Synthetic and Medicinal Chemistry

2025

Development of site- and stereoselective continuous flow deuterium labelling method for carbohydrates using high dispersion effect towards Ru/C of hydrogen flow

Sakurada, N., Sasaki, D., Ono, M., Yamada, T., Ikawa, T. & Sajiki, H., 2025/03/11, In: Reaction Chemistry and Engineering. 10, 4, p. 777-781 5 p.

Research output: Contribution to journal › Article › peer-review

Electrochemically assisted deprotection of acetals, ketals, and dithioacetals under neutral conditions

Abe, Y., Yamada, T., Yamamoto, T., Esaka, Y., Ikawa, T. & Sajiki, H., 2025/02/11, In: Green Chemistry. 27, 19, p. 5464-5470 7 p.

Research output: Contribution to journal › Article › peer-review

Room-Temperature Ligation of Iminophosphoranes with gem-Difluoroalkenes

Tanioka, M., Enomoto, F., Kitamura, F., Nakamura, R., Takano, A., Kanayama, S., Kohyama, A., Yamada, T. & Matsuya, Y., 2025, (Accepted/In press) In: Journal of Organic Chemistry.

Research output: Contribution to journal › Article › peer-review

Stable and Versatile Pd Precursors for the Preparation of Robust Pd Catalysts Under Continuous-Flow

Sakurada, N., Kobayashi, K., Abe, Y., Niwa, K., Yokoyama, T., Yamada, T., Ikawa, T. & Sajiki, H., 2025/02/16, In: ChemSusChem. 18, 4, e202401859.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Water-Compatible Staudinger-Diels-Alder Ligation

Tanioka, M., Kanayama, S., Kitamura, F., Takano, A., Ikeda, Y., Kohyama, A., Yamada, T. & Matsuya, Y., 2025/01/31, In: Journal of Organic Chemistry. 90, 4, p. 1501-1506 6 p.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

2024

Coerulein B: a water-soluble and water-compatible near-infrared photoredox catalyst

Tanioka, M., Oyama, M., Nakajima, K., Mori, M., Harada, M., Matsuya, Y. & Kamino, S., 2024/01/09, In: Physical Chemistry Chemical Physics. 26, 5, p. 4474-4479 6 p.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Gold-Catalyzed Synthesis of Ortho-Quinone Methide Analogues as Reactive Synthetic Precursors

Yamada, T., Fujii, A., Furugen, C., Kobayashi, K., Hyodo, T., Ikawa, T. & Sajiki, H., 2024/05/21, In: Advanced Synthesis and Catalysis. 366, 10, p. 2270-2276 7 p.

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Nonpolar selective emission (NPSE) of carbonyl-bridged rhodols

Tanioka, M., Mori, M., Harada, M., Matsuya, Y. & Kamino, S., 2024/05/28, In: Chemical Communications. 60, 50, p. 6407-6410 4 p.

Research output: Contribution to journal › Article › peer-review

Organocatalytic Fischer Indolization Using the 2,2′-Biphenol/ B(OH)₃ System

Sugimoto, K., Wada, Y., Kitamura, F. & Matsuya, Y., 2024/05/17, In: Synlett. 36, 2, p. 176-180 5 p.

Research output: Contribution to journal › Article › peer-review

Pt/CB-Catalyzed Chemoselective Hydrogenation Using In Situ-Generated Hydrogen by Microwave-Mediated Dehydrogenation of Methylcyclohexane under Continuous-Flow Conditions

Sakurada, N., Kitazono, T., Ikawa, T., Yamada, T. & Sajiki, H., 2024/06, In: Catalysts. 14, 6, 384.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

Three-Component Synthesis of Substituted Azepines by Gold/Magnesium Orthogonal-Relay Catalysis

Kosuge, S., Kiraku, Y., Tsuge, K., Sugimoto, K. & Matsuya, Y., 2024/11/19, In: Advanced Synthesis and Catalysis. 366, 22, p. 4674-4678 5 p.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

2023

Controllable conformation and reactivity of bicyclic α-methylene cyclopentanones and their NF-κB pathway inhibitory activity

Kohyama, A., Shiuchi, A., Zhou, Y., Tanioka, M., Sugimoto, K., Sakurai, H. & Matsuya, Y., 2023/05/10, In: Organic and Biomolecular Chemistry. 21, 22, p. 4656-4660 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

First atroposelective Chan-Lam coupling for the synthesis of C-N linked biaryls

Ishida, M., Adachi, R., Kobayashi, K., Yamamoto, Y., Kawahara, C., Yamada, T., Aoyama, H., Kanomata, K., Akai, S., Lam, P. Y. S., Sajiki, H. & Ikawa, T., 2023/12/19, In: Chemical Communications. 60, 6, p. 678-681 4 p.

