & Takamine, K., 2020/07/31, In: Frontiers in Nutrition. 7, 115.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access12 被引用数 (Scopus) -
2019
Evidence of functional ryanodine receptors in rat mesenteric collecting lymphatic vessels
Jo, M., Trujillo, A. N., Yang, Y. & Breslin, J. W., 2019/09, In: American Journal of Physiology - Heart and Circulatory Physiology. 317, 3, p. H561-H574研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access20 被引用数 (Scopus) -
Kami-shoyo-san ameliorates sociability deficits in ovariectomized mice, a putative female model of autism spectrum disorder, via facilitating dopamine D 1 and GABA A receptor functions
Guo, Q., Ebihara, K., Fujiwara, H., Toume, K., Awale, S., Araki, R., Yabe, T., Dong, E. & Matsumoto, K., 2019/05/23, In: Journal of Ethnopharmacology. 236, p. 231-239 9 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
7 被引用数 (Scopus) -
Kami-shoyo-san improves ASD-like behaviors caused by decreasing allopregnanolone biosynthesis in an SKF mouse model of autism
Guo, Q. Y., Ebihara, K., Shimodaira, T., Fujiwara, H., Toume, K., Dibwe, D. F., Awale, S., Araki, R., Yabe, T. & Matsumoto, K., 2019/01, In: PLoS ONE. 14, 1, e0211266.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access12 被引用数 (Scopus) -
Kamiuntanto increases prefrontal extracellular serotonin levels and ameliorates depression-like behaviors in mice
Hiraki, Y., Araki, R., Fujiwara, H., Ago, Y., Tanaka, T., Toume, K., Matsumoto, K. & Yabe, T., 2019/02, In: Journal of Pharmacological Sciences. 139, 2, p. 72-76 5 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access4 被引用数 (Scopus) -
Monoglycerol ester, galloylglucoside and phenolic derivatives from Gymnosporia senegalensis leaves
Tatsimo, J. S. N., Toume, K., Nagata, T., Havyarimana, L., Fujii, T. & Komatsu, K., 2019/04, In: Biochemical Systematics and Ecology. 83, p. 33-38 6 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
12 被引用数 (Scopus) -
Screening inducers of neuronal BDNF gene transcription using primary cortical cell cultures from BDNF-luciferase transgenic mice
Fukuchi, M., Okuno, Y., Nakayama, H., Nakano, A., Mori, H., Mitazaki, S., Nakano, Y., Toume, K., Jo, M., Takasaki, I., Watanabe, K., Shibahara, N., Komatsu, K., Tabuchi, A. & Tsuda, M., 2019/12/01, In: Scientific Reports. 9, 1, 11833.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access19 被引用数 (Scopus) -
Search of anti-allodynic compounds from Plantaginis Semen, a crude drug ingredient of Kampo formula “Goshajinkigan”
Toume, K., Hou, Z., Yu, H., Kato, M., Maesaka, M., Bai, Y., Hanazawa, S., Ge, Y., Andoh, T. & Komatsu, K., 2019/09/13, In: Natural Medicines. 73, 4, p. 761-768 8 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access14 被引用数 (Scopus) -
2018
Coculture of a Pathogenic Actinomycete and Animal Cells to Produce Nocarjamide, a Cyclic Nonapeptide with Wnt Signal-Activating Effect
Hara, Y., Arai, M. A., Toume, K., Masu, H., Sato, T., Komatsu, K., Yaguchi, T. & Ishibashi, M., 2018/09/21, In: Organic Letters. 20, 18, p. 5831-5834 4 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
21 被引用数 (Scopus) -
Polygalae radix extract ameliorates behavioral and neuromorphological abnormalities in chronic corticosterone-treated mice
Araki, R., Fujiwara, H., Matsumoto, K., Toume, K. & Yabe, T., 2018/10, In: Traditional & Kampo Medicine. 5, 2, p. 89-97 9 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
6 被引用数 (Scopus) -
2017
Hirsutine, an indole alkaloid of uncaria rhynchophylla, inhibits late step in dengue virus lifecycle
Hishiki, T., Kato, F., Tajima, S., Toume, K., Umezaki, M., Takasaki, T. & Miura, T., 2017/08/30, In: Frontiers in Microbiology. 8, AUG, 1674.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access43 被引用数 (Scopus) -
Identification of BMI1 Promoter Inhibitors from Beaumontia murtonii and Eugenia operculata
Kaneta, Y., Arai, M. A., Ishikawa, N., Toume, K., Koyano, T., Kowithayakorn, T., Chiba, T., Iwama, A. & Ishibashi, M., 2017/06/23, In: Journal of Natural Products. 80, 6, p. 1853-1859 7 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
12 被引用数 (Scopus) -
Prophylactic administration of aucubin inhibits paclitaxel-induced mechanical allodynia via the inhibition of endoplasmic reticulum stress in peripheral Schwann cells
Andoh, T., Uta, D., Kato, M., Toume, K., Komatsu, K. & Kuraishi, Y., 2017, In: Biological and Pharmaceutical Bulletin. 40, 4, p. 473-478 6 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access24 被引用数 (Scopus) -
2016
Anticancer effect of a Kampo preparation Daikenchuto
Nagata, T., Toume, K., Long, L. X., Hirano, K., Watanabe, T., Sekine, S., Okumura, T., Komatsu, K. & Tsukada, K., 2016/07/01, In: Natural Medicines. 70, 3, p. 627-633 7 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
14 被引用数 (Scopus) -
Cerasoidine, a Bis-aporphine Alkaloid Isolated from Polyalthia cerasoides during Screening for Wnt Signal Inhibitors
