Yu Nakashima

2025

Enhanced Production of Rebaudioside D and Rebaudioside M through V155T Substitution in the Glycosyltransferase UGT91D2 from Stevia rebaudiana

Shoji, T., Tanaka, Y., Nakashima, Y., Mizohata, E., Komaki, M., Sugawara, S., Takaya, J., Yonekura-Sakakibara, K., Morita, H., Saito, K. & Hirai, T., 2025/01/22, In: Journal of Agricultural and Food Chemistry. 73, 3, p. 2019-2032 14 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

2024

A Small-Molecule Inhibitor of Factor Inhibiting HIF Binding to a Tyrosine-Flip Pocket for the Treatment of Obesity

Wu, Y., Chen, Y., Corner, T. P., Nakashima, Y., Salah, E., Li, Z., Zhang, L., Yang, L., Tumber, A., Sun, Z., Wen, Y., Zhong, A., Yang, F., Li, X., Zhang, Z., Schofield, C. J. & Zhang, X., 2024/10/01, In: Angewandte Chemie - International Edition. 63, 40, e202410438.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

3 被引用数 (Scopus)

Peptide Epimerase Responsible for d-Amino Acid Introduction in Poly-γ-glutamic Acid Biosynthesis

Kato, H., Sakuta, M., Tsunoda, T., Nakashima, Y., Morita, H., Ogasawara, Y. & Dairi, T., 2024/01/08, In: Biomacromolecules. 25, 1, p. 349-354 6 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

2 被引用数 (Scopus)

Structure-Based Catalytic Mechanism of Amaryllidaceae O-Methyltransferases

Hnin, S. Y. Y., Nakashima, Y., Kodama, T. & Morita, H., 2024/08/02, In: ACS Catalysis. 14, 15, p. 11865-11880 16 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

1 被引用数 (Scopus)

Substrate Flexibilities of Norbelladine Synthase and Noroxomaritidine/ Norcraugsodine Reductase for Hydroxylated and/or Methoxylated Aldehydes

Hnin, S. Y. Y., Nakashima, Y. & Morita, H., 2024, In: Chemical and Pharmaceutical Bulletin. 72, 5, p. 507-511 5 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

4 被引用数 (Scopus)

Three neo-Clerodane Diterpenoids from Tinospora cordifolia Stems and Their Arginase Inhibitory Activities

Hoang, N. N., Hoshino, S., Kodama, T., Nakashima, Y., Do, K. M., Thao, H. X., Ikumi, N., Onaka, H. & Morita, H., 2024/06, In: Chemical and Pharmaceutical Bulletin. 72, 6, p. 540-546 7 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

1 被引用数 (Scopus)

2023

5-Substituted Pyridine-2,4-dicarboxylate Derivatives Have Potential for Selective Inhibition of Human Jumonji-C Domain-Containing Protein 5

Brewitz, L., Nakashima, Y., Piasecka, S. K., Salah, E., Fletcher, S. C., Tumber, A., Corner, T. P., Kennedy, T. J., Fiorini, G., Thalhammer, A., Christensen, K. E., Coleman, M. L. & Schofield, C. J., 2023/08/10, In: Journal of Medicinal Chemistry. 66, 15, p. 10849-10865 17 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

5 被引用数 (Scopus)

Arginase inhibitory activities of guaiane sesquiterpenoids from Curcuma comosa rhizomes

Hoang, N. N., Kodama, T., Nakashima, Y., Do, K. M., Hnin, S. Y. Y., Lee, Y. E., Prema, Ikumi, N. & Morita, H., 2023/09, In: Natural Medicines. 77, 4, p. 891-897 7 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

3 被引用数 (Scopus)

Phenolic Derivatives with Anti-Acetylcholinesterase Inhibitory Activities from Galeola nudifolia in Vietnam

Do, K. M., Nakashima, Y., Kodama, T., Lee, Y. E., Nguyen, H. M., Ikumi, N. & Morita, H., 2023/12, In: Chemistry and Biodiversity. 20, 12, e202301482.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

1 被引用数 (Scopus)

Structural basis for binding of the renal carcinoma target hypoxia-inducible factor 2α to prolyl hydroxylase domain 2

Figg, W. D., Fiorini, G., Chowdhury, R., Nakashima, Y., Tumber, A., McDonough, M. A. & Schofield, C. J., 2023/11, In: Proteins: Structure, Function and Genetics. 91, 11, p. 1510-1524 15 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

5 被引用数 (Scopus)

Structure-guided optimisation of N-hydroxythiazole-derived inhibitors of factor inhibiting hypoxia-inducible factor-α

Corner, T. P., Teo, R. Z. R., Wu, Y., Salah, E., Nakashima, Y., Fiorini, G., Tumber, A., Brasnett, A., Holt-Martyn, J. P., Figg, W. D., Zhang, X., Brewitz, L. & Schofield, C. J., 2023/10/27, In: Chemical Science. 14, 43, p. 12098-12120 23 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

