Research output per year
Research output per year
- 1 - 50 out of 136 results
Search results
-
2025
C-2 fluorinated castanospermines as potent and specific α-glucosidase inhibitors: synthesis and structure-activity relationship study
Li, Y.-X., Zhang, M., Shimadate, Y., Kato, A., Wang, J.-Z., Jia, Y.-M., Fleet, G. W. J. & Yu, C.-Y., 2025/03/19, In: Organic and Biomolecular Chemistry. 23, 12, p. 2854-2877 24 p.Research output: Contribution to journal › Article › peer-review
-
Enantiomeric C-6 fluorinated swainsonine derivatives as highly selective and potent inhibitors of α-mannosidase and α-L-rhamnosidase: Design, synthesis and structure-activity relationship study
Gao, F.-T., Zhang, M., Shimadate, Y., Kato, A., Li, Y.-X., Jia, Y.-M. & Yu, C.-Y., 2025/01/01, In: European Journal of Medicinal Chemistry. 282, p. 117031Research output: Contribution to journal › Article › peer-review
-
2024
Design and synthesis of 6-C-alkyl-DMDP type nanomolar inhibitors of β-galactosidase and β-glucosidase based on broussonetine S and related derivatives
Gao, F.-T., Wu, Q.-K., Zhang, M., Shimadate, Y., Qian, G., Song, Y.-Y., Kato, A., Li, Y.-X., Jia, Y.-M., Fleet, G. W. J. & Yu, C.-Y., 2024/06/06, (E-pub ahead of print) In: European Journal of Medicinal Chemistry. 275, p. 116570Research output: Contribution to journal › Article › peer-review
-
Synthesis of 8-epi-L-swainsonine, related C6 alkylated derivatives and their α-L-rhamnosidase inhibition
Shimadate, Y., Oshima, S., Kasamatsu, N., Yamamoto, S., Taguchi, A., Nash, R. J., Fleet, G. W. J., Okada, T., Toyooka, N. & Kato, A., 2024/03/01, In: Tetrahedron Letters. p. 155008Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Thioarylation of 6-Amino-2,3,6-trideoxy-d-manno-oct-2-ulosonic Acid (IminoKdo): Access to 3,6-Disubstituted Picolinates and Mechanistic Insights
Manmode, S., Hussain, N., Marin, O. J. G., Kato, A., Veytia-Bucheli, J. I., Vincent, S. P. & Gauthier, C., 2024/02/26, In: Chemistry - A European Journal. 30, 12, p. e202303904Research output: Contribution to journal › Article › peer-review
-
2023
Design and pharmacological chaperone effects of N-(4'-phenylbutyl)-DAB derivatives targeting the lipophilic pocket of lysosomal acid α-glucosidase
Kato, A., Nakagome, I., Kise, M., Yoshimura, K., Tanaka, N., Nash, R. J., Fleet, G. W. J., Kobayashi, Y., Ikeda, H., Okada, T. & Toyooka, N., 2023/07/13, In: Journal of Medicinal Chemistry. 66, 13, p. 9023-9039 17 p.Research output: Contribution to journal › Article › peer-review
5 Scopus citations -
Design and synthesis of iso-allo-DNJ and L-isoDALDP derivatives: pursuit of potent and selective inhibitors of α-glucosidase
Yang, L.-F., Zhang, M., Shimadate, Y., Kato, A., Hou, T.-Y. L., Li, Y.-X., Jia, Y.-M., Fleet, G. W. J. & Yu, C.-Y., 2023/04/26, In: Organic and Biomolecular Chemistry. 21, 16, p. 3453-3464 12 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Evaluation of nonnatural L-iminosugar C,C-glycosides, a new class of C-branched iminosugars, as glycosidase inhibitors
Désiré, J., Debbah, Z., Gueyrard, D., Marrot, J., Blériot, Y. & Kato, A., 2023/07/25, (E-pub ahead of print) In: Carbohydrate Research. 532, p. 108903Research output: Contribution to journal › Article › peer-review
5 Scopus citations -
Nanomolar β-glucosidase and β-galactosidase inhibition by enantiomeric α-1-C-alkyl-1,4-dideoxy-1,4-imino-arabinitol derivatives
Zi, D., Song, Y. Y., Lu, T. T., Kise, M., Kato, A., Wang, J. Z., Jia, Y. M., Li, Y. X., Fleet, G. W. J. & Yu, C. Y., 2023/02/05, In: European Journal of Medicinal Chemistry. 247, 115056.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
Synthesis of the purported structure of glyphaeaside C and proposed revisions to the structures of the glyphaeaside alkaloids
