抄録
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) has emerged as a promising anticancer agent because of its ability to selectively kill tumor cells. But TRAIL-resistance is a major problem of its therapy. A search for compounds for abrogating TRAIL-resistance has, thus, become an important strategy for anticancer drug discovery. In search of bioactive natural products for overcoming TRAIL-resistance, we previously reported some compounds with TRAIL-resistance overcoming activity. Bioassay guided fractionation of Entada scandens led to the isolation of four compounds (1-4). Of the isolates, compounds 1 and 3 showed moderate TRAIL-resistance overcoming activity in TRAIL-resistant human gastric adenocarcinoma (AGS) cells.
本文言語 | 英語 |
---|---|
ページ(範囲) | 993-995 |
ページ数 | 3 |
ジャーナル | Natural Product Communications |
巻 | 11 |
号 | 7 |
DOI | |
出版ステータス | 出版済み - 2016/07 |
ASJC Scopus 主題領域
- 薬理学
- 植物科学
- 創薬
- 補完代替医療