7 被引用数 (Scopus)

Structure of lasso peptide epimerase MslH reveals metal-dependent acid/base catalytic mechanism

Nakashima, Y., Kawakami, A., Ogasawara, Y., Maeki, M., Tokeshi, M., Dairi, T. & Morita, H., 2023/12, In: Nature Communications. 14, 1, 4752.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

6 被引用数 (Scopus)

2022

Catalytic potential of a fungal indole prenyltransferase toward β-carbolines, harmine and harman, and their prenylation effects on antibacterial activity

Hamdy, S. A., Kodama, T., Nakashima, Y., Han, X. & Morita, H., 2022/10, In: Journal of Bioscience and Bioengineering. 134, 4, p. 311-317 7 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

2 被引用数 (Scopus)

Dual Engineering of Olivetolic Acid Cyclase and Tetraketide Synthase to Generate Longer Alkyl-Chain Olivetolic Acid Analogs

Lee, Y. E., Nakashima, Y., Kodama, T., Chen, X. & Morita, H., 2022/01/14, In: Organic Letters. 24, 1, p. 410-414 5 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

10 被引用数 (Scopus)

Dual Engineering of Olivetolic Acid Cyclase and Tetraketide Synthase to Generate Longer Alkyl-Chain Olivetolic Acid Analogs

Lee, Y. E., Nakashima, Y., Kodama, T., Chen, X. & Morita, H., 2022/01/14, In: Organic Letters. 24, 1, p. 410-414 5 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Enzymatic formation of a prenyl β-carboline by a fungal indole prenyltransferase

Hamdy, S. A., Kodama, T., Nakashima, Y., Han, X., Matsui, T. & Morita, H., 2022/09, In: Natural Medicines. 76, 4, p. 873-879 7 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

3 被引用数 (Scopus)

Identification of a diarylpentanoid-producing polyketide synthase revealing an unusual biosynthetic pathway of 2-(2-phenylethyl)chromones in agarwood

Wang, X. H., Gao, B. W., Nakashima, Y., Mori, T., Zhang, Z. X., Kodama, T., Lee, Y. E., Zhang, Z. K., Wong, C. P., Liu, Q. Q., Qi, B. W., Wang, J., Li, J., Liu, X., Abe, I., Morita, H., Tu, P. F. & Shi, S. P., 2022/12, In: Nature Communications. 13, 1, 348.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

44 被引用数 (Scopus)

Structure-based redesign of Fe(ii)/2-oxoglutarate-dependent oxygenase AndA to catalyze spiro-ring formation

Mori, T., Nakashima, Y., Chen, H., Hoshino, S., Mitsuhashi, T. & Abe, I., 2022/04/11, In: Chemical Communications. 58, 36, p. 5510-5513 4 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

6 被引用数 (Scopus)

2021

2-Oxoglutarate derivatives can selectively enhance or inhibit the activity of human oxygenases

Nakashima, Y., Brewitz, L., Tumber, A., Salah, E. & Schofield, C. J., 2021/12, In: Nature Communications. 12, 1, 6478.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

22 被引用数 (Scopus)

Dual Engineering of Olivetolic Acid Cyclase and Tetraketide Synthase to Generate Longer Alkyl-Chain Olivetolic Acid Analogs

Yuan-E, L., Yu, N., Takeshi, K., Xinrui, C. & Hiroyuki, M., 2021, In: Organic Letters. 24, 1, p. 410-414

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Fluorinated derivatives of pyridine-2,4-dicarboxylate are potent inhibitors of human 2-oxoglutarate dependent oxygenases

Brewitz, L., Nakashima, Y., Tumber, A., Salah, E. & Schofield, C. J., 2021/07, In: Journal of Fluorine Chemistry. 247, 109804.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

11 被引用数 (Scopus)

Human Oxygenase Variants Employing a Single Protein Fe^II Ligand Are Catalytically Active

Brasnett, A., Pfeffer, I., Brewitz, L., Chowdhury, R., Nakashima, Y., Tumber, A., McDonough, M. A. & Schofield, C. J., 2021/06/21, In: Angewandte Chemie - International Edition. 60, 26, p. 14657-14663 7 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

13 被引用数 (Scopus)

Structural Basis of Prolyl Hydroxylase Domain Inhibition by Molidustat

Figg, W. D., McDonough, M. A., Chowdhury, R., Nakashima, Y., Zhang, Z., Holt-Martyn, J. P., Krajnc, A. & Schofield, C. J., 2021/07/06, In: ChemMedChem. 16, 13, p. 2082-2088 7 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

28 被引用数 (Scopus)

Synthesis of 2-oxoglutarate derivatives and their evaluation as cosubstrates and inhibitors of human aspartate/asparagine-β-hydroxylase

Brewitz, L., Nakashima, Y. & Schofield, C. J., 2021/01/28, In: Chemical Science. 12, 4, p. 1327-1342 16 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

14 被引用数 (Scopus)

