Faculty of Pharmaceutical Sciences

Projects

Projects per year 1996 2012 2013 2014 2015 2016 2018 2019 2020 2021 2022 2023 2024 2025 2029

• 80 Active
• 304 Finished

Projects per year

Search results

• Involvement of hypothalamic orexin in the development of insulin resistance associated with depression

  Tsuneki, H. (PI) & Sasaoka, T. (CoI)

  2009/04/01 → 2012/03/31

  Project: Research

  • Orexin 100%
  • Insulin Resistance 100%
  • Non Insulin Dependent Diabetes Mellitus 66%
  • Mouse Model of Depression 50%
  • Depressive Symptoms 50%

• In vivo patch-clamp analysis of itch transmission in central nerve system

  Uta, D. (PI)

  2013/04/01 → 2015/03/31

  Project: Research

• Investigation of the immunological function of the NASH-inducing transplanted NKT, and drug discovery

  Koizumi, K. (PI)

  2013/04/01 → 2015/03/31

  Project: Research

• Investigation of pathogenic mechanisms and Kampo medicine-based preventive and therapeutic strategy for ADHD using an epigenetic animal model.

  Matsumoto, K. (PI), Awale, S. (CoI), 藤原, 博典 (CoI) & Hori, E. (CoI)

  2015/04/01 → 2018/03/31

  Project: Research

• Inhibition activities of iminosugars against glycoprotein processing

  Adachi, I. (PI), Takahata, H. (CoI) & Kato, A. (CoI)

  2010/04/01 → 2012/03/31

  Project: Research

  • Inhibition Activity 100%
  • Azetidine 100%
  • Glycoprotein 100%
  • Iminosugars 100%
  • Enantiomer 100%

• Influx transport system for nutrients and drugs at the blood-testis barrier and its application

  Kubo, Y. (Principal Investigator), Hosoya, K.-I. (Co-Investigator(Kenkyū-buntansha)) & Akanuma, S.-I. (Co-Investigator(Kenkyū-buntansha))

  Japan Society for the Promotion of Science

  2020/04/01 → 2024/03/31

  Project: Research Project

• Impact of the cooperative effect of estrogen and orexin on abnormalities with emotion and metabolism in menopausal mice

  Sasaoka, T. (PI), Wada, T. (CoI) & Tsuneki, H. (CoI)

  2015/04/01 → 2017/03/31

  Project: Research

• Impact of obesity-induced dysregulation of renin-angiotensin-aldosterone system in the hypothalamus on the homeostasis of energy metabolism.

  Wada, T. (PI)

  2010/04/01 → 2012/03/31

  Project: Research

  • Dysregulation 100%
  • Mineralocorticoid Receptor Antagonists 100%
  • Homeostasis 100%
  • Energy Metabolism 100%
  • Obesity 100%

• Identification of Scientific evidence for Traditional Kampo theory by gene expression analysis

  Saiki, I. (PI) & Yokoyama, S. (CoI)

  2015/04/01 → 2018/03/31

  Project: Research

• Identification of roles of PRMT8 with dual catalytic activity in the brain

  Kim, J. (PI)

  2018/04/01 → 2022/03/31

  Project: Research

• How do Kampo formulations work?

  Saiki, I. (PI) & Yokoyama, S. (CoI)

  2012/04/01 → 2015/03/31

  Project: Research

• Genomic analysis of Shati/Nat8l to protect use methamphetamine

  Nitta, A. (PI)

  2017/06/30 → 2019/03/31

  Project: Research

  • Shati 100%
  • Nucleus Accumbens 65%
  • N-Acetyltransferase 56%
  • Knock-in Mouse Model 55%
  • Conditioned Place Preference 53%

• I型アレルギー疾患の制御にむけたFDCによるIgA抗体の産生制御機構の基礎的研究

  Kuniishi, M. (Principal Investigator)

  Japan Society for the Promotion of Science

  2022/04/01 → 2025/03/31

  Project: Research Project

• Functional interactions between inflammatory signal and growth singaling in the Warburg effect in cancer cells

  Sakurai, H. (PI)

  2016/04/01 → 2018/03/31

  Project: Research

• Functional coupling between ion channels and scramblases in human TMEM16F-expressing cells

  Shimizu, T. (PI)

  2013/04/01 → 2016/03/31

  Project: Research

• Functional and structural analyses of organic cation transporter in the intestine.

