Research output per year
Research output per year
Research output
- 1 - 50 out of 140 results
Search results
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2023
Impact of Goreisan components on rat mesenteric collecting lymphatic vessel pumping
Jo, M., Trujillo, A. N., Shibahara, N. & Breslin, J. W., 2023/04, In: Microcirculation. 30, 2-3, e12788.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
The extract based on the Kampo formula daikenchuto (Da Jian Zhong Tang) induces Bdnf expression and has neurotrophic effects in cultured cortical neurons
Nakayama, H., Ihara, D., Fukuchi, M., Toume, K., Yuri, C., Tsuda, M., Shibahara, N. & Tabuchi, A., 2023/06, In: Natural Medicines. 77, 3, p. 584-595 12 p.Research output: Contribution to journal › Article › peer-review
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Uncovering the metabolomic effects of Kampo formulas using 1H-NMR spectroscopy
Awale, S., Jo, M., Watanabe, S., Shibahara, N. & Matsumoto, K., 2023, In: Uncovering the metabolomic effects of Kampo formulas using 1H-NMR spectroscopy: A case study of goreisan..Research output: Contribution to journal › Article › peer-review
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Uncovering the metabolomic effects of Kampo formulas using 1H-NMR spectroscopy: A case study of goreisan
Awale, S., Jo, M., Watanabe, S., Shibahara, N. & Matsumoto, K., 2023/08, In: Traditional & Kampo Medicine. 10, 2, p. 142-149 8 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
2022
Immunostimulatory properties of heat-resistant RNA in a decoction of Glycyrrhizae Radix
Inujima, A., Koizumi, K. & Shibahara, N., 2022/01, In: Biomedicine and Pharmacotherapy. 145, 112457.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Kampo Formula-Pattern Models: The Development of 13 New Clinically Useful Standard Abdominal Pattern Models in the Fukushin Simulator
Yakubo, S., Baba, M., Odaguchi, H., Wakasugi, A., Sekine, M., Hanawa, T., Mitsuma, T., Namiki, T., Arai, M., Muramatsu, S. I., Shimada, Y. & Shibahara, N., 2022/04/29, In: Frontiers in Pharmacology. 13, 688074.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
2020
Development of a self-assessment questionnaire for kampo medical knowledge and skills: An evaluation of medical students before and after clinical clerkship
Nogami, T., Fujimoto, M., Watari, H., Takamura, A., Mihara, H., Kimbara, Y., Shibahara, N. & Shimada, Y., 2020/02, In: International Medical Journal. 27, 1, p. 83-87 5 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Immunostimulatory effects of cell wall-based nanoparticles in boiled glycyrrhizae radix water extracts involves tlr4
Iitsuka, H., Koizumi, K., Suzaki, M., Otsuka, Y., Jo, M. & Shibahara, N., 2020/06, In: Biomedical Reports. 12, 6, p. 303-308 6 p.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Suppression of Dynamical Network Biomarker Signals at the Predisease State (Mibyou) before Metabolic Syndrome in Mice by a Traditional Japanese Medicine (Kampo Formula) Bofutsushosan
Koizumi, K., Oku, M., Hayashi, S., Inujima, A., Shibahara, N., Chen, L., Igarashi, Y., Tobe, K., Saito, S., Kadowaki, M. & Aihara, K., 2020, In: Evidence-based Complementary and Alternative Medicine. 2020, 9129134.Research output: Contribution to journal › Article › peer-review
Open Access17 Scopus citations -
漢方診断ロジック形式知化に向けて解決すべき5つの課題と漢方診療専門医療機関6施設の合意形成による解決案の提示
小田口浩, 石毛達也, 伊藤雄一, 若杉安希乃, 関根麻理子, 花輪壽彦, 並木隆雄, 村松慎一, 新井信, 三潴忠道, 嶋田豊, 柴原直利 & 折笠秀樹, 2020, In: 日本東洋医学雑誌. 71, 3, p. 284-295 12 p.Research output: Contribution to journal › Article › peer-review
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2019
Identifying pre-disease signals before metabolic syndrome in mice by dynamical network biomarkers