Byatt, B. J., Kato, A. & Pyne, S. G., 2023/05/26, In: Journal of Natural Products. 86, 5, p. 1261-1273 13 p.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
2022
5-C-Branched Deoxynojirimycin: Strategy for Designing a 1-Deoxynojirimycin-Based Pharmacological Chaperone with a Nanomolar Affinity for Pompe Disease
Translated title of the contribution :5-C-Branched Deoxynojirimycin: Strategy for Designing a 1-Deoxynojirimycin-Based Pharmacological Chaperone with a Nanomolar Affinity for Pompe Disease Research output: Contribution to journal › Article › peer-review
12 Scopus citations -
Borylated 2,3,4,5-Tetrachlorophthalimide and Their 2,3,4,5-Tetrachlorobenzamide Analogues: Synthesis, Their Glycosidase Inhibition and Anticancer Properties in View to Boron Neutron Capture Therapy
Campkin, D. M., Shimadate, Y., Bartholomew, B., Bernhardt, P. V., Nash, R. J., Sakoff, J. A., Kato, A. & Simone, M. I., 2022/06/01, In: Molecules. 27, 11, 3447.Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations -
C-6 fluorinated casuarines as highly potent and selective amyloglucosidase inhibitors: Synthesis and structure-activity relationship study
Li, Y.-X., Wang, J.-Z., Shimadate, Y., Kise, M., Kato, A., Jia, Y.-M., Fleet, G. W. J. & Yu, C.-Y., 2022/12/15, In: European Journal of Medicinal Chemistry. 244, p. 114852Research output: Contribution to journal › Article › peer-review
4 Scopus citations -
Design, synthesis and glycosidase inhibition of C-4 branched LAB and DAB derivatives
Translated title of the contribution :Design, synthesis and glycosidase inhibition of C-4 branched LAB and DAB derivatives Research output: Contribution to journal › Article › peer-review
6 Scopus citations -
Diastereoselective Synthesis, Glycosidase Inhibition, and Docking Study of C-7-Fluorinated Casuarine and Australine Derivatives
Translated title of the contribution :Diastereoselective Synthesis, Glycosidase Inhibition, and Docking Study of C-7-Fluorinated Casuarine and Australine Derivatives Research output: Contribution to journal › Article
9 Scopus citations -
Divergent synthesis of decahydroquinoline-type poison-frog alkaloids.
Translated title of the contribution :Divergent synthesis of decahydroquinoline-type poison-frog alkaloids. Research output: Contribution to journal › Article › peer-review
5 Scopus citations -
Structural variation of the 3-acetamido-4,5,6-trihydroxyazepane iminosugar through epimerization and C-alkylation leads to low micromolar HexAB and NagZ inhibitors
Translated title of the contribution :Structural variation of the 3-acetamido-4,5,6-trihydroxyazepane iminosugar through epimerization and C-alkylation leads to low micromolar HexAB and NagZ inhibitors Research output: Contribution to journal › Article
4 Scopus citations -
Synthesis, conformational analysis and glycosidase inhibition of bicyclic nojirimycin C-glycosides based on an octahydrofuro[3,2-b]pyridine motif
Désiré, J., Foucart, Q., Poveda, A., Gourlaouen, G., Shimadate, Y., Kise, M., Proceviat, C., Ashmus, R., Vocadlo, D. J., Jiménez-Barbero, J., Kato, A. & Blériot, Y., 2022/01, In: Carbohydrate Research. 511, 108491.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
trans, trans-2-C-Aryl-3,4-dihydroxypyrrolidines as potent and selective β-glucosidase inhibitors: Pharmacological chaperones for Gaucher disease
Wang, J. Z., Shimadate, Y., Kise, M., Kato, A., Jia, Y. M., Li, Y. X., Fleet, G. W. J. & Yu, C. Y., 2022/08/05, In: European Journal of Medicinal Chemistry. 238, 114499.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
2021
Azobenzene derivatives show anti-cancer activity against pancreatic cancer cells only under nutrient starvation conditions via G0/G1 cell cycle arrest
Shinzawa, K., Kageta, D., Nash, R. J., Fleet, G. W. J., Imahori, T. & Kato, A., 2021/04/09, In: Tetrahedron. 85, 132077.Research output: Contribution to journal › Article › peer-review