  Hashimoto, Y. (PI)

  2015/04/01 → 2018/03/31

  Project: Research

• Functional Analysis of transcription factor SOX10 in melanoma for norvel therapeutics

  Yokoyama, S. (PI)

  2016/04/01 → 2018/03/31

  Project: Research

• Functional analysis of RPEL/Phactr variants: relationship between cell shape and nuclear information

  Tabuchi, A. (PI)

  2007/04/01 → 2009/03/31

  Project: Research

• Functional analysis of mutation and partial duplication of α7 nicotinic receptor subunit gene : implication in schizophrenia

  Tsuneki, H. (PI), Kurachi, M. (CoI) & Tsunoda, M. (CoI)

  2004/04/01 → 2007/03/31

  Project: Research

  • Partial Duplication 100%
  • Nicotinic Receptors 100%
  • Schizophrenia 100%
  • Functional Analysis 100%
  • Receptor Subunit 100%

• Investigation on naphthylisoquinoline alkaloids as potential antiausterity chemotherapy for pancreatic cancer

  Awale, S. (Principal Investigator) & Fujii, T. (Co-Investigator(Kenkyū-buntansha))

  Japan Society for the Promotion of Science

  2023/04/01 → 2028/03/31

  Project: Research Project

• Explore molecular basis underlying formation of chemical diversity in genus Panax through RNA-Seq analysis of three Panax species with different chemical compositions

  Zhu, S. (Principal Investigator)

  Japan Society for the Promotion of Science

  2014/04/01 → 2017/03/31

  Project: Research Project

• Exploratory Research for crude drugs having activated platelet-mediated inhibiting effect on diabetic microangiopathy

  Shibahara, N. (PI)

  2012/04/01 → 2015/03/31

  Project: Research

• Exploration of tumor-promoting inflammatory immune responses and its application for cancer treatment

  Hayakawa, Y. (PI)

  2014/04/01 → 2017/03/31

  Project: Research

• Experimental assessment of preventive effects of kampo medicines against metabolic syndromes through the modification of intestinal bile acid metabolism

  Watanabe, S. (PI)

  2018/04/01 → 2021/03/31

  Project: Research

• Evaluation of the importance of intracellular metabolism in individual differences in drug hypersensitivity using a mouse model of cutaneous adverse drug reaction

  Susukida, T. (PI)

  2021/04/01 → 2024/03/31

  Project: Research

• Evaluation of Cx43 proteins for PGE2 release from retinal pigment epithelial cells for understanding the pathological role in age-related macular degeneration.

  Hosoya, K.-I. (PI), Kubo, Y. (CoI), Sakai, H. (CoI) & Tachikawa, M. (CoPI)

  2016/04/01 → 2018/03/31

  Project: Research

• Evaluation of cationic drug transport system at the blood-retinal barrier to deliver the drugs to the retina

  Hosoya, K.-I. (PI), Akanuma, S.-I. (CoI), Kubo, Y. (CoI), Matsuya, Y. (CoI) & Takashima, T. (CoI)

  2013/04/01 → 2016/03/31

  Project: Research

• Establishment of new identification method of the endoplasmic reticulum membrane scramblases based on the amino acid primary sequence

  Nakao, H. (PI)

  2017/08/25 → 2019/03/31

  Project: Research

• Establishment of molecular simulation with mathematical model to enable the selection of molecular target drugs for lung cancer.

  Takaoka, Y. (Principal Investigator), Sugano, A. (Co-Investigator(Kenkyū-buntansha)), 永野達也 (Co-Investigator(Kenkyū-buntansha)) & Ota, M. (Co-Investigator(Kenkyū-buntansha))

  Japan Society for the Promotion of Science

  2021/04/01 → 2024/03/31

  Project: Research Project

• Establishment of highly effective therapy for food allergy by concomitant use of kakkonto with oral immunotherapy

  Yamamoto, T. (PI), Ito, Y. (CoI) & Nagata, Y. (CoI)

  2016/04/01 → 2019/03/31

  Project: Research

• Enhanced PDGF signaling contributes adipose tissue angiogenesis, expansion, and systemic glucose intolerance in obesity.

