Research output per year
Research output per year
Search results
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2025
Enhanced Production of Rebaudioside D and Rebaudioside M through V155T Substitution in the Glycosyltransferase UGT91D2 from Stevia rebaudiana
Shoji, T., Tanaka, Y., Nakashima, Y., Mizohata, E., Komaki, M., Sugawara, S., Takaya, J., Yonekura-Sakakibara, K., Morita, H., Saito, K. & Hirai, T., 2025/01/22, In: Journal of Agricultural and Food Chemistry. 73, 3, p. 2019-2032 14 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2024
A Small-Molecule Inhibitor of Factor Inhibiting HIF Binding to a Tyrosine-Flip Pocket for the Treatment of Obesity
Wu, Y., Chen, Y., Corner, T. P., Nakashima, Y., Salah, E., Li, Z., Zhang, L., Yang, L., Tumber, A., Sun, Z., Wen, Y., Zhong, A., Yang, F., Li, X., Zhang, Z., Schofield, C. J. & Zhang, X., 2024/10/01, In: Angewandte Chemie - International Edition. 63, 40, e202410438.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Peptide Epimerase Responsible for d-Amino Acid Introduction in Poly-γ-glutamic Acid Biosynthesis
Kato, H., Sakuta, M., Tsunoda, T., Nakashima, Y., Morita, H., Ogasawara, Y. & Dairi, T., 2024/01/08, In: Biomacromolecules. 25, 1, p. 349-354 6 p.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Structure-Based Catalytic Mechanism of Amaryllidaceae O-Methyltransferases
Hnin, S. Y. Y., Nakashima, Y., Kodama, T. & Morita, H., 2024/08/02, In: ACS Catalysis. 14, 15, p. 11865-11880 16 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Substrate Flexibilities of Norbelladine Synthase and Noroxomaritidine/ Norcraugsodine Reductase for Hydroxylated and/or Methoxylated Aldehydes
Hnin, S. Y. Y., Nakashima, Y. & Morita, H., 2024, In: Chemical and Pharmaceutical Bulletin. 72, 5, p. 507-511 5 p.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Three neo-Clerodane Diterpenoids from Tinospora cordifolia Stems and Their Arginase Inhibitory Activities
Hoang, N. N., Hoshino, S., Kodama, T., Nakashima, Y., Do, K. M., Thao, H. X., Ikumi, N., Onaka, H. & Morita, H., 2024/06, In: Chemical and Pharmaceutical Bulletin. 72, 6, p. 540-546 7 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
2023
5-Substituted Pyridine-2,4-dicarboxylate Derivatives Have Potential for Selective Inhibition of Human Jumonji-C Domain-Containing Protein 5
Brewitz, L., Nakashima, Y., Piasecka, S. K., Salah, E., Fletcher, S. C., Tumber, A., Corner, T. P., Kennedy, T. J., Fiorini, G., Thalhammer, A., Christensen, K. E., Coleman, M. L. & Schofield, C. J., 2023/08/10, In: Journal of Medicinal Chemistry. 66, 15, p. 10849-10865 17 p.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
Arginase inhibitory activities of guaiane sesquiterpenoids from Curcuma comosa rhizomes
Hoang, N. N., Kodama, T., Nakashima, Y., Do, K. M., Hnin, S. Y. Y., Lee, Y. E., Prema, Ikumi, N. & Morita, H., 2023/09, In: Natural Medicines. 77, 4, p. 891-897 7 p.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
Phenolic Derivatives with Anti-Acetylcholinesterase Inhibitory Activities from Galeola nudifolia in Vietnam
Do, K. M., Nakashima, Y., Kodama, T., Lee, Y. E., Nguyen, H. M., Ikumi, N. & Morita, H., 2023/12, In: Chemistry and Biodiversity. 20, 12, e202301482.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Structural basis for binding of the renal carcinoma target hypoxia-inducible factor 2α to prolyl hydroxylase domain 2
Figg, W. D., Fiorini, G., Chowdhury, R., Nakashima, Y., Tumber, A., McDonough, M. A. & Schofield, C. J., 2023/11, In: Proteins: Structure, Function and Genetics. 91, 11, p. 1510-1524 15 p.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
Structure-guided optimisation of N-hydroxythiazole-derived inhibitors of factor inhibiting hypoxia-inducible factor-α
Corner, T. P., Teo, R. Z. R., Wu, Y., Salah, E., Nakashima, Y., Fiorini, G., Tumber, A., Brasnett, A., Holt-Martyn, J. P., Figg, W. D., Zhang, X., Brewitz, L. & Schofield, C. J., 2023/10/27, In: Chemical Science. 14, 43, p. 12098-12120 23 p.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
Structure of lasso peptide epimerase MslH reveals metal-dependent acid/base catalytic mechanism
Nakashima, Y., Kawakami, A., Ogasawara, Y., Maeki, M., Tokeshi, M., Dairi, T. & Morita, H., 2023/12, In: Nature Communications. 14, 1, 4752.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
2022