5 Scopus citations -
Iminosugar C-Glycosides Work as Pharmacological Chaperones of NAGLU, a Glycosidase Involved in MPS IIIB Rare Disease**
Zhu, S., Jagadeesh, Y., Tran, A. T., Imaeda, S., Boraston, A., Alonzi, D. S., Poveda, A., Zhang, Y., Désiré, J., Charollais-Thoenig, J., Demotz, S., Kato, A., Butters, T. D., Jiménez-Barbero, J., Sollogoub, M. & Blériot, Y., 2021/08/05, In: Chemistry - A European Journal. 27, 44, p. 11291-11297 7 p.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
Synthesis and chelation study of a fluoroionophore and a glycopeptide based on an aza crown iminosugar structure
Bordes, A., Poveda, A., Fontelle, N., Ardá, A., Guillard, J., Ruan, Y. B., Marrot, J., Imaeda, S., Kato, A., Désiré, J., Xie, J., Jiménez-Barbero, J. & Blériot, Y., 2021/03, In: Carbohydrate Research. 501, 108258.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Synthesis and glycosidase inhibition of 5-C-alkyl-DNJ and 5-C-alkyl-L-ido-DNJ derivatives
Lu, T. T., Shimadate, Y., Cheng, B., Kanekiyo, U., Kato, A., Wang, J. Z., Li, Y. X., Jia, Y. M., Fleet, G. W. J. & Yu, C. Y., 2021/11/15, In: European Journal of Medicinal Chemistry. 224, 113716.Research output: Contribution to journal › Article › peer-review
Open Access15 Scopus citations -
2020
A divergent entry to 1,2,3,9-tetrahydroxyquinolizidines
Okada, T., Ozaki, T., Kato, A., Adachi, I. & Toyooka, N., 2020/06/18, In: Tetrahedron Letters. 61, 25, 152030.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Hanessian-Hullar reaction in the synthesis of highly substituted trans-3,4-dihydroxypyrrolidines: Rhamnulose iminosugar mimics inhibit α-glucosidase
Liu, Z., Yoshihara, A., Jenkinson, S. F., Wormald, M. R., Kelly, C., Heap, J. T., Marqvorsen, M. H. S., Estévez, R. J., Fleet, G. W. J., Nakagawa, S., Izumori, K., Nash, R. J. & Kato, A., 2020/01/03, In: Tetrahedron. 76, 1, 130758.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Synthesis of multimeric pyrrolidine iminosugar inhibitors of human β-glucocerebrosidase and α-galactosidase A: First example of a multivalent enzyme activity enhancer for Fabry disease
Martínez-Bailén, M., Carmona, A. T., Cardona, F., Matassini, C., Goti, A., Kubo, M., Kato, A., Robina, I. & Moreno-Vargas, A. J., 2020/04/15, In: European Journal of Medicinal Chemistry. 192, 112173.Research output: Contribution to journal › Article › peer-review
16 Scopus citations -
2019
Catalytic asymmetric synthesis of stereoisomers of 1-C-n-butyl-LABs for the SAR study of α-glucosidase inhibition
Natori, Y., Sakuma, T., Watanabe, H., Wakamatsu, H., Kato, A., Adachi, I., Takahata, H. & Yoshimura, Y., 2019/05/17, In: Tetrahedron. 75, 20, p. 2866-2876 11 p.Research output: Contribution to journal › Article › peer-review
4 Scopus citations -
Chain-Branched polyhydroxylated Octahydro-1H-Indoles as potential leads against lysosomal storage diseases
Estévez, J. C., González, M. A., Carmen Villaverde, M., Hirokami, Y., Kato, A., Sussman, F., Reza, D. & Estévez, R. J., 2019/06, In: Pharmaceuticals. 12, 2, 47.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Characterizing the selectivity of ER α-glucosidase inhibitors
O'Keefe, S., Roebuck, Q. P., Nakagome, I., Hirono, S., Kato, A., Nash, R. & High, S., 2019/07/01, In: Glycobiology. 29, 7, p. 530-542 13 p.Research output: Contribution to journal › Article › peer-review
Open Access18 Scopus citations -
Corrected structure of natural hyacinthacine c1 via total synthesis
Carroll, A. W., Willis, A. C., Hoshino, M., Kato, A. & Pyne, S. G., 2019/02/22, In: Journal of Natural Products. 82, 2, p. 358-367 10 p.Research output: Contribution to journal › Article › peer-review
10 Scopus citations -
Exploring substituent diversity on pyrrolidine-aryltriazole iminosugars: Structural basis of β-glucocerebrosidase inhibition
