Does the structure of transthyretin amyloid fibrils vary depending on the organ of accumulation?

Mineyuki Mizuguchi

doi:10.1016/j.str.2024.11.002

Does the structure of transthyretin amyloid fibrils vary depending on the organ of accumulation?

Mineyuki Mizuguchi^*

^*Corresponding author for this work

Structural Biology

Research output: Contribution to journal › Comment/debate

Abstract

In this issue of Structure, Nguyen et al.¹ reveal that amyloid fibrils of the transthyretin (TTR) V30M variant from the heart and nerves of the same patient exhibit structural homogeneity. This finding is crucial for advancing our understanding of V30M-TTR amyloid deposition, which leads to fatal ATTRv amyloidosis.

Original language	English
Pages (from-to)	2181-2182
Number of pages	2
Journal	Structure
Volume	32
Issue number	12
DOIs	https://doi.org/10.1016/j.str.2024.11.002
State	Published - 2024/12/05

ASJC Scopus subject areas

Structural Biology
Molecular Biology

Access to Document

10.1016/j.str.2024.11.002

Cite this

@article{51d1c8333dc94d538071fb50f16f6c1c,

title = "Does the structure of transthyretin amyloid fibrils vary depending on the organ of accumulation?",

abstract = "In this issue of Structure, Nguyen et al.1 reveal that amyloid fibrils of the transthyretin (TTR) V30M variant from the heart and nerves of the same patient exhibit structural homogeneity. This finding is crucial for advancing our understanding of V30M-TTR amyloid deposition, which leads to fatal ATTRv amyloidosis.",

author = "Mineyuki Mizuguchi",

note = "Publisher Copyright: {\textcopyright} 2024 Elsevier Inc.",

year = "2024",

month = dec,

day = "5",

doi = "10.1016/j.str.2024.11.002",

language = "英語",

volume = "32",

pages = "2181--2182",

journal = "Structure",

issn = "0969-2126",