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Microwave-assisted C–C bond formation of diarylacetylenes and aromatic hydrocarbons on carbon beads under continuous-flow conditions

Yamada, T., Teranishi, W., Sakurada, N., Ootori, S., Abe, Y., Matsuo, T., Morii, Y., Yoshimura, M., Yoshimura, T., Ikawa, T. & Sajiki, H., 2023/12, In: Communications Chemistry. 6, 1, 78.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

Nucleophile-Triggered π-Topological Transformation: A New Synthetic Approach to Near-Infrared-Emissive Rhodamines

Harada, M., Kutsuna, M., Kitamura, T., Usui, Y., Ujiki, M., Nakamura, Y., Obata, T., Tanioka, M., Uchiyama, M., Sawada, D. & Kamino, S., 2023/10/23, In: Chemistry - A European Journal. 29, 59, e202301969.

Research output: Contribution to journal › Article › peer-review

One-Pot Synthesis of Pentasubstituted Pyridines following the Gold(I)-Catalyzed Aza-Enyne Metathesis/6π-Electrocyclization-Aromatization Sequence

Kosuge, S., Araki, Y., Tsuge, K., Sugimoto, K. & Matsuya, Y., 2023/06/02, In: Journal of Organic Chemistry. 88, 11, p. 6973-6986 14 p.

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Oxidative Functionalization of Catechol Derivatives Substituted with Electron-Withdrawing Groups

Sawama, Y., Shimizu, H., Aijima, T., Udagawa, T., Kuwata, S., Yamada, T., Sajiki, H. & Akai, S., 2023/10/01, In: Chemical and Pharmaceutical Bulletin. 71, 10, p. 782-786 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

2022

Acceleration effect of mild organocatalytic system 2,2′-biphenol/B(OH)₃ for 2-aza-Cope rearrangement

Sugimoto, K., Yoshida, R. & Matsuya, Y., 2022/07/20, In: Tetrahedron Letters. 102, 153922.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

Aryl Boronic Esters Are Stable on Silica Gel and Reactive under Suzuki−Miyaura Coupling Conditions

Oka, N., Yamada, T., Sajiki, H., Akai, S. & Ikawa, T., 2022/05/20, In: Organic Letters. 24, 19, p. 3510-3514 5 p.

Research output: Contribution to journal › Article › peer-review

58 Scopus citations

Bridged eosin Y: a visible and near-infrared photoredox catalyst

Tanioka, M., Kuromiya, A., Ueda, R., Obata, T., Muranaka, A., Uchiyama, M. & Kamino, S., 2022/06/15, In: Chemical Communications. 58, 56, p. 7825-7828 4 p.

Research output: Contribution to journal › Article › peer-review

Open Access

14 Scopus citations

Catalytic Intramolecular Cyclization of Alkynyl Cyclic Acetals via Chemoselective Activation Leading to a Phenanthrene Core

Yamada, T., Fujii, A., Park, K., Furugen, C., Takagi, A., Ikawa, T. & Sajiki, H., 2022/05, In: Bulletin of the Chemical Society of Japan. 95, 5, p. 735-742 8 p.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Development of Silicon Carbide-Supported Palladium Catalysts and Their Application as Semihydrogenation Catalysts for Alkynes under Batch- and Continuous-Flow Conditions

Yamada, T., Yamamoto, H., Kawai, K., Park, K., Aono, N. & Sajiki, H., 2022/10, In: Catalysts. 12, 10, 1253.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

Highly Selective Hydrogenative Conversion of Nitriles into Tertiary, Secondary, and Primary Amines under Flow Reaction Conditions

Yamada, T., Park, K., Furugen, C., Jiang, J., Shimizu, E., Ito, N. & Sajiki, H., 2022/01/21, In: ChemSusChem. 15, 2, e202102138.

