Research output per year
Research output per year
- 43 results
Search results
-
2023
Impact of Goreisan components on rat mesenteric collecting lymphatic vessel pumping
Jo, M., Trujillo, A. N., Shibahara, N. & Breslin, J. W., 2023/04, In: Microcirculation. 30, 2-3, e12788.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Uncovering the metabolomic effects of Kampo formulas using 1H-NMR spectroscopy: A case study of goreisan
Awale, S., Jo, M., Watanabe, S., Shibahara, N. & Matsumoto, K., 2023/08, In: Traditional & Kampo Medicine. 10, 2, p. 142-149 8 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Uncovering the metabolomic effects of Kampo formulas using 1H-NMR spectroscopy
Awale, S., Jo, M., Watanabe, S., Shibahara, N. & Matsumoto, K., 2023, In: Uncovering the metabolomic effects of Kampo formulas using 1H-NMR spectroscopy: A case study of goreisan..Research output: Contribution to journal › Article › peer-review
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2022
Clinical study related to oketsu (blood stasis) “1st International Symposium on Kampo Medicine”
Naotoshi, S., Shimada, Y., Morita, A. & Du, J., 2022/12, In: Traditional & Kampo Medicine. 9, 3, p. 200-201 2 p.Research output: Contribution to journal › Letter › peer-review
1 Scopus citations -
2021
Erratum: Suppression of dynamical network biomarker signals at the predisease state (Mibyou) before metabolic syndrome in mice by a traditional Japanese medicine (Kampo Formula) bofutsushosan (Evidence-Based Complementary and Alternative Medicine (2020) 2020 (9129134) DOI: 10.1155/2020/9129134)
Koizumi, K., Oku, M., Hayashi, S., Inujima, A., Shibahara, N., Chen, L., Igarashi, Y., Tobe, K., Saito, S., Kadowaki, M. & Aihara, K., 2021, In: Evidence-based Complementary and Alternative Medicine. 2021, 9760307.Research output: Contribution to journal › Comment/debate
Open Access -
2020
Suppression of Dynamical Network Biomarker Signals at the Predisease State (Mibyou) before Metabolic Syndrome in Mice by a Traditional Japanese Medicine (Kampo Formula) Bofutsushosan
Koizumi, K., Oku, M., Hayashi, S., Inujima, A., Shibahara, N., Chen, L., Igarashi, Y., Tobe, K., Saito, S., Kadowaki, M. & Aihara, K., 2020, In: Evidence-based Complementary and Alternative Medicine. 2020, 9129134.Research output: Contribution to journal › Article › peer-review
Open Access17 Scopus citations -
2019
Identifying pre-disease signals before metabolic syndrome in mice by dynamical network biomarkers
Koizumi, K., Oku, M., Hayashi, S., Inujima, A., Shibahara, N., Chen, L., Igarashi, Y., Tobe, K., Saito, S., Kadowaki, M. & Aihara, K., 2019/12/01, In: Scientific Reports. 9, 1, 8767.Research output: Contribution to journal › Article › peer-review
Open Access44 Scopus citations -
Screening inducers of neuronal BDNF gene transcription using primary cortical cell cultures from BDNF-luciferase transgenic mice
Fukuchi, M., Okuno, Y., Nakayama, H., Nakano, A., Mori, H., Mitazaki, S., Nakano, Y., Toume, K., Jo, M., Takasaki, I., Watanabe, K., Shibahara, N., Komatsu, K., Tabuchi, A. & Tsuda, M., 2019/12/01, In: Scientific Reports. 9, 1, 11833.Research output: Contribution to journal › Article › peer-review
Open Access19 Scopus citations -
2018
Discovery of a sugar-based nanoparticle universally existing in boiling herbal water extracts and their immunostimulant effect