Martínez-Bailén, M., Carmona, A. T., Patterson-Orazem, A. C., Lieberman, R. L., Ide, D., Kubo, M., Kato, A., Robina, I. & Moreno-Vargas, A. J., 2019/05, In: Bioorganic Chemistry. 86, p. 652-664 13 p.Research output: Contribution to journal › Article › peer-review
18 Scopus citations -
Ginnalin B induces differentiation markers and modulates the proliferation/differentiation balance via the upregulation of NOTCH1 in human epidermal keratinocytes
Kato, A., Koyama, J., Shinzawa, K., Imaeda, S., Adachi, I., Nash, R. J., Fleet, G. W. J., Shintani, M., Takeuchi, C. & Ishikawa, F., 2019/06/01, In: Bioorganic and Medicinal Chemistry. 27, 11, p. 2172-2180 9 p.Research output: Contribution to journal › Article › peer-review
7 Scopus citations -
Isolation from Stevia rebaudiana of DMDP acetic acid, a novel iminosugar amino acid: synthesis and glycosidase inhibition profile of glycine and β-alanine pyrrolidine amino acids
Martínez, R. F., Jenkinson, S. F., Nakagawa, S., Kato, A., Wormald, M. R., Fleet, G. W. J., Hollinshead, J. & Nash, R. J., 2019/07/01, In: Amino Acids. 51, 7, p. 991-998 8 p.Research output: Contribution to journal › Article › peer-review
Open Access9 Scopus citations -
Synthesis and glycosidase inhibition of broussonetine M and its analogues
Wu, Q. K., Kinami, K., Kato, A., Li, Y. X., Jia, Y. M., Fleet, G. W. J. & Yu, C. Y., 2019/10/15, In: Molecules. 24, 20, 3712.Research output: Contribution to journal › Article › peer-review
Open Access12 Scopus citations -
Synthesis and glycosidase inhibition of conformationally locked DNJ and DMJ derivatives exploiting a 2-oxo-C -allyl iminosugar
Foucart, Q., Shimadate, Y., Marrot, J., Kato, A., Désiré, J. & Blériot, Y., 2019, In: Organic and Biomolecular Chemistry. 17, 30, p. 7204-7214 11 p.Research output: Contribution to journal › Article › peer-review
8 Scopus citations -
2018
2-Acetamido-2-deoxy-l-iminosugar C-Alkyl and C-Aryl Glycosides: Synthesis and Glycosidase Inhibition
Fontelle, N., Yamamoto, A., Arda, A., Jiménez-Barbero, J., Kato, A., Désiré, J. & Blériot, Y., 2018/11/01, In: European Journal of Organic Chemistry. 2018, 40, p. 5477-5488 12 p.Research output: Contribution to journal › Article › peer-review
Open Access10 Scopus citations -
Biological activities of 3,4,5-trihydroxypiperidines and their N- and O-derivatives
Prichard, K., Campkin, D., O'Brien, N., Kato, A., Fleet, G. W. J. & Simone, M. I., 2018/07, In: Chemical Biology and Drug Design. 92, 1, p. 1171-1197 27 p.Research output: Contribution to journal › Review article › peer-review
32 Scopus citations -
Design and synthesis of N–acetylglucosamine derived 5a-carbasugar analogues as glycosidase inhibitors
Narayana, C., Kumari, P., Ide, D., Hoshino, N., Kato, A. & Sagar, R., 2018/04/12, In: Tetrahedron. 74, 15, p. 1957-1964 8 p.Research output: Contribution to journal › Article › peer-review
10 Scopus citations -
Design of a new α-1-c-Alkyl-dab derivative acting as a pharmacological chaperone for β-glucocerebrosidase using ligand docking and molecular dynamics simulation
Nakagome, I., Kato, A., Yamaotsu, N., Yoshida, T., Ozawa, S. I., Adachi, I. & Hirono, S. S., 2018/10/18, In: Molecules. 23, 10, 2683.Research output: Contribution to journal › Article › peer-review
Open Access11 Scopus citations -
Discovery of a Potent α-Galactosidase Inhibitor by in Situ Analysis of a Library of Pyrrolizidine-(Thio)urea Hybrid Molecules Generated via Click Chemistry
Elías-Rodríguez, P., Pingitore, V., Carmona, A. T., Moreno-Vargas, A. J., Ide, D., Miyawaki, S., Kato, A., Álvarez, E. & Robina, I., 2018/08/17, In: Journal of Organic Chemistry. 83, 16, p. 8863-8873 11 p.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
Divergent synthesis of new α-glucosidase inhibitors obtained through a vinyl Grignard-mediated carbocyclisation