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Highly Selective Synthesis of cis-2,2,4,4-Tetramethylcyclobutane-1,3-diol via Solvent-Free Hydrogenation and Isomerization

Park, K., Furusato, S., Furugen, C., Ikawa, T., Yamada, T. & Sajiki, H., 2022/09, In: Asian Journal of Organic Chemistry. 11, 9, e202200263.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Structure-activity relationship and mechanistic study on guggulsterone derivatives; Discovery of new anti-pancreatic cancer candidate

Kohyama, A., Kim, M. J., Yokoyama, R., Sun, S., Omar, A. M., Phan, N. D., Meselhy, M. R., Tsuge, K., Awale, S. & Matsuya, Y., 2022/01/15, In: Bioorganic and Medicinal Chemistry. 54, 116563.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

2021

Au(I) Catalyzed Synthesis of Densely Substituted Pyrazolines and Dihydropyridines via Sequential Aza-Enyne Metathesis/6π-Electrocyclization

Sugimoto, K., Kosuge, S., Sugita, T., Miura, Y., Tsuge, K. & Matsuya, Y., 2021/05/21, In: Organic Letters. 23, 10, p. 3981-3985 5 p.

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Cis -3-Azido-2-methoxyindolines as safe and stable precursors to overcome the instability of fleeting 3-azidoindoles

Yamashiro, T., Abe, T., Tanioka, M., Kamino, S. & Sawada, D., 2021/12/21, In: Chemical Communications. 57, 98, p. 13381-13384 4 p.

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Inhibition of gastric H⁺,K⁺-ATPase by new dihydropyrazole derivative KYY-008

Fujii, T., Sugimoto, K., Noda, T., Shimizu, T., Matsuya, Y. & Sakai, H., 2021/08/27, In: Biochemical and Biophysical Research Communications. 567, p. 177-182 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

Morpholine-Substituted Rhodamine Analogue with Multi-Configurational Switches for Optical Sensing of pH Gradient under Extreme Acidic Environments

Koga, N., Tanioka, M., Kamino, S. & Sawada, D., 2021/02/19, In: Chemistry - A European Journal. 27, 11, p. 3761-3765 5 p.

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

2020

An improved synthesis of a salicylated divinylcarbinol derivative as a part of salicylic macrolides

Kohyama, A., Oguma, Y., Yamagishi, T., Sugimoto, K. & Matsuya, Y., 2020, In: Heterocycles. 100, 1, p. 137-144 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

Development of Carbon-Neutral Cellulose-Supported Heterogeneous Palladium Catalysts for Chemoselective Hydrogenation

Yamada, T., Teranishi, W., Park, K., Jiang, J., Tachikawa, T., Furusato, S. & Sajiki, H., 2020/08/20, In: ChemCatChem. 12, 16, p. 4052-4058 7 p.

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Pd catalysts supported on dual-pore monolithic silica beads for chemoselective hydrogenation under batch and flow reaction conditions

Yamada, T., Ogawa, A., Masuda, H., Teranishi, W., Fujii, A., Park, K., Ashikari, Y., Tomiyasu, N., Ichikawa, T., Miyamoto, R., Bai, H., Matsuyama, K., Nagaki, A. & Sajiki, H., 2020/09/21, In: Catalysis Science and Technology. 10, 18, p. 6359-6367 9 p.

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Stepwise structural and fluorescent colour conversion in rhodamine analogues based on light and acid stimulations

Tanioka, M., Kamino, S., Koga, N. & Sawada, D., 2020, In: Journal of Materials Chemistry C. 8, 2, p. 543-549 7 p.

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Synthesis of guggulsterone derivatives as potential anti-austerity agents against PANC-1 human pancreatic cancer cells

Kohyama, A., Yokoyama, R., Dibwe, D. F., El-Mekkawy, S., Meselhy, M. R., Awale, S. & Matsuya, Y., 2020/04/01, In: Bioorganic and Medicinal Chemistry Letters. 30, 7, 126964.

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

2019

2,2′-Biphenol/B(OH)₃ catalyst system for Nazarov cyclization

Sugimoto, K., Oshiro, M., Hada, R. & Matsuya, Y., 2019, In: Chemical and Pharmaceutical Bulletin. 67, 9, p. 1019-1022 4 p.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

Facile o-quinodimethane formation from benzocyclobutenes triggered by the Staudinger reaction at ambient temperature

Kohyama, A., Koresawa, E., Tsuge, K. & Matsuya, Y., 2019, In: Chemical Communications. 55, 44, p. 6205-6208 4 p.

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Microwave-Mediated Site-Selective Heating of Spherical-Carbon-Bead-Supported Platinum for the Continuous, Efficient Catalytic Dehydrogenative Aromatization of Saturated Cyclic Hydrocarbons

Ichikawa, T., Matsuo, T., Tachikawa, T., Yamada, T., Yoshimura, T., Yoshimura, M., Takagi, Y., Sawama, Y., Sugiyama, J. I., Monguchi, Y. & Sajiki, H., 2019/02/04, In: ACS Sustainable Chemistry and Engineering. 7, 3, p. 3052-3061 10 p.