Shono, T., Ishikawa, N., Toume, K., Arai, M. A., Masu, H., Koyano, T., Kowithayakorn, T. & Ishibashi, M., 2016/08/26, In: Journal of Natural Products. 79, 8, p. 2083-2088 6 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
23 被引用数 (Scopus) -
Characterization and quantification of monoterpenoids in different types of peony root and the related Paeonia species by liquid chromatography coupled with ion trap and time-of-flight mass spectrometry
Shi, Y. H., Zhu, S., Ge, Y. W., Toume, K., Wang, Z., Batkhuu, J. & Komatsu, K., 2016/09/10, In: Journal of Pharmaceutical and Biomedical Analysis. 129, p. 581-592 12 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
67 被引用数 (Scopus) -
Constituents from Entada scandens with TRAIL-resistance Overcoming Activity
Ahmed, F., Toume, K., Ishikawa, N., Arai, M. A., Sadhu, S. K. & Ishibashi, M., 2016/07, In: Natural Product Communications. 11, 7, p. 993-995 3 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access1 被引用数 (Scopus) -
Efficient use of a crude drug/herb library reveals Ephedra herb as a specific antagonist for T H 2-specific chemokine receptors CCR3, CCR4, and CCR8
Matsuo, K., Koizumi, K., Fujita, M., Morikawa, T., Jo, M., Shibahara, N., Saiki, I., Yoshie, O. & Nakayama, T., 2016/06/07, In: Frontiers in Cell and Developmental Biology. 4, JUN, 54.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access11 被引用数 (Scopus) -
Prophylactic administration of an extract from Plantaginis Semen and its major component aucubin inhibits mechanical allodynia caused by paclitaxel in mice
Andoh, T., Kato, M., Kitamura, R., Mizoguchi, S., Uta, D., Toume, K., Komatsu, K. & Kuraishi, Y., 2016/07/01, In: Journal of Traditional and Complementary Medicine. 6, 3, p. 305-308 4 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access15 被引用数 (Scopus) -
2015
9-Hydroxycanthin-6-one, a β-carboline alkaloid from eurycoma longifolia, is the first wnt signal inhibitor through activation of glycogen synthase kinase 3β without depending on casein kinase 1α
Ohishi, K., Toume, K., Arai, M. A., Koyano, T., Kowithayakorn, T., Mizoguchi, T., Itoh, M. & Ishibashi, M., 2015/05/22, In: Journal of Natural Products. 78, 5, p. 1139-1146 8 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
39 被引用数 (Scopus) -
Boehmenan, a lignan from Hibiscus ficulneus, showed Wnt signal inhibitory activity
Shono, T., Ishikawa, N., Toume, K., Arai, M. A., Ahmed, F., Sadhu, S. K. & Ishibashi, M., 2015/06/04, In: Bioorganic and Medicinal Chemistry Letters. 25, 14, p. 2735-2738 4 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
9 被引用数 (Scopus) -
Characterization of organic iodides with iodine-127 nuclear magnetic resonance spectroscopy
Kagawa, N., Suzuki, M., Kogure, N. & Toume, K., 2015/10/14, In: Tetrahedron Letters. 56, 42, p. 5795-5798 4 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
3 被引用数 (Scopus) -
Coronaridine, an iboga type alkaloid from Tabernaemontana divaricata, inhibits the Wnt signaling pathway by decreasing β-catenin mRNA expression
Ohishi, K., Toume, K., Arai, M. A., Sadhu, S. K., Ahmed, F. & Ishibashi, M., 2015/08/17, In: Bioorganic and Medicinal Chemistry Letters. 25, 18, p. 3937-3940 4 p., 22925.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
14 被引用数 (Scopus) -
Correction to Prenylated Flavonoids and Resveratrol Derivatives Isolated from Artocarpus communis with the Ability to Overcome TRAIL Resistance
Toume, K., Habu, T., Arai, M. A., Koyano, T., Kowithayakorn, T. & Ishibashi, M., 2015/04/24, In: Journal of Natural Products. 78, 4, p. 968 1 p.研究成果: ジャーナルへの寄稿 › コメント/討論
Open Access1 被引用数 (Scopus) -
Isolation of alkamides with death receptor-enhancing activities from Piper Chaba
Tahmina, H., Toume, K., Arai, M. A., Sadhu, S. K., Ahmed, F. & Ishibashi, M., 2015, In: Heterocycles. 90, 2, p. 1317-1322 6 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access2 被引用数 (Scopus) -
Limonoids with Wnt signal inhibitory activity isolated from the fruits of Azadirachta excelsa
Fuentes, R. G., Toume, K., Arai, M. A., Sadhu, S. K., Ahmed, F. & Ishibashi, M., 2015/03, In: Phytochemistry Letters. 11, p. 280-285 6 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
9 被引用数 (Scopus) -
Novel cytotoxic isobenzofuran derivatives from Streptomyces sp. IFM 11490
Yixizhuoma, Tsukahara, K., Toume, K., Ishikawa, N., Abdelfattah, M. S. & Ishibashi, M., 2015/11/18, In: Tetrahedron Letters. 56, 46, p. 6345-6347 3 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
16 被引用数 (Scopus) -
Prenylated flavonoids and resveratrol derivatives isolated from artocarpus communis with the ability to overcome TRAIL resistance
Toume, K., Habu, T., Arai, M. A., Koyano, T., Kowithayakorn, T. & Ishibashi, M., 2015/01/23, In: Journal of Natural Products. 78, 1, p. 103-110 8 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
32 被引用数 (Scopus)