Synthetic study towards construction of potential scaffold of antitumor agents andrastins

Shuqiang Yin; Kenji Sugimoto; Hideo Nemoto; Yuji Matsuya

doi:10.3987/COM-16-S(S)2

Synthetic study towards construction of potential scaffold of antitumor agents andrastins

Shuqiang Yin, Kenji Sugimoto, Hideo Nemoto, Yuji Matsuya^*

^*Corresponding author for this work

Synthetic and Medicinal Chemistry

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

For a construction of potential scaffold of antitumor agents andrastins, intramolecular Diels-Alder reaction of the triene composed of trans-fused AB ring with tethered D ring was examined. The reaction in refluxing toluene afforded a desired cis-fused hydrindane skeleton, the relative stereochemistries of which were unambiguously determined by X-ray crystallographic analysis.

Original language	English
Pages (from-to)	187-199
Number of pages	13
Journal	Heterocycles
Volume	95
Issue number	1
DOIs	https://doi.org/10.3987/COM-16-S(S)2
State	Published - 2017

ASJC Scopus subject areas

Analytical Chemistry
Pharmacology
Organic Chemistry

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10.3987/COM-16-S(S)2

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title = "Synthetic study towards construction of potential scaffold of antitumor agents andrastins",

abstract = "For a construction of potential scaffold of antitumor agents andrastins, intramolecular Diels-Alder reaction of the triene composed of trans-fused AB ring with tethered D ring was examined. The reaction in refluxing toluene afforded a desired cis-fused hydrindane skeleton, the relative stereochemistries of which were unambiguously determined by X-ray crystallographic analysis.",

author = "Shuqiang Yin and Kenji Sugimoto and Hideo Nemoto and Yuji Matsuya",

note = "Publisher Copyright: {\textcopyright}2017 The Japan Institute of Heterocyclic Chemistry.",

year = "2017",

doi = "10.3987/COM-16-S(S)2",

language = "英語",

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journal = "Heterocycles",

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publisher = "Japan Institute of Heterocyclic Chemistry",

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T1 - Synthetic study towards construction of potential scaffold of antitumor agents andrastins

AU - Yin, Shuqiang

AU - Sugimoto, Kenji

AU - Nemoto, Hideo

AU - Matsuya, Yuji

PY - 2017

Y1 - 2017

N2 - For a construction of potential scaffold of antitumor agents andrastins, intramolecular Diels-Alder reaction of the triene composed of trans-fused AB ring with tethered D ring was examined. The reaction in refluxing toluene afforded a desired cis-fused hydrindane skeleton, the relative stereochemistries of which were unambiguously determined by X-ray crystallographic analysis.

AB - For a construction of potential scaffold of antitumor agents andrastins, intramolecular Diels-Alder reaction of the triene composed of trans-fused AB ring with tethered D ring was examined. The reaction in refluxing toluene afforded a desired cis-fused hydrindane skeleton, the relative stereochemistries of which were unambiguously determined by X-ray crystallographic analysis.

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U2 - 10.3987/COM-16-S(S)2

DO - 10.3987/COM-16-S(S)2

M3 - 学術論文

AN - SCOPUS:85025709492

SN - 0385-5414

VL - 95

SP - 187

EP - 199

JO - Heterocycles

JF - Heterocycles

IS - 1

ER -

Synthetic study towards construction of potential scaffold of antitumor agents andrastins

Abstract

ASJC Scopus subject areas

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