Catalytic potential of a fungal indole prenyltransferase toward β-carbolines, harmine and harman, and their prenylation effects on antibacterial activity
Hamdy, S. A., Kodama, T., Nakashima, Y., Han, X. & Morita, H., 2022/10, In: Journal of Bioscience and Bioengineering. 134, 4, p. 311-317 7 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Dual Engineering of Olivetolic Acid Cyclase and Tetraketide Synthase to Generate Longer Alkyl-Chain Olivetolic Acid Analogs
Lee, Y. E., Nakashima, Y., Kodama, T., Chen, X. & Morita, H., 2022/01/14, In: Organic Letters. 24, 1, p. 410-414 5 p.Research output: Contribution to journal › Article › peer-review
10 Scopus citations -
Dual Engineering of Olivetolic Acid Cyclase and Tetraketide Synthase to Generate Longer Alkyl-Chain Olivetolic Acid Analogs
Lee, Y. E., Nakashima, Y., Kodama, T., Chen, X. & Morita, H., 2022/01/14, In: Organic Letters. 24, 1, p. 410-414 5 p.Research output: Contribution to journal › Article › peer-review
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Enzymatic formation of a prenyl β-carboline by a fungal indole prenyltransferase
Hamdy, S. A., Kodama, T., Nakashima, Y., Han, X., Matsui, T. & Morita, H., 2022/09, In: Natural Medicines. 76, 4, p. 873-879 7 p.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
Identification of a diarylpentanoid-producing polyketide synthase revealing an unusual biosynthetic pathway of 2-(2-phenylethyl)chromones in agarwood
Wang, X. H., Gao, B. W., Nakashima, Y., Mori, T., Zhang, Z. X., Kodama, T., Lee, Y. E., Zhang, Z. K., Wong, C. P., Liu, Q. Q., Qi, B. W., Wang, J., Li, J., Liu, X., Abe, I., Morita, H., Tu, P. F. & Shi, S. P., 2022/12, In: Nature Communications. 13, 1, 348.Research output: Contribution to journal › Article › peer-review
Open Access44 Scopus citations -
Structure-based redesign of Fe(ii)/2-oxoglutarate-dependent oxygenase AndA to catalyze spiro-ring formation
Mori, T., Nakashima, Y., Chen, H., Hoshino, S., Mitsuhashi, T. & Abe, I., 2022/04/11, In: Chemical Communications. 58, 36, p. 5510-5513 4 p.Research output: Contribution to journal › Article › peer-review
6 Scopus citations -
2021
2-Oxoglutarate derivatives can selectively enhance or inhibit the activity of human oxygenases
Nakashima, Y., Brewitz, L., Tumber, A., Salah, E. & Schofield, C. J., 2021/12, In: Nature Communications. 12, 1, 6478.Research output: Contribution to journal › Article › peer-review
Open Access22 Scopus citations -
Dual Engineering of Olivetolic Acid Cyclase and Tetraketide Synthase to Generate Longer Alkyl-Chain Olivetolic Acid Analogs
Yuan-E, L., Yu, N., Takeshi, K., Xinrui, C. & Hiroyuki, M., 2021, In: Organic Letters. 24, 1, p. 410-414Research output: Contribution to journal › Article › peer-review
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Fluorinated derivatives of pyridine-2,4-dicarboxylate are potent inhibitors of human 2-oxoglutarate dependent oxygenases
Brewitz, L., Nakashima, Y., Tumber, A., Salah, E. & Schofield, C. J., 2021/07, In: Journal of Fluorine Chemistry. 247, 109804.Research output: Contribution to journal › Article › peer-review
Open Access11 Scopus citations -
Human Oxygenase Variants Employing a Single Protein FeII Ligand Are Catalytically Active
Brasnett, A., Pfeffer, I., Brewitz, L., Chowdhury, R., Nakashima, Y., Tumber, A., McDonough, M. A. & Schofield, C. J., 2021/06/21, In: Angewandte Chemie - International Edition. 60, 26, p. 14657-14663 7 p.Research output: Contribution to journal › Article › peer-review
Open Access13 Scopus citations -
Structural Basis of Prolyl Hydroxylase Domain Inhibition by Molidustat
Figg, W. D., McDonough, M. A., Chowdhury, R., Nakashima, Y., Zhang, Z., Holt-Martyn, J. P., Krajnc, A. & Schofield, C. J., 2021/07/06, In: ChemMedChem. 16, 13, p. 2082-2088 7 p.Research output: Contribution to journal › Article › peer-review
Open Access28 Scopus citations -
Synthesis of 2-oxoglutarate derivatives and their evaluation as cosubstrates and inhibitors of human aspartate/asparagine-β-hydroxylase
Brewitz, L., Nakashima, Y. & Schofield, C. J., 2021/01/28, In: Chemical Science. 12, 4, p. 1327-1342 16 p.Research output: Contribution to journal › Article › peer-review
Open Access14 Scopus citations -
2020
A human protein hydroxylase that accepts D-residues
Choi, H., Hardy, A. P., Leissing, T. M., Chowdhury, R., Nakashima, Y., Ge, W., Markoulides, M., Scotti, J. S., Gerken, P. A., Thorbjornsrud, H., Kang, D., Hong, S., Lee, J., McDonough, M. A., Park, H. & Schofield, C. J., 2020/12/01, In: Communications Chemistry. 3, 1, 52.Research output: Contribution to journal › Article › peer-review