Koizumi, K., Oku, M., Hayashi, S., Inujima, A., Shibahara, N., Chen, L., Igarashi, Y., Tobe, K., Saito, S., Kadowaki, M. & Aihara, K., 2019/12/01, In: Scientific Reports. 9, 1, 8767.Research output: Contribution to journal › Article › peer-review
Open Access46 Scopus citations -
Incidence of kampo medicine-induced interstitial pneumonia: 10 year retrospective study at a university hospital kampo medicine department
Nogami, T., Fujimoto, M., Shimada, Y., Watari, H., Kitahara, H., Kimbara, Y., Nakagawa, H. & Shibahara, N., 2019/04, In: Traditional & Kampo Medicine. 6, 1, p. 26-31 6 p.Research output: Contribution to journal › Article › peer-review
7 Scopus citations -
Incidence of kampo medicine-induced interstitial pneumonia: 10 year retrospective study at a university hospital kampo medicine department
Nogami, T., Fujimoto, M., Shimada, Y., Watari, H., Kitahara, H., Kimbara, Y., Nakagawa, H. & Shibahara, N., 2019, In: Traditional & Kampo Medicine. 6, p. 26-31 6 p.Research output: Contribution to journal › Article › peer-review
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Kampo medicine resolves a case of polypharmacy with improvement sustained for 10 years
Nogami, T., Fujimoto, M., Watari, H., Kimbara, Y., Shibahara, N. & Shimada, Y., 2019/04/25, In: Traditional & Kampo Medicine.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Pharmacological effects of yokukansankachimpihange on urinary catecholamine in restraint-stressed mice
Michihara, S., Han, L. K., Fujita, N., Shibahara, N. & Takahashi, R., 2019, In: Yakugaku Zasshi. 139, 10, p. 1305-1312 8 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Screening inducers of neuronal BDNF gene transcription using primary cortical cell cultures from BDNF-luciferase transgenic mice
Fukuchi, M., Okuno, Y., Nakayama, H., Nakano, A., Mori, H., Mitazaki, S., Nakano, Y., Toume, K., Jo, M., Takasaki, I., Watanabe, K., Shibahara, N., Komatsu, K., Tabuchi, A. & Tsuda, M., 2019/12/01, In: Scientific Reports. 9, 1, 11833.Research output: Contribution to journal › Article › peer-review
Open Access19 Scopus citations -
Shikonin induces an anti‑tumor effect on murine mammary cancer via p38‑dependent apoptosis
Xu, J., Koizumi, K., Liu, M., Mizuno, Y., Suzaki, M., Iitsuka, H., Inujima, A., Fujimoto, M., Shibahara, N. & Shimada, Y., 2019/03, In: Oncology Reports. 41, 3, p. 2020-2026 7 p.Research output: Contribution to journal › Article › peer-review
Open Access28 Scopus citations -
2018
Discovery of a sugar-based nanoparticle universally existing in boiling herbal water extracts and their immunostimulant effect
Iitsuka, H., Koizumi, K., Inujima, A., Suzaki, M., Mizuno, Y., Takeshita, Y., Eto, T., Otsuka, Y., Shimada, R., Liu, M., Ikeda, K., Nakano, M., Suzuki, R., Maruyama, K., Zhou, Y., Sakurai, H. & Shibahara, N., 2018/12, In: Biochemistry and Biophysics Reports. 16, p. 62-68 7 p.Research output: Contribution to journal › Article › peer-review
Open Access22 Scopus citations -
Impact of different post-harvest processing methods on the chemical compositions of peony root
Zhu, S., Shirakawa, A., Shi, Y., Yu, X., Tamura, T., Shibahara, N., Yoshimatsu, K. & Komatsu, K., 2018/06/01, In: Natural Medicines. 72, 3, p. 757-767 11 p.Research output: Contribution to journal › Article › peer-review
Open Access20 Scopus citations -
Partial depletion of CD206-positive M2-like macrophages induces proliferation of beige progenitors and enhances browning after cold stimulation
Igarashi, Y., Nawaz, A., Kado, T., Bilal, M., Kuwano, T., Yamamoto, S., Sasahara, M., Jiuxiang, X., Inujima, A., Koizumi, K., Imura, J., Shibahara, N., Usui, I., Fujisaka, S. & Tobe, K., 2018/12/01, In: Scientific Reports. 8, 1, 14567.Research output: Contribution to journal › Article › peer-review