Knudsen, I. M. B., Hedberg, C., Ladefoged, L. K., Ide, D., Brinkø, A., Eikeland, E. Z., Kato, A. & Jensen, H. H., 2018, In: Organic and Biomolecular Chemistry. 16, 34, p. 6250-6261 12 p.Research output: Contribution to journal › Article › peer-review
5 Scopus citations -
Synthetic Routes to 3,4,5-Trihydroxypiperidines via Stereoselective and Biocatalysed Protocols, and Strategies to N- and O-Derivatisation
Prichard, K. L., O'Brien, N., Ghorbani, M., Wood, A., Barnes, E., Kato, A., Houston, T. A. & Simone, M. I., 2018/12/31, In: European Journal of Organic Chemistry. 2018, 48, p. 6830-6842 13 p.Research output: Contribution to journal › Review article › peer-review
9 Scopus citations -
Total Synthesis of Natural Hyacinthacine C5 and Six Related Hyacinthacine C5 Epimers
Carroll, A. W., Savaspun, K., Willis, A. C., Hoshino, M., Kato, A. & Pyne, S. G., 2018/05/18, In: Journal of Organic Chemistry. 83, 10, p. 5558-5576 19 p.Research output: Contribution to journal › Article › peer-review
26 Scopus citations -
2017
Discovery of hyaluronidase inhibitors from natural products and their mechanistic characterization under DMSO-perturbed assay conditions
Tomohara, K., Ito, T., Onikata, S., Kato, A. & Adachi, I., 2017, In: Bioorganic and Medicinal Chemistry Letters. 27, 7, p. 1620-1623 4 p.Research output: Contribution to journal › Article › peer-review
14 Scopus citations -
In silico analyses of essential interactions of iminosugars with the Hex A active site and evaluation of their pharmacological chaperone effects for Tay-Sachs disease
Kato, A., Nakagome, I., Nakagawa, S., Kinami, K., Adachi, I., Jenkinson, S. F., Désiré, J., Blériot, Y., Nash, R. J., Fleet, G. W. J. & Hirono, S., 2017, In: Organic and Biomolecular Chemistry. 15, 44, p. 9297-9304 8 p.Research output: Contribution to journal › Article › peer-review
21 Scopus citations -
Multiple production of α,α-disubstituted amino acid derivatives through direct chemical derivatization of natural plant extracts: An apparently difficult but successful route
Tomohara, K., Ito, T., Furusawa, K., Hasegawa, N., Tsuge, K., Kato, A. & Adachi, I., 2017, In: Tetrahedron Letters. 58, 32, p. 3143-3147 5 p.Research output: Contribution to journal › Article › peer-review
11 Scopus citations -
Multivalency To Inhibit and Discriminate Hexosaminidases
Alvarez-Dorta, D., King, D. T., Legigan, T., Ide, D., Adachi, I., Deniaud, D., Désiré, J., Kato, A., Vocadlo, D., Gouin, S. G. & Blériot, Y., 2017/07/06, In: Chemistry - A European Journal. 23, 38, p. 9022-9025 4 p.Research output: Contribution to journal › Article › peer-review
Open Access30 Scopus citations -
Selective trihydroxylated azepane inhibitors of NagZ, a glycosidase involved in Pseudomonas aeruginosa resistance to β-lactam antibiotics
Bouquet, J., King, D. T., Vadlamani, G., Benzie, G. R., Iorga, B., Ide, D., Adachi, I., Kato, A., Vocadlo, D. J., Mark, B. L., Blériot, Y. & Désiré, J., 2017, In: Organic and Biomolecular Chemistry. 15, 21, p. 4609-4619 11 p.Research output: Contribution to journal › Article › peer-review
Open Access11 Scopus citations -
Strategy for designing selective α-L-rhamnosidase inhibitors: Synthesis and biological evaluation of L-DMDP cyclic isothioureas
Miyawaki, S., Hirokami, Y., Kinami, K., Hoshino, M., Minehira, D., Miyamoto, D., Nash, R. J., Fleet, G. W. J., Adachi, I., Toyooka, N. & Kato, A., 2017, In: Bioorganic and Medicinal Chemistry. 25, 1, p. 107-115 9 p.Research output: Contribution to journal › Article › peer-review
9 Scopus citations -
Synthesis and characterization of novel, conjugated, fluorescent DNJ derivatives for α-glucosidase recognition
Hatano, A., Kanno, Y., Kondo, Y., Sunaga, Y., Umezawa, H., Okada, M., Yamada, H., Iwaki, R., Kato, A. & Fukui, K., 2017, In: Bioorganic and Medicinal Chemistry. 25, 2, p. 773-778 6 p.Research output: Contribution to journal › Article › peer-review
16 Scopus citations