Iitsuka, H., Koizumi, K., Inujima, A., Suzaki, M., Mizuno, Y., Takeshita, Y., Eto, T., Otsuka, Y., Shimada, R., Liu, M., Ikeda, K., Nakano, M., Suzuki, R., Maruyama, K., Zhou, Y., Sakurai, H. & Shibahara, N., 2018/12, In: Biochemistry and Biophysics Reports. 16, p. 62-68 7 p.Research output: Contribution to journal › Article › peer-review
Open Access22 Scopus citations -
Impact of different post-harvest processing methods on the chemical compositions of peony root
Zhu, S., Shirakawa, A., Shi, Y., Yu, X., Tamura, T., Shibahara, N., Yoshimatsu, K. & Komatsu, K., 2018/06/01, In: Natural Medicines. 72, 3, p. 757-767 11 p.Research output: Contribution to journal › Article › peer-review
Open Access20 Scopus citations -
Partial depletion of CD206-positive M2-like macrophages induces proliferation of beige progenitors and enhances browning after cold stimulation
Igarashi, Y., Nawaz, A., Kado, T., Bilal, M., Kuwano, T., Yamamoto, S., Sasahara, M., Jiuxiang, X., Inujima, A., Koizumi, K., Imura, J., Shibahara, N., Usui, I., Fujisaka, S. & Tobe, K., 2018/12/01, In: Scientific Reports. 8, 1, 14567.Research output: Contribution to journal › Article › peer-review
Open Access27 Scopus citations -
2017
Diosgenin-rich yam extract enhances cognitive function: A placebo-controlled, randomized, double-blind, crossover study of healthy adults
Tohda, C., Yang, X., Matsui, M., Inada, Y., Kadomoto, E., Nakada, S., Watari, H. & Shibahara, N., 2017/10/24, In: Nutrients. 9, 10, 1160.Research output: Contribution to journal › Article › peer-review
Open Access60 Scopus citations -
2016
Efficient use of a crude drug/herb library reveals Ephedra herb as a specific antagonist for T H 2-specific chemokine receptors CCR3, CCR4, and CCR8
Matsuo, K., Koizumi, K., Fujita, M., Morikawa, T., Jo, M., Shibahara, N., Saiki, I., Yoshie, O. & Nakayama, T., 2016/06/07, In: Frontiers in Cell and Developmental Biology. 4, JUN, 54.Research output: Contribution to journal › Article › peer-review
Open Access11 Scopus citations -
2015
Comparing the effects of kamikihito in Japan and Kami-Guibi-Tang in Korea on memory enhancement: Working towards the development of a global study
Watari, H., Shigyo, M., Tanabe, N., Tohda, M., Cho, K. H., Kyung, P. S., Jung, W. S., Shimada, Y., Shibahara, N., Kuboyama, T. & Tohda, C., 2015/03, In: Phytotherapy Research. 29, 3, p. 351-356 6 p.Research output: Contribution to journal › Article › peer-review
5 Scopus citations -
Herbal plant-derived compound, 1,2,3,4,6-penta-O-galloyl-β-d-glucose, increases cross-presentation by dendritic cells
Inujima, A., Yamada, M., Takeno, N., Hoshina, A., Oe, M., Shinohara, K., Shibahara, N., Sakurai, H., Saiki, I. & Koizumi, K., 2015/09, In: Traditional & Kampo Medicine. 2, 2, p. 43-49 7 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Immune adjuvant effect of juzentaihoto, a Japanese traditional herbal medicine, on tumor vaccine therapy in a mouse model
Takeno, N., Inujima, A., Shinohara, K., Yamada, M., Shibahara, N., Sakurai, H., Saiki, I. & Koizumi, K., 2015/12, In: International Journal of Oncology. 47, 6, p. 2115-2122 8 p.Research output: Contribution to journal › Article › peer-review
Open Access15 Scopus citations -
Inhibitory effect of Moutan Cortex aqueous fraction on mast cell-mediated allergic inflammation
Kee, J. Y., Inujima, A., Andoh, T., Tanaka, K., Li, F., Kuraishi, Y., Sakurai, H., Shibahara, N., Saiki, I. & Koizumi, K., 2015/04, In: Natural Medicines. 69, 2, p. 209-217 9 p.Research output: Contribution to journal › Article › peer-review