Open Access27 Scopus citations -
2017
Diosgenin-rich yam extract enhances cognitive function: A placebo-controlled, randomized, double-blind, crossover study of healthy adults
Tohda, C., Yang, X., Matsui, M., Inada, Y., Kadomoto, E., Nakada, S., Watari, H. & Shibahara, N., 2017/10/24, In: Nutrients. 9, 10, 1160.Research output: Contribution to journal › Article › peer-review
Open Access64 Scopus citations -
2016
Chrysin inhibits lymphangiogenesis in vitro
Prangsaengtong, O., Athikomkulchai, S., Xu, J., Koizumi, K., Inujima, A., Shibahara, N., Shimada, Y., Tadtong, S. & Awale, S., 2016/04, In: Biological and Pharmaceutical Bulletin. 39, 4, p. 466-472 7 p.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
Efficient use of a crude drug/herb library reveals Ephedra herb as a specific antagonist for T H 2-specific chemokine receptors CCR3, CCR4, and CCR8
Matsuo, K., Koizumi, K., Fujita, M., Morikawa, T., Jo, M., Shibahara, N., Saiki, I., Yoshie, O. & Nakayama, T., 2016/06/07, In: Frontiers in Cell and Developmental Biology. 4, JUN, 54.Research output: Contribution to journal › Article › peer-review
Open Access11 Scopus citations -
2015
Comparing the effects of kamikihito in Japan and Kami-Guibi-Tang in Korea on memory enhancement: Working towards the development of a global study
Watari, H., Shigyo, M., Tanabe, N., Tohda, M., Cho, K. H., Kyung, P. S., Jung, W. S., Shimada, Y., Shibahara, N., Kuboyama, T. & Tohda, C., 2015/03, In: Phytotherapy Research. 29, 3, p. 351-356 6 p.Research output: Contribution to journal › Article › peer-review
5 Scopus citations -
Herbal plant-derived compound, 1,2,3,4,6-penta-O-galloyl-β-d-glucose, increases cross-presentation by dendritic cells
Inujima, A., Yamada, M., Takeno, N., Hoshina, A., Oe, M., Shinohara, K., Shibahara, N., Sakurai, H., Saiki, I. & Koizumi, K., 2015/09, In: Traditional & Kampo Medicine. 2, 2, p. 43-49 7 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Immune adjuvant effect of juzentaihoto, a Japanese traditional herbal medicine, on tumor vaccine therapy in a mouse model
Takeno, N., Inujima, A., Shinohara, K., Yamada, M., Shibahara, N., Sakurai, H., Saiki, I. & Koizumi, K., 2015/12, In: International Journal of Oncology. 47, 6, p. 2115-2122 8 p.Research output: Contribution to journal › Article › peer-review
Open Access15 Scopus citations -
Inhibitory effect of Moutan Cortex aqueous fraction on mast cell-mediated allergic inflammation
Kee, J. Y., Inujima, A., Andoh, T., Tanaka, K., Li, F., Kuraishi, Y., Sakurai, H., Shibahara, N., Saiki, I. & Koizumi, K., 2015/04, In: Natural Medicines. 69, 2, p. 209-217 9 p.Research output: Contribution to journal › Article › peer-review
17 Scopus citations -
Role of chemokine CX3CL1 in progression of multiple myeloma via CX3CR1 in bone microenvironments
Wada, A., Ito, A., Iitsuka, H., Tsuneyama, K., Miyazono, T., Murakami, J., Shibahara, N., Sakurai, H., Saiki, I., Nakayama, T., Yoshie, O., Koizumi, K. & Sugiyama, T., 2015/06/01, In: Oncology Reports. 33, 6, p. 2935-2939 5 p.Research output: Contribution to journal › Article › peer-review
Open Access21 Scopus citations -
2014
CXCL16 suppresses liver metastasis of colorectal cancer by promoting TNF-α-induced apoptosis by tumor-associated macrophages
Kee, J. Y., Ito, A., Hojo, S., Hashimoto, I., Igarashi, Y., Tsuneyama, K., Tsukada, K., Irimura, T., Shibahara, N., Takasaki, I., Inujima, A., Nakayama, T., Yoshie, O., Sakurai, H., Saiki, I. & Koizumi, K., 2014/12/15, In: BMC Cancer. 14, 1, 949.Research output: Contribution to journal › Article › peer-review
Open Access47 Scopus citations -