Open Access10 Scopus citations -
2019
Lipidomics links oxidized phosphatidylcholines and coronary arteritis in Kawasaki disease
Y, N., Y, S., Y, M., K, F., K, H., S, T., H, S., Y, O., T, K., K, T., K, H., T, M., R, A., M, A., K, Y., T, T., H, N., H, T., S, O. & T., H., 2019, In: Cardiovascular Research. -, 1, p. 0-0Research output: Contribution to journal › Article › peer-review
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2018
A tryptophan prenyltransferase with broad substrate tolerance from bacillus subtilis subsp. Natto
Sugita, T., Okada, M., Nakashima, Y., Tian, T. & Abe, I., 2018/07/04, In: ChemBioChem. 19, 13, p. 1396-1399 4 p.Research output: Contribution to journal › Article › peer-review
5 Scopus citations -
Molecular Insight into the Mg2+-Dependent Allosteric Control of Indole Prenylation by Aromatic Prenyltransferase AmbP1
Awakawa, T., Mori, T., Nakashima, Y., Zhai, R., Wong, C. P., Hillwig, M. L., Liu, X. & Abe, I., 2018/06/04, In: Angewandte Chemie - International Edition. 57, 23, p. 6810-6813 4 p.Research output: Contribution to journal › Article › peer-review
15 Scopus citations -
Results of paleomagnetic and geochronological studies of sedimentary rocks from Kema and Silasa formations of the Sikhote-Alin Orogen
Arkhipov, V., M., Peskov, Yu., A., Didenko, N., A., Otoh, S., Kudymov, V., A., Nagata, M., Kouchi, Y., Yamamoto & K., 2018, In: Nurgaliev, D., Shcherbakov, V., Kosterov, A., and Spassov, S., eds., Recent Advances in Rock Magnetism, Environmental Magnetism and Paleomagnetism, Springer. -, p. 3-12Research output: Contribution to journal › Article › peer-review
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Structural and Computational Bases for Dramatic Skeletal Rearrangement in Anditomin Biosynthesis
Nakashima, Y., Mitsuhashi, T., Matsuda, Y., Senda, M., Sato, H., Yamazaki, M., Uchiyama, M., Senda, T. & Abe, I., 2018/08/01, In: Journal of the American Chemical Society. 140, 30, p. 9743-9750 8 p.Research output: Contribution to journal › Article › peer-review
42 Scopus citations -
Structure function and engineering of multifunctional non-heme iron dependent oxygenases in fungal meroterpenoid biosynthesis
Nakashima, Y., Mori, T., Nakamura, H., Awakawa, T., Hoshino, S., Senda, M., Senda, T. & Abe, I., 2018/12/01, In: Nature Communications. 9, 1, 104.Research output: Contribution to journal › Article › peer-review
Open Access -
Two Distinct Substrate Binding Modes for the Normal and Reverse Prenylation of Hapalindoles by the Prenyltransferase AmbP3
Wong, C. P., Awakawa, T., Nakashima, Y., Mori, T., Zhu, Q., Liu, X. & Abe, I., 2018/01/08, In: Angewandte Chemie - International Edition. 57, 2, p. 560-563 4 p.Research output: Contribution to journal › Article › peer-review
21 Scopus citations -
2016
Discovery of Key Dioxygenases that Diverged the Paraherquonin and Acetoxydehydroaustin Pathways in Penicillium brasilianum
Matsuda, Y., Iwabuchi, T., Fujimoto, T., Awakawa, T., Nakashima, Y., Mori, T., Zhang, H., Hayashi, F. & Abe, I., 2016/09/28, In: Journal of the American Chemical Society. 138, 38, p. 12671-12677 7 p.Research output: Contribution to journal › Article › peer-review
103 Scopus citations -
Metagenomic analysis of the sponge Discodermia reveals the production of the cyanobacterial natural product kasumigamide by 'entotheonella'
Nakashima, Y., Egami, Y., Kimura, M., Wakimoto, T. & Abe, I., 2016/10, In: PLoS ONE. 11, 10, e0164468.Research output: Contribution to journal › Article › peer-review
Open Access35 Scopus citations -
Stereospecific prenylation of tryptophan by a cyanobacterial post-translational modification enzyme
Okada, M., Sugita, T., Akita, K., Nakashima, Y., Tian, T., Li, C., Mori, T. & Abe, I., 2016, In: Organic and Biomolecular Chemistry. 14, 40, p. 9639-9644 6 p.Research output: Contribution to journal › Article › peer-review
Open Access24 Scopus citations -
2014
Calyculin biogenesis from a pyrophosphate protoxin produced by a sponge symbiont
Wakimoto, T., Egami, Y., Nakashima, Y., Wakimoto, Y., Mori, T., Awakawa, T., Ito, T., Kenmoku, H., Asakawa, Y., Piel, J. & Abe, I., 2014/08, In: Nature Chemical Biology. 10, 8, p. 648-655 8 p.Research output: Contribution to journal › Article › peer-review
103 Scopus citations