17 Scopus citations -
Role of chemokine CX3CL1 in progression of multiple myeloma via CX3CR1 in bone microenvironments
Wada, A., Ito, A., Iitsuka, H., Tsuneyama, K., Miyazono, T., Murakami, J., Shibahara, N., Sakurai, H., Saiki, I., Nakayama, T., Yoshie, O., Koizumi, K. & Sugiyama, T., 2015/06/01, In: Oncology Reports. 33, 6, p. 2935-2939 5 p.Research output: Contribution to journal › Article › peer-review
Open Access20 Scopus citations -
2014
CXCL16 suppresses liver metastasis of colorectal cancer by promoting TNF-α-induced apoptosis by tumor-associated macrophages
Kee, J. Y., Ito, A., Hojo, S., Hashimoto, I., Igarashi, Y., Tsuneyama, K., Tsukada, K., Irimura, T., Shibahara, N., Takasaki, I., Inujima, A., Nakayama, T., Yoshie, O., Sakurai, H., Saiki, I. & Koizumi, K., 2014/12/15, In: BMC Cancer. 14, 1, 949.Research output: Contribution to journal › Article › peer-review
Open Access46 Scopus citations -
2013
Chemokine CXCL16 suppresses liver metastasis of colorectal cancer via augmentation of tumor-infiltrating natural killer T cells in a murine model
Kee, J. Y., Ito, A., Hojo, S., Hashimoto, I., Igarashi, Y., Tsukada, K., Irimura, T., Shibahara, N., Nakayama, T., Yoshie, O., Sakurai, H., Saiki, I. & Koizumi, K., 2013/03, In: Oncology Reports. 29, 3, p. 975-982 8 p.Research output: Contribution to journal › Article › peer-review
Open Access41 Scopus citations -
Effect of goreisan on urinary concentrating ability and expression of aquaporin-2 in 5/6 nephrectomized rats
Jo, M., Fujimoto, T., Kaneko, M., Oka, H. & Shibahara, N., 2013, In: Journal of Traditional Medicines. 30, 4, p. 145-157 13 p.Research output: Contribution to journal › Article › peer-review
11 Scopus citations -
The long-term effects of a Kampo medicine, juzentaihoto, on maintenance of antibody titer in elderly people after influenza vaccination
Saiki, I., Koizumi, K., Goto, H., Inujima, A., Namiki, T., Raimura, M., Kogure, T., Tatsumi, T., Inoue, H., Sakai, S., Oka, H., Fujimoto, M., Hikiami, H., Sakurai, H., Shibahara, N., Shimada, Y. & Origasa, H., 2013, In: Evidence-based Complementary and Alternative Medicine. 2013, 568074.Research output: Contribution to journal › Article › peer-review
Open Access18 Scopus citations -
2012
Calpain 1 and -2 play opposite roles in cord formation of lymphatic endothelial cells via eNOS regulation
Prangsaengtong, O., Senda, K., Doki, Y., Park, J. Y., Jo, M., Sakurai, H., Shibahara, N., Saiki, I. & Koizumi, K., 2012/06, In: Human cell : official journal of Human Cell Research Society. 25, 2, p. 36-44 9 p.Research output: Contribution to journal › Article › peer-review
9 Scopus citations -
Effect of keishibukuryogan on endothelial function in patients with at least one component of the diagnostic criteria for metabolic syndrome: A controlled clinical trial with crossover design
Nagata, Y., Goto, H., Hikiami, H., Nogami, T., Fujimoto, M., Shibahara, N. & Shimada, Y., 2012, In: Evidence-based Complementary and Alternative Medicine. 2012, 359282.Research output: Contribution to journal › Article › peer-review
Open Access24 Scopus citations -
Synthesis and evaluation of 1-(substituted)-3-prop-2-ynylureas as antiangiogenic agents
Sanphanya, K., Wattanapitayakul, S. K., Prangsaengtong, O., Jo, M., Koizumi, K., Shibahara, N., Priprem, A., Fokin, V. V. & Vajragupta, O., 2012/04/15, In: Bioorganic and Medicinal Chemistry Letters. 22, 8, p. 3001-3005 5 p.Research output: Contribution to journal › Article › peer-review