Effect of Goreisan on the urinary concentrating ability and the expressions of aquaporins in 5/6 nephrectomized rats
Jo, M. & Shibahara, N., 2014, In: Folia Pharmacologica Japonica. 143, 2, p. 65-68 4 p.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Effects of goshajinkigan, hachimijiogan, and rokumigan on mechanical allodynia induced by paclitaxel in mice
Andoh, T., Kitamura, R., Fushimi, H., Komatsu, K., Shibahara, N. & Kuraishi, Y., 2014/10/01, In: Journal of Traditional and Complementary Medicine. 4, 4, p. 293-297 5 p.Research output: Contribution to journal › Article › peer-review
Open Access14 Scopus citations -
急性呼吸促迫症候群とショックを伴ったMRSA腸炎疑診例に対する漢方治療経験
Translated title of the contribution :Kampo Treatment Experience in a Case of Suspected MRSA Infection Related Enteritis Complicated by ARDS and Shock Research output: Contribution to journal › Article
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自己免疫性膵炎による閉塞性黄疸に茵蔯蒿湯を使用した2症例
Translated title of the contribution :Two Cases of Autoimmune Pancreatitis-Induced Obstructive Jaundice Treated with Inchinkoto Research output: Contribution to journal › Article
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2013
Chemokine CXCL16 suppresses liver metastasis of colorectal cancer via augmentation of tumor-infiltrating natural killer T cells in a murine model
Kee, J. Y., Ito, A., Hojo, S., Hashimoto, I., Igarashi, Y., Tsukada, K., Irimura, T., Shibahara, N., Nakayama, T., Yoshie, O., Sakurai, H., Saiki, I. & Koizumi, K., 2013/03, In: Oncology Reports. 29, 3, p. 975-982 8 p.Research output: Contribution to journal › Article › peer-review
Open Access42 Scopus citations -
Effect of goreisan on urinary concentrating ability and expression of aquaporin-2 in 5/6 nephrectomized rats
Jo, M., Fujimoto, T., Kaneko, M., Oka, H. & Shibahara, N., 2013, In: Journal of Traditional Medicines. 30, 4, p. 145-157 13 p.Research output: Contribution to journal › Article › peer-review
11 Scopus citations -
Enhancement of lymphangiogenesis in vitro via the regulations of HIF-1 α expression and nuclear translocation by deoxyshikonin
Prangsaengtong, O., Park, J. Y., Inujima, A., Igarashi, Y., Shibahara, N. & Koizumi, K., 2013, In: Evidence-based Complementary and Alternative Medicine. 2013, 148297.Research output: Contribution to journal › Article › peer-review
Open Access16 Scopus citations -
Involvement of descending monoaminergic systems in antiallodynic effect of goshajinkigan in oxaliplatin-treated mice
Kitamura, R., Andoh, T., Fushimi, H., Komatsu, K., Shibahara, N. & Kuraishi, Y., 2013, In: Journal of Traditional Medicines. 30, 4, p. 183-189 7 p.Research output: Contribution to journal › Article › peer-review
10 Scopus citations -
Shikonin inhibits lymphangiogenesis in vitro via the modulation of cell adhesion
Park, J. Y., Koizumi, K., Prangsaengtong, O., Inujima, A., Igarashi, Y., Jo, M. & Shibahara, N., 2013, In: Journal of Traditional Medicines. 30, 4, p. 176-182 7 p.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
The long-term effects of a Kampo medicine, juzentaihoto, on maintenance of antibody titer in elderly people after influenza vaccination
Saiki, I., Koizumi, K., Goto, H., Inujima, A., Namiki, T., Raimura, M., Kogure, T., Tatsumi, T., Inoue, H., Sakai, S., Oka, H., Fujimoto, M., Hikiami, H., Sakurai, H., Shibahara, N., Shimada, Y. & Origasa, H., 2013, In: Evidence-based Complementary and Alternative Medicine. 2013, 568074.Research output: Contribution to journal › Article › peer-review
Open Access18 Scopus citations -
2012
Calpain 1 and -2 play opposite roles in cord formation of lymphatic endothelial cells via eNOS regulation
