Development of site- and stereoselective continuous flow deuterium labelling method for carbohydrates using high dispersion effect towards Ru/C of hydrogen flow

Naoya Sakurada; Daiki Sasaki; Manato Ono; Tsuyoshi Yamada; Takashi Ikawa; Hironao Sajiki

doi:10.1039/d5re00026b

Development of site- and stereoselective continuous flow deuterium labelling method for carbohydrates using high dispersion effect towards Ru/C of hydrogen flow

Naoya Sakurada, Daiki Sasaki, Manato Ono, Tsuyoshi Yamada, Takashi Ikawa^*, Hironao Sajiki^*

^*Corresponding author for this work

Synthetic and Medicinal Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

A site- and stereoselective deuterium labelling method for carbohydrates has been developed using a Ru/C catalyst under continuous flow conditions. It has been demonstrated that enhancing the void fraction of the catalyst cartridge leads to improved incorporation, while maintaining high selectivity over 150 h. This scalable, sustainable approach has the potential to reduce energy use, waste and Ru consumption, thus broadening continuous flow applications in organic synthesis.

Original language	English
Pages (from-to)	777-781
Number of pages	5
Journal	Reaction Chemistry and Engineering
Volume	10
Issue number	4
DOIs	https://doi.org/10.1039/d5re00026b
State	Published - 2025/03/11

ASJC Scopus subject areas

Catalysis
Chemistry (miscellaneous)
Chemical Engineering (miscellaneous)
Process Chemistry and Technology
Fluid Flow and Transfer Processes

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10.1039/d5re00026b

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abstract = "A site- and stereoselective deuterium labelling method for carbohydrates has been developed using a Ru/C catalyst under continuous flow conditions. It has been demonstrated that enhancing the void fraction of the catalyst cartridge leads to improved incorporation, while maintaining high selectivity over 150 h. This scalable, sustainable approach has the potential to reduce energy use, waste and Ru consumption, thus broadening continuous flow applications in organic synthesis.",

author = "Naoya Sakurada and Daiki Sasaki and Manato Ono and Tsuyoshi Yamada and Takashi Ikawa and Hironao Sajiki",

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AU - Sakurada, Naoya

AU - Sasaki, Daiki

AU - Ono, Manato

AU - Yamada, Tsuyoshi

AU - Ikawa, Takashi

AU - Sajiki, Hironao

PY - 2025/3/11

Y1 - 2025/3/11

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AB - A site- and stereoselective deuterium labelling method for carbohydrates has been developed using a Ru/C catalyst under continuous flow conditions. It has been demonstrated that enhancing the void fraction of the catalyst cartridge leads to improved incorporation, while maintaining high selectivity over 150 h. This scalable, sustainable approach has the potential to reduce energy use, waste and Ru consumption, thus broadening continuous flow applications in organic synthesis.

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M3 - 学術論文

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Development of site- and stereoselective continuous flow deuterium labelling method for carbohydrates using high dispersion effect towards Ru/C of hydrogen flow

Abstract

ASJC Scopus subject areas

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