12 Scopus citations -
2011
Ameliorative effects of yokukansan on learning and memory deficits in olfactory bulbectomized mice
Yamada, M., Hayashida, M., Zhao, Q., Shibahara, N., Tanaka, K., Miyata, T. & Matsumoto, K., 2011/06/01, In: Journal of Ethnopharmacology. 135, 3, p. 737-746 10 p.Research output: Contribution to journal › Article › peer-review
52 Scopus citations -
Cinnamaldehyde and paeonol increase HIF-1α Activity in proximal tubular epithelial cells under hypoxia
Oka, H., Goto, H., Nogami, T., Watari, H., Shimada, Y., Koizumi, K., Shibahara, N., Nakamura, S., Zhou, Y., Sakurai, H. & Saiki, I., 2011, In: Journal of Traditional Medicines. 28, 3, p. 149-157 9 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Effect of hachimijiogan against renal dysfunction and involvement of hypoxia-inducible factor-1 in the remnant kidney model
Goto, H., Oka, H., Koizumi, K., Nakamura, S., Tsuneyama, K., Zhou, Y., Jo, M., Fujimoto, T., Sakurai, H., Shibahara, N., Saiki, I. & Shimada, Y., 2011, In: Evidence-based Complementary and Alternative Medicine. 2011, 348686.Research output: Contribution to journal › Article › peer-review
Open Access10 Scopus citations -
Keishibukuryogan reduces renal injury in the early stage of renal failure in the remnant kidney model
Nakagawa, T., Tashiro, I., Fujimoto, M., Jo, M., Sakai, S., Oka, H., Goto, H., Shimada, Y. & Shibahara, N., 2011, In: Evidence-based Complementary and Alternative Medicine. 2011, 914249.Research output: Contribution to journal › Article › peer-review
Open Access10 Scopus citations -
Traditional Japanese formula kigikenchuto accelerates healing of pressure-loading skin ulcer in rats
Hikiami, H., Kimura, M., Shibahara, N., Yoshida, T., Jo, M., Kaneko, M., Nogami, T., Fujimoto, M., Goto, H. & Shimada, Y., 2011, In: Evidence-based Complementary and Alternative Medicine. 2011, 592791.Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations -
2009
Therapeutic effect of kakkonto in a mouse model of food allergy with gastrointestinal symptoms
Yamamoto, T., Fujiwara, K., Yoshida, M., Kageyama-Yahara, N., Kuramoto, H., Shibahara, N. & Kadowaki, M., 2009/02, In: International Archives of Allergy and Immunology. 148, 3, p. 175-185 11 p.Research output: Contribution to journal › Article › peer-review
45 Scopus citations -
2008
Keishibukuryogan ameliorates glucose intolerance and hyperlipidemia in Otsuka Long-Evans Tokushima Fatty (OLETF) rats
Nakagawa, T., Goto, H., Hussein, G., Hikiami, H., Shibahara, N. & Shimada, Y., 2008/04, In: Diabetes Research and Clinical Practice. 80, 1, p. 40-47 8 p.Research output: Contribution to journal › Article › peer-review
12 Scopus citations -
2007
Effects of keishibukuryogan on vascular function in adjuvant-induced arthritis rats
Nozaki, K., Goto, H., Nakagawa, T., Hikiami, H., Koizumi, K., Shibahara, N. & Shimada, Y., 2007/06, In: Biological and Pharmaceutical Bulletin. 30, 6, p. 1042-1047 6 p.Research output: Contribution to journal › Article › peer-review
Open Access18 Scopus citations -
Protective effects of keishibukuryogan on the kidney of spontaneously diabetic WBN/Kob rats
Nakagawa, T., Goto, H., Hikiami, H., Yokozawa, T., Shibahara, N. & Shimada, Y., 2007/03/21, In: Journal of Ethnopharmacology. 110, 2, p. 311-317 7 p.Research output: Contribution to journal › Article › peer-review