Prangsaengtong, O., Senda, K., Doki, Y., Park, J. Y., Jo, M., Sakurai, H., Shibahara, N., Saiki, I. & Koizumi, K., 2012/06, In: Human cell : official journal of Human Cell Research Society. 25, 2, p. 36-44 9 p.Research output: Contribution to journal › Article › peer-review
9 Scopus citations -
Effect of keishibukuryogan on endothelial function in patients with at least one component of the diagnostic criteria for metabolic syndrome: A controlled clinical trial with crossover design
Nagata, Y., Goto, H., Hikiami, H., Nogami, T., Fujimoto, M., Shibahara, N. & Shimada, Y., 2012, In: Evidence-based Complementary and Alternative Medicine. 2012, 359282.Research output: Contribution to journal › Article › peer-review
Open Access24 Scopus citations -
Glycerol-induced renal damage improved by 7-O-galloyl-D-sedoheptulose treatment through attenuating oxidative stress
Park, C. H., Tanaka, T., Cho, E. J., Park, J. C., Shibahara, N. & Yokozawa, T., 2012, In: Biological and Pharmaceutical Bulletin. 35, 1, p. 34-41 8 p.Research output: Contribution to journal › Article › peer-review
Open Access29 Scopus citations -
Synthesis and evaluation of 1-(substituted)-3-prop-2-ynylureas as antiangiogenic agents
Sanphanya, K., Wattanapitayakul, S. K., Prangsaengtong, O., Jo, M., Koizumi, K., Shibahara, N., Priprem, A., Fokin, V. V. & Vajragupta, O., 2012/04/15, In: Bioorganic and Medicinal Chemistry Letters. 22, 8, p. 3001-3005 5 p.Research output: Contribution to journal › Article › peer-review
12 Scopus citations -
周期的な右季肋部痛を呈した肝子宮内膜症の１例
渡り英俊, 柴原直利, 海老澤茂, 野上達也, 藤本誠, 引網宏彰 & 嶋田豊, 2012/11/10, In: 日本内科学会雑誌. 101, 11, p. 3233-3235 3 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
2011
[Dementia in view from a concept of five viscera in Kampo medicine].
Shibahara, N. & Jo, M., 2011/10, In: Nihon rinsho. Japanese journal of clinical medicine. 69 Suppl 8, p. 380-383 4 p.Research output: Contribution to journal › Article › peer-review
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Ameliorative effects of yokukansan on learning and memory deficits in olfactory bulbectomized mice
Yamada, M., Hayashida, M., Zhao, Q., Shibahara, N., Tanaka, K., Miyata, T. & Matsumoto, K., 2011/06/01, In: Journal of Ethnopharmacology. 135, 3, p. 737-746 10 p.Research output: Contribution to journal › Article › peer-review
52 Scopus citations -
Anti-aging effects of oligomeric proanthocyanidins isolated from persimmon fruits
Yokozawa, T., Lee1, Y. A., Cho, E. J., Matsumoto, K., Park, C. H. & Shibahara, N., 2011, In: Drug Discoveries & Therapeutics. 5, 3, p. 109-118 10 p.Research output: Contribution to journal › Article › peer-review
Open Access24 Scopus citations -
Chotosan (Diaoteng San)-induced improvement of cognitive deficits in senescence-accelerated mouse (SAMP8) involves the amelioration of angiogenic/neurotrophic factors and neuroplasticity systems in the brain
Zhao, Q., Yokozawa, T., Tsuneyama, K., Tanaka, K., Miyata, T., Shibahara, N. & Matsumoto, K., 2011/09/23, In: Chinese Medicine. 6, 33.Research output: Contribution to journal › Article › peer-review
Open Access22 Scopus citations -
Cinnamaldehyde and paeonol increase HIF-1α Activity in proximal tubular epithelial cells under hypoxia
Oka, H., Goto, H., Nogami, T., Watari, H., Shimada, Y., Koizumi, K., Shibahara, N., Nakamura, S., Zhou, Y., Sakurai, H. & Saiki, I., 2011, In: Journal of Traditional Medicines. 28, 3, p. 149-157 9 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Database for crude drugs and Kampo medicine.
Arita, M., Yoshimoto, M., Suwa, K., Hirai, A., Kanaya, S., Shibahara, N. & Tanaka, K., 2011, In: Genome informatics. International Conference on Genome Informatics. 25, 1, p. 1-11 11 p.Research output: Contribution to journal › Article › peer-review
3 Scopus citations