2020

A human protein hydroxylase that accepts D-residues

Choi, H., Hardy, A. P., Leissing, T. M., Chowdhury, R., Nakashima, Y., Ge, W., Markoulides, M., Scotti, J. S., Gerken, P. A., Thorbjornsrud, H., Kang, D., Hong, S., Lee, J., McDonough, M. A., Park, H. & Schofield, C. J., 2020/12/01, In: Communications Chemistry. 3, 1, 52.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

10 被引用数 (Scopus)

2019

Lipidomics links oxidized phosphatidylcholines and coronary arteritis in Kawasaki disease

Y, N., Y, S., Y, M., K, F., K, H., S, T., H, S., Y, O., T, K., K, T., K, H., T, M., R, A., M, A., K, Y., T, T., H, N., H, T., S, O. & T., H., 2019, In: Cardiovascular Research. -, 1, p. 0-0

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

2018

A tryptophan prenyltransferase with broad substrate tolerance from bacillus subtilis subsp. Natto

Sugita, T., Okada, M., Nakashima, Y., Tian, T. & Abe, I., 2018/07/04, In: ChemBioChem. 19, 13, p. 1396-1399 4 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

5 被引用数 (Scopus)

Molecular Insight into the Mg²⁺-Dependent Allosteric Control of Indole Prenylation by Aromatic Prenyltransferase AmbP1

Awakawa, T., Mori, T., Nakashima, Y., Zhai, R., Wong, C. P., Hillwig, M. L., Liu, X. & Abe, I., 2018/06/04, In: Angewandte Chemie - International Edition. 57, 23, p. 6810-6813 4 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

15 被引用数 (Scopus)

Results of paleomagnetic and geochronological studies of sedimentary rocks from Kema and Silasa formations of the Sikhote-Alin Orogen

Arkhipov, V., M., Peskov, Yu., A., Didenko, N., A., Otoh, S., Kudymov, V., A., Nagata, M., Kouchi, Y., Yamamoto & K., 2018, In: Nurgaliev, D., Shcherbakov, V., Kosterov, A., and Spassov, S., eds., Recent Advances in Rock Magnetism, Environmental Magnetism and Paleomagnetism, Springer. -, p. 3-12

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Structural and Computational Bases for Dramatic Skeletal Rearrangement in Anditomin Biosynthesis

Nakashima, Y., Mitsuhashi, T., Matsuda, Y., Senda, M., Sato, H., Yamazaki, M., Uchiyama, M., Senda, T. & Abe, I., 2018/08/01, In: Journal of the American Chemical Society. 140, 30, p. 9743-9750 8 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

42 被引用数 (Scopus)

Structure function and engineering of multifunctional non-heme iron dependent oxygenases in fungal meroterpenoid biosynthesis

Nakashima, Y., Mori, T., Nakamura, H., Awakawa, T., Hoshino, S., Senda, M., Senda, T. & Abe, I., 2018/12/01, In: Nature Communications. 9, 1, 104.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

61 被引用数 (SciVal)

Two Distinct Substrate Binding Modes for the Normal and Reverse Prenylation of Hapalindoles by the Prenyltransferase AmbP3

Wong, C. P., Awakawa, T., Nakashima, Y., Mori, T., Zhu, Q., Liu, X. & Abe, I., 2018/01/08, In: Angewandte Chemie - International Edition. 57, 2, p. 560-563 4 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

21 被引用数 (Scopus)

2016

Discovery of Key Dioxygenases that Diverged the Paraherquonin and Acetoxydehydroaustin Pathways in Penicillium brasilianum

Matsuda, Y., Iwabuchi, T., Fujimoto, T., Awakawa, T., Nakashima, Y., Mori, T., Zhang, H., Hayashi, F. & Abe, I., 2016/09/28, In: Journal of the American Chemical Society. 138, 38, p. 12671-12677 7 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

103 被引用数 (Scopus)

Metagenomic analysis of the sponge Discodermia reveals the production of the cyanobacterial natural product kasumigamide by 'entotheonella'

Nakashima, Y., Egami, Y., Kimura, M., Wakimoto, T. & Abe, I., 2016/10, In: PLoS ONE. 11, 10, e0164468.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

35 被引用数 (Scopus)

Stereospecific prenylation of tryptophan by a cyanobacterial post-translational modification enzyme

Okada, M., Sugita, T., Akita, K., Nakashima, Y., Tian, T., Li, C., Mori, T. & Abe, I., 2016, In: Organic and Biomolecular Chemistry. 14, 40, p. 9639-9644 6 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

24 被引用数 (Scopus)

2014

Calyculin biogenesis from a pyrophosphate protoxin produced by a sponge symbiont

Wakimoto, T., Egami, Y., Nakashima, Y., Wakimoto, Y., Mori, T., Awakawa, T., Ito, T., Kenmoku, H., Asakawa, Y., Piel, J. & Abe, I., 2014/08, In: Nature Chemical Biology. 10, 8, p. 648-655 8 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

103 被引用数 (Scopus)

中嶋 優

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中嶋優