29 Scopus citations -
2006
Cinnamaldehyde induces endothelium-dependent and -independent vasorelaxant action on isolated rat aorta
Yanaga, A., Goto, H., Nakagawa, T., Hikiami, H., Shibahara, N. & Shimada, Y., 2006/12, In: Biological and Pharmaceutical Bulletin. 29, 12, p. 2415-2418 4 p.Research output: Contribution to journal › Article › peer-review
Open Access88 Scopus citations -
Keishibukuryogan (Gui-Zhi-Fu-Ling-Wan), a Kampo formula, decreases disease activity and soluble vascular adhesion molecule-1 in patients with rheumatoid arthritis
Nozaki, K., Hikiami, H., Goto, H., Nakagawa, T., Shibahara, N. & Shimada, Y., 2006/09, In: Evidence-based Complementary and Alternative Medicine. 3, 3, p. 359-364 6 p.Research output: Contribution to journal › Article › peer-review
Open Access37 Scopus citations -
2005
Effect of curcuma herbs on vasomotion and hemorheology in spontaneously hypertensive rat
Goto, H., Sasaki, Y., Fushimi, H., Shibahara, N., Shimada, Y. & Komatsu, K., 2005, In: American Journal of Chinese Medicine. 33, 3, p. 449-457 9 p.Research output: Contribution to journal › Article › peer-review
23 Scopus citations -
Effects of two formulations for overcoming oketsu on vascular function and expression patterns of plasma proteins in spontaneously diabetic rats
Goto, H., Kiga, C., Nakagawa, T., Koizumi, K., Sakurai, H., Shibagaki, Y., Ogawa, K., Shibahara, N., Shimada, Y. & Saiki, I., 2005, In: Journal of Traditional Medicines. 22, 4, p. 237-243 7 p.Research output: Contribution to journal › Article › peer-review
4 Scopus citations -
Long-term treatment with Hachimi-jio-gan attenuates kidney damage in spontaneously diabetic WBN/Kob rats
Nakagawa, T., Yokozawa, T., Yamabe, N., Rhyn, D. Y., Goto, H., Shimada, Y. & Shibahara, N., 2005/09, In: Journal of Pharmacy and Pharmacology. 57, 9, p. 1205-1212 8 p.Research output: Contribution to journal › Article › peer-review
21 Scopus citations -
Oren-gedoku-to and Keishi-bukuryo-gan-ryo inhibit the progression of atherosclerosis in diet-induced hypercholesterolemic rabbits
Sekiya, N., Kainuma, M., Hikiami, H., Nakagawa, T., Kouta, K., Shibahara, N., Shimada, Y. & Terasawa, K., 2005/02, In: Biological and Pharmaceutical Bulletin. 28, 2, p. 294-298 5 p.Research output: Contribution to journal › Article › peer-review
Open Access52 Scopus citations -
Protective effects of γ-aminobutyric acid in rats with streptozotocin-induced diabetes
Nakagawa, T., Yokozawa, T., Kim, H. J. & Shibahara, N., 2005/08, In: Journal of Nutritional Science and Vitaminology. 51, 4, p. 278-282 5 p.Research output: Contribution to journal › Article › peer-review
Open Access27 Scopus citations -
Quantitative analysis of Chinese crude drug, “Shigao (Gypsum)” extract by atomic absorption spectrometry
Fushimi, H., Oda, S., Itoh, T., Shibahara, N., Kita, T., Komatsu, K. & Terasawa, K., 2005, In: Journal of Traditional Medicines. 22, 1, p. 24-28 5 p.Research output: Contribution to journal › Article › peer-review
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2003
Inhibitory effects of Oren-gedoku-to (Huanglian-Jie-Du-Tang) on free radical-induced lysis of human red blood cells
Sekiya, N., Shibahara, N., Sakakibara, I., Hattori, N., Goto, H. & Terasawa, K., 2003/02, In: Phytotherapy Research. 17, 2, p. 147-151 5 p.Research output: Contribution to journal › Article › peer-review
Open Access15 Scopus citations