  Wada, T. (PI), Sasaoka, T. (CoI), Sasahara, M. (CoI) & Ishii, Y. (CoI)

  2012/04/01 → 2015/03/31

  Project: Research

• Engineering of type III polyketide synthase by deletion and addition of residues

  Morita, H. (PI)

  2014/04/01 → 2016/03/31

  Project: Research

• Engineering of plant-specific polyketide scaffold synthetic enzymes to produce structural diversity of compounds

  Morita, H. (PI), Matsui, T. (CoI) & Kodama, T. (CoI)

  2014/04/01 → 2017/03/31

  Project: Research

• Engineering of DABB-family enzymes to novel polyketide cyclase

  Morita, H. (CoI)

  2017/04/01 → 2020/03/31

  Project: Research

• Engineered biosynthesis based on functional redesign of aromatic prenyltransferases

  Taura, F. (PI)

  2021/04/01 → 2024/03/31

  Project: Research

• Elucidation of underlying mechanism of onset of stress vulnerability by environmental chemicals to explore biomakers

  Hirano, T. (Principal Investigator)

  Japan Society for the Promotion of Science

  2017/08/25 → 2019/03/31

  Project: Research Project

• Elucidation of the unidentified molecular structure of the cell volume-sensitive anion channel

  Sakai, H. (PI) & Shimizu, T. (CoI)

  2012/04/01 → 2014/03/31

  Project: Research

  • Volume-regulated Anion Channel 100%
  • Molecular Structure 100%
  • Cell Volume 100%
  • Chemical Structure 100%
  • Anion Channel 100%

• Elucidation of the splicing regulatory function of an intrinsically disordered protein PQBP1

  Mizuguchi, M. (PI) & Obita, T. (CoI)

  2015/04/01 → 2018/03/31

  Project: Research

• Elucidation of the role of miRNA on the control of cellular function by ultrasound

  Tabuchi, Y. (PI)

  2020/04/01 → 2023/03/31

  Project: Research

• Elucidation of the pathogenic mechanism of HLA-related drug hypersensitivity focusing on the intracellular energy metabolism environment of immune cells

  Susukida, T. (Principal Investigator)

  Japan Society for the Promotion of Science

  2024/04/01 → 2027/03/31

  Project: Research Project

• Elucidation of the molecular mechanism producing diterpenes with various tetracyclic skeletons in plant cells

  Yamamura, Y. (PI) & Lee, J. (CoI)

  2015/04/01 → 2018/03/31

  Project: Research

• Elucidation of the molecular components and regulatory mechanism of anion channels controlling the cell homeostasis and death

  Sakai, H. (PI) & Shimizu, T. (CoI)

  2015/04/01 → 2017/03/31

  Project: Research

• Elucidation of the mechanisms underlying comorbidity of alcohol use disorder in bipolar disorder

  Yano, Y. (Principal Investigator)

  Japan Society for the Promotion of Science

  2025/04/01 → 2028/03/31

  Project: Research Project

• Elucidation of the mechanism of liver cancer induced by abnormal lipid metabolism in enterohepatic association

  Nakagawa, Y. (PI)

  2021/04/05 → 2025/03/31

  Project: Research

• Elucidation of the exhaustion process of NK cells in tumor

  Hayakawa, Y. (Principal Investigator) & 山口哲志 (Co-Investigator(Kenkyū-buntansha))

  Japan Society for the Promotion of Science

  2025/04/01 → 2028/03/31

  Project: Research Project

• Elucidation of the biosynthetic mechanism that leads to the diversity of the tetracyclic skeleton of diterpenes

  Yamamura, Y. (PI)

  2013/04/01 → 2015/03/31

  Project: Research

• Elucidation of spinal mechanism of chronic myalgia using novel in vivo patch clamp method and search for therapeutic agents.

  Uta, D. (PI)

  2019/04/01 → 2023/03/31

  Project: Research

• Elucidation of regulatory mechanisms of prevention of influenza A virus infection by functional polysaccharides from food resources

  Lee, J. (PI) & Hayashi, K. (CoPI)

  2011/04/01 → 2014/03/31

  Project: Research

  • Functional Polysaccharide 100%
  • Regulatory Mechanism 100%
  • Influenza-like Illness 100%
  • Influenza Prevention 100%
  • Food Resources 100%

• Elucidation of mechanism of itch transmission to spinal cord using in vivo patch clamp and three-dimensional electron microscope.

  Uta, D. (PI), Sakamoto, H. (CoI) & Kiguchi, N. (CoI)

  2015/04/01 → 2019/03/31

  Project: Research

• Elucidation of dynamic control of biomembrane functions by phospholipid transfer proteins

  Nakano, M. (PI) & Ikeda, K. (CoI)

  2014/04/01 → 2017/03/31

  Project: Research