Structure-based redesign of Fe(ii)/2-oxoglutarate-dependent oxygenase AndA to catalyze spiro-ring formation

Takahiro Mori; Yu Nakashima; Heping Chen; Shotaro Hoshino; Takaaki Mitsuhashi; Ikuro Abe

doi:10.1039/d2cc00736c

Structure-based redesign of Fe(ii)/2-oxoglutarate-dependent oxygenase AndA to catalyze spiro-ring formation

Takahiro Mori^*, Yu Nakashima, Heping Chen, Shotaro Hoshino, Takaaki Mitsuhashi, Ikuro Abe^*

^*Corresponding author for this work

Section of Natural Products & Drug Discovery, Division of Medicinal Resources, Institute of Natural Medicine

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Structure- and mechanism-based redesign of the Fe(ii)/2-oxoglutarate-dependent oxygenase AndA was performed. The function of AndA was expanded to catalyze a spiro-ring formation reaction from an isomerization reaction. The redesigned AndA variants produced two unnatural novel spiro-ring containing compounds through two and three consecutive oxidation reactions.

Original language	English
Pages (from-to)	5510-5513
Number of pages	4
Journal	Chemical Communications
Volume	58
Issue number	36
DOIs	https://doi.org/10.1039/d2cc00736c
State	Published - 2022/04/11

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Catalysis
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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title = "Structure-based redesign of Fe(ii)/2-oxoglutarate-dependent oxygenase AndA to catalyze spiro-ring formation",

abstract = "Structure- and mechanism-based redesign of the Fe(ii)/2-oxoglutarate-dependent oxygenase AndA was performed. The function of AndA was expanded to catalyze a spiro-ring formation reaction from an isomerization reaction. The redesigned AndA variants produced two unnatural novel spiro-ring containing compounds through two and three consecutive oxidation reactions.",

author = "Takahiro Mori and Yu Nakashima and Heping Chen and Shotaro Hoshino and Takaaki Mitsuhashi and Ikuro Abe",

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AU - Mori, Takahiro

AU - Nakashima, Yu

AU - Chen, Heping

AU - Hoshino, Shotaro

AU - Mitsuhashi, Takaaki

AU - Abe, Ikuro

PY - 2022/4/11

Y1 - 2022/4/11

N2 - Structure- and mechanism-based redesign of the Fe(ii)/2-oxoglutarate-dependent oxygenase AndA was performed. The function of AndA was expanded to catalyze a spiro-ring formation reaction from an isomerization reaction. The redesigned AndA variants produced two unnatural novel spiro-ring containing compounds through two and three consecutive oxidation reactions.

AB - Structure- and mechanism-based redesign of the Fe(ii)/2-oxoglutarate-dependent oxygenase AndA was performed. The function of AndA was expanded to catalyze a spiro-ring formation reaction from an isomerization reaction. The redesigned AndA variants produced two unnatural novel spiro-ring containing compounds through two and three consecutive oxidation reactions.

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DO - 10.1039/d2cc00736c

M3 - 学術論文

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JF - Chemical Communications

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Structure-based redesign of Fe(ii)/2-oxoglutarate-dependent oxygenase AndA to catalyze spiro-ring formation

Abstract

ASJC Scopus subject areas

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