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Synthetic studies on pyrroloindolizidine skeleton based on gold-catalyzed hydroamination-enamine cyclization-ring-closing metathesis strategy

Sugimoto, K., Matsuo, N., Tominaga, D. & Matsuya, Y., 2019, In: Heterocycles. 99, 2, p. 875-890 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2018

Direct Deuteration of Acrylic and Methacrylic Acid Derivatives Catalyzed by Platinum on Carbon in Deuterium Oxide

Park, K., Matsuda, T., Yamada, T., Monguchi, Y., Sawama, Y., Doi, N., Sasai, Y., Kondo, S. I., Sawama, Y. & Sajiki, H., 2018/06/15, In: Advanced Synthesis and Catalysis. 360, 12, p. 2303-2307 5 p.

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Free radical generation by non-equilibrium atmospheric pressure plasma in alcohol-water mixtures: An EPR-spin trapping study

Uchiyama, H., Ishikawa, K., Zhao, Q. L., Andocs, G., Nojima, N., Takeda, K., Krishna, M. C., Ishijima, T., Matsuya, Y., Hori, M., Noguchi, K. & Kondo, T., 2018/02/08, In: Journal of Physics D: Applied Physics. 51, 9, 095202.

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Organocatalytic Nitroaldol Reaction Associated with Deuterium-Labeling

Yamada, T., Kuwata, M., Takakura, R., Monguchi, Y., Sajiki, H. & Sawama, Y., 2018/02/15, In: Advanced Synthesis and Catalysis. 360, 4, p. 637-641 5 p.

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Stereoselective synthesis of a pivotal chiral intermediate for natural salicylic macrolides

Oguma, Y., Yamamoto, N., Sugimoto, K. & Matsuya, Y., 2018, In: Heterocycles. 97, 1, p. 283-291 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

Synthetic studies toward isoschizogamine: Construction of pentacyclic core structure

Sugimoto, K., Fujiwara, H., Takada, A., Kim, D. G., Ueda, H. & Tokuyama, H., 2018, In: Heterocycles. 97, 2, p. 1028-1049 22 p.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

2017

Synthetic study towards construction of potential scaffold of antitumor agents andrastins

Yin, S., Sugimoto, K., Nemoto, H. & Matsuya, Y., 2017, In: Heterocycles. 95, 1, p. 187-199 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

2016

An enantiocontrolled entry to the tricyclic polar segment of (+)-fusarisetin A

Kohyama, A., Kanoh, N., Kwon, E. & Iwabuchi, Y., 2016/02/03, In: Tetrahedron Letters. 57, 5, p. 517-519 3 p.

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

A novel method for determining peroxisomal fatty acid β-oxidation

Morita, M., Matsumoto, S., Okazaki, A., Tomita, K., Watanabe, S., Kawaguchi, K., Minato, D., Matsuya, Y., Shimozawa, N. & Imanaka, T., 2016/09/01, In: Journal of Inherited Metabolic Disease. 39, 5, p. 725-731 7 p.

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Construction of cis-fused hydrindane skeleton with a lactone tether utilizing intramolecular diels-Alder reaction

Yin, S., Takai, K., Minato, D., Sugimoto, K., Ohtsu, H., Tsuge, K. & Matsuya, Y., 2016, In: Heterocycles. 93, 2, p. 783-791 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

Highly Efficient Access to Both Geometric Isomers of Silyl Enol Ethers: Sequential 1,2-Brook/Wittig Reactions

Matsuya, Y., Wada, K., Minato, D. & Sugimoto, K., 2016/08/16, In: Angewandte Chemie - International Edition. 55, 34, p. 10079-10082 4 p.

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Mild and Direct Multiple Deuterium-Labeling of Saturated Fatty Acids

Yamada, T., Park, K., Yasukawa, N., Morita, K., Monguchi, Y., Sawama, Y. & Sajiki, H., 2016/10/20, In: Advanced Synthesis and Catalysis. 358, 20, p. 3277-3282 6 p.

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Synthesis of Substituted Quinolizidines via a Gold-Catalyzed Double Cyclization Cascade

Nonaka, S., Sugimoto, K., Ueda, H. & Tokuyama, H., 2016/02/04, In: Advanced Synthesis and Catalysis. 358, 3, p. 380-385 6 p.

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Synthetic and Medicinal Chemistry

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