First atroposelective Chan-Lam coupling for the synthesis of C-N linked biaryls

Moeka Ishida; Rina Adachi; Kazuki Kobayashi; Yukiko Yamamoto; Chinatsu Kawahara; Tsuyoshi Yamada; Hiroshi Aoyama; Kyohei Kanomata; Shuji Akai; Patrick Y.S. Lam; Hironao Sajiki; Takashi Ikawa

doi:10.1039/d3cc05447k

First atroposelective Chan-Lam coupling for the synthesis of C-N linked biaryls

Moeka Ishida, Rina Adachi, Kazuki Kobayashi, Yukiko Yamamoto, Chinatsu Kawahara, Tsuyoshi Yamada, Hiroshi Aoyama, Kyohei Kanomata, Shuji Akai, Patrick Y.S. Lam, Hironao Sajiki, Takashi Ikawa^*

^*Corresponding author for this work

Synthetic and Medicinal Chemistry

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

The first atroposelective Chan-Lam coupling for the synthesis of C-N axial enantiomers is reported with good yields and ee. MnO₂ additive is crucial for the success of the coupling. The longstanding problem of the lack of enantioselective synthesis to make chiral C-N linked atropisomers is solved.

Original language	English
Pages (from-to)	678-681
Number of pages	4
Journal	Chemical Communications
Volume	60
Issue number	6
DOIs	https://doi.org/10.1039/d3cc05447k
State	Published - 2023/12/19

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Catalysis
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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title = "First atroposelective Chan-Lam coupling for the synthesis of C-N linked biaryls",

abstract = "The first atroposelective Chan-Lam coupling for the synthesis of C-N axial enantiomers is reported with good yields and ee. MnO2 additive is crucial for the success of the coupling. The longstanding problem of the lack of enantioselective synthesis to make chiral C-N linked atropisomers is solved.",

author = "Moeka Ishida and Rina Adachi and Kazuki Kobayashi and Yukiko Yamamoto and Chinatsu Kawahara and Tsuyoshi Yamada and Hiroshi Aoyama and Kyohei Kanomata and Shuji Akai and Lam, {Patrick Y.S.} and Hironao Sajiki and Takashi Ikawa",

note = "Publisher Copyright: {\textcopyright} 2024 The Royal Society of Chemistry.",

year = "2023",

month = dec,

day = "19",

doi = "10.1039/d3cc05447k",

language = "英語",

volume = "60",

pages = "678--681",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

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TY - JOUR

T1 - First atroposelective Chan-Lam coupling for the synthesis of C-N linked biaryls

AU - Ishida, Moeka

AU - Adachi, Rina

AU - Kobayashi, Kazuki

AU - Yamamoto, Yukiko

AU - Kawahara, Chinatsu

AU - Yamada, Tsuyoshi

AU - Aoyama, Hiroshi

AU - Kanomata, Kyohei

AU - Akai, Shuji

AU - Lam, Patrick Y.S.

AU - Sajiki, Hironao

AU - Ikawa, Takashi

PY - 2023/12/19

Y1 - 2023/12/19

N2 - The first atroposelective Chan-Lam coupling for the synthesis of C-N axial enantiomers is reported with good yields and ee. MnO2 additive is crucial for the success of the coupling. The longstanding problem of the lack of enantioselective synthesis to make chiral C-N linked atropisomers is solved.

AB - The first atroposelective Chan-Lam coupling for the synthesis of C-N axial enantiomers is reported with good yields and ee. MnO2 additive is crucial for the success of the coupling. The longstanding problem of the lack of enantioselective synthesis to make chiral C-N linked atropisomers is solved.

UR - http://www.scopus.com/inward/record.url?scp=85181438469&partnerID=8YFLogxK

U2 - 10.1039/d3cc05447k

DO - 10.1039/d3cc05447k

M3 - 学術論文

C2 - 38165949

AN - SCOPUS:85181438469

SN - 1359-7345

VL - 60

SP - 678

EP - 681

JO - Chemical Communications

JF - Chemical Communications

IS - 6

ER -

First atroposelective Chan-Lam coupling for the synthesis of C-N linked biaryls

Abstract

ASJC Scopus subject areas

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