TY - JOUR
T1 - A new megastigmane, known porphyrinic and galloylated bioactive derivatives from the leaves of Gymnosporia senegalensis
AU - Tatsimo Ndendoung, Simplice Jöel
AU - Tamokou, Jean De Dieu
AU - Toume, Kazufumi
AU - Havyarimana, Léopold
AU - Ekom, Steve Endeguele
AU - Komatsu, Katsuko
N1 - Publisher Copyright:
© The Author(s) 2022.
PY - 2022/2
Y1 - 2022/2
N2 - Investigation of the non-polar (rich in chlorophyll) and polar fractions of the ethyl acetate extract of Gymnosporia senegalensis (Lam.) Loes. leaves led to the isolation of nine compounds, including one new megastigmane derivative, (3R*,5S*,6R*,7E,9ξ)-7-megastigmene-3,6,9-triol-3-O-β-D-(6′-O-galloyl)glucopyranoside (1), four known galloylated derivatives (2, 3, 8, 9), three known chlorophyll derivatives (4–6), and one known fatty acid (7). The structures of the isolates were determined by means of spectroscopic and spectrometric data, as well as by comparison with literature values. The extracts and isolated compounds were tested for their antibacterial, antifungal, and antioxidant activities. The isolates showed weak to high antimicrobial activities with phaeophytin A (4) being the most active one whereas phaeophorbide-a (5) and Chlorine e6 trimethyl ester (6) exhibited the highest antioxidant activities.
AB - Investigation of the non-polar (rich in chlorophyll) and polar fractions of the ethyl acetate extract of Gymnosporia senegalensis (Lam.) Loes. leaves led to the isolation of nine compounds, including one new megastigmane derivative, (3R*,5S*,6R*,7E,9ξ)-7-megastigmene-3,6,9-triol-3-O-β-D-(6′-O-galloyl)glucopyranoside (1), four known galloylated derivatives (2, 3, 8, 9), three known chlorophyll derivatives (4–6), and one known fatty acid (7). The structures of the isolates were determined by means of spectroscopic and spectrometric data, as well as by comparison with literature values. The extracts and isolated compounds were tested for their antibacterial, antifungal, and antioxidant activities. The isolates showed weak to high antimicrobial activities with phaeophytin A (4) being the most active one whereas phaeophorbide-a (5) and Chlorine e6 trimethyl ester (6) exhibited the highest antioxidant activities.
KW - Celastraceae
KW - Gymnosporia senegalensis
KW - antimicrobial
KW - antioxidant
KW - chlorophyll
KW - megastigmane
UR - http://www.scopus.com/inward/record.url?scp=85125773885&partnerID=8YFLogxK
U2 - 10.1177/17475198211072498
DO - 10.1177/17475198211072498
M3 - 学術論文
AN - SCOPUS:85125773885
SN - 1747-5198
VL - 46
JO - Journal of Chemical Research
JF - Journal of Chemical Research
IS - 1
ER -